Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APOE
  • Mouse genes Apoe
  • Rat genes Apoe
  • Zfish genes apoea,apoeb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apoe

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	APOE	IDA		Human	PMID:11305869
Molecular Function	GO:0001540	amyloid-beta binding	APOE	IPI	UniProtKB:P05067:PRO_0000000092|UniProtKB:P05067:PRO_0000000093	Human	PMID:22138302
Molecular Function	GO:0001540	amyloid-beta binding	APOE	IDA		Human	PMID:25207746
Molecular Function	GO:0001540	amyloid-beta binding	APOE	IDA		Human	PMID:8089103
Molecular Function	GO:0001540	amyloid-beta binding	APOE	IPI	CHEBI:64645	Human	PMID:9003062
Molecular Function	GO:0001540	amyloid-beta binding	APOE	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:9211985
Molecular Function	GO:0001540	amyloid-beta binding	Apoe	IDA		Rat	PMID:22138302|RGD:6903908
Molecular Function	GO:0016209	antioxidant activity	APOE	IDA		Human	PMID:9685360
Molecular Function	GO:0120020	cholesterol transfer activity	Apoe	IDA		Mouse	PMID:15269218
Molecular Function	GO:0019899	enzyme binding	APOE	IPI	UniProtKB:P04180	Human	PMID:15654758
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	APOE	IDA		Human	PMID:23676495
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	APOE	IDA		Human	PMID:9488694
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	Apoe	IDA		Mouse	MGI:MGI:5514108|PMID:23676495
Molecular Function	GO:0008201	heparin binding	APOE	IDA		Human	PMID:2745454
Molecular Function	GO:0008201	heparin binding	APOE	IDA		Human	PMID:7635945
Molecular Function	GO:0046848	hydroxyapatite binding	Apoe	IDA		Rat	PMID:21839718|RGD:6903929
Molecular Function	GO:0042802	identical protein binding	APOE	IDA		Human	PMID:4066713
Molecular Function	GO:0042802	identical protein binding	APOE	IDA		Human	PMID:8340399
Molecular Function	GO:0008289	lipid binding	APOE	IDA		Human	PMID:4066713
Molecular Function	GO:0005319	lipid transporter activity	APOE	IDA		Human	PMID:17305370
Molecular Function	GO:0005319	lipid transporter activity	Apoe	IDA		Rat	PMID:12482838|RGD:634663
Molecular Function	GO:0005319	lipid transporter activity	Apoe	IDA		Rat	PMID:2492020|RGD:1626397
Molecular Function	GO:0071813	lipoprotein particle binding	Apoe	IDA		Mouse	PMID:11553788
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	APOE	IDA		Human	PMID:1530612
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	APOE	IPI	UniProtKB:Q92673	Human	PMID:17326667
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	APOE	IDA		Human	PMID:210175
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	APOE	IDA		Human	PMID:7635945
Molecular Function	GO:0046911	metal chelating activity	APOE	IDA		Human	PMID:9685360
Molecular Function	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	APOE	IDA		Human	PMID:15654758
Molecular Function	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	Apoe	IMP		Mouse	MGI:MGI:3850619|PMID:15654758
Molecular Function	GO:0005543	phospholipid binding	APOE	IDA		Human	PMID:4066713
Molecular Function	GO:0005543	phospholipid binding	Apoe	IDA		Rat	PMID:2492020|RGD:1626397
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q14114	Human	PMID:12950167
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:O95477	Human	PMID:14754908
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q07954	Human	PMID:15182176
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:15615705
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:17116874
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P00738	Human	PMID:19758344
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P01130	Human	PMID:20030366
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q07954	Human	PMID:20030366
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P50502	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q16543	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q53EL6	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9BQ95	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:O75069	Human	PMID:21593558
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:22528093
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P01130	Human	PMID:24447298
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P27958:PRO_0000037569	Human	PMID:25122793
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:25122793
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P27958:PRO_0000037572	Human	PMID:25122793
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:25122793
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P40967	Human	PMID:26387950
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P08603	Human	PMID:26468283
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P37840	Human	PMID:26921451
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P37840	Human	PMID:28887769
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9UBD9	Human	PMID:29507344
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9NZC2	Human	PMID:30341064
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q92673	Human	PMID:30448281
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P37840	Human	PMID:31270237
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:O75409	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P02795	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P09382	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P10636-6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P11137-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P17028	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P26441	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P52756	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q06481-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q13829	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q14114-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q3SYB3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q6PID6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q6ZNA4-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q8IUW3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q8IUW6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q8IY40	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q8TBC4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q8WTV0-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9BYZ2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9H6J7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9H816	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9HBG4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9NS23-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9NUB4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9NYH9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9UIJ7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9Y3D2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:Q9Y6C2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P10636	Human	PMID:7972031
Molecular Function	GO:0005515	protein binding	APOE	IPI	UniProtKB:P02652	Human	PMID:8245722
Molecular Function	GO:0005515	protein binding	Apoe	IPI	UniProtKB:Q9QZM3	Mouse	MGI:MGI:6162766|PMID:29507344
Molecular Function	GO:0005515	protein binding	Apoe	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0046983	protein dimerization activity	APOE	IPI	UniProtKB:P02649	Human	PMID:22138302
Molecular Function	GO:0042803	protein homodimerization activity	APOE	IDA		Human	PMID:8089103
Molecular Function	GO:0042803	protein homodimerization activity	APOE	IPI	UniProtKB:P02649	Human	PMID:8245722
Molecular Function	GO:0042803	protein homodimerization activity	APOE	IDA		Human	PMID:9211985
Molecular Function	GO:0044877	protein-containing complex binding	APOE	IDA		Human	PMID:25207746
Molecular Function	GO:0005102	signaling receptor binding	APOE	IPI	UniProtKB:Q9NZC2	Human	PMID:27477018
Molecular Function	GO:0005102	signaling receptor binding	Apoe	IPI	UniProtKB:Q9QYP1	Rat	PMID:17889837|RGD:8553452
Molecular Function	GO:0048156	tau protein binding	APOE	IPI	UniProtKB:P10636	Human	PMID:7566652
Molecular Function	GO:0070326	very-low-density lipoprotein particle receptor binding	APOE	IPI	UniProtKB:Q14114	Human	PMID:12950167
Molecular Function	GO:0070326	very-low-density lipoprotein particle receptor binding	APOE	IDA		Human	PMID:1384047
Cellular Component	GO:0072562	blood microparticle	APOE	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	Apoe	IDA		Rat	PMID:2493483|RGD:7495790
Cellular Component	GO:0042627	chylomicron	APOE	IDA		Human	PMID:16935699
Cellular Component	GO:0042627	chylomicron	APOE	IDA		Human	PMID:8245722
Cellular Component	GO:0042627	chylomicron	Apoe	IDA		Rat	PMID:6631239|RGD:12904654
Cellular Component	GO:0062023	collagen-containing extracellular matrix	APOE	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	APOE	HDA		Human	PMID:27559042
Cellular Component	GO:0005737	cytoplasm	Apoe	IDA		Rat	PMID:7616121|RGD:1599197
Cellular Component	GO:0005737	cytoplasm	Apoe	IDA		Rat	PMID:8875469|RGD:1626380
Cellular Component	GO:0030425	dendrite	Apoe	IDA		Rat	PMID:8875469|RGD:1626380
Cellular Component	GO:0034365	discoidal high-density lipoprotein particle	Apoe	IDA		Rat	PMID:2493483|RGD:7495790
Cellular Component	GO:0005769	early endosome	Apoe	IDA		Rat	PMID:19809892|RGD:2317724
Cellular Component	GO:0005783	endoplasmic reticulum	APOE	IDA		Human	PMID:25122793
Cellular Component	GO:0005783	endoplasmic reticulum	Apoe	IDA		Rat	PMID:2493483|RGD:7495790
Cellular Component	GO:0005768	endosome	Apoe	IDA		Rat	PMID:2493483|RGD:7495790
Cellular Component	GO:0070062	extracellular exosome	APOE	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	APOE	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	APOE	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	APOE	IDA		Human	PMID:26387950
Cellular Component	GO:0031012	extracellular matrix	APOE	IDA		Human	PMID:9488694
Cellular Component	GO:0005576	extracellular region	APOE	IDA		Human	PMID:16805831
Cellular Component	GO:0005576	extracellular region	APOE	HDA		Human	PMID:27068509
Cellular Component	GO:0005576	extracellular region	APOE	IDA		Human	PMID:8089103
Cellular Component	GO:0005615	extracellular space	APOE	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	APOE	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	APOE	IDA		Human	PMID:8340399
Cellular Component	GO:0005615	extracellular space	Apoe	IDA		Mouse	MGI:MGI:5527477|PMID:23640054
Cellular Component	GO:0005615	extracellular space	Apoe	IDA		Mouse	MGI:MGI:4415751|PMID:20005821
Cellular Component	GO:0005615	extracellular space	Apoe	IDA		Mouse	PMID:15269218
Cellular Component	GO:0005615	extracellular space	Apoe	IDA		Mouse	PMID:9300780
Cellular Component	GO:0005615	extracellular space	Apoe	IDA		Mouse	PMID:9186920
Cellular Component	GO:0005615	extracellular space	Apoe	IDA		Mouse	PMID:7798939
Cellular Component	GO:0005615	extracellular space	Apoe	IDA		Rat	PMID:16947119|RGD:1599198
Cellular Component	GO:1903561	extracellular vesicle	APOE	HDA		Human	PMID:24769233
Cellular Component	GO:0031232	extrinsic component of external side of plasma membrane	Apoe	IDA		Rat	PMID:7616121|RGD:1599197
Cellular Component	GO:0098978	glutamatergic synapse	APOE	IDA		Human	PMID:22637583
Cellular Component	GO:0098978	glutamatergic synapse	Apoe	IMP		Mouse	PMID:27683909
Cellular Component	GO:0098978	glutamatergic synapse	Apoe	IDA		Mouse	PMID:27683909
Cellular Component	GO:0005794	Golgi apparatus	APOE	IDA		Human	PMID:25122793
Cellular Component	GO:0005794	Golgi apparatus	Apoe	IDA		Rat	PMID:11839466|RGD:1599196
Cellular Component	GO:0005794	Golgi apparatus	Apoe	IDA		Rat	PMID:7806565|RGD:1626382
Cellular Component	GO:0034364	high-density lipoprotein particle	APOE	IDA		Human	PMID:14754908
Cellular Component	GO:0034364	high-density lipoprotein particle	APOE	IDA		Human	PMID:210174
Cellular Component	GO:0034364	high-density lipoprotein particle	APOE	IDA		Human	PMID:22138302
Cellular Component	GO:0034364	high-density lipoprotein particle	APOE	IDA		Human	PMID:2280190
Cellular Component	GO:0034364	high-density lipoprotein particle	APOE	IDA		Human	PMID:8071364
Cellular Component	GO:0034364	high-density lipoprotein particle	APOE	IDA		Human	PMID:9211985
Cellular Component	GO:0034364	high-density lipoprotein particle	Apoe	IDA		Rat	PMID:1906919|RGD:12880364
Cellular Component	GO:0034364	high-density lipoprotein particle	Apoe	IDA		Rat	PMID:9211985|RGD:12790643
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	APOE	IDA		Human	PMID:17336988
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	APOE	IDA		Human	PMID:22138302
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	APOE	IDA		Human	PMID:2280190
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	APOE	IDA		Human	PMID:9211985
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	Apoe	IDA		Rat	PMID:9211985|RGD:12790643
Cellular Component	GO:0005770	late endosome	Apoe	IDA		Rat	PMID:7806565|RGD:1626382
Cellular Component	GO:1990777	lipoprotein particle	APOE	IDA		Human	PMID:22138302
Cellular Component	GO:0034362	low-density lipoprotein particle	APOE	IDA		Human	PMID:22138302
Cellular Component	GO:0034362	low-density lipoprotein particle	APOE	IDA		Human	PMID:2280190
Cellular Component	GO:0034362	low-density lipoprotein particle	APOE	IDA		Human	PMID:8245722
Cellular Component	GO:0034362	low-density lipoprotein particle	APOE	IDA		Human	PMID:9211985
Cellular Component	GO:0034362	low-density lipoprotein particle	Apoe	IDA		Mouse	MGI:MGI:3850619|PMID:15654758
Cellular Component	GO:0034362	low-density lipoprotein particle	Apoe	IDA		Rat	PMID:7119568|RGD:12904664
Cellular Component	GO:0034362	low-density lipoprotein particle	Apoe	IDA		Rat	PMID:9211985|RGD:12790643
Cellular Component	GO:0005764	lysosome	Apoe	IDA		Rat	PMID:2493483|RGD:7495790
Cellular Component	GO:0042470	melanosome	APOE	IDA		Human	PMID:26387950
Cellular Component	GO:0016020	membrane	APOE	HDA		Human	PMID:19946888
Cellular Component	GO:0005874	microtubule	Apoe	IDA		Rat	PMID:19809892|RGD:2317724
Cellular Component	GO:0097487	multivesicular body, internal vesicle	APOE	IDA		Human	PMID:26387950
Cellular Component	GO:0043025	neuronal cell body	Apoe	IDA		Rat	PMID:8875469|RGD:1626380
Cellular Component	GO:0005635	nuclear envelope	Apoe	IDA		Rat	PMID:2493483|RGD:7495790
Cellular Component	GO:0005634	nucleus	APOE	HDA		Human	PMID:21630459
Cellular Component	GO:0005886	plasma membrane	Apoe	IDA		Rat	PMID:21169230|RGD:6904144
Cellular Component	GO:0045202	synapse	Apoe	IDA		Rat	PMID:28620701|RGD:13703133
Cellular Component	GO:0043083	synaptic cleft	APOE	IDA		Human	PMID:22637583
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOE	IDA		Human	PMID:17154273
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOE	IDA		Human	PMID:22138302
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOE	IDA		Human	PMID:2280190
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOE	IDA		Human	PMID:8071364
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOE	IDA		Human	PMID:8245722
Cellular Component	GO:0034361	very-low-density lipoprotein particle	APOE	IDA		Human	PMID:9211985
Cellular Component	GO:0034361	very-low-density lipoprotein particle	Apoe	IDA		Rat	PMID:9211985|RGD:12790643
Biological Process	GO:0007568	aging	Apoe	IDA		Rat	PMID:19809892|RGD:2317724
Biological Process	GO:0097113	AMPA glutamate receptor clustering	APOE	IDA		Human	PMID:24328732
Biological Process	GO:0042982	amyloid precursor protein metabolic process	APOE	IDA		Human	PMID:21593558
Biological Process	GO:0048844	artery morphogenesis	Apoe	IGI	MGI:MGI:88052	Mouse	PMID:16230502
Biological Process	GO:0071397	cellular response to cholesterol	Apoe	IEP		Rat	PMID:21169230|RGD:6904144
Biological Process	GO:0071361	cellular response to ethanol	Apoe	IEP		Rat	PMID:17478430|RGD:12904650
Biological Process	GO:0071363	cellular response to growth factor stimulus	Apoe	IEP		Rat	PMID:19713443|RGD:2317725
Biological Process	GO:0071363	cellular response to growth factor stimulus	Apoe	IEP		Rat	PMID:20535563|RGD:6904215
Biological Process	GO:0071347	cellular response to interleukin-1	Apoe	IEP		Rat	PMID:22171672|RGD:6903907
Biological Process	GO:0019934	cGMP-mediated signaling	APOE	IDA		Human	PMID:8995232
Biological Process	GO:0006707	cholesterol catabolic process	Apoe	IMP		Mouse	PMID:9826706
Biological Process	GO:0033344	cholesterol efflux	APOE	IDA		Human	PMID:11162594
Biological Process	GO:0033344	cholesterol efflux	APOE	IDA		Human	PMID:16443932
Biological Process	GO:0033344	cholesterol efflux	APOE	IDA		Human	PMID:23620513
Biological Process	GO:0033344	cholesterol efflux	Apoe	IDA		Mouse	PMID:15269218
Biological Process	GO:0033344	cholesterol efflux	Apoe	IMP	MGI:MGI:2137814	Mouse	PMID:11551841
Biological Process	GO:0042632	cholesterol homeostasis	APOE	IGI	UniProtKB:P01130	Human	PMID:24412220
Biological Process	GO:0042632	cholesterol homeostasis	APOE	IDA		Human	PMID:9649566
Biological Process	GO:0042632	cholesterol homeostasis	Apoe	IMP		Mouse	MGI:MGI:5517507|PMID:23741427
Biological Process	GO:0042632	cholesterol homeostasis	Apoe	IGI	MGI:MGI:88052	Mouse	PMID:11120757
Biological Process	GO:0042632	cholesterol homeostasis	Apoe	IMP	MGI:MGI:2137814	Mouse	PMID:1423598
Biological Process	GO:0042632	cholesterol homeostasis	Apoe	IGI	MGI:MGI:88052	Mouse	PMID:16230502
Biological Process	GO:0042632	cholesterol homeostasis	Apoe	IMP	MGI:MGI:1857129	Mouse	PMID:7798939
Biological Process	GO:0008203	cholesterol metabolic process	APOE	IMP		Human	PMID:3771793
Biological Process	GO:0008203	cholesterol metabolic process	APOE	IDA		Human	PMID:9649566
Biological Process	GO:0008203	cholesterol metabolic process	Apoe	IMP	MGI:MGI:2137814	Mouse	PMID:1423598
Biological Process	GO:0008203	cholesterol metabolic process	Apoe	IMP	MGI:MGI:2137814	Mouse	PMID:8647961
Biological Process	GO:0034382	chylomicron remnant clearance	APOE	IDA		Human	PMID:1911868
Biological Process	GO:0034382	chylomicron remnant clearance	APOE	IMP		Human	PMID:7175379
Biological Process	GO:0072359	circulatory system development	Apoe	IMP		Mouse	PMID:19816508
Biological Process	GO:0055089	fatty acid homeostasis	APOE	IDA		Human	PMID:24345162
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	APOE	IDA		Human	PMID:16443932
Biological Process	GO:0010467	gene expression	Apoe	IGI	MGI:MGI:88057	Mouse	PMID:26397958
Biological Process	GO:0034380	high-density lipoprotein particle assembly	APOE	IDA		Human	PMID:14754908
Biological Process	GO:0034380	high-density lipoprotein particle assembly	APOE	IDA		Human	PMID:17305370
Biological Process	GO:0034384	high-density lipoprotein particle clearance	APOE	IDA		Human	PMID:210175
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	APOE	IGI	UniProtKB:P08226	Human	PMID:12401887
Biological Process	GO:0071831	intermediate-density lipoprotein particle clearance	APOE	IDA		Human	PMID:1917954
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Apoe	IDA		Mouse	PMID:8185566
Biological Process	GO:0055088	lipid homeostasis	Apoe	IMP	MGI:MGI:1857303	Mouse	PMID:17720994
Biological Process	GO:0006629	lipid metabolic process	Apoe	IGI	MGI:MGI:88052	Mouse	PMID:11120757
Biological Process	GO:0006869	lipid transport	Apoe	IDA		Rat	PMID:12482838|RGD:634663
Biological Process	GO:0006869	lipid transport	Apoe	IDA		Rat	PMID:2492020|RGD:1626397
Biological Process	GO:0010877	lipid transport involved in lipid storage	Apoe	IMP		Mouse	MGI:MGI:5517507|PMID:23741427
Biological Process	GO:0042158	lipoprotein biosynthetic process	APOE	IDA		Human	PMID:23620513
Biological Process	GO:0042158	lipoprotein biosynthetic process	Apoe	IGI	MGI:MGI:88049	Mouse	PMID:14595002
Biological Process	GO:0042159	lipoprotein catabolic process	Apoe	IMP	MGI:MGI:1857303	Mouse	PMID:17720994
Biological Process	GO:0042157	lipoprotein metabolic process	Apoe	IGI	MGI:MGI:88052	Mouse	PMID:11120757
Biological Process	GO:0042157	lipoprotein metabolic process	Apoe	IMP	MGI:MGI:1857129	Mouse	PMID:9788969
Biological Process	GO:0042157	lipoprotein metabolic process	Apoe	IGI	MGI:MGI:88052	Mouse	PMID:13130124
Biological Process	GO:0042157	lipoprotein metabolic process	Apoe	IDA		Rat	PMID:2492020|RGD:1626397
Biological Process	GO:0035641	locomotory exploration behavior	APOE	IMP		Human	PMID:24412220
Biological Process	GO:0015909	long-chain fatty acid transport	APOE	IDA		Human	PMID:24345162
Biological Process	GO:0007616	long-term memory	APOE	IGI	UniProtKB:P01130|UniProtKB:P35951	Human	PMID:24412220
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	Apoe	IMP		Mouse	MGI:MGI:3850619|PMID:15654758
Biological Process	GO:0051651	maintenance of location in cell	Apoe	IMP	MGI:MGI:1857303	Mouse	PMID:17720994
Biological Process	GO:0032438	melanosome organization	APOE	IMP		Human	PMID:26387950
Biological Process	GO:0032438	melanosome organization	Apoe	IMP		Mouse	MGI:MGI:6830356|PMID:26387950
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	Apoe	IMP		Mouse	MGI:MGI:3621689|PMID:14741101
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	APOE	IDA		Human	PMID:24154541
Biological Process	GO:0030195	negative regulation of blood coagulation	APOE	IDA		Human	PMID:8995232
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	APOE	IDA		Human	PMID:9685360
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	APOE	IDA		Human	PMID:16805831
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	APOE	IGI	UniProtKB:O00755	Human	PMID:16805831
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	APOE	IGI	UniProtKB:O00755|UniProtKB:O00755,UniProtKB:O54908|UniProtKB:O00755,UniProtKB:O75197|UniProtKB:O00755,UniProtKB:O75581	Human	PMID:16805831
Biological Process	GO:0045541	negative regulation of cholesterol biosynthetic process	APOE	IDA		Human	PMID:1917954
Biological Process	GO:0045541	negative regulation of cholesterol biosynthetic process	Apoe	IDA		Rat	PMID:9225228|RGD:10059686
Biological Process	GO:0010596	negative regulation of endothelial cell migration	APOE	IMP		Human	PMID:23142051
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	APOE	IDA		Human	PMID:9685360
Biological Process	GO:0010629	negative regulation of gene expression	Apoe	IMP		Mouse	MGI:MGI:6148510|PMID:18377911
Biological Process	GO:0050728	negative regulation of inflammatory response	Apoe	IGI	UniProtKB:P22893	Mouse	MGI:MGI:5301204|PMID:21784977
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	APOE	IDA		Human	PMID:16273551
Biological Process	GO:0043407	negative regulation of MAP kinase activity	APOE	IDA		Human	PMID:9685360
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Apoe	IDA		Rat	PMID:17314289|RGD:1625020
Biological Process	GO:0010977	negative regulation of neuron projection development	APOE	IDA		Human	PMID:7592957
Biological Process	GO:0010544	negative regulation of platelet activation	APOE	IDA		Human	PMID:8995232
Biological Process	GO:0051248	negative regulation of protein metabolic process	APOE	IGI	UniProtKB:O00755	Human	PMID:16805831
Biological Process	GO:0050709	negative regulation of protein secretion	APOE	IMP		Human	PMID:27044754
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Apoe	IGI	UniProtKB:P21274	Mouse	MGI:MGI:3795340|PMID:18382765
Biological Process	GO:0090209	negative regulation of triglyceride metabolic process	Apoe	IGI	MGI:MGI:103298	Mouse	PMID:9240444
Biological Process	GO:0031175	neuron projection development	APOE	IDA		Human	PMID:8939961
Biological Process	GO:0007263	nitric oxide mediated signal transduction	APOE	IDA		Human	PMID:8995232
Biological Process	GO:0097114	NMDA glutamate receptor clustering	APOE	IDA		Human	PMID:24328732
Biological Process	GO:0048709	oligodendrocyte differentiation	Apoe	IEP		Rat	PMID:21972082|RGD:6903911
Biological Process	GO:0014012	peripheral nervous system axon regeneration	Apoe	IEP		Rat	PMID:2120218|RGD:2311210
Biological Process	GO:0033700	phospholipid efflux	APOE	IDA		Human	PMID:11162594
Biological Process	GO:0044794	positive regulation by host of viral process	APOE	IMP		Human	PMID:25122793
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	Apoe	IMP		Mouse	MGI:MGI:3621689|PMID:14741101
Biological Process	GO:0045773	positive regulation of axon extension	Apoe	IDA		Rat	PMID:21040802|RGD:6904146
Biological Process	GO:0010875	positive regulation of cholesterol efflux	APOE	IDA		Human	PMID:12042316
Biological Process	GO:0010875	positive regulation of cholesterol efflux	APOE	IGI	UniProtKB:P08226	Human	PMID:12401887
Biological Process	GO:0010875	positive regulation of cholesterol efflux	APOE	IDA		Human	PMID:14754908
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Apoe	IMP		Mouse	MGI:MGI:6448697|PMID:31902528
Biological Process	GO:0090205	positive regulation of cholesterol metabolic process	APOE	IDA		Human	PMID:15654758
Biological Process	GO:0090205	positive regulation of cholesterol metabolic process	Apoe	IMP		Mouse	MGI:MGI:3850619|PMID:15654758
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	APOE	IDA		Human	PMID:15654758
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	Apoe	IMP		Mouse	MGI:MGI:3850619|PMID:15654758
Biological Process	GO:0060999	positive regulation of dendritic spine development	APOE	IDA		Human	PMID:24328732
Biological Process	GO:1902952	positive regulation of dendritic spine maintenance	APOE	IDA		Human	PMID:24328732
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	APOE	IMP		Human	PMID:28111074
Biological Process	GO:0045807	positive regulation of endocytosis	APOE	IDA		Human	PMID:7683668
Biological Process	GO:0045807	positive regulation of endocytosis	APOE	IDA		Human	PMID:8300609
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	APOE	IMP		Human	PMID:28111074
Biological Process	GO:1905855	positive regulation of heparan sulfate binding	APOE	IDA		Human	PMID:7683668
Biological Process	GO:1905860	positive regulation of heparan sulfate proteoglycan binding	APOE	IDA		Human	PMID:8300609
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	APOE	IDA		Human	PMID:12042316
Biological Process	GO:1903002	positive regulation of lipid transport across blood-brain barrier	APOE	IDA		Human	PMID:24345162
Biological Process	GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process	APOE	IDA		Human	PMID:15950758
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	APOE	IDA		Human	PMID:15950758
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	APOE	IGI	UniProtKB:P05067:PRO_0000000092	Human	PMID:25015123
Biological Process	GO:0010976	positive regulation of neuron projection development	APOE	IDA		Human	PMID:23845000
Biological Process	GO:0010976	positive regulation of neuron projection development	APOE	IDA		Human	PMID:7592957
Biological Process	GO:0010976	positive regulation of neuron projection development	Apoe	IMP		Mouse	MGI:MGI:5825420|PMID:23845000
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	APOE	IDA		Human	PMID:8995232
Biological Process	GO:1902995	positive regulation of phospholipid efflux	APOE	IDA		Human	PMID:12042316
Biological Process	GO:0017038	protein import	APOE	IDA		Human	PMID:24446231
Biological Process	GO:0006898	receptor-mediated endocytosis	APOE	IDA		Human	PMID:1917954
Biological Process	GO:1905906	regulation of amyloid fibril formation	APOE	IDA		Human	PMID:25207746
Biological Process	GO:1902991	regulation of amyloid precursor protein catabolic process	APOE	IDA		Human	PMID:28164773
Biological Process	GO:1900221	regulation of amyloid-beta clearance	APOE	IDA		Human	PMID:24446231
Biological Process	GO:0042981	regulation of apoptotic process	Apoe	IMP		Mouse	MGI:MGI:6212700|PMID:29336888
Biological Process	GO:2000822	regulation of behavioral fear response	APOE	IMP		Human	PMID:24412220
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	APOE	IDA		Human	PMID:16443932
Biological Process	GO:1905890	regulation of cellular response to very-low-density lipoprotein particle stimulus	APOE	IDA		Human	PMID:7592957
Biological Process	GO:0090181	regulation of cholesterol metabolic process	APOE	IGI	UniProtKB:P35951	Human	PMID:24412220
Biological Process	GO:0010468	regulation of gene expression	Apoe	IMP	MGI:MGI:1857303	Mouse	PMID:17720994
Biological Process	GO:0045088	regulation of innate immune response	Apoe	IMP		Mouse	MGI:MGI:6212700|PMID:29336888
Biological Process	GO:0097006	regulation of plasma lipoprotein particle levels	Apoe	IMP		Mouse	MGI:MGI:5517507|PMID:23741427
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	APOE	IMP		Human	PMID:28111074
Biological Process	GO:0051246	regulation of protein metabolic process	APOE	IGI	UniProtKB:P01130|UniProtKB:P35951	Human	PMID:24412220
Biological Process	GO:0043254	regulation of protein-containing complex assembly	APOE	IDA		Human	PMID:25207746
Biological Process	GO:0050807	regulation of synapse organization	Apoe	IDA		Mouse	PMID:27683909
Biological Process	GO:0050807	regulation of synapse organization	Apoe	IMP		Mouse	PMID:27683909
Biological Process	GO:0090207	regulation of triglyceride metabolic process	Apoe	IDA		Rat	PMID:9225228|RGD:10059686
Biological Process	GO:0061771	response to caloric restriction	APOE	IGI	UniProtKB:P01130	Human	PMID:24412220
Biological Process	GO:0061771	response to caloric restriction	APOE	IGI	UniProtKB:P35951	Human	PMID:24412220
Biological Process	GO:1904421	response to D-galactosamine	Apoe	IEP		Rat	PMID:6631239|RGD:12904654
Biological Process	GO:0002021	response to dietary excess	Apoe	IMP	MGI:MGI:1857303	Mouse	PMID:17720994
Biological Process	GO:0045471	response to ethanol	Apoe	IEP		Rat	PMID:11839466|RGD:1599196
Biological Process	GO:0032868	response to insulin	Apoe	IEP		Rat	PMID:22691999|RGD:6903858
Biological Process	GO:0006979	response to oxidative stress	Apoe	IMP	MGI:MGI:2137814	Mouse	PMID:8773783
Biological Process	GO:0032526	response to retinoic acid	Apoe	IEP		Rat	PMID:21907828|RGD:6903285
Biological Process	GO:0034612	response to tumor necrosis factor	Apoe	IEP		Rat	PMID:12934668|RGD:12904642
Biological Process	GO:0010043	response to zinc ion	Apoe	IEP		Rat	PMID:1883846|RGD:10059683
Biological Process	GO:0043691	reverse cholesterol transport	APOE	IDA		Human	PMID:8127890
Biological Process	GO:0070328	triglyceride homeostasis	Apoe	IMP		Mouse	MGI:MGI:5517507|PMID:23741427
Biological Process	GO:0070328	triglyceride homeostasis	Apoe	IMP		Mouse	MGI:MGI:5514108|PMID:23676495
Biological Process	GO:0006641	triglyceride metabolic process	APOE	IMP		Human	PMID:3771793
Biological Process	GO:0006641	triglyceride metabolic process	APOE	IDA		Human	PMID:9649566
Biological Process	GO:0071830	triglyceride-rich lipoprotein particle clearance	APOE	IMP		Human	PMID:23676495
Biological Process	GO:0071830	triglyceride-rich lipoprotein particle clearance	Apoe	IMP		Mouse	MGI:MGI:5514108|PMID:23676495
Biological Process	GO:0042311	vasodilation	Apoe	IMP	MGI:MGI:2137814	Mouse	PMID:9826706
Biological Process	GO:0034447	very-low-density lipoprotein particle clearance	APOE	IDA		Human	PMID:1917954
Biological Process	GO:0034447	very-low-density lipoprotein particle clearance	APOE	IDA		Human	PMID:2762297
Biological Process	GO:0034447	very-low-density lipoprotein particle clearance	APOE	IMP		Human	PMID:9649566
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling	APOE	IGI	UniProtKB:P08226	Human	PMID:12401887
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling	APOE	IDA		Human	PMID:15654758
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling	Apoe	IMP		Mouse	MGI:MGI:3850619|PMID:15654758
Biological Process	GO:0019068	virion assembly	APOE	IMP		Human	PMID:25122793

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern