Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APOA2
  • Mouse genes Apoa2
  • Rat genes Apoa2
  • Zfish genes afp4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apoa2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034190	apolipoprotein receptor binding	APOA2	IPI	UniProtKB:O95477	Human	PMID:11162594
Molecular Function	GO:0015485	cholesterol binding	APOA2	IDA		Human	PMID:218942
Molecular Function	GO:0120020	cholesterol transfer activity	APOA2	IDA		Human	PMID:9651324
Molecular Function	GO:0120020	cholesterol transfer activity	Apoa2	IDA		Rat	PMID:1537840|RGD:1626399
Molecular Function	GO:0019899	enzyme binding	APOA2	IPI	UniProtKB:P04180	Human	PMID:14967812
Molecular Function	GO:0019899	enzyme binding	APOA2	IPI	UniProtKB:P11150	Human	PMID:14967812
Molecular Function	GO:0031072	heat shock protein binding	APOA2	IPI	UniProtKB:P10809	Human	PMID:11027668
Molecular Function	GO:0008035	high-density lipoprotein particle binding	Apoa2	IMP	MGI:MGI:2157148	Mouse	PMID:14729860
Molecular Function	GO:0070653	high-density lipoprotein particle receptor binding	APOA2	IPI	UniProtKB:Q8WTV0	Human	PMID:10764676
Molecular Function	GO:0055102	lipase inhibitor activity	APOA2	IDA		Human	PMID:14967812
Molecular Function	GO:0008289	lipid binding	APOA2	IDA		Human	PMID:14967812
Molecular Function	GO:0005319	lipid transporter activity	APOA2	IDA		Human	PMID:1606170
Molecular Function	GO:0031210	phosphatidylcholine binding	APOA2	IDA		Human	PMID:17264082
Molecular Function	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	APOA2	IDA		Human	PMID:14967812
Molecular Function	GO:0005543	phospholipid binding	APOA2	IDA		Human	PMID:218942
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q8NCW5	Human	PMID:11991719
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:P02647	Human	PMID:14967812
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q92597	Human	PMID:17786215
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q8NEC5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q8NEC5	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:O00258	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:P15941-11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:P27105	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:P30825	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:P43628	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q13113	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q8NEC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q8WWF3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q96RD7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q9BQA9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q9H5X1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA2	IPI	UniProtKB:Q9NWC5	Human	PMID:32296183
Molecular Function	GO:0046982	protein heterodimerization activity	APOA2	IPI	UniProtKB:P05090	Human	PMID:7918467
Molecular Function	GO:0046982	protein heterodimerization activity	APOA2	IPI	UniProtKB:P02649	Human	PMID:8245722
Molecular Function	GO:0046982	protein heterodimerization activity	APOA2	IPI	UniProtKB:P04114	Human	PMID:8245722
Molecular Function	GO:0042803	protein homodimerization activity	APOA2	IDA		Human	PMID:17264082
Molecular Function	GO:0005102	signaling receptor binding	APOA2	IPI	UniProtKB:Q9NZC2	Human	PMID:27477018
Cellular Component	GO:0072562	blood microparticle	APOA2	HDA		Human	PMID:22516433
Cellular Component	GO:0042627	chylomicron	APOA2	IDA		Human	PMID:8245722
Cellular Component	GO:0070062	extracellular exosome	APOA2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	APOA2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	APOA2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	Apoa2	IDA		Mouse	PMID:6403543
Cellular Component	GO:0005615	extracellular space	Apoa2	IDA		Mouse	PMID:9186920
Cellular Component	GO:0005615	extracellular space	Apoa2	IDA		Mouse	PMID:1596514
Cellular Component	GO:0034364	high-density lipoprotein particle	APOA2	IDA		Human	PMID:17264082
Cellular Component	GO:0034364	high-density lipoprotein particle	APOA2	IDA		Human	PMID:210174
Cellular Component	GO:0034364	high-density lipoprotein particle	APOA2	IDA		Human	PMID:3104518
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	APOA2	IDA		Human	PMID:16682745
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOA2	IDA		Human	PMID:8245722
Biological Process	GO:0002526	acute inflammatory response	Apoa2	IEP		Rat	PMID:3108158|RGD:1599163
Biological Process	GO:0031100	animal organ regeneration	Apoa2	IDA		Rat	PMID:2123716|RGD:1599161
Biological Process	GO:0033344	cholesterol efflux	APOA2	IDA		Human	PMID:11162594
Biological Process	GO:0042632	cholesterol homeostasis	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0042632	cholesterol homeostasis	Apoa2	IMP	MGI:MGI:2157148	Mouse	PMID:10357838
Biological Process	GO:0042632	cholesterol homeostasis	Apoa2	IGI	MGI:MGI:96216	Mouse	PMID:10357838
Biological Process	GO:0042632	cholesterol homeostasis	Apoa2	IDA		Mouse	PMID:8422330
Biological Process	GO:0008203	cholesterol metabolic process	Apoa2	IMP	MGI:MGI:2157148	Mouse	PMID:8647961
Biological Process	GO:0008203	cholesterol metabolic process	Apoa2	IMP	MGI:MGI:2157148	Mouse	PMID:10357838
Biological Process	GO:0008203	cholesterol metabolic process	Apoa2	IGI	MGI:MGI:96216	Mouse	PMID:10357838
Biological Process	GO:0030301	cholesterol transport	Apoa2	IDA		Rat	PMID:1537840|RGD:1626399
Biological Process	GO:0046340	diacylglycerol catabolic process	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0060030	dorsal convergence	afp4	IMP	ZFIN:ZDB-MRPHLNO-141016-3	Zfish	PMID:25013380
Biological Process	GO:0090504	epiboly	afp4	IMP	ZFIN:ZDB-MRPHLNO-141016-2	Zfish	PMID:25013380
Biological Process	GO:0034380	high-density lipoprotein particle assembly	APOA2	IDA		Human	PMID:218942
Biological Process	GO:0034384	high-density lipoprotein particle clearance	APOA2	IDA		Human	PMID:10764676
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	APOA2	IDA		Human	PMID:8106353
Biological Process	GO:0006869	lipid transport	Apoa2	IMP	MGI:MGI:2157148	Mouse	PMID:14729860
Biological Process	GO:0042157	lipoprotein metabolic process	Apoa2	IDA		Mouse	PMID:7837794
Biological Process	GO:0042157	lipoprotein metabolic process	Apoa2	IDA		Mouse	PMID:9150245
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	APOA2	IDA		Human	PMID:8106353
Biological Process	GO:0060621	negative regulation of cholesterol import	APOA2	IDA		Human	PMID:10764676
Biological Process	GO:0032375	negative regulation of cholesterol transport	APOA2	IMP		Human	PMID:8636092
Biological Process	GO:0060695	negative regulation of cholesterol transporter activity	APOA2	IDA		Human	PMID:8106353
Biological Process	GO:0002719	negative regulation of cytokine production involved in immune response	APOA2	IDA		Human	PMID:12458630
Biological Process	GO:0060192	negative regulation of lipase activity	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0060192	negative regulation of lipase activity	Apoa2	IMP	MGI:MGI:2157148	Mouse	PMID:10357838
Biological Process	GO:0050995	negative regulation of lipid catabolic process	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0018206	peptidyl-methionine modification	APOA2	IDA		Human	PMID:12576517
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0009395	phospholipid catabolic process	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0033700	phospholipid efflux	APOA2	IDA		Human	PMID:11162594
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0032757	positive regulation of interleukin-8 production	APOA2	IDA		Human	PMID:11591715
Biological Process	GO:0050996	positive regulation of lipid catabolic process	APOA2	IDA		Human	PMID:8640403
Biological Process	GO:0050766	positive regulation of phagocytosis	APOA2	IDA		Human	PMID:20495215
Biological Process	GO:0018158	protein oxidation	APOA2	IDA		Human	PMID:12576517
Biological Process	GO:0050821	protein stabilization	APOA2	IDA		Human	PMID:20495215
Biological Process	GO:0030300	regulation of intestinal cholesterol absorption	Apoa2	IMP	MGI:MGI:2157148	Mouse	PMID:8962133
Biological Process	GO:0031647	regulation of protein stability	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0043627	response to estrogen	Apoa2	IEP		Rat	PMID:2504861|RGD:1599162
Biological Process	GO:0051384	response to glucocorticoid	Apoa2	IEP		Rat	PMID:1903065|RGD:1599160
Biological Process	GO:0009749	response to glucose	APOA2	IDA		Human	PMID:14988251
Biological Process	GO:0009410	response to xenobiotic stimulus	Apoa2	IEP		Rat	PMID:1547188|RGD:1599159
Biological Process	GO:0043691	reverse cholesterol transport	APOA2	IDA		Human	PMID:14967812
Biological Process	GO:0034370	triglyceride-rich lipoprotein particle remodeling	APOA2	IDA		Human	PMID:14967812

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern