Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Apob

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes APOB
- Mouse genes Apob
- Rat genes Apob
- Zfish genes apoba,apobb.1,apobb.2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apob

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0120020	cholesterol transfer activity	APOB	IMP		Human	PMID:15797858
Molecular Function	GO:0008201	heparin binding	APOB	IDA		Human	PMID:16233946
Molecular Function	GO:0035473	lipase binding	APOB	IPI	UniProtKB:P07867	Human	PMID:9685400
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	APOB	IMP		Human	PMID:15797858
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	APOB	IMP		Human	PMID:2563166
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	APOB	IPI	UniProtKB:Q9NZC2	Human	PMID:27477018
Molecular Function	GO:0005543	phospholipid binding	APOB	IDA		Human	PMID:7126555
Molecular Function	GO:0005515	protein binding	APOB	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:16203724
Molecular Function	GO:0005515	protein binding	APOB	IPI	UniProtKB:P29991:PRO_0000037946	Human	PMID:21911577
Molecular Function	GO:0005515	protein binding	APOB	IPI	UniProtKB:Q8NBP7	Human	PMID:22580899
Molecular Function	GO:0005515	protein binding	APOB	IPI	UniProtKB:P01130	Human	PMID:24447298
Molecular Function	GO:0005515	protein binding	APOB	IPI	UniProtKB:P55157	Human	PMID:25108285
Molecular Function	GO:0005515	protein binding	APOB	IPI	UniProtKB:P55157	Human	PMID:26224785
Molecular Function	GO:0005515	protein binding	APOB	IPI	UniProtKB:Q5JRA6	Human	PMID:27138255
Molecular Function	GO:0005515	protein binding	APOB	IPI	UniProtKB:Q96PC5-7	Human	PMID:27138255
Molecular Function	GO:0005515	protein binding	APOB	IPI	UniProtKB:P55157	Human	PMID:27487388
Molecular Function	GO:0005515	protein binding	APOB	IPI	UniProtKB:P02652	Human	PMID:8245722
Molecular Function	GO:0005515	protein binding	Apob	IPI	RGD:1308388	Rat	PMID:11830580\|RGD:1582567
Molecular Function	GO:0005515	protein binding	Apob	IPI	UniProtKB:P04639	Rat	PMID:18391222\|RGD:13432334
Cellular Component	GO:0042627	chylomicron	APOB	IDA		Human	PMID:4363408
Cellular Component	GO:0042627	chylomicron	APOB	IDA		Human	PMID:8245722
Cellular Component	GO:0005737	cytoplasm	APOB	IDA		Human	PMID:22580899
Cellular Component	GO:0005829	cytosol	APOB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	Apob	IDA		Mouse	PMID:12072432
Cellular Component	GO:0070971	endoplasmic reticulum exit site	APOB	IDA		Human	PMID:27138255
Cellular Component	GO:0070062	extracellular exosome	APOB	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	APOB	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	Apob	IDA		Rat	PMID:16227197\|RGD:1599170
Cellular Component	GO:0034364	high-density lipoprotein particle	Apob	IDA		Rat	PMID:12091487\|RGD:1626402
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	APOB	IDA		Human	PMID:1917954
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	APOB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Apob	IDA		Rat	PMID:12091487\|RGD:1626402
Cellular Component	GO:0034362	low-density lipoprotein particle	APOB	IDA		Human	PMID:4363408
Cellular Component	GO:0034362	low-density lipoprotein particle	Apob	IDA		Rat	PMID:2429674\|RGD:11353963
Cellular Component	GO:0034359	mature chylomicron	APOB	IDA		Human	PMID:4363408
Cellular Component	GO:0043025	neuronal cell body	APOB	IDA		Human	PMID:22897442
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOB	IDA		Human	PMID:15308631
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOB	IDA		Human	PMID:4363408
Cellular Component	GO:0034361	very-low-density lipoprotein particle	Apob	IDA		Rat	PMID:12091487\|RGD:1626402
Cellular Component	GO:0034361	very-low-density lipoprotein particle	Apob	IDA		Rat	PMID:17500069\|RGD:2325767
Cellular Component	GO:0031983	vesicle lumen	Apob	IDA		Rat	PMID:12091487\|RGD:1626402
Cellular Component	GO:0012506	vesicle membrane	Apob	IDA		Rat	PMID:12091487\|RGD:1626402
Biological Process	GO:0048844	artery morphogenesis	Apob	IGI	MGI:MGI:88057	Mouse	PMID:16230502
Biological Process	GO:0071379	cellular response to prostaglandin stimulus	Apob	IEP		Rat	PMID:16545597\|RGD:2325771
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Apob	IEP		Rat	PMID:17405916\|RGD:2325768
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	apobb.1	IDA		Zfish	PMID:18618001
Biological Process	GO:0033344	cholesterol efflux	Apob	IGI	MGI:MGI:104539	Mouse	PMID:22363685
Biological Process	GO:0042632	cholesterol homeostasis	APOB	IMP		Human	PMID:2563166
Biological Process	GO:0042632	cholesterol homeostasis	Apob	IGI	MGI:MGI:88057	Mouse	PMID:11120757
Biological Process	GO:0042632	cholesterol homeostasis	Apob	IGI	MGI:MGI:96765	Mouse	PMID:11120757
Biological Process	GO:0042632	cholesterol homeostasis	Apob	IMP	MGI:MGI:3665449	Mouse	PMID:8921909
Biological Process	GO:0042632	cholesterol homeostasis	Apob	IMP	MGI:MGI:1857625	Mouse	PMID:7878058
Biological Process	GO:0042632	cholesterol homeostasis	Apob	IMP	MGI:MGI:1857304	Mouse	PMID:9202070
Biological Process	GO:0042632	cholesterol homeostasis	Apob	IMP	MGI:MGI:1857304	Mouse	PMID:9502790
Biological Process	GO:0042632	cholesterol homeostasis	Apob	IMP	MGI:MGI:1857303	Mouse	PMID:9202070
Biological Process	GO:0042632	cholesterol homeostasis	Apob	IGI	MGI:MGI:88057	Mouse	PMID:16230502
Biological Process	GO:0042632	cholesterol homeostasis	Apob	IMP	MGI:MGI:2157108	Mouse	PMID:9852051
Biological Process	GO:0008203	cholesterol metabolic process	APOB	IMP		Human	PMID:2563166
Biological Process	GO:0030301	cholesterol transport	APOB	IMP		Human	PMID:2563166
Biological Process	GO:0030301	cholesterol transport	Apob	IMP	MGI:MGI:2157090	Mouse	PMID:7593600
Biological Process	GO:0051649	establishment of localization in cell	Apob	IGI	MGI:MGI:103298	Mouse	PMID:13130124
Biological Process	GO:0009566	fertilization	Apob	IMP	MGI:MGI:2157090	Mouse	PMID:8855280
Biological Process	GO:0030317	flagellated sperm motility	Apob	IMP	MGI:MGI:2157090	Mouse	PMID:8855280
Biological Process	GO:0001701	in utero embryonic development	Apob	IMP	MGI:MGI:1857625	Mouse	PMID:7878058
Biological Process	GO:0001701	in utero embryonic development	Apob	IMP	MGI:MGI:2157775	Mouse	PMID:9502790
Biological Process	GO:0016042	lipid catabolic process	Apob	IMP	MGI:MGI:2183298	Mouse	PMID:16455790
Biological Process	GO:0006629	lipid metabolic process	Apob	IDA		Mouse	PMID:12072432
Biological Process	GO:0006629	lipid metabolic process	Apob	IGI	MGI:MGI:96765	Mouse	PMID:11120757
Biological Process	GO:0006629	lipid metabolic process	Apob	IGI	MGI:MGI:88057	Mouse	PMID:11120757
Biological Process	GO:0006629	lipid metabolic process	Apob	IMP	MGI:MGI:1857141	Mouse	PMID:8460149
Biological Process	GO:0006629	lipid metabolic process	Apob	IMP	MGI:MGI:2183298	Mouse	PMID:15790761
Biological Process	GO:0006629	lipid metabolic process	Apob	IDA		Rat	PMID:9931432\|RGD:1626403
Biological Process	GO:0042158	lipoprotein biosynthetic process	Apob	IGI	MGI:MGI:103298	Mouse	PMID:13130124
Biological Process	GO:0042159	lipoprotein catabolic process	Apob	IGI	MGI:MGI:107202	Mouse	PMID:15863839
Biological Process	GO:0042157	lipoprotein metabolic process	Apob	IGI	MGI:MGI:88057	Mouse	PMID:11120757
Biological Process	GO:0042157	lipoprotein metabolic process	Apob	IGI	MGI:MGI:96765	Mouse	PMID:13130124
Biological Process	GO:0042157	lipoprotein metabolic process	Apob	IMP	MGI:MGI:2157108	Mouse	PMID:9852051
Biological Process	GO:0042157	lipoprotein metabolic process	Apob	IMP	MGI:MGI:3665449	Mouse	PMID:10705993
Biological Process	GO:0042157	lipoprotein metabolic process	Apob	IMP	MGI:MGI:1857303	Mouse	PMID:10713055
Biological Process	GO:0042157	lipoprotein metabolic process	Apob	IMP	MGI:MGI:1857625	Mouse	PMID:7878058
Biological Process	GO:0042157	lipoprotein metabolic process	Apob	IGI	MGI:MGI:88057	Mouse	PMID:13130124
Biological Process	GO:0042157	lipoprotein metabolic process	Apob	IGI	MGI:MGI:96765	Mouse	PMID:11120757
Biological Process	GO:0042953	lipoprotein transport	Apob	IGI	MGI:MGI:103298	Mouse	PMID:13130124
Biological Process	GO:0042953	lipoprotein transport	Apob	IMP	MGI:MGI:2183298	Mouse	PMID:13130124
Biological Process	GO:0034383	low-density lipoprotein particle clearance	APOB	IMP		Human	PMID:15797858
Biological Process	GO:0034383	low-density lipoprotein particle clearance	APOB	IMP		Human	PMID:2563166
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	APOB	IMP		Human	PMID:15797858
Biological Process	GO:0007399	nervous system development	Apob	IMP	MGI:MGI:3665449	Mouse	PMID:8921909
Biological Process	GO:0007399	nervous system development	Apob	IMP	MGI:MGI:2157775	Mouse	PMID:9502790
Biological Process	GO:0007399	nervous system development	Apob	IMP	MGI:MGI:1857625	Mouse	PMID:7878058
Biological Process	GO:0010886	positive regulation of cholesterol storage	APOB	IDA		Human	PMID:19114110
Biological Process	GO:0010628	positive regulation of gene expression	Apob	IMP		Mouse	PMID:22897442
Biological Process	GO:0010884	positive regulation of lipid storage	APOB	IDA		Human	PMID:18322245
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	APOB	IDA		Human	PMID:17244792
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	APOB	IDA		Human	PMID:18322245
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	APOB	IDA		Human	PMID:19114110
Biological Process	GO:0009791	post-embryonic development	Apob	IMP	MGI:MGI:2157108	Mouse	PMID:9852051
Biological Process	GO:0045540	regulation of cholesterol biosynthetic process	Apob	IMP	MGI:MGI:2183298	Mouse	PMID:16455790
Biological Process	GO:0009743	response to carbohydrate	Apob	IDA		Rat	PMID:16672736\|RGD:1599166
Biological Process	GO:0032355	response to estradiol	Apob	IEP		Rat	PMID:9402089\|RGD:11353967
Biological Process	GO:0032496	response to lipopolysaccharide	Apob	IEP		Rat	PMID:16719989\|RGD:1599165
Biological Process	GO:0010033	response to organic substance	Apob	IEP		Rat	PMID:15066220\|RGD:2325765
Biological Process	GO:0010033	response to organic substance	Apob	IEP		Rat	PMID:16227197\|RGD:1599170
Biological Process	GO:0010033	response to organic substance	Apob	IEP		Rat	PMID:17203948\|RGD:2325770
Biological Process	GO:0010269	response to selenium ion	Apob	IEP		Rat	PMID:16581047\|RGD:1599167
Biological Process	GO:0009615	response to virus	APOB	IEP		Human	PMID:16548883
Biological Process	GO:0007283	spermatogenesis	Apob	IMP	MGI:MGI:2157090	Mouse	PMID:8855280
Biological Process	GO:0019433	triglyceride catabolic process	Apob	IMP	MGI:MGI:2183298	Mouse	PMID:16455790
Biological Process	GO:0019433	triglyceride catabolic process	Apob	IMP		Rat	PMID:9290048\|RGD:1626404
Biological Process	GO:0006642	triglyceride mobilization	Apob	IMP	MGI:MGI:2183298	Mouse	PMID:10893242

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.