Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Arpc2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ARPC2
- Mouse genes Arpc2
- Rat genes Arpc2
- Zfish genes arpc2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arpc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	ARPC2	IDA		Human	PMID:11741539
Molecular Function	GO:0035650	AP-1 adaptor complex binding	Arpc2	IDA		Rat	PMID:22689987\|RGD:8554651
Molecular Function	GO:0071933	Arp2/3 complex binding	Arpc2	IDA		Rat	PMID:22689987\|RGD:8554651
Molecular Function	GO:0051117	ATPase binding	Arpc2	IPI	RGD:69437	Rat	PMID:18297063\|RGD:8554748
Molecular Function	GO:0051117	ATPase binding	Arpc2	IPI	RGD:631345	Rat	PMID:23403943\|RGD:11530034
Molecular Function	GO:0035254	glutamate receptor binding	Arpc2	IPI	RGD:61862	Rat	PMID:18297063\|RGD:8554748
Molecular Function	GO:0019894	kinesin binding	Arpc2	IDA		Rat	PMID:22689987\|RGD:8554651
Molecular Function	GO:0005515	protein binding	ARPC2	IPI	UniProtKB:P59998	Human	PMID:11162547
Molecular Function	GO:0005515	protein binding	ARPC2	IPI	UniProtKB:P18206	Human	PMID:12473693
Molecular Function	GO:0005515	protein binding	ARPC2	IPI	UniProtKB:Q9BR76	Human	PMID:16027158
Molecular Function	GO:0005515	protein binding	ARPC2	IPI	UniProtKB:Q9BR76	Human	PMID:17350576
Molecular Function	GO:0005515	protein binding	ARPC2	IPI	UniProtKB:Q7Z6K5-1	Human	PMID:24132237
Molecular Function	GO:0005515	protein binding	ARPC2	IPI	UniProtKB:Q16236	Human	PMID:32911434
Molecular Function	GO:0005515	protein binding	Arpc2	IPI	PR:O89053	Mouse	PMID:18836449
Molecular Function	GO:0005515	protein binding	Arpc2	IPI	PR:Q9WUM3	Mouse	PMID:18836449
Molecular Function	GO:0005515	protein binding	Arpc2	IPI	PR:Q9JIY0	Mouse	PMID:22553210
Molecular Function	GO:0005515	protein binding	Arpc2	IPI	RGD:736068	Rat	PMID:17456547\|RGD:11567219
Molecular Function	GO:0005515	protein binding	Arpc2	IPI	RGD:2382	Rat	PMID:22619279\|RGD:10047170
Molecular Function	GO:0005515	protein binding	Arpc2	IPI	UniProtKB:O89046	Rat	PMID:22619279\|RGD:10047170
Molecular Function	GO:0005515	protein binding	Arpc2	IPI	UniProtKB:Q9BR76	Rat	PMID:22619279\|RGD:10047170
Molecular Function	GO:0005515	protein binding	Arpc2	IPI	RGD:2322545	Rat	PMID:23546604\|RGD:11530027
Molecular Function	GO:0044877	protein-containing complex binding	Arpc2	IPI	RGD:2382\|RGD:1345208	Rat	PMID:17350576\|RGD:11567223
Molecular Function	GO:0044877	protein-containing complex binding	Arpc2	IPI	RGD:2382\|RGD:2155	Rat	PMID:18775315\|RGD:11530062
Molecular Function	GO:0044877	protein-containing complex binding	Arpc2	IPI	RGD:619839\|RGD:2155	Rat	PMID:18775315\|RGD:11530062
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ARPC2	IDA		Human	PMID:11741539
Cellular Component	GO:0061834	actin filament branch point	Arpc2	IDA		Rat	PMID:18256280\|RGD:2306202
Cellular Component	GO:0097440	apical dendrite	Arpc2	IDA		Rat	PMID:18509026\|RGD:11530067
Cellular Component	GO:0005885	Arp2/3 protein complex	ARPC2	IDA		Human	PMID:11741539
Cellular Component	GO:0043679	axon terminus	Arpc2	IDA		Rat	PMID:18509026\|RGD:11530067
Cellular Component	GO:0031252	cell leading edge	Arpc2	IDA		Mouse	PMID:18836449
Cellular Component	GO:0031252	cell leading edge	Arpc2	IDA		Rat	PMID:16027158\|RGD:11534986
Cellular Component	GO:0009986	cell surface	Arpc2	IDA		Rat	PMID:11598004\|RGD:11576278
Cellular Component	GO:0061830	concave side of sperm head	Arpc2	IDA		Rat	PMID:23403943\|RGD:11530034
Cellular Component	GO:0005737	cytoplasm	Arpc2	IDA		Rat	PMID:17224451\|RGD:2306207
Cellular Component	GO:0043198	dendritic shaft	Arpc2	IDA		Rat	PMID:18509026\|RGD:11530067
Cellular Component	GO:0043197	dendritic spine	Arpc2	IDA		Rat	PMID:18509026\|RGD:11530067
Cellular Component	GO:0005768	endosome	Arpc2	IDA		Mouse	PMID:22689987
Cellular Component	GO:0070062	extracellular exosome	ARPC2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ARPC2	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ARPC2	HDA		Human	PMID:23533145
Cellular Component	GO:0031941	filamentous actin	Arpc2	IDA		Rat	PMID:10797548\|RGD:11049163
Cellular Component	GO:0005925	focal adhesion	ARPC2	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	Arpc2	IDA		Mouse	PMID:12473693
Cellular Component	GO:0098978	glutamatergic synapse	Arpc2	EXP		Mouse	PMID:24413018
Cellular Component	GO:0098978	glutamatergic synapse	Arpc2	IDA		Mouse	PMID:24413018
Cellular Component	GO:0030426	growth cone	Arpc2	IDA		Rat	PMID:10797548\|RGD:11049163
Cellular Component	GO:0030027	lamellipodium	ARPC2	IDA		Human	PMID:9230079
Cellular Component	GO:0030027	lamellipodium	Arpc2	IDA		Rat	PMID:15684033\|RGD:11575050
Cellular Component	GO:0036195	muscle cell projection membrane	Arpc2	IDA		Mouse	PMID:22553210
Cellular Component	GO:0005654	nucleoplasm	ARPC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043204	perikaryon	Arpc2	IDA		Rat	PMID:18509026\|RGD:11530067
Cellular Component	GO:0090725	peripheral region of growth cone	Arpc2	IDA		Rat	PMID:18256280\|RGD:2306202
Cellular Component	GO:0005886	plasma membrane	Arpc2	IDA		Mouse	PMID:22689987
Cellular Component	GO:0061825	podosome core	Arpc2	IDA		Rat	PMID:17224451\|RGD:2306207
Cellular Component	GO:0061826	podosome ring	Arpc2	IDA		Rat	PMID:17224451\|RGD:2306207
Cellular Component	GO:0098794	postsynapse	Arpc2	IDA		Rat	PMID:18509026\|RGD:11530067
Cellular Component	GO:0032587	ruffle membrane	Arpc2	IDA		Rat	PMID:17224451\|RGD:2306207
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Arpc2	IDA		Rat	PMID:18509026\|RGD:11530067
Cellular Component	GO:0030141	secretory granule	Arpc2	IDA		Rat	PMID:14617808\|RGD:11575051
Cellular Component	GO:0045202	synapse	Arpc2	IDA		Mouse	PMID:24413018
Cellular Component	GO:0045202	synapse	Arpc2	EXP		Mouse	PMID:24413018
Cellular Component	GO:0045202	synapse	Arpc2	IDA		Rat	PMID:18297063\|RGD:8554748
Cellular Component	GO:0061835	ventral surface of cell	Arpc2	IDA		Rat	PMID:11598004\|RGD:11576278
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	ARPC2	IDA		Human	PMID:11741539
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Arpc2	IMP		Rat	PMID:15252126\|RGD:2306210
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Arpc2	IEP		Rat	PMID:24152438\|RGD:11049153
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Arpc2	IEP		Rat	PMID:10797548\|RGD:11049163
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Arpc2	IDA		Rat	PMID:22619279\|RGD:10047170
Biological Process	GO:0072752	cellular response to rapamycin	Arpc2	IDA		Rat	PMID:11598004\|RGD:11576278
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Arpc2	IDA		Mouse	PMID:18836449
Biological Process	GO:2000814	positive regulation of barbed-end actin filament capping	Arpc2	IMP		Rat	PMID:15252126\|RGD:2306210
Biological Process	GO:0051491	positive regulation of filopodium assembly	Arpc2	IMP		Rat	PMID:18256280\|RGD:2306202
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ARPC2	IMP		Human	PMID:18560548
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	Arpc2	IMP		Rat	PMID:15252126\|RGD:2306210
Biological Process	GO:0071803	positive regulation of podosome assembly	Arpc2	IMP		Rat	PMID:17224451\|RGD:2306207
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	Arpc2	IMP		Rat	PMID:20739464\|RGD:10054052
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Arpc2	IMP		Rat	PMID:24152438\|RGD:11049153
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Arpc2	IMP		Mouse	PMID:22689987
Biological Process	GO:0070528	protein kinase C signaling	Arpc2	IDA		Rat	PMID:16027158\|RGD:11534986
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	Arpc2	IMP		Rat	PMID:20739464\|RGD:10054052
Biological Process	GO:0034021	response to silicon dioxide	Arpc2	IEP		Rat	PMID:18685790\|RGD:4893904

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.