Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APPL1
  • Mouse genes Appl1
  • Rat genes Appl1
  • Zfish genes appl1,hesx1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Appl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048487	beta-tubulin binding	APPL1	IDA		Human	PMID:26583432
Molecular Function	GO:0042802	identical protein binding	APPL1	IPI	UniProtKB:Q9UKG1	Human	PMID:17502098
Molecular Function	GO:0042802	identical protein binding	APPL1	IPI	UniProtKB:Q9UKG1	Human	PMID:17581628
Molecular Function	GO:0042802	identical protein binding	APPL1	IPI	UniProtKB:Q9UKG1	Human	PMID:18034774
Molecular Function	GO:0042802	identical protein binding	APPL1	IPI	UniProtKB:Q9UKG1	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	APPL1	IPI	UniProtKB:Q9UKG1	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	APPL1	IPI	UniProtKB:Q9UKG1	Human	PMID:32296183
Molecular Function	GO:0035091	phosphatidylinositol binding	APPL1	IDA		Human	PMID:18034774
Molecular Function	GO:0001786	phosphatidylserine binding	APPL1	IDA		Human	PMID:18034774
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P31751	Human	PMID:10490823
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P42336	Human	PMID:10490823
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P43146	Human	PMID:12011067
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P20339	Human	PMID:15016378
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8NEU8	Human	PMID:15016378
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q12933	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8NEU8	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q91VH1	Human	PMID:16622416
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P31751	Human	PMID:17030088
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8NEU8	Human	PMID:17030088
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P20339	Human	PMID:17581628
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q9UL25	Human	PMID:17581628
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P20339	Human	PMID:18034774
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8NEU8	Human	PMID:18034774
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P35222,UniProtKB:Q13547,UniProtKB:Q8NEU8,UniProtKB:Q92769	Human	PMID:19433865
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q9Y230	Human	PMID:19433865
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8K3G9	Human	PMID:19661063
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q01968	Human	PMID:21233288
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:O14908	Human	PMID:21291857
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:O14908,UniProtKB:P31751	Human	PMID:21291857
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P17643	Human	PMID:21291857
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P07355	Human	PMID:21645192
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q03001	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8NEU8	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8WXH0	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:O15379	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8NEU8	Human	PMID:24879834
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q12933	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:O95363	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P43362	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P50221	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8NEU8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8TAI7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q9C0C9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q9Y3I0	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P36897	Human	PMID:26583432
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q05513	Human	PMID:26583432
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8NEU8	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P20339	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:O95363	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P43362	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q12933	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8NEU8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:O95363	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P20339	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q05BL1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q8NEU8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q96PV4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q9BV57	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:Q9C0C9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL1	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Appl1	IPI	UniProtKB:P26450,UniProtKB:Q8K3G9	Mouse	MGI:MGI:5698780|PMID:25328665
Molecular Function	GO:0005515	protein binding	Appl1	IPI	UniProtKB:P15209	Mouse	MGI:MGI:5825424|PMID:21849472
Molecular Function	GO:0005515	protein binding	Appl1	IPI	UniProtKB:Q91VH1	Mouse	MGI:MGI:4420367|PMID:19661063
Molecular Function	GO:0005515	protein binding	Appl1	IPI	RGD:2082	Rat	PMID:17848569|RGD:2313331
Molecular Function	GO:0005515	protein binding	appl1	IPI	UniProtKB:Q7ZVP2	Zfish	PMID:18455989
Molecular Function	GO:0042803	protein homodimerization activity	APPL1	IDA		Human	PMID:18034774
Molecular Function	GO:0043422	protein kinase B binding	APPL1	IPI	UniProtKB:P47197	Human	PMID:17848569
Molecular Function	GO:0044877	protein-containing complex binding	APPL1	IPI	ComplexPortal:CPX-880	Human	PMID:15016378
Cellular Component	GO:0005737	cytoplasm	APPL1	IDA		Human	PMID:19433865
Cellular Component	GO:0005737	cytoplasm	APPL1	IDA		Human	PMID:19661063
Cellular Component	GO:0005737	cytoplasm	APPL1	IDA		Human	PMID:21291857
Cellular Component	GO:0031410	cytoplasmic vesicle	APPL1	IDA		Human	PMID:18034774
Cellular Component	GO:0005829	cytosol	APPL1	IDA		Human	PMID:17848569
Cellular Component	GO:0005769	early endosome	APPL1	IDA		Human	PMID:21645192
Cellular Component	GO:0005769	early endosome	Appl1	IDA		Mouse	MGI:MGI:5825424|PMID:21849472
Cellular Component	GO:0005769	early endosome	appl1	IDA		Zfish	PMID:18455989
Cellular Component	GO:0032009	early phagosome	Appl1	IDA		Mouse	MGI:MGI:6271154|PMID:25568335
Cellular Component	GO:0005768	endosome	APPL1	IDA		Human	PMID:26583432
Cellular Component	GO:0005768	endosome	Appl1	IDA		Mouse	MGI:MGI:6271154|PMID:25568335
Cellular Component	GO:0005768	endosome	Appl1	IDA		Mouse	MGI:MGI:6270783|PMID:27219021
Cellular Component	GO:0005768	endosome	appl1	IGI	ZFIN:ZDB-GENE-031118-30	Zfish	PMID:18455989
Cellular Component	GO:0010008	endosome membrane	APPL1	IDA		Human	PMID:15016378
Cellular Component	GO:0070062	extracellular exosome	APPL1	HDA		Human	PMID:18570454
Cellular Component	GO:0070062	extracellular exosome	APPL1	HDA		Human	PMID:19056867
Cellular Component	GO:0098978	glutamatergic synapse	APPL1	IDA		Human	PMID:21236345
Cellular Component	GO:0098978	glutamatergic synapse	APPL1	IMP		Human	PMID:21236345
Cellular Component	GO:0097708	intracellular vesicle	APPL1	IDA		Human	PMID:21291857
Cellular Component	GO:0044354	macropinosome	Appl1	IDA		Mouse	MGI:MGI:6270783|PMID:27219021
Cellular Component	GO:0016020	membrane	APPL1	IDA		Human	PMID:18034774
Cellular Component	GO:0005634	nucleus	APPL1	IDA		Human	PMID:15016378
Cellular Component	GO:0005634	nucleus	APPL1	IDA		Human	PMID:18034774
Cellular Component	GO:0005634	nucleus	APPL1	IDA		Human	PMID:19433865
Cellular Component	GO:0005634	nucleus	APPL1	IDA		Human	PMID:26583432
Cellular Component	GO:0005886	plasma membrane	APPL1	IDA		Human	PMID:18034774
Cellular Component	GO:0098794	postsynapse	Appl1	IDA		Rat	PMID:21236345|RGD:155230803
Cellular Component	GO:0098793	presynapse	Appl1	IDA		Rat	PMID:21236345|RGD:155230803
Cellular Component	GO:0001726	ruffle	Appl1	IDA		Mouse	MGI:MGI:6271154|PMID:25568335
Cellular Component	GO:0012506	vesicle membrane	APPL1	IDA		Human	PMID:17848569
Biological Process	GO:0033211	adiponectin-activated signaling pathway	APPL1	IMP		Human	PMID:19661063
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	Appl1	IMP		Mouse	MGI:MGI:5700256|PMID:26445298
Biological Process	GO:0030900	forebrain development	hesx1	IGI	ZFIN:ZDB-GENO-080909-1,ZFIN:ZDB-MRPHLNO-111104-1	Zfish	PMID:22007134
Biological Process	GO:0008286	insulin receptor signaling pathway	APPL1	IMP		Human	PMID:26073777
Biological Process	GO:0099558	maintenance of synapse structure	APPL1	IDA		Human	PMID:21236345
Biological Process	GO:0099558	maintenance of synapse structure	APPL1	IMP		Human	PMID:21236345
Biological Process	GO:1905450	negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	Appl1	IMP		Mouse	MGI:MGI:6271154|PMID:25568335
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Appl1	IMP		Mouse	MGI:MGI:5698780|PMID:25328665
Biological Process	GO:0046326	positive regulation of glucose import	APPL1	IMP		Human	PMID:24879834
Biological Process	GO:1905303	positive regulation of macropinocytosis	Appl1	IMP		Mouse	MGI:MGI:6270783|PMID:27219021
Biological Process	GO:0048023	positive regulation of melanin biosynthetic process	APPL1	IMP		Human	PMID:21291857
Biological Process	GO:0006606	protein import into nucleus	APPL1	IDA		Human	PMID:26583432
Biological Process	GO:0010762	regulation of fibroblast migration	Appl1	IMP		Mouse	MGI:MGI:5700256|PMID:26445298
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	APPL1	IDA		Human	PMID:15016378
Biological Process	GO:0046324	regulation of glucose import	APPL1	IMP		Human	PMID:17848569
Biological Process	GO:0045088	regulation of innate immune response	Appl1	IMP		Mouse	MGI:MGI:6270783|PMID:27219021
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	APPL1	IMP		Human	PMID:17848569
Biological Process	GO:0034143	regulation of toll-like receptor 4 signaling pathway	Appl1	IMP		Mouse	MGI:MGI:6270783|PMID:27219021
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	APPL1	IMP		Human	PMID:26583432

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern