Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Arf6

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ARF6
- Mouse genes Arf6
- Rat genes Arf6
- Zfish genes arf6a,arf6b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arf6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003925	G protein activity	ARF6	IDA		Human	PMID:32103017
Molecular Function	GO:0019003	GDP binding	ARF6	IDA		Human	PMID:15126638
Molecular Function	GO:0019003	GDP binding	ARF6	IDA		Human	PMID:32103017
Molecular Function	GO:0005525	GTP binding	ARF6	IDA		Human	PMID:10391955
Molecular Function	GO:0005525	GTP binding	ARF6	IDA		Human	PMID:15126638
Molecular Function	GO:0005525	GTP binding	ARF6	IDA		Human	PMID:32103017
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:O75154	Human	PMID:16148947
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:Q86YS3	Human	PMID:16148947
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:P21283	Human	PMID:16415858
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:O75154	Human	PMID:17030804
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:O75154	Human	PMID:18511905
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:O60271	Human	PMID:19644450
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:Q9ULP9	Human	PMID:20727515
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:Q9ULP9-2	Human	PMID:20727515
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:Q02241	Human	PMID:22522702
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:Q02241	Human	PMID:22580824
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:Q9NZ52	Human	PMID:23143332
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:O00213	Human	PMID:24056087
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:Q9NZ52	Human	PMID:24056087
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARF6	IPI	UniProtKB:P53365	Human	PMID:9312003
Molecular Function	GO:0005515	protein binding	Arf6	IPI	UniProtKB:O60271\|UniProtKB:Q02241\|UniProtKB:Q86YS3\|UniProtKB:Q9UJY5	Mouse	MGI:MGI:5426069\|PMID:22522702
Molecular Function	GO:0005515	protein binding	Arf6	IPI	UniProtKB:Q58A65\|UniProtKB:Q9ESN9	Mouse	MGI:MGI:4457975\|PMID:20493856
Molecular Function	GO:0005515	protein binding	Arf6	IPI	PR:Q61937	Mouse	PMID:24616519
Molecular Function	GO:0005515	protein binding	Arf6	IPI	PR:Q9DCD5	Mouse	PMID:22841714
Molecular Function	GO:0031996	thioesterase binding	ARF6	IPI	UniProtKB:P35125	Human	PMID:15509780
Cellular Component	GO:0005938	cell cortex	ARF6	IDA		Human	PMID:10913182
Cellular Component	GO:0032154	cleavage furrow	ARF6	IDA		Human	PMID:23603394
Cellular Component	GO:0005737	cytoplasm	Arf6	IDA		Mouse	PMID:8947846
Cellular Component	GO:0005829	cytosol	ARF6	IDA		Human	PMID:32103017
Cellular Component	GO:0005829	cytosol	ARF6	IDA		Human	PMID:10391955
Cellular Component	GO:0005769	early endosome	Arf6	IDA		Rat	PMID:18353411\|RGD:2306454
Cellular Component	GO:0030139	endocytic vesicle	ARF6	IDA		Human	PMID:19948740
Cellular Component	GO:0005768	endosome	ARF6	IDA		Human	PMID:20682791
Cellular Component	GO:0005768	endosome	Arf6	IDA		Mouse	MGI:MGI:4948831\|PMID:16751103
Cellular Component	GO:0070062	extracellular exosome	ARF6	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ARF6	HDA		Human	PMID:23533145
Cellular Component	GO:0031527	filopodium membrane	ARF6	IDA		Human	PMID:14978216
Cellular Component	GO:0090543	Flemming body	ARF6	IDA		Human	PMID:23603394
Cellular Component	GO:0005925	focal adhesion	ARF6	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Arf6	IDA		Rat	PMID:16672654\|RGD:8554141
Cellular Component	GO:0098978	glutamatergic synapse	Arf6	IMP		Rat	PMID:16672654\|RGD:8554141
Cellular Component	GO:0016020	membrane	ARF6	IDA		Human	PMID:10391955
Cellular Component	GO:0016020	membrane	ARF6	HDA		Human	PMID:19946888
Cellular Component	GO:0043209	myelin sheath	Arf6	HDA		Mouse	MGI:MGI:3834050\|PMID:17634366
Cellular Component	GO:0005886	plasma membrane	ARF6	IDA		Human	PMID:32103017
Cellular Component	GO:0005886	plasma membrane	ARF6	IDA		Human	PMID:10036235
Cellular Component	GO:0005886	plasma membrane	ARF6	IDA		Human	PMID:17398095
Cellular Component	GO:0005886	plasma membrane	ARF6	IDA		Human	PMID:19948740
Cellular Component	GO:0005886	plasma membrane	Arf6	IDA		Mouse	PMID:8947846
Cellular Component	GO:0005886	plasma membrane	Arf6	IDA		Rat	PMID:11950936\|RGD:727254
Cellular Component	GO:0098794	postsynapse	Arf6	IDA		Rat	PMID:26731518\|RGD:11556875
Cellular Component	GO:0098793	presynapse	Arf6	IDA		Rat	PMID:26731518\|RGD:11556875
Cellular Component	GO:0055037	recycling endosome	Arf6	IDA		Rat	PMID:18353411\|RGD:2306454
Cellular Component	GO:0055037	recycling endosome	Arf6	IDA		Rat	PMID:26446845\|RGD:11554955
Cellular Component	GO:0055038	recycling endosome membrane	ARF6	IDA		Human	PMID:10036235
Cellular Component	GO:0055038	recycling endosome membrane	ARF6	IDA		Human	PMID:21951725
Cellular Component	GO:0001726	ruffle	ARF6	IDA		Human	PMID:9312003
Cellular Component	GO:0001726	ruffle	Arf6	IDA		Rat	PMID:11950936\|RGD:727254
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Arf6	IDA		Rat	PMID:26446845\|RGD:11554955
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ARF6	IDA		Human	PMID:10036235
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ARF6	IMP		Human	PMID:10913182
Biological Process	GO:0032456	endocytic recycling	ARF6	IDA		Human	PMID:10036235
Biological Process	GO:0032456	endocytic recycling	Arf6	IDA		Rat	PMID:26446845\|RGD:11554955
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	arf6b	IGI	ZFIN:ZDB-MRPHLNO-120425-5	Zfish	PMID:22399807
Biological Process	GO:1902217	erythrocyte apoptotic process	Arf6	IMP	MGI:MGI:3662650	Mouse	PMID:16880525
Biological Process	GO:0090162	establishment of epithelial cell polarity	Arf6	IMP		Mouse	PMID:20080746
Biological Process	GO:0097284	hepatocyte apoptotic process	Arf6	IMP	MGI:MGI:3662650	Mouse	PMID:16880525
Biological Process	GO:0035622	intrahepatic bile duct development	arf6a	IGI	ZFIN:ZDB-MRPHLNO-210712-1,ZFIN:ZDB-MRPHLNO-120425-4	Zfish	PMID:33192543
Biological Process	GO:0035622	intrahepatic bile duct development	arf6b	IGI	ZFIN:ZDB-MRPHLNO-210712-1,ZFIN:ZDB-MRPHLNO-120425-4	Zfish	PMID:33192543
Biological Process	GO:0035622	intrahepatic bile duct development	arf6a	IGI	ZFIN:ZDB-MRPHLNO-120425-4	Zfish	PMID:26379158
Biological Process	GO:0035622	intrahepatic bile duct development	arf6a	IGI	ZFIN:ZDB-MRPHLNO-151230-4,ZFIN:ZDB-MRPHLNO-151230-5	Zfish	PMID:26379158
Biological Process	GO:0035622	intrahepatic bile duct development	arf6b	IGI	ZFIN:ZDB-MRPHLNO-120425-4	Zfish	PMID:26379158
Biological Process	GO:0035622	intrahepatic bile duct development	arf6b	IGI	ZFIN:ZDB-MRPHLNO-151230-4,ZFIN:ZDB-MRPHLNO-151230-5	Zfish	PMID:26379158
Biological Process	GO:0001889	liver development	Arf6	IMP	MGI:MGI:3662650	Mouse	PMID:16880525
Biological Process	GO:0099562	maintenance of postsynaptic density structure	Arf6	IDA		Rat	PMID:16672654\|RGD:8554141
Biological Process	GO:0099562	maintenance of postsynaptic density structure	Arf6	IMP		Rat	PMID:16672654\|RGD:8554141
Biological Process	GO:2000171	negative regulation of dendrite development	Arf6	IMP		Rat	PMID:12032543\|RGD:625544
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	Arf6	IDA		Mouse	MGI:MGI:6119883\|PMID:29420262
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ARF6	IMP		Human	PMID:10036235
Biological Process	GO:0120183	positive regulation of focal adhesion disassembly	Arf6	IMP		Mouse	MGI:MGI:6189265\|PMID:25490267
Biological Process	GO:0051549	positive regulation of keratinocyte migration	Arf6	IMP		Mouse	MGI:MGI:6189265\|PMID:25490267
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	Arf6	IDA		Mouse	MGI:MGI:4948831\|PMID:16751103
Biological Process	GO:0050714	positive regulation of protein secretion	ARF6	IMP		Human	PMID:27044754
Biological Process	GO:0034394	protein localization to cell surface	Arf6	IDA		Mouse	MGI:MGI:4948831\|PMID:16751103
Biological Process	GO:0036010	protein localization to endosome	ARF6	IMP		Human	PMID:21951725
Biological Process	GO:0036010	protein localization to endosome	Arf6	IMP		Mouse	MGI:MGI:5516175\|PMID:23572513
Biological Process	GO:0060998	regulation of dendritic spine development	Arf6	IMP		Mouse	MGI:MGI:4887338\|PMID:16325184
Biological Process	GO:0060998	regulation of dendritic spine development	Arf6	IMP		Rat	PMID:16672654\|RGD:8554141
Biological Process	GO:0051489	regulation of filopodium assembly	ARF6	IDA		Human	PMID:14978216
Biological Process	GO:0010975	regulation of neuron projection development	Arf6	IMP		Mouse	PMID:27330119
Biological Process	GO:1905606	regulation of presynapse assembly	Arf6	IDA		Rat	PMID:16672654\|RGD:8554141
Biological Process	GO:1905606	regulation of presynapse assembly	Arf6	IMP		Rat	PMID:16672654\|RGD:8554141
Biological Process	GO:0035020	regulation of Rac protein signal transduction	ARF6	IDA		Human	PMID:10036235
Biological Process	GO:0097178	ruffle assembly	ARF6	IDA		Human	PMID:10036235
Biological Process	GO:0048488	synaptic vesicle endocytosis	Arf6	IDA		Rat	PMID:26731518\|RGD:11556875
Biological Process	GO:0048488	synaptic vesicle endocytosis	Arf6	IMP		Rat	PMID:26731518\|RGD:11556875

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.