Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APLN
  • Mouse genes Apln
  • Rat genes Apln
  • Zfish genes apln
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apln

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031704	apelin receptor binding	APLN	IDA		Human	PMID:28137936
Molecular Function	GO:0031704	apelin receptor binding	Apln	IDA		Rat	PMID:11336787|RGD:1626239
Molecular Function	GO:0031704	apelin receptor binding	Apln	IDA		Rat	PMID:26611206|RGD:11534624
Molecular Function	GO:0031704	apelin receptor binding	apln	IDA		Zfish	PMID:30631305
Molecular Function	GO:0005179	hormone activity	APLN	IMP		Human	PMID:28137936
Molecular Function	GO:0042802	identical protein binding	Apln	IPI	RGD:620672	Rat	PMID:15486224|RGD:1576349
Cellular Component	GO:0005576	extracellular region	APLN	IDA		Human	PMID:28137936
Cellular Component	GO:0005615	extracellular space	Apln	IDA		Rat	PMID:16674982|RGD:1626173
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Apln	IDA		Rat	PMID:15166125|RGD:1626235
Biological Process	GO:0035479	angioblast cell migration from lateral mesoderm to midline	apln	IGI	ZFIN:ZDB-GENE-090313-116	Zfish	PMID:26017639
Biological Process	GO:0060183	apelin receptor signaling pathway	APLN	IDA		Human	PMID:11359874
Biological Process	GO:0060183	apelin receptor signaling pathway	APLN	IMP		Human	PMID:28137936
Biological Process	GO:0060183	apelin receptor signaling pathway	Apln	IDA		Mouse	MGI:MGI:5902690|PMID:11359874
Biological Process	GO:0060183	apelin receptor signaling pathway	Apln	IDA		Rat	PMID:11359874|RGD:12907555
Biological Process	GO:0042074	cell migration involved in gastrulation	apln	IDA		Zfish	PMID:24407481
Biological Process	GO:0090134	cell migration involved in mesendoderm migration	apln	IGI	ZFIN:ZDB-GENO-140611-4	Zfish	PMID:24407481
Biological Process	GO:0060976	coronary vasculature development	Apln	IMP		Mouse	MGI:MGI:5914956|PMID:28890073
Biological Process	GO:0061371	determination of heart left/right asymmetry	apln	IMP	ZFIN:ZDB-MRPHLNO-070522-5	Zfish	PMID:31223282
Biological Process	GO:0071910	determination of liver left/right asymmetry	apln	IMP	ZFIN:ZDB-MRPHLNO-070522-5	Zfish	PMID:31223282
Biological Process	GO:0042756	drinking behavior	Apln	IMP		Rat	PMID:10617103|RGD:632247
Biological Process	GO:0042756	drinking behavior	Apln	IMP		Rat	PMID:11359874|RGD:12907555
Biological Process	GO:0007631	feeding behavior	Apln	IMP		Rat	PMID:14642423|RGD:1626236
Biological Process	GO:0007507	heart development	apln	IMP	ZFIN:ZDB-MRPHLNO-070522-5	Zfish	PMID:17336905
Biological Process	GO:0007507	heart development	apln	IMP	ZFIN:ZDB-MRPHLNO-070522-6	Zfish	PMID:17336905
Biological Process	GO:0007507	heart development	apln	IMP		Zfish	PMID:17336906
Biological Process	GO:0007507	heart development	apln	IMP		Zfish	PMID:17336905
Biological Process	GO:0001945	lymph vessel development	apln	IMP	ZFIN:ZDB-MRPHLNO-070522-5	Zfish	PMID:24311379
Biological Process	GO:0001945	lymph vessel development	apln	IGI	ZFIN:ZDB-GENE-040303-4	Zfish	PMID:24311379
Biological Process	GO:0008078	mesodermal cell migration	apln	IMP		Zfish	PMID:17336906
Biological Process	GO:0008078	mesodermal cell migration	apln	IMP	ZFIN:ZDB-MRPHLNO-070522-5	Zfish	PMID:17336905
Biological Process	GO:0008078	mesodermal cell migration	apln	IMP		Zfish	PMID:17336905
Biological Process	GO:0045776	negative regulation of blood pressure	Apln	IMP		Rat	PMID:10617103|RGD:632247
Biological Process	GO:0045776	negative regulation of blood pressure	Apln	IMP		Rat	PMID:11359874|RGD:12907555
Biological Process	GO:0045776	negative regulation of blood pressure	Apln	IDA		Rat	PMID:15486224|RGD:1576349
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	APLN	IGI	RNAcentral:URS00000F0F49_9606,RNAcentral:URS00000F6E49_9606	Human	PMID:23263626
Biological Process	GO:0010629	negative regulation of gene expression	APLN	IGI	RNAcentral:URS00000F0F49_9606|RNAcentral:URS00000F6E49_9606	Human	PMID:23263626
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	Apln	IDA		Rat	PMID:12798955|RGD:1626237
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	APLN	IMP		Human	PMID:23263626
Biological Process	GO:0045906	negative regulation of vasoconstriction	Apln	IMP		Rat	PMID:17318790|RGD:1626185
Biological Process	GO:0008284	positive regulation of cell population proliferation	Apln	IMP		Rat	PMID:14670994|RGD:1304273
Biological Process	GO:0051461	positive regulation of corticotropin secretion	Apln	IMP		Rat	PMID:16896162|RGD:1626228
Biological Process	GO:0051466	positive regulation of corticotropin-releasing hormone secretion	Apln	IMP		Rat	PMID:15541902|RGD:1626234
Biological Process	GO:1904022	positive regulation of G protein-coupled receptor internalization	APLN	IDA		Human	PMID:11359874
Biological Process	GO:1904022	positive regulation of G protein-coupled receptor internalization	Apln	IDA		Mouse	MGI:MGI:5902690|PMID:11359874
Biological Process	GO:1904022	positive regulation of G protein-coupled receptor internalization	Apln	IDA		Rat	PMID:11359874|RGD:12907555
Biological Process	GO:0045823	positive regulation of heart contraction	Apln	IMP		Rat	PMID:26611206|RGD:11534624
Biological Process	GO:0010460	positive regulation of heart rate	Apln	IDA		Rat	PMID:12798955|RGD:1626237
Biological Process	GO:0031652	positive regulation of heat generation	Apln	IMP		Rat	PMID:15541902|RGD:1626234
Biological Process	GO:1902895	positive regulation of miRNA transcription	APLN	IDA		Human	PMID:23263626
Biological Process	GO:0042327	positive regulation of phosphorylation	Apln	IMP		Rat	PMID:16556853|RGD:1626230
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	APLN	IDA		Human	PMID:23263626
Biological Process	GO:0050878	regulation of body fluid levels	Apln	IMP		Rat	PMID:12787050|RGD:1304389
Biological Process	GO:0002026	regulation of the force of heart contraction	Apln	IMP		Rat	PMID:17055480|RGD:1626171
Biological Process	GO:0001666	response to hypoxia	apln	IDA		Zfish	PMID:18617693
Biological Process	GO:0002040	sprouting angiogenesis	apln	IGI	ZFIN:ZDB-GENO-151105-15	Zfish	PMID:32955436

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern