Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APLP2
  • Mouse genes Aplp2
  • Rat genes Aplp2
  • Zfish genes aplp2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aplp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	APLP2	IPI	UniProtKB:Q06481	Human	PMID:16193067
Molecular Function	GO:0005515	protein binding	APLP2	IPI	UniProtKB:P05067-4	Human	PMID:16193067
Molecular Function	GO:0005515	protein binding	APLP2	IPI	UniProtKB:P51693	Human	PMID:16193067
Molecular Function	GO:0005515	protein binding	APLP2	IPI	UniProtKB:O75618	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	APLP2	IPI	UniProtKB:P05412	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	APLP2	IPI	UniProtKB:P14921	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	APLP2	IPI	UniProtKB:P05412	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	APLP2	IPI	UniProtKB:Q93074	Human	PMID:21293490
Molecular Function	GO:0005515	protein binding	APLP2	IPI	UniProtKB:Q92870	Human	PMID:8855266
Molecular Function	GO:0005515	protein binding	Aplp2	IPI	UniProtKB:P12023	Mouse	MGI:MGI:4399021|PMID:16193067
Molecular Function	GO:0005515	protein binding	Aplp2	IPI	UniProtKB:P12023	Mouse	MGI:MGI:3829123|PMID:17934213
Molecular Function	GO:0005515	protein binding	Aplp2	IPI	PR:Q9QXJ1	Mouse	PMID:8894693
Molecular Function	GO:0005515	protein binding	Aplp2	IPI	PR:P70166	Mouse	PMID:16314516
Molecular Function	GO:0005515	protein binding	Aplp2	IPI	RGD:2122	Rat	PMID:9461550|RGD:634556
Molecular Function	GO:0005515	protein binding	Aplp2	IPI	RGD:620853	Rat	PMID:9461550|RGD:634556
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	APLP2	IDA		Human	PMID:25301953
Cellular Component	GO:0070062	extracellular exosome	APLP2	HDA		Human	PMID:19199708
Cellular Component	GO:0016020	membrane	APLP2	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	APLP2	IDA		Human	PMID:7702756
Cellular Component	GO:0097444	spine apparatus	Aplp2	IDA		Mouse	PMID:28450540
Cellular Component	GO:0097444	spine apparatus	Aplp2	IMP		Mouse	PMID:28450540
Biological Process	GO:0008203	cholesterol metabolic process	Aplp2	IGI	MGI:MGI:88059	Mouse	PMID:17920016
Biological Process	GO:0009790	embryo development	Aplp2	IGI	MGI:MGI:88059	Mouse	PMID:15689559
Biological Process	GO:0030198	extracellular matrix organization	Aplp2	IGI	MGI:MGI:88046,MGI:MGI:88059	Mouse	PMID:15385965
Biological Process	GO:0030900	forebrain development	Aplp2	IGI	MGI:MGI:88059	Mouse	PMID:15689559
Biological Process	GO:0030900	forebrain development	Aplp2	IGI	MGI:MGI:88046,MGI:MGI:88059	Mouse	PMID:15385965
Biological Process	GO:0006878	intracellular copper ion homeostasis	Aplp2	IMP	MGI:MGI:2137246	Mouse	PMID:10526140
Biological Process	GO:0007626	locomotory behavior	Aplp2	IGI	MGI:MGI:88059	Mouse	PMID:9461064
Biological Process	GO:0007617	mating behavior	Aplp2	IGI	MGI:MGI:88059	Mouse	PMID:9461064
Biological Process	GO:0030901	midbrain development	Aplp2	IGI	MGI:MGI:88059	Mouse	PMID:15689559
Biological Process	GO:0050885	neuromuscular process controlling balance	Aplp2	IGI	MGI:MGI:88059	Mouse	PMID:9461064
Biological Process	GO:0007176	regulation of epidermal growth factor-activated receptor activity	Aplp2	IGI	MGI:MGI:88059	Mouse	PMID:17556541
Biological Process	GO:0043393	regulation of protein binding	Aplp2	IGI	MGI:MGI:88059	Mouse	PMID:17920016
Biological Process	GO:0001967	suckling behavior	Aplp2	IGI	MGI:MGI:88059	Mouse	PMID:9461064

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern