Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ARG2
  • Mouse genes Arg2
  • Rat genes Arg2
  • Zfish genes arg2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arg2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004053	arginase activity	ARG2	IMP		Human	PMID:16128822
Molecular Function	GO:0004053	arginase activity	Arg2	IDA		Rat	PMID:11829529|RGD:634667
Molecular Function	GO:0004053	arginase activity	Arg2	IDA		Rat	PMID:16537391|RGD:1582129
Molecular Function	GO:0050998	nitric-oxide synthase binding	Arg2	IPI	RGD:3184	Rat	PMID:16537391|RGD:1582129
Molecular Function	GO:0005515	protein binding	ARG2	IPI	UniProtKB:Q3SYB3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Arg2	IPI	RGD:3184	Rat	PMID:16537391|RGD:1582129
Molecular Function	GO:0005515	protein binding	Arg2	IPI	UniProtKB:P29476	Rat	PMID:16537391|RGD:1582129
Cellular Component	GO:0005739	mitochondrion	Arg2	IDA		Mouse	MGI:MGI:5908533|PMID:25009204
Cellular Component	GO:0005739	mitochondrion	Arg2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Arg2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Arg2	IDA		Rat	PMID:14871882|RGD:1358311
Cellular Component	GO:0005739	mitochondrion	Arg2	IDA		Rat	PMID:16537391|RGD:1582129
Biological Process	GO:0006915	apoptotic process	Arg2	IEP		Rat	PMID:17874066|RGD:4143285
Biological Process	GO:0019547	arginine catabolic process to ornithine	Arg2	IDA		Rat	PMID:15753084|RGD:8693655
Biological Process	GO:0006525	arginine metabolic process	Arg2	IMP		Rat	PMID:16537391|RGD:1582129
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Arg2	IEP		Rat	PMID:11250887|RGD:4144048
Biological Process	GO:0071353	cellular response to interleukin-4	Arg2	IEP		Rat	PMID:14618299|RGD:4144042
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Arg2	IEP		Rat	PMID:11250887|RGD:4144048
Biological Process	GO:0071346	cellular response to type II interferon	Arg2	IEP		Rat	PMID:11250887|RGD:4144048
Biological Process	GO:0030324	lung development	Arg2	IEP		Rat	PMID:18192591|RGD:4143284
Biological Process	GO:0060135	maternal process involved in female pregnancy	Arg2	IEP		Rat	PMID:16735458|RGD:4143426
Biological Process	GO:0007494	midgut development	Arg2	IEP		Rat	PMID:10050048|RGD:4144052
Biological Process	GO:1905403	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process	Arg2	IMP		Mouse	MGI:MGI:5908764|PMID:27745970
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	Arg2	IMP		Mouse	MGI:MGI:5908533|PMID:25009204
Biological Process	GO:0071644	negative regulation of chemokine (C-C motif) ligand 4 production	Arg2	IMP		Mouse	MGI:MGI:5908771|PMID:27074721
Biological Process	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	Arg2	IMP		Mouse	MGI:MGI:5908771|PMID:27074721
Biological Process	GO:1900425	negative regulation of defense response to bacterium	Arg2	IMP		Mouse	MGI:MGI:5908771|PMID:27074721
Biological Process	GO:0032696	negative regulation of interleukin-13 production	Arg2	IMP		Mouse	MGI:MGI:5810834|PMID:27214549
Biological Process	GO:0032700	negative regulation of interleukin-17 production	Arg2	IMP		Mouse	MGI:MGI:5810834|PMID:27214549
Biological Process	GO:0071641	negative regulation of macrophage inflammatory protein 1 alpha production	Arg2	IMP		Mouse	MGI:MGI:5908771|PMID:27074721
Biological Process	GO:0051001	negative regulation of nitric-oxide synthase activity	Arg2	IMP		Rat	PMID:16537391|RGD:1582129
Biological Process	GO:0045988	negative regulation of striated muscle contraction	Arg2	IMP		Rat	PMID:16537391|RGD:1582129
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ARG2	IMP		Human	PMID:28614294
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Arg2	IMP		Mouse	MGI:MGI:5908771|PMID:27074721
Biological Process	GO:0002829	negative regulation of type 2 immune response	Arg2	IMP		Mouse	MGI:MGI:5810834|PMID:27214549
Biological Process	GO:2000774	positive regulation of cellular senescence	ARG2	IDA		Human	PMID:22928666
Biological Process	GO:0032651	regulation of interleukin-1 beta production	Arg2	IMP		Mouse	MGI:MGI:5908771|PMID:27074721
Biological Process	GO:1905541	regulation of L-arginine import across plasma membrane	Arg2	IDA		Rat	PMID:11120661|RGD:4144049
Biological Process	GO:0045428	regulation of nitric oxide biosynthetic process	Arg2	IEP		Rat	PMID:11829529|RGD:634667
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	Arg2	IMP		Mouse	MGI:MGI:5810834|PMID:27214549
Biological Process	GO:0014075	response to amine	Arg2	IEP		Rat	PMID:16168957|RGD:4110830
Biological Process	GO:0043200	response to amino acid	Arg2	IEP		Rat	PMID:15458774|RGD:4143261
Biological Process	GO:0048678	response to axon injury	Arg2	IEP		Rat	PMID:15735325|RGD:4143237
Biological Process	GO:0046686	response to cadmium ion	Arg2	IEP		Rat	PMID:16570515|RGD:4143188
Biological Process	GO:0009749	response to glucose	Arg2	IEP		Rat	PMID:15254879|RGD:4143262
Biological Process	GO:0009635	response to herbicide	Arg2	IEP		Rat	PMID:20388547|RGD:2317876
Biological Process	GO:0009725	response to hormone	Arg2	IEP		Rat	PMID:14532164|RGD:4144043
Biological Process	GO:0001666	response to hypoxia	Arg2	IEP		Rat	PMID:20039818|RGD:4143278
Biological Process	GO:0046689	response to mercury ion	Arg2	IEP		Rat	PMID:17874066|RGD:4143285
Biological Process	GO:0007584	response to nutrient	Arg2	IEP		Rat	PMID:18348861|RGD:4143283
Biological Process	GO:0010269	response to selenium ion	Arg2	IEP		Rat	PMID:14624471|RGD:4143267
Biological Process	GO:0033197	response to vitamin E	Arg2	IEP		Rat	PMID:14624471|RGD:4143267
Biological Process	GO:0009410	response to xenobiotic stimulus	Arg2	IEP		Rat	PMID:15888029|RGD:4143232
Biological Process	GO:0006941	striated muscle contraction	Arg2	IMP		Mouse	PMID:16537391
Biological Process	GO:0001657	ureteric bud development	Arg2	IEP		Mouse	MGI:MGI:3655805|PMID:16545622

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern