Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ARF4
  • Mouse genes Arf4
  • Rat genes Arf4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ARF4	IDA		Human	PMID:12446727
Molecular Function	GO:0005525	GTP binding	ARF4	IDA		Human	PMID:12446727
Molecular Function	GO:0106274	NAD+-protein-arginine ADP-ribosyltransferase activity	ARF4	IDA		Human	PMID:1899243
Molecular Function	GO:0005515	protein binding	ARF4	IPI	UniProtKB:Q92538	Human	PMID:17956946
Molecular Function	GO:0005515	protein binding	ARF4	IPI	UniProtKB:Q96PM5	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ARF4	IPI	UniProtKB:Q9H190	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ARF4	IPI	UniProtKB:O75154-1	Human	PMID:26258637
Molecular Function	GO:0005515	protein binding	ARF4	IPI	UniProtKB:Q9UNS2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Arf4	IPI	UniProtKB:A2ARV4	Mouse	MGI:MGI:6467684|PMID:20048263
Molecular Function	GO:0005515	protein binding	Arf4	IPI	UniProtKB:Q8BYR5	Mouse	MGI:MGI:5470054|PMID:22111578
Molecular Function	GO:0005515	protein binding	Arf4	IPI	PR:E9PZ36	Mouse	PMID:24586199
Cellular Component	GO:0005737	cytoplasm	Arf4	IDA		Mouse	PMID:8947846
Cellular Component	GO:0005829	cytosol	ARF4	IDA		Human	PMID:12446727
Cellular Component	GO:0043197	dendritic spine	ARF4	IDA		Human	PMID:23050017
Cellular Component	GO:0070062	extracellular exosome	ARF4	HDA		Human	PMID:20458337
Cellular Component	GO:0098978	glutamatergic synapse	Arf4	IDA		Mouse	PMID:23050017
Cellular Component	GO:0098978	glutamatergic synapse	Arf4	IMP		Mouse	PMID:23050017
Cellular Component	GO:0005794	Golgi apparatus	Arf4	IDA		Mouse	PMID:24586199
Cellular Component	GO:0016020	membrane	ARF4	HDA		Human	PMID:19946888
Cellular Component	GO:0005886	plasma membrane	Arf4	IDA		Mouse	PMID:8947846
Cellular Component	GO:0032587	ruffle membrane	ARF4	IDA		Human	PMID:12446727
Biological Process	GO:0031584	activation of phospholipase D activity	ARF4	IDA		Human	PMID:12446727
Biological Process	GO:0045176	apical protein localization	Arf4	IMP	MGI:MGI:3857506	Mouse	PMID:24586199
Biological Process	GO:0007420	brain development	Arf4	IEP		Rat	PMID:11295238|RGD:2316175
Biological Process	GO:0016477	cell migration	ARF4	IDA		Human	PMID:22004728
Biological Process	GO:0060996	dendritic spine development	ARF4	IDA		Human	PMID:23050017
Biological Process	GO:0060996	dendritic spine development	Arf4	IMP	MGI:MGI:3879059	Mouse	PMID:23050017
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Arf4	IDA		Rat	PMID:12446727|RGD:728363
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	Arf4	IMP	MGI:MGI:3857506	Mouse	PMID:24586199
Biological Process	GO:0007612	learning	Arf4	IMP	MGI:MGI:3879059	Mouse	PMID:23050017
Biological Process	GO:0043066	negative regulation of apoptotic process	ARF4	IDA		Human	PMID:19041174
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ARF4	IDA		Human	PMID:12446727
Biological Process	GO:0061512	protein localization to cilium	Arf4	IMP		Mouse	PMID:24586199
Biological Process	GO:0099175	regulation of postsynapse organization	Arf4	IMP		Mouse	PMID:23050017
Biological Process	GO:0099175	regulation of postsynapse organization	Arf4	IDA		Mouse	PMID:23050017
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	ARF4	IDA		Human	PMID:19041174
Biological Process	GO:0050807	regulation of synapse organization	Arf4	IDA		Mouse	PMID:23050017
Biological Process	GO:0050807	regulation of synapse organization	Arf4	IMP		Mouse	PMID:23050017
Biological Process	GO:0048678	response to axon injury	Arf4	IEP		Rat	PMID:11295238|RGD:2316175
Biological Process	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ARF4	IGI	UniProtKB:P61204	Human	PMID:24768165
Biological Process	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ARF4	IGI	UniProtKB:P84085	Human	PMID:24768165

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern