Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ARAF
  • Mouse genes Araf
  • Rat genes Araf
  • Zfish genes araf
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Araf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	Araf	IDA		Rat	PMID:10648842|RGD:2298801
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P36507	Human	PMID:11909642
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:O43615	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:O94906	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:O95848	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P00966	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P01112	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P31327	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P53611	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P62070	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:Q12805	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:Q3ZCQ8	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:Q8IXH7	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:Q96KB5	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:Q9UNS2	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P31947	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P63104	Human	PMID:19933840
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P63104	Human	PMID:20052757
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P62258	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P63104	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:O43187	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P58753	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:Q92985	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P36507	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:Q8IXH7	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P01112	Human	PMID:24441586
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P36507	Human	PMID:24746704
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P08238	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P31947	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P36507	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P62258	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P63104	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:Q3ZCQ8	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P31947	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P36507	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P63104	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P36507	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P62258	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P63104	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	ARAF	IPI	UniProtKB:P01112	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	Araf	IPI	PR:P08556	Mouse	PMID:9488663
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ARAF	IDA		Human	PMID:19667065
Molecular Function	GO:0046332	SMAD binding	araf	IDA		Zfish	PMID:23591895
Cellular Component	GO:0005829	cytosol	Araf	IDA		Rat	PMID:9779826|RGD:70317
Cellular Component	GO:0005739	mitochondrion	Araf	IDA		Mouse	PMID:12931191
Biological Process	GO:0043066	negative regulation of apoptotic process	ARAF	IDA		Human	PMID:19667065
Biological Process	GO:1900108	negative regulation of nodal signaling pathway	araf	IDA		Zfish	PMID:23591895
Biological Process	GO:1900108	negative regulation of nodal signaling pathway	araf	IMP	ZFIN:ZDB-MRPHLNO-130508-1,ZFIN:ZDB-MRPHLNO-130508-2	Zfish	PMID:23591895
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	araf	IDA		Zfish	PMID:23591895
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ARAF	IDA		Human	PMID:19667065
Biological Process	GO:0006468	protein phosphorylation	Araf	IDA		Rat	PMID:10648842|RGD:2298801
Biological Process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	ARAF	IMP		Human	PMID:22609986
Biological Process	GO:0032006	regulation of TOR signaling	ARAF	IMP		Human	PMID:22609986

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern