Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ARHGEF2
  • Mouse genes Arhgef2
  • Rat genes Arhgef2
  • Zfish genes arhgef1a,arhgef2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arhgef2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ARHGEF2	IDA		Human	PMID:9857026
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Arhgef2	IDA		Mouse	PMID:15996550
Molecular Function	GO:0008017	microtubule binding	ARHGEF2	IDA		Human	PMID:9857026
Molecular Function	GO:0008017	microtubule binding	Arhgef2	IDA		Mouse	PMID:15996550
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:P63104	Human	PMID:14970201
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:Q9Y239	Human	PMID:19043560
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:O43353	Human	PMID:21887730
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:Q13546	Human	PMID:21887730
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:Q9Y572	Human	PMID:21887730
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:Q8N5L8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:O43524	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:Q8N5L8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:P61586	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:Q8N5L8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARHGEF2	IPI	UniProtKB:Q8NI38	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Arhgef2	IPI	UniProtKB:Q61097	Mouse	MGI:MGI:5568272|PMID:24525234
Molecular Function	GO:0005515	protein binding	Arhgef2	IPI	UniProtKB:O35646	Mouse	MGI:MGI:5009755|PMID:21406564
Molecular Function	GO:0005515	protein binding	Arhgef2	IPI	MGI:MGI:2442401	Mouse	PMID:15996550
Molecular Function	GO:0005515	protein binding	Arhgef2	IPI	PR:Q9QWY8	Mouse	PMID:21352810
Molecular Function	GO:0005515	protein binding	Arhgef2	IPI	PR:Q6R891	Mouse	PMID:15996550
Molecular Function	GO:0005515	protein binding	Arhgef2	IPI	UniProtKB:P19490	Rat	PMID:19208802|RGD:13432301
Molecular Function	GO:0031267	small GTPase binding	ARHGEF2	IDA		Human	PMID:9857026
Cellular Component	GO:0005737	cytoplasm	ARHGEF2	IDA		Human	PMID:21887730
Cellular Component	GO:0005856	cytoskeleton	ARHGEF2	IDA		Human	PMID:21887730
Cellular Component	GO:0043198	dendritic shaft	Arhgef2	IDA		Mouse	PMID:15996550
Cellular Component	GO:0005925	focal adhesion	ARHGEF2	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Arhgef2	IDA		Rat	PMID:19208802|RGD:13432301
Cellular Component	GO:0098978	glutamatergic synapse	Arhgef2	IMP		Rat	PMID:19208802|RGD:13432301
Cellular Component	GO:0005874	microtubule	ARHGEF2	IDA		Human	PMID:9857026
Cellular Component	GO:0043025	neuronal cell body	Arhgef2	IDA		Mouse	PMID:15996550
Cellular Component	GO:0002102	podosome	Arhgef2	IDA		Mouse	PMID:21352810
Cellular Component	GO:0014069	postsynaptic density	Arhgef2	IDA		Mouse	PMID:17114649
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Arhgef2	IDA		Rat	PMID:19208802|RGD:13432301
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Arhgef2	IMP		Rat	PMID:19208802|RGD:13432301
Cellular Component	GO:0032991	protein-containing complex	ARHGEF2	IDA		Human	PMID:21887730
Cellular Component	GO:0032587	ruffle membrane	ARHGEF2	IDA		Human	PMID:19043560
Cellular Component	GO:0031982	vesicle	ARHGEF2	IDA		Human	PMID:21887730
Biological Process	GO:0007015	actin filament organization	ARHGEF2	IMP		Human	PMID:9857026
Biological Process	GO:0007015	actin filament organization	Arhgef2	IPI	UniProtKB:Q7TN74	Mouse	PMID:15996550
Biological Process	GO:0007015	actin filament organization	Arhgef2	IPI	PR:Q6R891	Mouse	PMID:15996550
Biological Process	GO:0055059	asymmetric neuroblast division	ARHGEF2	IDA		Human	PMID:28453519
Biological Process	GO:0055059	asymmetric neuroblast division	Arhgef2	IMP		Mouse	MGI:MGI:5907381|PMID:28453519
Biological Process	GO:0000902	cell morphogenesis	ARHGEF2	IMP		Human	PMID:11912491
Biological Process	GO:0000902	cell morphogenesis	Arhgef2	IDA		Mouse	PMID:15996550
Biological Process	GO:0071225	cellular response to muramyl dipeptide	ARHGEF2	IDA		Human	PMID:21887730
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Arhgef2	IMP		Mouse	MGI:MGI:4457234|PMID:19448628
Biological Process	GO:0007026	negative regulation of microtubule depolymerization	ARHGEF2	IMP		Human	PMID:11912491
Biological Process	GO:0050768	negative regulation of neurogenesis	Arhgef2	IMP		Mouse	MGI:MGI:4457234|PMID:19448628
Biological Process	GO:0071802	negative regulation of podosome assembly	Arhgef2	IMP		Mouse	PMID:21352810
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ARHGEF2	IDA		Human	PMID:21887730
Biological Process	GO:0045666	positive regulation of neuron differentiation	ARHGEF2	IDA		Human	PMID:28453519
Biological Process	GO:0045666	positive regulation of neuron differentiation	Arhgef2	IMP		Mouse	MGI:MGI:5907381|PMID:28453519
Biological Process	GO:2001224	positive regulation of neuron migration	Arhgef2	IMP		Mouse	MGI:MGI:5907381|PMID:28453519
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ARHGEF2	IDA		Human	PMID:19043560
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ARHGEF2	IDA		Human	PMID:21887730
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ARHGEF2	IDA		Human	PMID:21887730
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ARHGEF2	IDA		Human	PMID:21887730
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ARHGEF2	IDA		Human	PMID:21887730
Biological Process	GO:0035023	regulation of Rho protein signal transduction	Arhgef2	IDA		Mouse	PMID:15996550

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern