Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APOA1
  • Mouse genes Apoa1
  • Rat genes Apoa1
  • Zfish genes apoa1a,apoa1b,apoa4b.1,apoa4b.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apoa1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	APOA1	IDA		Human	PMID:11297421
Molecular Function	GO:0001540	amyloid-beta binding	APOA1	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:9211985
Molecular Function	GO:0001540	amyloid-beta binding	Apoa1	IPI	UniProtKB:P05067:PRO_0000000093	Rat	PMID:9211985|RGD:12790643
Molecular Function	GO:0034191	apolipoprotein A-I receptor binding	APOA1	IPI	UniProtKB:O95477	Human	PMID:16443932
Molecular Function	GO:0034190	apolipoprotein receptor binding	APOA1	IPI	UniProtKB:O95477	Human	PMID:11162594
Molecular Function	GO:0045499	chemorepellent activity	APOA1	IDA		Human	PMID:23726972
Molecular Function	GO:0015485	cholesterol binding	APOA1	IDA		Human	PMID:15464323
Molecular Function	GO:0120020	cholesterol transfer activity	APOA1	IDA		Human	PMID:9651324
Molecular Function	GO:0120020	cholesterol transfer activity	APOA1	IMP		Human	PMID:15464323
Molecular Function	GO:0120020	cholesterol transfer activity	Apoa1	IDA		Mouse	PMID:15269218
Molecular Function	GO:0120020	cholesterol transfer activity	Apoa1	IDA		Rat	PMID:11773045|RGD:1298673
Molecular Function	GO:0120020	cholesterol transfer activity	Apoa1	IDA		Rat	PMID:1537840|RGD:1626399
Molecular Function	GO:0019899	enzyme binding	APOA1	IPI	UniProtKB:P04180	Human	PMID:1587806
Molecular Function	GO:0031072	heat shock protein binding	APOA1	IPI	UniProtKB:P10809	Human	PMID:11027668
Molecular Function	GO:0008035	high-density lipoprotein particle binding	Apoa1	IDA		Mouse	PMID:11744719
Molecular Function	GO:0008035	high-density lipoprotein particle binding	Apoa1	IDA		Mouse	PMID:14595002
Molecular Function	GO:0070653	high-density lipoprotein particle receptor binding	APOA1	IPI	UniProtKB:Q8WTV0	Human	PMID:10764676
Molecular Function	GO:0070653	high-density lipoprotein particle receptor binding	APOA1	IPI	UniProtKB:Q8WTV0	Human	PMID:12651854
Molecular Function	GO:0042802	identical protein binding	APOA1	IPI	UniProtKB:P02647	Human	PMID:17676061
Molecular Function	GO:0042802	identical protein binding	APOA1	IPI	UniProtKB:P02647	Human	PMID:18719128
Molecular Function	GO:0042802	identical protein binding	APOA1	IPI	UniProtKB:P02647	Human	PMID:20133843
Molecular Function	GO:0042802	identical protein binding	APOA1	IPI	UniProtKB:P02647	Human	PMID:20884842
Molecular Function	GO:0042802	identical protein binding	APOA1	IPI	UniProtKB:P02647	Human	PMID:22184756
Molecular Function	GO:0042802	identical protein binding	APOA1	IPI	UniProtKB:P02647	Human	PMID:22609356
Molecular Function	GO:0042802	identical protein binding	APOA1	IPI	UniProtKB:P02647	Human	PMID:24316228
Molecular Function	GO:0042802	identical protein binding	APOA1	IPI	UniProtKB:P02647	Human	PMID:24702826
Molecular Function	GO:0042802	identical protein binding	APOA1	IPI	UniProtKB:P02647	Human	PMID:8049247
Molecular Function	GO:0042802	identical protein binding	Apoa1	IPI	PR:Q00623	Mouse	PMID:8049247
Molecular Function	GO:0042802	identical protein binding	Apoa1	IPI	PR:Q00623	Mouse	PMID:11744719
Molecular Function	GO:0055102	lipase inhibitor activity	Apoa1	IDA		Rat	PMID:10419291|RGD:1626385
Molecular Function	GO:0008289	lipid binding	Apoa1	IDA		Mouse	PMID:8049247
Molecular Function	GO:0005319	lipid transporter activity	Apoa1	IDA		Mouse	PMID:11744719
Molecular Function	GO:0005319	lipid transporter activity	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:1496008
Molecular Function	GO:0071813	lipoprotein particle binding	Apoa1	IDA		Mouse	PMID:8049247
Molecular Function	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	APOA1	IDA		Human	PMID:4335615
Molecular Function	GO:0005543	phospholipid binding	APOA1	IDA		Human	PMID:12810715
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:P05067	Human	PMID:11297421
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:Q8NCW5	Human	PMID:11991719
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:O95477	Human	PMID:12084722
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:Q91V24	Human	PMID:12917409
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:P02652	Human	PMID:14967812
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:P04180	Human	PMID:1587806
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:P04180	Human	PMID:17676061
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:Q92597	Human	PMID:17786215
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:P00738	Human	PMID:19758344
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:Q1LVI2|UniProtKB:Q6DHK1|UniProtKB:Q8NCW5	Human	PMID:23719382
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:Q96DZ9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:Q96DZ9-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:Q07021	Human	PMID:28565870
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:P37840	Human	PMID:28887769
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:O95477	Human	PMID:30458687
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:P37840	Human	PMID:31270237
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:Q96DZ9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOA1	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Apoa1	IPI	UniProtKB:Q08460	Mouse	MGI:MGI:3852248|PMID:19423573
Molecular Function	GO:0005515	protein binding	Apoa1	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Apoa1	IPI	PR:P41233	Mouse	PMID:16204232
Molecular Function	GO:0005515	protein binding	Apoa1	IPI	UniProtKB:Q7TMA5	Rat	PMID:18391222|RGD:13432334
Molecular Function	GO:0005102	signaling receptor binding	APOA1	IPI	UniProtKB:Q9NZC2	Human	PMID:27477018
Cellular Component	GO:0072562	blood microparticle	APOA1	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	Apoa1	IDA		Rat	PMID:2493483|RGD:7495790
Cellular Component	GO:0062023	collagen-containing extracellular matrix	APOA1	HDA		Human	PMID:27559042
Cellular Component	GO:0031410	cytoplasmic vesicle	APOA1	IDA		Human	PMID:14703508
Cellular Component	GO:0034365	discoidal high-density lipoprotein particle	Apoa1	IDA		Rat	PMID:2493483|RGD:7495790
Cellular Component	GO:0030139	endocytic vesicle	APOA1	IDA		Human	PMID:14747463
Cellular Component	GO:0070062	extracellular exosome	APOA1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	APOA1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	APOA1	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	APOA1	HDA		Human	PMID:27068509
Cellular Component	GO:0005576	extracellular region	Apoa1	IDA		Mouse	PMID:15793583
Cellular Component	GO:0005576	extracellular region	apoa1a	IDA		Zfish	PMID:11748832
Cellular Component	GO:0005615	extracellular space	APOA1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	APOA1	IDA		Human	PMID:19433579
Cellular Component	GO:0005615	extracellular space	APOA1	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	APOA1	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:10357841
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:9186920
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:1596514
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:6403543
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:9275209
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:7751823
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:9507992
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:11744719
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:9300780
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:14595002
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:12859204
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Mouse	PMID:7798939
Cellular Component	GO:0005615	extracellular space	Apoa1	IDA		Rat	PMID:2579677|RGD:1599153
Cellular Component	GO:1903561	extracellular vesicle	APOA1	HDA		Human	PMID:24769233
Cellular Component	GO:0034364	high-density lipoprotein particle	APOA1	IDA		Human	PMID:15464323
Cellular Component	GO:0034364	high-density lipoprotein particle	APOA1	IDA		Human	PMID:210174
Cellular Component	GO:0034364	high-density lipoprotein particle	APOA1	IDA		Human	PMID:21571275
Cellular Component	GO:0034364	high-density lipoprotein particle	APOA1	IDA		Human	PMID:3104518
Cellular Component	GO:0034364	high-density lipoprotein particle	APOA1	IDA		Human	PMID:9211985
Cellular Component	GO:0034364	high-density lipoprotein particle	Apoa1	IDA		Rat	PMID:9211985|RGD:12790643
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	Apoa1	IDA		Rat	PMID:9211985|RGD:12790643
Cellular Component	GO:0034362	low-density lipoprotein particle	Apoa1	IDA		Rat	PMID:9211985|RGD:12790643
Cellular Component	GO:0005634	nucleus	Apoa1	IDA		Rat	PMID:9672881|RGD:1599151
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	APOA1	IDA		Human	PMID:16682745
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOA1	IDA		Human	PMID:17154273
Biological Process	GO:0030325	adrenal gland development	Apoa1	IMP	MGI:MGI:2180783	Mouse	PMID:8647961
Biological Process	GO:0031100	animal organ regeneration	Apoa1	IDA		Rat	PMID:2123716|RGD:1599161
Biological Process	GO:0043534	blood vessel endothelial cell migration	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:16339487
Biological Process	GO:0006695	cholesterol biosynthetic process	Apoa1	IMP	MGI:MGI:2180783	Mouse	PMID:8647961
Biological Process	GO:0033344	cholesterol efflux	APOA1	IDA		Human	PMID:11162594
Biological Process	GO:0033344	cholesterol efflux	APOA1	IMP		Human	PMID:12202492
Biological Process	GO:0033344	cholesterol efflux	APOA1	IDA		Human	PMID:14703508
Biological Process	GO:0033344	cholesterol efflux	APOA1	IDA		Human	PMID:15358760
Biological Process	GO:0033344	cholesterol efflux	APOA1	IDA		Human	PMID:16443932
Biological Process	GO:0033344	cholesterol efflux	APOA1	IDA		Human	PMID:21481393
Biological Process	GO:0033344	cholesterol efflux	Apoa1	IDA		Mouse	PMID:11744719
Biological Process	GO:0033344	cholesterol efflux	Apoa1	IDA		Mouse	PMID:15269218
Biological Process	GO:0033344	cholesterol efflux	Apoa1	IDA		Mouse	PMID:9186920
Biological Process	GO:0033344	cholesterol efflux	Apoa1	IDA		Mouse	PMID:12869555
Biological Process	GO:0033344	cholesterol efflux	Apoa1	IMP	MGI:MGI:2180783	Mouse	PMID:9275209
Biological Process	GO:0042632	cholesterol homeostasis	APOA1	IMP		Human	PMID:15464323
Biological Process	GO:0042632	cholesterol homeostasis	APOA1	IDA		Human	PMID:21571275
Biological Process	GO:0070508	cholesterol import	APOA1	IMP		Human	PMID:14718538
Biological Process	GO:0008203	cholesterol metabolic process	APOA1	IMP		Human	PMID:15464323
Biological Process	GO:0008203	cholesterol metabolic process	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:7751823
Biological Process	GO:0008203	cholesterol metabolic process	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:9795222
Biological Process	GO:0008203	cholesterol metabolic process	Apoa1	IGI	MGI:MGI:104663	Mouse	PMID:15995171
Biological Process	GO:0008203	cholesterol metabolic process	Apoa1	IGI	MGI:MGI:104993	Mouse	PMID:15995171
Biological Process	GO:0008203	cholesterol metabolic process	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:10357841
Biological Process	GO:0008203	cholesterol metabolic process	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:15466405
Biological Process	GO:0008203	cholesterol metabolic process	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:9327769
Biological Process	GO:0008203	cholesterol metabolic process	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:17071966
Biological Process	GO:0030301	cholesterol transport	APOA1	IDA		Human	PMID:10559507
Biological Process	GO:0030301	cholesterol transport	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:9684752
Biological Process	GO:0030301	cholesterol transport	Apoa1	IDA		Mouse	PMID:9300780
Biological Process	GO:0030301	cholesterol transport	Apoa1	IMP	MGI:MGI:2180783	Mouse	PMID:9507992
Biological Process	GO:0030301	cholesterol transport	Apoa1	IDA		Rat	PMID:11773045|RGD:1298673
Biological Process	GO:0030301	cholesterol transport	Apoa1	IDA		Rat	PMID:1537840|RGD:1626399
Biological Process	GO:0001935	endothelial cell proliferation	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:16339487
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	APOA1	IDA		Human	PMID:16443932
Biological Process	GO:0008211	glucocorticoid metabolic process	Apoa1	IMP	MGI:MGI:2180783	Mouse	PMID:8647961
Biological Process	GO:0034380	high-density lipoprotein particle assembly	APOA1	IDA		Human	PMID:190223
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	APOA1	IDA		Human	PMID:21481393
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	APOA1	IDA		Human	PMID:4335615
Biological Process	GO:0007229	integrin-mediated signaling pathway	APOA1	IDA		Human	PMID:23726972
Biological Process	GO:0019915	lipid storage	Apoa1	IMP	MGI:MGI:2180783	Mouse	PMID:8647961
Biological Process	GO:0042158	lipoprotein biosynthetic process	Apoa1	IGI	MGI:MGI:88057	Mouse	PMID:14595002
Biological Process	GO:0042158	lipoprotein biosynthetic process	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:16245952
Biological Process	GO:0050919	negative chemotaxis	APOA1	IDA		Human	PMID:23726972
Biological Process	GO:0060354	negative regulation of cell adhesion molecule production	APOA1	IDA		Human	PMID:21571275
Biological Process	GO:0002719	negative regulation of cytokine production involved in immune response	APOA1	IDA		Human	PMID:12458630
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	APOA1	IDA		Human	PMID:21571275
Biological Process	GO:0051346	negative regulation of hydrolase activity	Apoa1	IGI	MGI:MGI:104993	Mouse	PMID:15995171
Biological Process	GO:0050728	negative regulation of inflammatory response	APOA1	IDA		Human	PMID:21571275
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	APOA1	IDA		Human	PMID:12458630
Biological Process	GO:0060192	negative regulation of lipase activity	Apoa1	IDA		Rat	PMID:10419291|RGD:1626385
Biological Process	GO:0060761	negative regulation of response to cytokine stimulus	APOA1	IDA		Human	PMID:21571275
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	APOA1	IDA		Human	PMID:21571275
Biological Process	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	APOA1	IDA		Human	PMID:14967812
Biological Process	GO:0018206	peptidyl-methionine modification	APOA1	IDA		Human	PMID:12576517
Biological Process	GO:0014012	peripheral nervous system axon regeneration	Apoa1	IEP		Rat	PMID:2120218|RGD:2311210
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process	APOA1	IDA		Human	PMID:4335615
Biological Process	GO:0033700	phospholipid efflux	APOA1	IDA		Human	PMID:11162594
Biological Process	GO:0033700	phospholipid efflux	APOA1	IDA		Human	PMID:14703508
Biological Process	GO:0055091	phospholipid homeostasis	APOA1	IDA		Human	PMID:21571275
Biological Process	GO:0006644	phospholipid metabolic process	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:9795222
Biological Process	GO:0015914	phospholipid transport	Apoa1	IDA		Rat	PMID:11773045|RGD:1298673
Biological Process	GO:0010875	positive regulation of cholesterol efflux	APOA1	IDA		Human	PMID:27472885
Biological Process	GO:0090205	positive regulation of cholesterol metabolic process	APOA1	IDA		Human	PMID:4335615
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	APOA1	IDA		Human	PMID:4335615
Biological Process	GO:0051345	positive regulation of hydrolase activity	APOA1	IDA		Human	PMID:7638166
Biological Process	GO:0050766	positive regulation of phagocytosis	APOA1	IDA		Human	PMID:20495215
Biological Process	GO:1902995	positive regulation of phospholipid efflux	APOA1	IDA		Human	PMID:27472885
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	APOA1	IDA		Human	PMID:23726972
Biological Process	GO:0051496	positive regulation of stress fiber assembly	APOA1	IDA		Human	PMID:23726972
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	APOA1	IDA		Human	PMID:23726972
Biological Process	GO:0051347	positive regulation of transferase activity	Apoa1	IMP	MGI:MGI:1857127	Mouse	PMID:16245952
Biological Process	GO:0018158	protein oxidation	APOA1	IDA		Human	PMID:12576517
Biological Process	GO:0050821	protein stabilization	APOA1	IDA		Human	PMID:17655203
Biological Process	GO:0050821	protein stabilization	APOA1	IDA		Human	PMID:20495215
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	APOA1	IDA		Human	PMID:16443932
Biological Process	GO:0030300	regulation of intestinal cholesterol absorption	Apoa1	IDA		Mouse	PMID:10073953
Biological Process	GO:0001932	regulation of protein phosphorylation	Apoa1	IDA		Mouse	PMID:12869555
Biological Process	GO:0043627	response to estrogen	Apoa1	IEP		Rat	PMID:2504861|RGD:1599162
Biological Process	GO:0007584	response to nutrient	Apoa1	IEP		Rat	PMID:2504861|RGD:1599162
Biological Process	GO:0007584	response to nutrient	Apoa1	IEP		Rat	PMID:7556148|RGD:1599154
Biological Process	GO:0009410	response to xenobiotic stimulus	Apoa1	IEP		Rat	PMID:18519978|RGD:2325760
Biological Process	GO:0009410	response to xenobiotic stimulus	Apoa1	IEP		Rat	PMID:7556148|RGD:1599154
Biological Process	GO:0043691	reverse cholesterol transport	APOA1	IMP		Human	PMID:15464323
Biological Process	GO:0070328	triglyceride homeostasis	APOA1	IDA		Human	PMID:21571275
Biological Process	GO:0051180	vitamin transport	APOA1	IMP		Human	PMID:15140193

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern