Comparative GO Graph (mouse, human, rat)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Aqp2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes AQP2
- Mouse genes Aqp2
- Rat genes Aqp2
- Zfish genes
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aqp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Aqp2	IDA		Rat	PMID:15336526\|RGD:1358309
Molecular Function	GO:0015168	glycerol transmembrane transporter activity	AQP2	IDA		Human	PMID:8584435
Molecular Function	GO:0030165	PDZ domain binding	Aqp2	IPI	RGD:1303184	Rat	PMID:15196935\|RGD:2313141
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:O43889-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:A2RU14	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:A5PKU2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:A8MZ59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:O14735	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:P15941-11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:P24593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:P52803	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:P54315	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q01453	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q13113	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q59EV6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q5BJF2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q5J8X5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q5QGT7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q5SQN1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q5W0B7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q6IN84	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q6UX06	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q7Z2K6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q8IXM6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q8N2M4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q8NH19	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q8TAF8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q8TED1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q92520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q96EC8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q96RD7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q9BRI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q9BVC6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q9BXS9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q9H2L4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q9NVC3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q9UKR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP2	IPI	UniProtKB:Q9Y5U4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Aqp2	IPI	RGD:621725	Rat	PMID:17636261\|RGD:2313120
Molecular Function	GO:0005515	protein binding	Aqp2	IPI	RGD:628878	Rat	PMID:17636261\|RGD:2313120
Molecular Function	GO:0005515	protein binding	Aqp2	IPI	RGD:2843	Rat	PMID:19209902\|RGD:2313119
Molecular Function	GO:0005515	protein binding	Aqp2	IPI	RGD:3376	Rat	PMID:19209902\|RGD:2313119
Molecular Function	GO:0005515	protein binding	Aqp2	IPI	RGD:621170	Rat	PMID:19209902\|RGD:2313119
Molecular Function	GO:0015250	water channel activity	AQP2	EXP		Human	PMID:11076974
Molecular Function	GO:0015250	water channel activity	AQP2	IMP		Human	PMID:8140421
Molecular Function	GO:0015250	water channel activity	AQP2	EXP		Human	PMID:9829975
Molecular Function	GO:0015250	water channel activity	Aqp2	IDA		Mouse	PMID:10191086
Molecular Function	GO:0005372	water transmembrane transporter activity	AQP2	IDA		Human	PMID:8584435
Molecular Function	GO:0005372	water transmembrane transporter activity	AQP2	IDA		Human	PMID:9321919
Molecular Function	GO:0005372	water transmembrane transporter activity	Aqp2	IMP		Rat	PMID:9321919\|RGD:8553743
Cellular Component	GO:0016324	apical plasma membrane	AQP2	IDA		Human	PMID:15509592
Cellular Component	GO:0016324	apical plasma membrane	AQP2	IDA		Human	PMID:16928804
Cellular Component	GO:0016324	apical plasma membrane	Aqp2	IDA		Mouse	PMID:27402760
Cellular Component	GO:0016324	apical plasma membrane	Aqp2	IDA		Mouse	PMID:10322639
Cellular Component	GO:0016324	apical plasma membrane	Aqp2	IDA		Mouse	PMID:21178974
Cellular Component	GO:0016324	apical plasma membrane	Aqp2	IDA		Mouse	PMID:11423561
Cellular Component	GO:0016324	apical plasma membrane	Aqp2	IDA		Mouse	PMID:15550389
Cellular Component	GO:0016324	apical plasma membrane	Aqp2	IDA		Rat	PMID:11518698\|RGD:631239
Cellular Component	GO:0016324	apical plasma membrane	Aqp2	IDA		Rat	PMID:15037626\|RGD:1303982
Cellular Component	GO:0016324	apical plasma membrane	Aqp2	IDA		Rat	PMID:15579502\|RGD:2313211
Cellular Component	GO:0016324	apical plasma membrane	Aqp2	IDA		Rat	PMID:17804457\|RGD:8554499
Cellular Component	GO:0016324	apical plasma membrane	Aqp2	IDA		Rat	PMID:18971210\|RGD:2312654
Cellular Component	GO:0016323	basolateral plasma membrane	Aqp2	IDA		Rat	PMID:15579502\|RGD:2313211
Cellular Component	GO:0016323	basolateral plasma membrane	Aqp2	IDA		Rat	PMID:17339611\|RGD:2313139
Cellular Component	GO:0030136	clathrin-coated vesicle	Aqp2	IDA		Rat	PMID:18843259\|RGD:2313123
Cellular Component	GO:0005737	cytoplasm	Aqp2	IDA		Mouse	PMID:27402760
Cellular Component	GO:0005737	cytoplasm	Aqp2	IDA		Rat	PMID:15579502\|RGD:2313211
Cellular Component	GO:0005737	cytoplasm	Aqp2	IDA		Rat	PMID:19008911\|RGD:2312636
Cellular Component	GO:0031410	cytoplasmic vesicle	Aqp2	IDA		Mouse	PMID:18505797
Cellular Component	GO:0005769	early endosome	Aqp2	IDA		Rat	PMID:18843259\|RGD:2313123
Cellular Component	GO:0070382	exocytic vesicle	Aqp2	IDA		Rat	PMID:15037626\|RGD:1303982
Cellular Component	GO:0070062	extracellular exosome	AQP2	IDA		Human	PMID:15326289
Cellular Component	GO:0070062	extracellular exosome	AQP2	IDA		Human	PMID:16501490
Cellular Component	GO:0070062	extracellular exosome	AQP2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	AQP2	HDA		Human	PMID:23533145
Cellular Component	GO:0098576	lumenal side of membrane	Aqp2	IDA		Mouse	PMID:17409310
Cellular Component	GO:0005764	lysosome	Aqp2	IDA		Rat	PMID:18843259\|RGD:2313123
Cellular Component	GO:0016020	membrane	AQP2	IDA		Human	PMID:22375059
Cellular Component	GO:0016020	membrane	Aqp2	IDA		Mouse	PMID:15632412
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Aqp2	IDA		Mouse	PMID:27402760
Cellular Component	GO:0005886	plasma membrane	AQP2	IDA		Human	PMID:24733887
Cellular Component	GO:0005886	plasma membrane	AQP2	IMP		Human	PMID:8140421
Cellular Component	GO:0005886	plasma membrane	AQP2	IDA		Human	PMID:9321919
Cellular Component	GO:0005886	plasma membrane	Aqp2	IDA		Mouse	MGI:MGI:3640049\|PMID:16735444
Cellular Component	GO:0005886	plasma membrane	Aqp2	IDA		Mouse	PMID:10191086
Cellular Component	GO:0005886	plasma membrane	Aqp2	IMP		Rat	PMID:9321919\|RGD:8553743
Cellular Component	GO:0032991	protein-containing complex	Aqp2	IDA		Rat	PMID:15196935\|RGD:2313141
Cellular Component	GO:0032991	protein-containing complex	Aqp2	IDA		Rat	PMID:15823548\|RGD:1600561
Cellular Component	GO:0055037	recycling endosome	Aqp2	IDA		Mouse	PMID:10191086
Cellular Component	GO:0005791	rough endoplasmic reticulum	Aqp2	IDA		Rat	PMID:15905145\|RGD:1581707
Cellular Component	GO:0005802	trans-Golgi network	Aqp2	IDA		Rat	PMID:15905145\|RGD:1581707
Cellular Component	GO:0030133	transport vesicle	Aqp2	IDA		Rat	PMID:15196935\|RGD:2313141
Biological Process	GO:0030042	actin filament depolymerization	Aqp2	IDA		Rat	PMID:18678705\|RGD:2313131
Biological Process	GO:0007568	aging	Aqp2	IEP		Rat	PMID:18367658\|RGD:2313133
Biological Process	GO:0006915	apoptotic process	Aqp2	IMP		Rat	PMID:18717646\|RGD:2313130
Biological Process	GO:0006884	cell volume homeostasis	Aqp2	IMP		Rat	PMID:18094031\|RGD:2313135
Biological Process	GO:0071280	cellular response to copper ion	AQP2	IDA		Human	PMID:8584435
Biological Process	GO:0071288	cellular response to mercury ion	AQP2	IDA		Human	PMID:8584435
Biological Process	GO:0042631	cellular response to water deprivation	Aqp2	IDA		Mouse	PMID:10191086
Biological Process	GO:0042631	cellular response to water deprivation	Aqp2	IDA		Rat	PMID:15196935\|RGD:2313141
Biological Process	GO:0007565	female pregnancy	Aqp2	IEP		Rat	PMID:18293204\|RGD:2313134
Biological Process	GO:0015793	glycerol transmembrane transport	AQP2	IDA		Human	PMID:8584435
Biological Process	GO:0006972	hyperosmotic response	Aqp2	IEP		Rat	PMID:19138132\|RGD:2313121
Biological Process	GO:0072205	metanephric collecting duct development	Aqp2	IEP		Mouse	MGI:MGI:3806730\|PMID:18618131
Biological Process	GO:0051928	positive regulation of calcium ion transport	Aqp2	IMP		Rat	PMID:18094031\|RGD:2313135
Biological Process	GO:0051289	protein homotetramerization	AQP2	IDA		Human	PMID:24733887
Biological Process	GO:0003091	renal water homeostasis	AQP2	IMP		Human	PMID:8140421
Biological Process	GO:0003091	renal water homeostasis	Aqp2	IDA		Mouse	PMID:27402760
Biological Process	GO:0003097	renal water transport	Aqp2	IMP	MGI:MGI:1856830	Mouse	PMID:3184310
Biological Process	GO:0051592	response to calcium ion	Aqp2	IEP		Rat	PMID:19138132\|RGD:2313121
Biological Process	GO:0033762	response to glucagon	Aqp2	IEP		Rat	PMID:18829741\|RGD:2313122
Biological Process	GO:0009725	response to hormone	Aqp2	IEP		Rat	PMID:17376764\|RGD:2313137
Biological Process	GO:0032496	response to lipopolysaccharide	Aqp2	IEP		Rat	PMID:18824919\|RGD:2313129
Biological Process	GO:0010226	response to lithium ion	Aqp2	IEP		Rat	PMID:19244398\|RGD:2313118
Biological Process	GO:0009651	response to salt stress	Aqp2	IEP		Rat	PMID:12176047\|RGD:625535
Biological Process	GO:0042594	response to starvation	Aqp2	IEP		Rat	PMID:15610244\|RGD:2313140
Biological Process	GO:0009414	response to water deprivation	Aqp2	IEP		Rat	PMID:18367658\|RGD:2313133
Biological Process	GO:0006833	water transport	AQP2	IMP		Human	PMID:8140421
Biological Process	GO:0006833	water transport	AQP2	IDA		Human	PMID:8584435
Biological Process	GO:0006833	water transport	AQP2	IDA		Human	PMID:9321919
Biological Process	GO:0006833	water transport	Aqp2	IDA		Mouse	PMID:10191086
Biological Process	GO:0006833	water transport	Aqp2	IEP		Rat	PMID:11518698\|RGD:631239
Biological Process	GO:0006833	water transport	Aqp2	IMP		Rat	PMID:9321919\|RGD:8553743

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.