Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APOA4
  • Mouse genes Apoa4
  • Rat genes Apoa4
  • Zfish genes apoa4a,apoa4b.1,apoa4b.2,apoa4b.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apoa4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016209	antioxidant activity	APOA4	IDA		Human	PMID:16945374
Molecular Function	GO:0120020	cholesterol transfer activity	APOA4	IDA		Human	PMID:1935934
Molecular Function	GO:0005507	copper ion binding	APOA4	IDA		Human	PMID:16945374
Molecular Function	GO:0042802	identical protein binding	APOA4	IPI	UniProtKB:P06727	Human	PMID:22579246
Molecular Function	GO:0008289	lipid binding	APOA4	IMP		Human	PMID:16159879
Molecular Function	GO:0031210	phosphatidylcholine binding	APOA4	IDA		Human	PMID:11940599
Molecular Function	GO:0031210	phosphatidylcholine binding	APOA4	IDA		Human	PMID:1935934
Molecular Function	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	APOA4	IDA		Human	PMID:1935934
Molecular Function	GO:0005515	protein binding	APOA4	IPI	UniProtKB:P20393	Human	PMID:24311788
Molecular Function	GO:0005515	protein binding	APOA4	IPI	UniProtKB:P43360	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA4	IPI	UniProtKB:Q6RW13-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA4	IPI	UniProtKB:Q8IZR5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA4	IPI	UniProtKB:Q96DZ9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOA4	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOA4	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Molecular Function	GO:0042803	protein homodimerization activity	APOA4	IDA		Human	PMID:1935934
Cellular Component	GO:0072562	blood microparticle	APOA4	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	APOA4	IDA		Human	PMID:1935934
Cellular Component	GO:0042627	chylomicron	APOA4	IDA		Human	PMID:3095477
Cellular Component	GO:0042627	chylomicron	Apoa4	IDA		Rat	PMID:6591177|RGD:634658
Cellular Component	GO:0062023	collagen-containing extracellular matrix	APOA4	HDA		Human	PMID:27559042
Cellular Component	GO:0070062	extracellular exosome	APOA4	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	APOA4	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	APOA4	IDA		Human	PMID:1935934
Cellular Component	GO:0005615	extracellular space	APOA4	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	Apoa4	IDA		Mouse	PMID:9186920
Cellular Component	GO:0005615	extracellular space	Apoa4	IDA		Mouse	PMID:9300780
Cellular Component	GO:0005615	extracellular space	Apoa4	IDA		Mouse	PMID:7798939
Cellular Component	GO:0034364	high-density lipoprotein particle	APOA4	IDA		Human	PMID:3095477
Cellular Component	GO:0045202	synapse	Apoa4	EXP		Rat	PMID:15169875|RGD:13702216
Cellular Component	GO:0045202	synapse	Apoa4	IDA		Rat	PMID:15169875|RGD:13702216
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOA4	IDA		Human	PMID:17154273
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOA4	IDA		Human	PMID:3095477
Biological Process	GO:0033344	cholesterol efflux	APOA4	IDA		Human	PMID:11162594
Biological Process	GO:0033344	cholesterol efflux	APOA4	IDA		Human	PMID:1935934
Biological Process	GO:0042632	cholesterol homeostasis	APOA4	IDA		Human	PMID:1935934
Biological Process	GO:0008203	cholesterol metabolic process	APOA4	IDA		Human	PMID:1935934
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	APOA4	IDA		Human	PMID:1935934
Biological Process	GO:0042744	hydrogen peroxide catabolic process	APOA4	IDA		Human	PMID:16945374
Biological Process	GO:0002227	innate immune response in mucosa	APOA4	IDA		Human	PMID:15254593
Biological Process	GO:0002227	innate immune response in mucosa	Apoa4	IMP		Mouse	MGI:MGI:3046601|PMID:15254593
Biological Process	GO:0007159	leukocyte cell-cell adhesion	APOA4	IDA		Human	PMID:15254593
Biological Process	GO:0016042	lipid catabolic process	APOA4	IDA		Human	PMID:3095477
Biological Process	GO:0055088	lipid homeostasis	APOA4	IDA		Human	PMID:3095477
Biological Process	GO:0006869	lipid transport	APOA4	IDA		Human	PMID:1935934
Biological Process	GO:0006869	lipid transport	APOA4	IDA		Human	PMID:3095477
Biological Process	GO:0034445	negative regulation of plasma lipoprotein oxidation	APOA4	IDA		Human	PMID:16945374
Biological Process	GO:0014012	peripheral nervous system axon regeneration	Apoa4	IEP		Rat	PMID:2120218|RGD:2311210
Biological Process	GO:0046470	phosphatidylcholine metabolic process	APOA4	IDA		Human	PMID:1935934
Biological Process	GO:0033700	phospholipid efflux	APOA4	IDA		Human	PMID:11162594
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	APOA4	IDA		Human	PMID:1935934
Biological Process	GO:0045723	positive regulation of fatty acid biosynthetic process	APOA4	IDA		Human	PMID:2307668
Biological Process	GO:0051006	positive regulation of lipoprotein lipase activity	APOA4	IDA		Human	PMID:2307668
Biological Process	GO:0010898	positive regulation of triglyceride catabolic process	APOA4	IDA		Human	PMID:2307668
Biological Process	GO:0065005	protein-lipid complex assembly	APOA4	IMP		Human	PMID:16159879
Biological Process	GO:0032374	regulation of cholesterol transport	APOA4	IDA		Human	PMID:11940599
Biological Process	GO:0030300	regulation of intestinal cholesterol absorption	Apoa4	IMP	MGI:MGI:2157162	Mouse	PMID:9323588
Biological Process	GO:0019430	removal of superoxide radicals	APOA4	IDA		Human	PMID:16945374
Biological Process	GO:0006982	response to lipid hydroperoxide	APOA4	IDA		Human	PMID:16945374
Biological Process	GO:0035634	response to stilbenoid	Apoa4	IEP		Mouse	MGI:MGI:4943399|PMID:17086191
Biological Process	GO:0034014	response to triglyceride	Apoa4	IEP		Rat	PMID:21472381|RGD:5685689
Biological Process	GO:0043691	reverse cholesterol transport	APOA4	IDA		Human	PMID:3095477
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling	APOA4	IDA		Human	PMID:2307668

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern