Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Aqp4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes AQP4
- Mouse genes Aqp4
- Rat genes Aqp4
- Zfish genes aqp4
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aqp4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Aqp4	IPI	RGD:2143	Rat	PMID:16650285\|RGD:2292708
Molecular Function	GO:0005515	protein binding	AQP4	IPI	UniProtKB:O43889-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	AQP4	IPI	UniProtKB:Q5T9L3-1	Human	PMID:28734904
Molecular Function	GO:0005515	protein binding	AQP4	IPI	UniProtKB:Q5T9L3-1	Human	PMID:31286866
Molecular Function	GO:0005515	protein binding	AQP4	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP4	IPI	UniProtKB:Q9UM19	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Aqp4	IPI	UniProtKB:Q9EPK8	Mouse	MGI:MGI:4939848\|PMID:21262839
Molecular Function	GO:0005515	protein binding	Aqp4	IPI	UniProtKB:Q9ERZ8	Rat	PMID:21262839\|RGD:13432264
Molecular Function	GO:0005515	protein binding	Aqp4	IPI	UniProtKB:Q9HBA0	Rat	PMID:21262839\|RGD:13432264
Molecular Function	GO:0015250	water channel activity	AQP4	EXP		Human	PMID:17178220
Molecular Function	GO:0015250	water channel activity	AQP4	EXP		Human	PMID:18511455
Molecular Function	GO:0015250	water channel activity	AQP4	IDA		Human	PMID:19383790
Molecular Function	GO:0015250	water channel activity	AQP4	IDA		Human	PMID:8601457
Molecular Function	GO:0015250	water channel activity	Aqp4	IDA		Mouse	MGI:MGI:80378\|PMID:8660998
Molecular Function	GO:0015250	water channel activity	Aqp4	IDA		Mouse	MGI:MGI:6294219\|PMID:18286643
Molecular Function	GO:0015250	water channel activity	Aqp4	IDA		Rat	PMID:21251984\|RGD:11060722
Molecular Function	GO:0015250	water channel activity	Aqp4	IDA		Rat	PMID:7528931\|RGD:730277
Molecular Function	GO:0005372	water transmembrane transporter activity	aqp4	IDA		Zfish	PMID:20149227
Cellular Component	GO:0097450	astrocyte end-foot	Aqp4	IDA		Mouse	MGI:MGI:5435611\|PMID:22896675
Cellular Component	GO:0097450	astrocyte end-foot	Aqp4	IDA		Rat	PMID:29055082\|RGD:14397568
Cellular Component	GO:0009925	basal plasma membrane	Aqp4	IDA		Rat	PMID:9875338\|RGD:8696009
Cellular Component	GO:0016323	basolateral plasma membrane	Aqp4	IDA		Mouse	MGI:MGI:6152210\|PMID:27751903
Cellular Component	GO:0016323	basolateral plasma membrane	Aqp4	IDA		Mouse	PMID:21705333
Cellular Component	GO:0016323	basolateral plasma membrane	Aqp4	IDA		Mouse	PMID:21178974
Cellular Component	GO:0016323	basolateral plasma membrane	Aqp4	IDA		Mouse	PMID:10021464
Cellular Component	GO:0016323	basolateral plasma membrane	Aqp4	IDA		Mouse	PMID:10662735
Cellular Component	GO:0016323	basolateral plasma membrane	Aqp4	IDA		Rat	PMID:12507761\|RGD:628590
Cellular Component	GO:0016323	basolateral plasma membrane	Aqp4	IDA		Rat	PMID:9875338\|RGD:8696009
Cellular Component	GO:0031253	cell projection membrane	Aqp4	IDA		Rat	PMID:9875338\|RGD:8696009
Cellular Component	GO:0005911	cell-cell junction	Aqp4	IDA		Mouse	MGI:MGI:5050074\|PMID:18718702
Cellular Component	GO:0005911	cell-cell junction	Aqp4	IDA		Mouse	PMID:12673830
Cellular Component	GO:0005737	cytoplasm	AQP4	IDA		Human	PMID:18392839
Cellular Component	GO:0005737	cytoplasm	Aqp4	IDA		Mouse	MGI:MGI:5050074\|PMID:18718702
Cellular Component	GO:0009897	external side of plasma membrane	AQP4	IDA		Human	PMID:17645239
Cellular Component	GO:0005886	plasma membrane	AQP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	AQP4	IDA		Human	PMID:16814974
Cellular Component	GO:0005886	plasma membrane	AQP4	IDA		Human	PMID:8601457
Cellular Component	GO:0005886	plasma membrane	Aqp4	IDA		Mouse	MGI:MGI:5050074\|PMID:18718702
Cellular Component	GO:0005886	plasma membrane	Aqp4	IDA		Mouse	MGI:MGI:6294219\|PMID:18286643
Cellular Component	GO:0005886	plasma membrane	Aqp4	IDA		Mouse	PMID:16582023
Cellular Component	GO:0005886	plasma membrane	Aqp4	IDA		Rat	PMID:16325200\|RGD:14397562
Cellular Component	GO:0032991	protein-containing complex	Aqp4	IDA		Rat	PMID:20153404\|RGD:5490127
Cellular Component	GO:0042383	sarcolemma	AQP4	IDA		Human	PMID:29055082
Cellular Component	GO:0042383	sarcolemma	Aqp4	IDA		Mouse	MGI:MGI:6294239\|PMID:29055082
Cellular Component	GO:0042383	sarcolemma	Aqp4	IDA		Rat	PMID:20849844\|RGD:5490121
Cellular Component	GO:0042383	sarcolemma	Aqp4	IDA		Rat	PMID:29055082\|RGD:14397568
Cellular Component	GO:0030315	T-tubule	Aqp4	IDA		Rat	PMID:20849844\|RGD:5490121
Biological Process	GO:0015670	carbon dioxide transport	Aqp4	IDA		Rat	PMID:19273840\|RGD:8553588
Biological Process	GO:0098609	cell-cell adhesion	Aqp4	IMP		Rat	PMID:16325200\|RGD:14397562
Biological Process	GO:0071392	cellular response to estradiol stimulus	Aqp4	IEP		Rat	PMID:21471464\|RGD:5490119
Biological Process	GO:0071333	cellular response to glucose stimulus	Aqp4	IMP		Rat	PMID:22449442\|RGD:8695996
Biological Process	GO:0071347	cellular response to interleukin-1	Aqp4	IEP		Rat	PMID:22449442\|RGD:8695996
Biological Process	GO:0071354	cellular response to interleukin-6	Aqp4	IEP		Rat	PMID:22449442\|RGD:8695996
Biological Process	GO:0071346	cellular response to type II interferon	AQP4	IDA		Human	PMID:17645239
Biological Process	GO:0090660	cerebrospinal fluid circulation	Aqp4	IMP		Mouse	MGI:MGI:5435611\|PMID:22896675
Biological Process	GO:0033326	cerebrospinal fluid secretion	Aqp4	IMP		Mouse	MGI:MGI:6277731\|PMID:30293570
Biological Process	GO:0051649	establishment of localization in cell	Aqp4	IMP	MGI:MGI:1857808	Mouse	PMID:10613915
Biological Process	GO:0007565	female pregnancy	Aqp4	IEP		Rat	PMID:18579859\|RGD:5490155
Biological Process	GO:0042538	hyperosmotic salinity response	Aqp4	IEP		Rat	PMID:18248364\|RGD:2307072
Biological Process	GO:0009992	intracellular water homeostasis	Aqp4	IDA		Mouse	MGI:MGI:6294219\|PMID:18286643
Biological Process	GO:0009992	intracellular water homeostasis	Aqp4	IDA		Rat	PMID:21251984\|RGD:11060722
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	AQP4	IEP		Human	PMID:16814974
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	AQP4	IEP		Human	PMID:17645239
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	Aqp4	IDA		Mouse	MGI:MGI:6152210\|PMID:27751903
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	Aqp4	IMP	MGI:MGI:1857808	Mouse	PMID:12034763
Biological Process	GO:0060354	negative regulation of cell adhesion molecule production	Aqp4	IMP		Rat	PMID:22449442\|RGD:8695996
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Aqp4	IMP		Rat	PMID:22449442\|RGD:8695996
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Aqp4	IMP		Rat	PMID:22449442\|RGD:8695996
Biological Process	GO:0051289	protein homotetramerization	AQP4	IDA		Human	PMID:19383790
Biological Process	GO:0051289	protein homotetramerization	Aqp4	IDA		Rat	PMID:16325200\|RGD:14397562
Biological Process	GO:0010574	regulation of vascular endothelial growth factor production	Aqp4	IMP		Rat	PMID:22449442\|RGD:8695996
Biological Process	GO:0070295	renal water absorption	Aqp4	IMP	MGI:MGI:1857808	Mouse	PMID:10795927
Biological Process	GO:0070295	renal water absorption	Aqp4	IMP	MGI:MGI:1857808	Mouse	PMID:10662735
Biological Process	GO:0070295	renal water absorption	Aqp4	IGI	MGI:MGI:103201	Mouse	PMID:10662735
Biological Process	GO:0051384	response to glucocorticoid	Aqp4	IEP		Rat	PMID:21724913\|RGD:5490118
Biological Process	GO:0009314	response to radiation	Aqp4	IEP		Rat	PMID:20137298\|RGD:5490128
Biological Process	GO:0007605	sensory perception of sound	Aqp4	IMP	MGI:MGI:1857808	Mouse	PMID:11406631
Biological Process	GO:0055085	transmembrane transport	aqp4	IDA		Zfish	PMID:20149227\|ZFIN:ZDB-PUB-100223-9
Biological Process	GO:0006833	water transport	AQP4	IDA		Human	PMID:19383790
Biological Process	GO:0006833	water transport	AQP4	IDA		Human	PMID:8601457
Biological Process	GO:0006833	water transport	Aqp4	IDA		Mouse	MGI:MGI:6294219\|PMID:18286643
Biological Process	GO:0006833	water transport	Aqp4	IMP	MGI:MGI:1857808	Mouse	PMID:10613915
Biological Process	GO:0006833	water transport	Aqp4	IDA		Rat	PMID:7528931\|RGD:730277
Biological Process	GO:0006833	water transport	aqp4	IDA		Zfish	PMID:20149227\|ZFIN:ZDB-PUB-100223-9

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.