Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Arrb1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ARRB1
- Mouse genes Arrb1
- Rat genes Arrb1
- Zfish genes arrb1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arrb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031691	alpha-1A adrenergic receptor binding	Arrb1	IPI	RGD:736081	Rat	PMID:18523139\|RGD:5510010
Molecular Function	GO:0031692	alpha-1B adrenergic receptor binding	Arrb1	IDA		Rat	PMID:18523139\|RGD:5510010
Molecular Function	GO:0031701	angiotensin receptor binding	ARRB1	IPI	UniProtKB:P30556	Human	PMID:15611106
Molecular Function	GO:0035612	AP-2 adaptor complex binding	Arrb1	IDA		Rat	PMID:15728179\|RGD:1601545
Molecular Function	GO:1990763	arrestin family protein binding	ARRB1	IPI	UniProtKB:Q8N5I2	Human	PMID:23886940
Molecular Function	GO:1990763	arrestin family protein binding	Arrb1	IPI	UniProtKB:Q8N5I2	Rat	PMID:23886940\|RGD:13432293
Molecular Function	GO:0035615	clathrin adaptor activity	Arrb1	IDA		Rat	PMID:15728179\|RGD:1601545
Molecular Function	GO:0030276	clathrin binding	Arrb1	IDA		Rat	PMID:17513300\|RGD:5490984
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Arrb1	IMP		Mouse	MGI:MGI:4453294\|PMID:19915011
Molecular Function	GO:0019899	enzyme binding	Arrb1	IPI	RGD:736102	Rat	PMID:12399592\|RGD:631798
Molecular Function	GO:0031762	follicle-stimulating hormone receptor binding	Arrb1	IPI	RGD:2632	Rat	PMID:16899567\|RGD:4140424
Molecular Function	GO:0005096	GTPase activator activity	ARRB1	IMP		Human	PMID:15611106
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ARRB1	IPI	UniProtKB:P08069	Human	PMID:15878855
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	Arrb1	IDA		Mouse	MGI:MGI:4453294\|PMID:19915011
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Arrb1	IPI	RGD:2581	Rat	PMID:19339617\|RGD:5509970
Molecular Function	GO:0051219	phosphoprotein binding	Arrb1	IPI	UniProtKB:O14640	Rat	PMID:11742073\|RGD:8554243
Molecular Function	GO:0051219	phosphoprotein binding	Arrb1	IPI	UniProtKB:O14641	Rat	PMID:11742073\|RGD:8554243
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:O43298	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q14749	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P16220	Human	PMID:16325578
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q9Y4K3	Human	PMID:16378096
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P12931	Human	PMID:16432186
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P51810	Human	PMID:16524428
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:O75688	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:O95218	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P06396	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P06702	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P11142	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P14618	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P19338	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P27348	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P35813	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q13428	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q13523	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q14978	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q15208	Human	PMID:17620599
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:O15169	Human	PMID:19202075
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P12931	Human	PMID:19202075
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P25101	Human	PMID:19202075
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q8TEY7	Human	PMID:19363159
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P53779	Human	PMID:19782076
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q99683	Human	PMID:19782076
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P25490	Human	PMID:19879840
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P53779	Human	PMID:19879840
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q00987	Human	PMID:19879840
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q16665	Human	PMID:21685944
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P04637	Human	PMID:21857681
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q00987	Human	PMID:21857681
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P45984	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q14749	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P25106	Human	PMID:22457824
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q9NPB9	Human	PMID:23341447
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P50148	Human	PMID:23353685
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q5JWF2	Human	PMID:23353685
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P20963	Human	PMID:24502978
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P45984	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q7DB77	Human	PMID:25519916
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q14749	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:O43298	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P45984	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q14749	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:O43298	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P14859-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P45984	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:P63010-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ARRB1	IPI	UniProtKB:Q14749	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Arrb1	IPI	UniProtKB:O35387\|UniProtKB:O54946\|UniProtKB:P23804\|UniProtKB:Q60795	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Arrb1	IPI	UniProtKB:P58660	Mouse	MGI:MGI:6092781\|PMID:18952848
Molecular Function	GO:0005515	protein binding	Arrb1	IPI	PR:Q04736	Mouse	PMID:11546805
Molecular Function	GO:0005515	protein binding	Arrb1	IPI	PR:Q61614	Mouse	PMID:11546805
Molecular Function	GO:0005515	protein binding	Arrb1	IPI	UniProtKB:P11345	Rat	PMID:10725339\|RGD:13524618
Molecular Function	GO:0005515	protein binding	Arrb1	IPI	UniProtKB:P55085	Rat	PMID:10725339\|RGD:13524618
Molecular Function	GO:0005515	protein binding	Arrb1	IPI	UniProtKB:P53667	Rat	PMID:17500066\|RGD:8554055
Molecular Function	GO:0005515	protein binding	Arrb1	IPI	UniProtKB:Q96GD0	Rat	PMID:17500066\|RGD:8554055
Molecular Function	GO:0005515	protein binding	Arrb1	IPI	RGD:620218	Rat	PMID:21223624\|RGD:10059408
Molecular Function	GO:0005515	protein binding	Arrb1	IPI	UniProtKB:P04637	Rat	PMID:21857681\|RGD:13432274
Molecular Function	GO:0005515	protein binding	arrb1	IPI	ZFIN:ZDB-GENE-030131-1117,ZFIN:ZDB-GENE-060824-1	Zfish	PMID:19879840
Molecular Function	GO:0005515	protein binding	arrb1	IPI	ZFIN:ZDB-GENE-070615-28	Zfish	PMID:26358189
Molecular Function	GO:0045309	protein phosphorylated amino acid binding	Arrb1	IDA		Rat	PMID:17513300\|RGD:5490984
Molecular Function	GO:0005102	signaling receptor binding	Arrb1	IPI	RGD:730975	Rat	PMID:23604254\|RGD:13506840
Molecular Function	GO:0003713	transcription coactivator activity	ARRB1	IMP		Human	PMID:16325578
Molecular Function	GO:0044325	transmembrane transporter binding	Arrb1	IPI	RGD:69337	Rat	PMID:20650893\|RGD:5509917
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ARRB1	IPI	UniProtKB:Q00987	Human	PMID:15878855
Molecular Function	GO:0031896	V2 vasopressin receptor binding	Arrb1	IDA		Rat	PMID:17513300\|RGD:5490984
Cellular Component	GO:0016323	basolateral plasma membrane	Arrb1	IDA		Rat	PMID:16899567\|RGD:4140424
Cellular Component	GO:0000785	chromatin	ARRB1	IDA		Human	PMID:16325578
Cellular Component	GO:0005737	cytoplasm	ARRB1	IDA		Human	PMID:10823817
Cellular Component	GO:0005737	cytoplasm	ARRB1	IDA		Human	PMID:15611106
Cellular Component	GO:0005737	cytoplasm	ARRB1	IDA		Human	PMID:16325578
Cellular Component	GO:0005737	cytoplasm	Arrb1	IDA		Rat	PMID:16899567\|RGD:4140424
Cellular Component	GO:0031410	cytoplasmic vesicle	ARRB1	IDA		Human	PMID:15611106
Cellular Component	GO:0005829	cytosol	Arrb1	IDA		Mouse	MGI:MGI:4453294\|PMID:19915011
Cellular Component	GO:0005829	cytosol	Arrb1	IDA		Rat	PMID:15514408\|RGD:1578803
Cellular Component	GO:0043197	dendritic spine	Arrb1	IDA		Rat	PMID:1517224\|RGD:631708
Cellular Component	GO:0005768	endosome	Arrb1	IDA		Rat	PMID:25016018\|RGD:13506837
Cellular Component	GO:0005622	intracellular anatomical structure	Arrb1	IDA		Mouse	PMID:11171997
Cellular Component	GO:0016604	nuclear body	ARRB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ARRB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ARRB1	IDA		Human	PMID:16325578
Cellular Component	GO:0005634	nucleus	Arrb1	IDA		Rat	PMID:21223624\|RGD:10059408
Cellular Component	GO:0014069	postsynaptic density	Arrb1	IDA		Rat	PMID:1517224\|RGD:631708
Cellular Component	GO:0045211	postsynaptic membrane	Arrb1	IDA		Rat	PMID:1517224\|RGD:631708
Cellular Component	GO:0031143	pseudopodium	Arrb1	IDA		Mouse	MGI:MGI:2673740\|PMID:12821670
Biological Process	GO:0035162	embryonic hemopoiesis	arrb1	IMP	ZFIN:ZDB-MRPHLNO-100311-1	Zfish	PMID:19879840
Biological Process	GO:0006897	endocytosis	Arrb1	IDA		Rat	PMID:12519791\|RGD:1304268
Biological Process	GO:0098508	endothelial to hematopoietic transition	arrb1	IMP	ZFIN:ZDB-MRPHLNO-100311-1	Zfish	PMID:26358189
Biological Process	GO:0042699	follicle-stimulating hormone signaling pathway	Arrb1	IDA		Rat	PMID:16899567\|RGD:4140424
Biological Process	GO:0002031	G protein-coupled receptor internalization	ARRB1	IMP		Human	PMID:10521508
Biological Process	GO:0002031	G protein-coupled receptor internalization	ARRB1	IMP		Human	PMID:12582207
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Arrb1	IDA		Rat	PMID:1517224\|RGD:631708
Biological Process	GO:0048368	lateral mesoderm development	arrb1	IMP	ZFIN:ZDB-MRPHLNO-100311-1	Zfish	PMID:19879840
Biological Process	GO:0043066	negative regulation of apoptotic process	Arrb1	IMP		Rat	PMID:24378649\|RGD:13506838
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Arrb1	IMP		Mouse	MGI:MGI:4453294\|PMID:19915011
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Arrb1	IMP		Rat	PMID:19254952\|RGD:5509898
Biological Process	GO:0034260	negative regulation of GTPase activity	Arrb1	IDA		Rat	PMID:1517224\|RGD:631708
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ARRB1	IDA		Human	PMID:16378096
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ARRB1	IDA		Human	PMID:16378096
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Arrb1	IMP		Rat	PMID:26621121\|RGD:11537517
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ARRB1	IDA		Human	PMID:16378096
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	ARRB1	IMP		Human	PMID:23886940
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Arrb1	IMP		Mouse	MGI:MGI:5916812\|PMID:23886940
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	arrb1	IGI	ZFIN:ZDB-GENE-070615-28	Zfish	PMID:26358189
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	arrb1	IMP	ZFIN:ZDB-MRPHLNO-100311-1	Zfish	PMID:26358189
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Arrb1	IMP		Rat	PMID:19254952\|RGD:5509898
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ARRB1	IDA		Human	PMID:16378096
Biological Process	GO:0007602	phototransduction	Arrb1	IMP	MGI:MGI:2388373	Mouse	PMID:11853756
Biological Process	GO:0008284	positive regulation of cell population proliferation	Arrb1	IMP		Rat	PMID:25486571\|RGD:13506834
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Arrb1	IMP		Rat	PMID:19171933\|RGD:5510006
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ARRB1	IDA		Human	PMID:10644702
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Arrb1	IMP		Mouse	MGI:MGI:4453294\|PMID:19915011
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Arrb1	IMP		Rat	PMID:19289825\|RGD:5509998
Biological Process	GO:0035066	positive regulation of histone acetylation	ARRB1	IMP		Human	PMID:16325578
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Arrb1	IMP		Mouse	MGI:MGI:4453294\|PMID:19915011
Biological Process	GO:0043410	positive regulation of MAPK cascade	Arrb1	IDA		Rat	PMID:12167719\|RGD:631797
Biological Process	GO:0043410	positive regulation of MAPK cascade	Arrb1	IDA		Rat	PMID:12519791\|RGD:1304268
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Arrb1	IMP		Mouse	MGI:MGI:4453294\|PMID:19915011
Biological Process	GO:0032092	positive regulation of protein binding	Arrb1	IMP		Mouse	MGI:MGI:4453294\|PMID:19915011
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ARRB1	IMP		Human	PMID:23633677
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Arrb1	IMP		Rat	PMID:24378649\|RGD:13506838
Biological Process	GO:0031398	positive regulation of protein ubiquitination	Arrb1	IMP		Rat	PMID:20650893\|RGD:5509917
Biological Process	GO:0002092	positive regulation of receptor internalization	ARRB1	IMP		Human	PMID:22457824
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	ARRB1	IMP		Human	PMID:15611106
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	Arrb1	IMP		Rat	PMID:19171933\|RGD:5510006
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ARRB1	IMP		Human	PMID:16325578
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Arrb1	IDA		Rat	PMID:16325578\|RGD:8554401
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ARRB1	IMP		Human	PMID:15878855
Biological Process	GO:0016567	protein ubiquitination	ARRB1	IMP		Human	PMID:15878855
Biological Process	GO:0042981	regulation of apoptotic process	Arrb1	IMP		Mouse	MGI:MGI:4453294\|PMID:19915011
Biological Process	GO:1900136	regulation of chemokine activity	arrb1	IGI	ZFIN:ZDB-MRPHLNO-120821-1,ZFIN:ZDB-MRPHLNO-120821-3,ZFIN:ZDB-MRPHLNO-121119-1	Zfish	PMID:22791893
Biological Process	GO:0006355	regulation of DNA-templated transcription	Arrb1	IDA		Rat	PMID:11742073\|RGD:8554243
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	Arrb1	IMP	MGI:MGI:2157962	Mouse	PMID:11171997
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	Arrb1	IMP	MGI:MGI:2157962	Mouse	PMID:9400383
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	Arrb1	IDA		Rat	PMID:1517224\|RGD:631708
Biological Process	GO:1903978	regulation of microglial cell activation	arrb1	IMP	ZFIN:ZDB-MRPHLNO-100311-1	Zfish	PMID:26354363
Biological Process	GO:0001919	regulation of receptor recycling	arrb1	IGI	ZFIN:ZDB-MRPHLNO-120821-1,ZFIN:ZDB-MRPHLNO-120821-3,ZFIN:ZDB-MRPHLNO-121119-1	Zfish	PMID:22791893
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ARRB1	IMP		Human	PMID:16325578
Biological Process	GO:0009410	response to xenobiotic stimulus	Arrb1	IEP		Rat	PMID:21223624\|RGD:10059408
Biological Process	GO:0043149	stress fiber assembly	ARRB1	IMP		Human	PMID:15611106
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ARRB1	IMP		Human	PMID:23886940
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Arrb1	IMP		Mouse	MGI:MGI:5916812\|PMID:23886940

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.