Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Aqp8

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes AQP8
- Mouse genes Aqp8
- Rat genes Aqp8
- Zfish genes aqp8a.1,aqp8a.2,aqp8b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aqp8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	Aqp8	IMP		Mouse	MGI:MGI:3703401\|PMID:16624991
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	Aqp8	IDA		Rat	PMID:15988592\|RGD:155663547
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	Aqp8	IDA		Rat	PMID:16624991\|RGD:155663530
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	Aqp8	IDA		Rat	PMID:17189259\|RGD:155663531
Molecular Function	GO:0015264	methylammonium channel activity	AQP8	IDA		Human	PMID:15948717
Molecular Function	GO:0015264	methylammonium channel activity	Aqp8	IDA		Rat	PMID:15948717\|RGD:11060918
Molecular Function	GO:0015264	methylammonium channel activity	Aqp8	IDA		Rat	PMID:15988592\|RGD:155663547
Molecular Function	GO:0015264	methylammonium channel activity	Aqp8	IDA		Rat	PMID:23299935\|RGD:155663538
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:A0PK00	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:Q04941	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:Q86Y82	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:Q8IY26	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:Q9BQA9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:Q9Y6X1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:O75190-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:P04792	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:P60891	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AQP8	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0015265	urea channel activity	Aqp8	IDA		Mouse	MGI:MGI:1099926\|PMID:9388476
Molecular Function	GO:0015204	urea transmembrane transporter activity	aqp8a.1	IDA		Zfish	PMID:20149227
Molecular Function	GO:0015204	urea transmembrane transporter activity	aqp8a.2	IDA		Zfish	PMID:20149227
Molecular Function	GO:0015250	water channel activity	AQP8	IDA		Human	PMID:15948717
Molecular Function	GO:0015250	water channel activity	AQP8	IMP		Human	PMID:18948439
Molecular Function	GO:0015250	water channel activity	Aqp8	IDA		Mouse	MGI:MGI:1099926\|PMID:9388476
Molecular Function	GO:0015250	water channel activity	Aqp8	IMP		Mouse	MGI:MGI:3703401\|PMID:16624991
Molecular Function	GO:0015250	water channel activity	Aqp8	IDA		Mouse	MGI:MGI:7388218\|PMID:15948717
Molecular Function	GO:0015250	water channel activity	Aqp8	IMP		Mouse	MGI:MGI:3612624\|PMID:15647389
Molecular Function	GO:0015250	water channel activity	Aqp8	IDA		Rat	PMID:11932260\|RGD:625402
Molecular Function	GO:0015250	water channel activity	Aqp8	IDA		Rat	PMID:12774023\|RGD:1298925
Molecular Function	GO:0015250	water channel activity	Aqp8	IDA		Rat	PMID:15749715\|RGD:155663529
Molecular Function	GO:0015250	water channel activity	Aqp8	IDA		Rat	PMID:15948717\|RGD:11060918
Molecular Function	GO:0015250	water channel activity	Aqp8	IDA		Rat	PMID:16177191\|RGD:155663527
Molecular Function	GO:0015250	water channel activity	Aqp8	IMP		Rat	PMID:16624991\|RGD:155663530
Molecular Function	GO:0015250	water channel activity	Aqp8	IMP		Rat	PMID:17189259\|RGD:155663531
Molecular Function	GO:0015250	water channel activity	Aqp8	IMP		Rat	PMID:18059526\|RGD:155663542
Molecular Function	GO:0015250	water channel activity	Aqp8	IDA		Rat	PMID:20132793\|RGD:155663528
Molecular Function	GO:0005372	water transmembrane transporter activity	aqp8a.1	IDA		Zfish	PMID:20149227
Molecular Function	GO:0005372	water transmembrane transporter activity	aqp8a.2	IDA		Zfish	PMID:20149227
Molecular Function	GO:0005372	water transmembrane transporter activity	aqp8b	IDA		Zfish	PMID:20149227
Cellular Component	GO:0045177	apical part of cell	AQP8	IDA		Human	PMID:12801959
Cellular Component	GO:0016324	apical plasma membrane	Aqp8	IDA		Mouse	MGI:MGI:7408451\|PMID:15859952
Cellular Component	GO:0016324	apical plasma membrane	Aqp8	IDA		Rat	PMID:11436986\|RGD:155663551
Cellular Component	GO:0016324	apical plasma membrane	Aqp8	IDA		Rat	PMID:16177191\|RGD:155663527
Cellular Component	GO:0016323	basolateral plasma membrane	Aqp8	IDA		Rat	PMID:11205061\|RGD:155663525
Cellular Component	GO:0031526	brush border membrane	Aqp8	IDA		Rat	PMID:18059526\|RGD:155663542
Cellular Component	GO:0046691	intracellular canaliculus	AQP8	IDA		Human	PMID:18948439
Cellular Component	GO:0046691	intracellular canaliculus	Aqp8	IDA		Mouse	MGI:MGI:7388219\|PMID:14512882
Cellular Component	GO:0046691	intracellular canaliculus	Aqp8	IDA		Rat	PMID:11436986\|RGD:155663551
Cellular Component	GO:0046691	intracellular canaliculus	Aqp8	IDA		Rat	PMID:11932260\|RGD:625402
Cellular Component	GO:0046691	intracellular canaliculus	Aqp8	IDA		Rat	PMID:12774023\|RGD:1298925
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Aqp8	IDA		Rat	PMID:11278499\|RGD:67930
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Aqp8	IDA		Rat	PMID:11932260\|RGD:625402
Cellular Component	GO:0097708	intracellular vesicle	Aqp8	IDA		Mouse	MGI:MGI:7388219\|PMID:14512882
Cellular Component	GO:0005743	mitochondrial inner membrane	AQP8	IDA		Human	PMID:22622463
Cellular Component	GO:0005743	mitochondrial inner membrane	AQP8	IDA		Human	PMID:34292591
Cellular Component	GO:0005743	mitochondrial inner membrane	Aqp8	IDA		Rat	PMID:15749715\|RGD:155663529
Cellular Component	GO:0005743	mitochondrial inner membrane	Aqp8	IDA		Rat	PMID:23299935\|RGD:155663538
Cellular Component	GO:0031966	mitochondrial membrane	Aqp8	IDA		Rat	PMID:33892285\|RGD:155663536
Cellular Component	GO:0005739	mitochondrion	Aqp8	IDA		Mouse	MGI:MGI:7408451\|PMID:15859952
Cellular Component	GO:0005739	mitochondrion	Aqp8	IDA		Mouse	MGI:MGI:7388219\|PMID:14512882
Cellular Component	GO:0005886	plasma membrane	Aqp8	IDA		Mouse	MGI:MGI:3612624\|PMID:15647389
Cellular Component	GO:0005886	plasma membrane	Aqp8	IDA		Mouse	MGI:MGI:7408451\|PMID:15859952
Cellular Component	GO:0005886	plasma membrane	Aqp8	IDA		Rat	PMID:11278499\|RGD:67930
Cellular Component	GO:0005886	plasma membrane	Aqp8	IDA		Rat	PMID:33892285\|RGD:155663536
Cellular Component	GO:0005790	smooth endoplasmic reticulum	Aqp8	IDA		Mouse	MGI:MGI:7388219\|PMID:14512882
Biological Process	GO:0140157	ammonium import across plasma membrane	Aqp8	IDA		Mouse	MGI:MGI:3703401\|PMID:16624991
Biological Process	GO:0140157	ammonium import across plasma membrane	Aqp8	IDA		Rat	PMID:16624991\|RGD:155663530
Biological Process	GO:0140157	ammonium import across plasma membrane	Aqp8	IDA		Rat	PMID:17189259\|RGD:155663531
Biological Process	GO:0072488	ammonium transmembrane transport	AQP8	IMP		Human	PMID:22622463
Biological Process	GO:0072488	ammonium transmembrane transport	Aqp8	IDA		Rat	PMID:15988592\|RGD:155663547
Biological Process	GO:0030183	B cell differentiation	Aqp8	IMP		Mouse	MGI:MGI:5907956\|PMID:27256569
Biological Process	GO:0015722	canalicular bile acid transport	Aqp8	IDA		Rat	PMID:11932260\|RGD:625402
Biological Process	GO:1990748	cellular detoxification	AQP8	IMP		Human	PMID:34292591
Biological Process	GO:0071320	cellular response to cAMP	AQP8	IEP		Human	PMID:17636236
Biological Process	GO:0080170	hydrogen peroxide transmembrane transport	AQP8	IMP		Human	PMID:23541115
Biological Process	GO:0080170	hydrogen peroxide transmembrane transport	AQP8	IMP		Human	PMID:30579780
Biological Process	GO:0080170	hydrogen peroxide transmembrane transport	Aqp8	IMP		Mouse	MGI:MGI:5907956\|PMID:27256569
Biological Process	GO:0080170	hydrogen peroxide transmembrane transport	Aqp8	IMP		Rat	PMID:31372390\|RGD:155663517
Biological Process	GO:0080170	hydrogen peroxide transmembrane transport	Aqp8	IMP		Rat	PMID:33892285\|RGD:155663536
Biological Process	GO:0072489	methylammonium transmembrane transport	Aqp8	IMP		Rat	PMID:23299935\|RGD:155663538
Biological Process	GO:0015843	methylammonium transport	AQP8	IDA		Human	PMID:15948717
Biological Process	GO:0015843	methylammonium transport	Aqp8	IDA		Rat	PMID:15948717\|RGD:11060918
Biological Process	GO:0015843	methylammonium transport	Aqp8	IDA		Rat	PMID:15988592\|RGD:155663547
Biological Process	GO:0045540	regulation of cholesterol biosynthetic process	AQP8	IMP		Human	PMID:30579780
Biological Process	GO:0035377	transepithelial water transport	Aqp8	IDA		Rat	PMID:16177191\|RGD:155663527
Biological Process	GO:0055085	transmembrane transport	aqp8b	IDA		Zfish	PMID:20149227\|ZFIN:ZDB-PUB-100223-9
Biological Process	GO:0071918	urea transmembrane transport	aqp8a.2	IDA		Zfish	PMID:20149227\|ZFIN:ZDB-PUB-100223-9
Biological Process	GO:0071918	urea transmembrane transport	aqp8a.1	IDA		Zfish	PMID:20149227\|ZFIN:ZDB-PUB-100223-9
Biological Process	GO:0015840	urea transport	Aqp8	IDA		Mouse	MGI:MGI:1099926\|PMID:9388476
Biological Process	GO:0006833	water transport	AQP8	IDA		Human	PMID:15948717
Biological Process	GO:0006833	water transport	Aqp8	IDA		Mouse	MGI:MGI:7388218\|PMID:15948717
Biological Process	GO:0006833	water transport	Aqp8	IDA		Mouse	MGI:MGI:1099926\|PMID:9388476
Biological Process	GO:0006833	water transport	Aqp8	IMP		Mouse	MGI:MGI:3703401\|PMID:16624991
Biological Process	GO:0006833	water transport	Aqp8	IMP	MGI:MGI:3613030	Mouse	PMID:15647389
Biological Process	GO:0006833	water transport	Aqp8	IDA		Rat	PMID:11932260\|RGD:625402
Biological Process	GO:0006833	water transport	Aqp8	IDA		Rat	PMID:12774023\|RGD:1298925
Biological Process	GO:0006833	water transport	Aqp8	IDA		Rat	PMID:15749715\|RGD:155663529
Biological Process	GO:0006833	water transport	Aqp8	IDA		Rat	PMID:15948717\|RGD:11060918
Biological Process	GO:0006833	water transport	Aqp8	IMP		Rat	PMID:16624991\|RGD:155663530
Biological Process	GO:0006833	water transport	Aqp8	IMP		Rat	PMID:17189259\|RGD:155663531
Biological Process	GO:0006833	water transport	Aqp8	IMP		Rat	PMID:18059526\|RGD:155663542
Biological Process	GO:0006833	water transport	Aqp8	IDA		Rat	PMID:20132793\|RGD:155663528
Biological Process	GO:0006833	water transport	aqp8b	IDA		Zfish	PMID:20149227\|ZFIN:ZDB-PUB-100223-9

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.