Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AREG
  • Mouse genes Areg
  • Rat genes Areg
  • Zfish genes areg
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Areg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Areg	IDA		Rat	PMID:15509566|RGD:1578718
Molecular Function	GO:0008083	growth factor activity	Areg	IDA		Rat	PMID:2234093|RGD:69755
Molecular Function	GO:0005515	protein binding	AREG	IPI	UniProtKB:P26447	Human	PMID:19740107
Molecular Function	GO:0005515	protein binding	AREG	IPI	UniProtKB:P26447	Human	PMID:30083275
Molecular Function	GO:0005515	protein binding	AREG	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AREG	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0048018	receptor ligand activity	AREG	IDA		Human	PMID:8702723
Molecular Function	GO:0048018	receptor ligand activity	Areg	IGI	MGI:MGI:95294	Mouse	PMID:26243875
Molecular Function	GO:0048018	receptor ligand activity	Areg	IGI	MGI:MGI:95294	Mouse	PMID:23333074
Molecular Function	GO:0048018	receptor ligand activity	Areg	IGI	MGI:MGI:95294	Mouse	PMID:30770250
Molecular Function	GO:0048018	receptor ligand activity	Areg	IGI	MGI:MGI:95294	Mouse	PMID:23086930
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	AREG	IDA		Human	PMID:8702723
Cellular Component	GO:0009986	cell surface	AREG	IDA		Human	PMID:12743035
Cellular Component	GO:0005737	cytoplasm	Areg	IDA		Mouse	PMID:8588926
Cellular Component	GO:0005615	extracellular space	AREG	IDA		Human	PMID:8702723
Cellular Component	GO:0005615	extracellular space	AREG	IDA		Human	PMID:12743035
Cellular Component	GO:0005615	extracellular space	AREG	IDA		Human	PMID:22184114
Cellular Component	GO:0005615	extracellular space	Areg	IDA		Mouse	PMID:23086930
Cellular Component	GO:0005615	extracellular space	Areg	IGI	MGI:MGI:95294	Mouse	PMID:30770250
Cellular Component	GO:0005615	extracellular space	Areg	IDA		Rat	PMID:2234093|RGD:69755
Cellular Component	GO:0005622	intracellular anatomical structure	Areg	IDA		Mouse	PMID:8588926
Cellular Component	GO:0005634	nucleus	Areg	IDA		Mouse	PMID:8588926
Biological Process	GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis	Areg	IMP	MGI:MGI:2176531	Mouse	PMID:17369357
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	AREG	IDA		Human	PMID:12743035
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Areg	IGI	MGI:MGI:95294	Mouse	PMID:23333074
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Areg	IGI	MGI:MGI:95294	Mouse	PMID:23086930
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Areg	IGI	MGI:MGI:95294	Mouse	PMID:30770250
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Areg	IGI	MGI:MGI:95294	Mouse	PMID:26243875
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Areg	IDA		Rat	PMID:15509566|RGD:1578718
Biological Process	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	Areg	IMP	MGI:MGI:2176531	Mouse	PMID:17369357
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	AREG	IDA		Human	PMID:8702723
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	AREG	IDA		Human	PMID:12743035
Biological Process	GO:0014009	glial cell proliferation	Areg	IDA		Rat	PMID:2234093|RGD:69755
Biological Process	GO:0060749	mammary gland alveolus development	Areg	IGI	MGI:MGI:95290	Mouse	PMID:10331984
Biological Process	GO:0060749	mammary gland alveolus development	Areg	IGI	MGI:MGI:98724	Mouse	PMID:10331984
Biological Process	GO:0060744	mammary gland branching involved in thelarche	Areg	IMP	MGI:MGI:2176531	Mouse	PMID:10331984
Biological Process	GO:0060744	mammary gland branching involved in thelarche	Areg	IMP	MGI:MGI:2176531	Mouse	PMID:17369357
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Areg	IDA		Rat	PMID:15509566|RGD:1578718
Biological Process	GO:0031175	neuron projection development	Areg	IMP		Rat	PMID:1530950|RGD:2292669
Biological Process	GO:0008284	positive regulation of cell population proliferation	AREG	IMP		Human	PMID:12743035
Biological Process	GO:0008284	positive regulation of cell population proliferation	Areg	IDA		Mouse	PMID:8702723
Biological Process	GO:0008284	positive regulation of cell population proliferation	Areg	IDA		Rat	PMID:15509566|RGD:1578718
Biological Process	GO:0008284	positive regulation of cell population proliferation	Areg	IMP		Rat	PMID:8621257|RGD:2292668
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Areg	IDA		Mouse	PMID:8702723
Biological Process	GO:0042327	positive regulation of phosphorylation	Areg	IDA		Rat	PMID:15509566|RGD:1578718
Biological Process	GO:0051591	response to cAMP	Areg	IEP		Rat	PMID:16088955|RGD:2292666
Biological Process	GO:0032355	response to estradiol	Areg	IDA		Mouse	PMID:17369357
Biological Process	GO:0051384	response to glucocorticoid	Areg	IMP		Rat	PMID:1530950|RGD:2292669
Biological Process	GO:0042542	response to hydrogen peroxide	Areg	IEP		Rat	PMID:8806670|RGD:2292667
Biological Process	GO:0014070	response to organic cyclic compound	Areg	IEP		Rat	PMID:16088955|RGD:2292666
Biological Process	GO:0043434	response to peptide hormone	Areg	IEP		Rat	PMID:16088955|RGD:2292666

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern