Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APPL2
  • Mouse genes Appl2
  • Rat genes Appl2
  • Zfish genes appl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Appl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	APPL2	IPI	UniProtKB:Q8NEU8	Human	PMID:18034774
Molecular Function	GO:0035091	phosphatidylinositol binding	APPL2	IDA		Human	PMID:18034774
Molecular Function	GO:0001786	phosphatidylserine binding	APPL2	IDA		Human	PMID:18034774
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:P20339	Human	PMID:15016378
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UKG1	Human	PMID:15016378
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UKG1	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UL26	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:P23945	Human	PMID:17030088
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UKG1	Human	PMID:17030088
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UKG1	Human	PMID:18034774
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:P35222,UniProtKB:Q13547,UniProtKB:Q92769,UniProtKB:Q9UKG1	Human	PMID:19433865
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9Y230	Human	PMID:19433865
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:P07355	Human	PMID:21645192
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q13636	Human	PMID:23055524
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UKG1	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9H5I1	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q60949	Human	PMID:24879834
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q86TI0	Human	PMID:24879834
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UKG1	Human	PMID:24879834
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:P51148	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:P78560	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9H5I1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UKG1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UL26	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UPY8	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UKG1	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:P51148	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:P78560	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9H5I1	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UKG1	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UL26	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:P0CG20	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:P51148	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q7L775	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9BVG8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9H5I1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UKG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APPL2	IPI	UniProtKB:Q9UL26	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Appl2	IPI	UniProtKB:Q8BQS5|UniProtKB:Q91VH1|UniProtKB:Q9UKG1	Mouse	MGI:MGI:4420367|PMID:19661063
Molecular Function	GO:0005515	protein binding	Appl2	IPI	UniProtKB:Q86TI0	Mouse	MGI:MGI:5755211|PMID:24879834
Molecular Function	GO:0005515	protein binding	Appl2	IPI	UniProtKB:Q921E2|UniProtKB:Q9CQD1	Mouse	MGI:MGI:6271154|PMID:25568335
Molecular Function	GO:0005515	protein binding	Appl2	IPI	UniProtKB:Q60949	Mouse	MGI:MGI:5755211|PMID:24879834
Molecular Function	GO:0005515	protein binding	Appl2	IPI	UniProtKB:P26450,UniProtKB:Q8K3H0	Mouse	MGI:MGI:5698780|PMID:25328665
Molecular Function	GO:0005515	protein binding	appl2	IPI	UniProtKB:Q7ZVP2	Zfish	PMID:18455989
Molecular Function	GO:0042803	protein homodimerization activity	APPL2	IDA		Human	PMID:18034774
Molecular Function	GO:0044877	protein-containing complex binding	APPL2	IPI	ComplexPortal:CPX-880	Human	PMID:15016378
Cellular Component	GO:0005737	cytoplasm	Appl2	IDA		Mouse	MGI:MGI:4420367|PMID:19661063
Cellular Component	GO:0005737	cytoplasm	Appl2	IDA		Mouse	MGI:MGI:6271154|PMID:25568335
Cellular Component	GO:0031410	cytoplasmic vesicle	APPL2	IDA		Human	PMID:18034774
Cellular Component	GO:0032009	early phagosome	Appl2	IDA		Mouse	MGI:MGI:6271154|PMID:25568335
Cellular Component	GO:0036186	early phagosome membrane	Appl2	IDA		Mouse	MGI:MGI:6270783|PMID:27219021
Cellular Component	GO:0005768	endosome	APPL2	IDA		Human	PMID:21645192
Cellular Component	GO:0005768	endosome	appl2	IGI	ZFIN:ZDB-GENE-031118-30	Zfish	PMID:18455989
Cellular Component	GO:0010008	endosome membrane	APPL2	IDA		Human	PMID:15016378
Cellular Component	GO:0010008	endosome membrane	APPL2	IDA		Human	PMID:21645192
Cellular Component	GO:0070062	extracellular exosome	APPL2	HDA		Human	PMID:19056867
Cellular Component	GO:0044354	macropinosome	Appl2	IDA		Mouse	MGI:MGI:6270783|PMID:27219021
Cellular Component	GO:0016020	membrane	APPL2	IDA		Human	PMID:18034774
Cellular Component	GO:0005634	nucleus	APPL2	IDA		Human	PMID:15016378
Cellular Component	GO:0005634	nucleus	APPL2	IDA		Human	PMID:18034774
Cellular Component	GO:0005886	plasma membrane	APPL2	IDA		Human	PMID:18034774
Cellular Component	GO:0005886	plasma membrane	Appl2	IDA		Mouse	MGI:MGI:6270783|PMID:27219021
Cellular Component	GO:0001726	ruffle	Appl2	IDA		Mouse	MGI:MGI:6271154|PMID:25568335
Cellular Component	GO:0032587	ruffle membrane	Appl2	IDA		Mouse	MGI:MGI:6270783|PMID:27219021
Cellular Component	GO:0031982	vesicle	APPL2	IDA		Human	PMID:21645192
Biological Process	GO:0033211	adiponectin-activated signaling pathway	Appl2	IMP		Mouse	MGI:MGI:4420367|PMID:19661063
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	Appl2	IMP		Mouse	MGI:MGI:5700256|PMID:26445298
Biological Process	GO:0009631	cold acclimation	Appl2	IMP		Mouse	MGI:MGI:6150753|PMID:29467283
Biological Process	GO:0002024	diet induced thermogenesis	Appl2	IMP		Mouse	MGI:MGI:6150753|PMID:29467283
Biological Process	GO:0042593	glucose homeostasis	APPL2	IMP		Human	PMID:24879834
Biological Process	GO:1900077	negative regulation of cellular response to insulin stimulus	Appl2	IMP		Mouse	MGI:MGI:4420367|PMID:19661063
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	Appl2	IMP		Mouse	MGI:MGI:5698780|PMID:25328665
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	Appl2	IMP		Mouse	MGI:MGI:4420367|PMID:19661063
Biological Process	GO:0046325	negative regulation of glucose import	APPL2	IMP		Human	PMID:24879834
Biological Process	GO:0046325	negative regulation of glucose import	Appl2	IMP		Mouse	MGI:MGI:4420367|PMID:19661063
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	Appl2	IMP		Mouse	MGI:MGI:6271956|PMID:28965332
Biological Process	GO:0050768	negative regulation of neurogenesis	Appl2	IMP		Mouse	MGI:MGI:6272332|PMID:29675572
Biological Process	GO:0050768	negative regulation of neurogenesis	Appl2	IMP		Mouse	MGI:MGI:6271956|PMID:28965332
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Appl2	IMP		Mouse	MGI:MGI:6150753|PMID:29467283
Biological Process	GO:1905451	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	Appl2	IMP		Mouse	MGI:MGI:6271154|PMID:25568335
Biological Process	GO:1905303	positive regulation of macropinocytosis	Appl2	IMP		Mouse	MGI:MGI:6270783|PMID:27219021
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	Appl2	IMP		Mouse	MGI:MGI:6271154|PMID:25568335
Biological Process	GO:0051289	protein homotetramerization	APPL2	IDA		Human	PMID:23055524
Biological Process	GO:0006606	protein import into nucleus	APPL2	IDA		Human	PMID:26583432
Biological Process	GO:0010762	regulation of fibroblast migration	Appl2	IMP		Mouse	MGI:MGI:5700256|PMID:26445298
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	APPL2	IDA		Human	PMID:15016378
Biological Process	GO:0045088	regulation of innate immune response	Appl2	IMP		Mouse	MGI:MGI:6270783|PMID:27219021
Biological Process	GO:0034143	regulation of toll-like receptor 4 signaling pathway	Appl2	IMP		Mouse	MGI:MGI:6270783|PMID:27219021
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	APPL2	IMP		Human	PMID:26583432

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern