Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APOC3
  • Mouse genes Apoc3
  • Rat genes Apoc3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apoc3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030234	enzyme regulator activity	APOC3	IDA		Human	PMID:11060345
Molecular Function	GO:0070653	high-density lipoprotein particle receptor binding	APOC3	IPI	UniProtKB:Q61009	Human	PMID:9254056
Molecular Function	GO:0055102	lipase inhibitor activity	APOC3	IDA		Human	PMID:15576844
Molecular Function	GO:0055102	lipase inhibitor activity	APOC3	IDA		Human	PMID:182536
Molecular Function	GO:0055102	lipase inhibitor activity	APOC3	IDA		Human	PMID:18635818
Molecular Function	GO:0055102	lipase inhibitor activity	APOC3	IDA		Human	PMID:3973011
Molecular Function	GO:0005543	phospholipid binding	APOC3	IDA		Human	PMID:11060345
Molecular Function	GO:0005543	phospholipid binding	APOC3	IDA		Human	PMID:4066713
Molecular Function	GO:0005515	protein binding	APOC3	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOC3	IPI	UniProtKB:Q8TED1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APOC3	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Cellular Component	GO:0042627	chylomicron	APOC3	IDA		Human	PMID:8245722
Cellular Component	GO:0062023	collagen-containing extracellular matrix	APOC3	HDA		Human	PMID:27068509
Cellular Component	GO:0062023	collagen-containing extracellular matrix	APOC3	HDA		Human	PMID:27559042
Cellular Component	GO:0070062	extracellular exosome	APOC3	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	APOC3	IDA		Human	PMID:11060345
Cellular Component	GO:0005615	extracellular space	Apoc3	IDA		Rat	PMID:21183731|RGD:7207206
Cellular Component	GO:0005615	extracellular space	Apoc3	IDA		Rat	PMID:6419747|RGD:1599195
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	APOC3	IDA		Human	PMID:17336988
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	APOC3	IDA		Human	PMID:17438339
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOC3	IDA		Human	PMID:16935699
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOC3	IDA		Human	PMID:17154273
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOC3	IDA		Human	PMID:3973011
Biological Process	GO:0071333	cellular response to glucose stimulus	Apoc3	IDA		Rat	PMID:21183731|RGD:7207206
Biological Process	GO:0033344	cholesterol efflux	APOC3	IDA		Human	PMID:11162594
Biological Process	GO:0033344	cholesterol efflux	APOC3	IDA		Human	PMID:16443932
Biological Process	GO:0042632	cholesterol homeostasis	APOC3	IMP		Human	PMID:18767813
Biological Process	GO:0008203	cholesterol metabolic process	Apoc3	IMP	MGI:MGI:1857128	Mouse	PMID:8089130
Biological Process	GO:0008203	cholesterol metabolic process	Apoc3	IMP	MGI:MGI:1857128	Mouse	PMID:11590213
Biological Process	GO:0008203	cholesterol metabolic process	Apoc3	IMP	MGI:MGI:3758464	Mouse	PMID:8864964
Biological Process	GO:0034382	chylomicron remnant clearance	APOC3	IDA		Human	PMID:4020294
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	APOC3	IDA		Human	PMID:16443932
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	APOC3	IMP		Human	PMID:17438339
Biological Process	GO:0006954	inflammatory response	Apoc3	IEP		Rat	PMID:8491512|RGD:1599189
Biological Process	GO:0042953	lipoprotein transport	Apoc3	IDA		Rat	PMID:4020294|RGD:1599181
Biological Process	GO:0060621	negative regulation of cholesterol import	APOC3	IMP		Human	PMID:15778093
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	APOC3	IDA		Human	PMID:11060345
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	APOC3	IDA		Human	PMID:18635818
Biological Process	GO:0010987	negative regulation of high-density lipoprotein particle clearance	APOC3	IMP		Human	PMID:15778093
Biological Process	GO:0050995	negative regulation of lipid catabolic process	APOC3	IDA		Human	PMID:15576844
Biological Process	GO:0045833	negative regulation of lipid metabolic process	APOC3	IDA		Human	PMID:182536
Biological Process	GO:0051005	negative regulation of lipoprotein lipase activity	APOC3	IDA		Human	PMID:11060345
Biological Process	GO:0051005	negative regulation of lipoprotein lipase activity	APOC3	IDA		Human	PMID:18635818
Biological Process	GO:0051005	negative regulation of lipoprotein lipase activity	APOC3	IDA		Human	PMID:3973011
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	APOC3	IMP		Human	PMID:15778093
Biological Process	GO:0090324	negative regulation of oxidative phosphorylation	Apoc3	IDA		Rat	PMID:11177239|RGD:1599177
Biological Process	GO:0048261	negative regulation of receptor-mediated endocytosis	APOC3	IDA		Human	PMID:1917954
Biological Process	GO:0010897	negative regulation of triglyceride catabolic process	APOC3	IDA		Human	PMID:18635818
Biological Process	GO:0010897	negative regulation of triglyceride catabolic process	APOC3	IDA		Human	PMID:3973011
Biological Process	GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	APOC3	IDA		Human	PMID:1917954
Biological Process	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	APOC3	IDA		Human	PMID:3973011
Biological Process	GO:0033700	phospholipid efflux	APOC3	IDA		Human	PMID:11162594
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	Apoc3	IMP		Rat	PMID:23542898|RGD:10054091
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	APOC3	IDA		Human	PMID:16443932
Biological Process	GO:0070542	response to fatty acid	Apoc3	IEP		Rat	PMID:20938723|RGD:10054090
Biological Process	GO:0007584	response to nutrient	Apoc3	IEP		Rat	PMID:7811230|RGD:1599187
Biological Process	GO:0043434	response to peptide hormone	Apoc3	IDA		Rat	PMID:8429259|RGD:1599190
Biological Process	GO:0034014	response to triglyceride	Apoc3	IEP		Rat	PMID:6698975|RGD:10054046
Biological Process	GO:0033189	response to vitamin A	Apoc3	IEP		Rat	PMID:7811230|RGD:1599187
Biological Process	GO:0009410	response to xenobiotic stimulus	Apoc3	IEP		Rat	PMID:10386582|RGD:10054089
Biological Process	GO:0009410	response to xenobiotic stimulus	Apoc3	IEP		Rat	PMID:9888873|RGD:1599178
Biological Process	GO:0019433	triglyceride catabolic process	APOC3	IDA		Human	PMID:11060345
Biological Process	GO:0019433	triglyceride catabolic process	Apoc3	IMP	MGI:MGI:1857128	Mouse	PMID:11590213
Biological Process	GO:0070328	triglyceride homeostasis	APOC3	IMP		Human	PMID:18767813
Biological Process	GO:0006641	triglyceride metabolic process	APOC3	IMP		Human	PMID:17142127
Biological Process	GO:0006641	triglyceride metabolic process	Apoc3	IMP	MGI:MGI:1857128	Mouse	PMID:8089130
Biological Process	GO:0006641	triglyceride metabolic process	Apoc3	IMP	MGI:MGI:1857128	Mouse	PMID:11590213
Biological Process	GO:0006642	triglyceride mobilization	Apoc3	IMP	MGI:MGI:3758464	Mouse	PMID:8864964
Biological Process	GO:0006642	triglyceride mobilization	Apoc3	IMP	MGI:MGI:1857128	Mouse	PMID:11551841

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern