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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Arrb2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arrb2
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:007188914-3-3 protein bindingArrb2IDARatPMID:19008961|RGD:5510009
Molecular FunctionGO:0031691alpha-1A adrenergic receptor bindingArrb2IPIRGD:736081RatPMID:18523139|RGD:5510010
Molecular FunctionGO:0031692alpha-1B adrenergic receptor bindingArrb2IDARatPMID:18523139|RGD:5510010
Molecular FunctionGO:0031701angiotensin receptor bindingARRB2IPIUniProtKB:P30556HumanPMID:15611106
Molecular FunctionGO:1990763arrestin family protein bindingArrb2IPIUniProtKB:Q8N5I2RatPMID:23886940|RGD:13432293
Molecular FunctionGO:0031748D1 dopamine receptor bindingArrb2IPIRGD:2518RatPMID:19200235|RGD:5510003
Molecular FunctionGO:0019899enzyme bindingARRB2IPIUniProtKB:Q96EB6HumanPMID:23382074
Molecular FunctionGO:0031762follicle-stimulating hormone receptor bindingArrb2IPIRGD:2632RatPMID:16899567|RGD:4140424
Molecular FunctionGO:0001664G protein-coupled receptor bindingARRB2IPIUniProtKB:P61073HumanPMID:10644702
Molecular FunctionGO:0042802identical protein bindingArrb2IPIUniProtKB:P29067RatPMID:17984062|RGD:13432292
Molecular FunctionGO:0051019mitogen-activated protein kinase bindingArrb2IPIRGD:3046RatPMID:19200235|RGD:5510003
Molecular FunctionGO:0051019mitogen-activated protein kinase bindingArrb2IPIRGD:70500RatPMID:19200235|RGD:5510003
Molecular FunctionGO:0060090molecular adaptor activityARRB2IDAHumanPMID:26839314
Molecular FunctionGO:0031859platelet activating factor receptor bindingArrb2IPIRGD:61897RatPMID:23911909|RGD:8657085
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q03167HumanPMID:12958365
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:O15111HumanPMID:15125834
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q04206HumanPMID:15125834
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P31750HumanPMID:16051150
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q9Y4K3HumanPMID:16378096
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P51810HumanPMID:16524428
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:O14556HumanPMID:16820410
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P16104HumanPMID:16820410
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P18754HumanPMID:16820410
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q14562HumanPMID:16820410
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q15058HumanPMID:16820410
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P07550HumanPMID:17148612
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:O75688HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:O95218HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P06396HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P06702HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P11142HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P14618HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P19338HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P27348HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P35813HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q08499HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q13428HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q13523HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q14978HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q15208HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P45984HumanPMID:19060904
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P06213-1HumanPMID:19122674
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P12931HumanPMID:19122674
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P12931HumanPMID:19202075
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P25101HumanPMID:19202075
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q8TEY7HumanPMID:19363159
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q99683HumanPMID:19782076
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q08499HumanPMID:19955404
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q08499-2HumanPMID:19955404
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q08499-2HumanPMID:20664520
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P40417HumanPMID:20802461
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q9Q2G4HumanPMID:22190034
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q5NUL3-1HumanPMID:22282525
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q5NUL3-2HumanPMID:22282525
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P25106HumanPMID:22300987
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P25106HumanPMID:22457824
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P07550HumanPMID:23208550
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q9NPB9HumanPMID:23341447
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:Q96P20HumanPMID:23809162
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P08908HumanPMID:24157794
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P11362HumanPMID:24157794
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:O75688HumanPMID:25241761
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P45984HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P45984HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingARRB2IPIUniProtKB:P45984HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingArrb2IPIUniProtKB:Q7TMA4MouseMGI:MGI:4839696|PMID:20813258
Molecular FunctionGO:0005515protein bindingArrb2IPIUniProtKB:P58660MouseMGI:MGI:6092781|PMID:18952848
Molecular FunctionGO:0005515protein bindingArrb2IPIRGD:2520RatPMID:15361545|RGD:1600943
Molecular FunctionGO:0005515protein bindingArrb2IPIUniProtKB:Q2NL51RatPMID:16051150|RGD:8553389
Molecular FunctionGO:0005515protein bindingArrb2IPIUniProtKB:Q9WV60RatPMID:16051150|RGD:8553389
Molecular FunctionGO:0005515protein bindingArrb2IPIUniProtKB:P53667RatPMID:17500066|RGD:8554055
Molecular FunctionGO:0005515protein bindingArrb2IPIUniProtKB:Q00987RatPMID:17984062|RGD:13432292
Molecular FunctionGO:0005515protein bindingArrb2IPIUniProtKB:P31749RatPMID:18191226|RGD:8554084
Molecular FunctionGO:0005515protein bindingArrb2IPIUniProtKB:Q00987RatPMID:18191226|RGD:8554084
Molecular FunctionGO:0019904protein domain specific bindingArrb2IPIRGD:2520RatPMID:12890920|RGD:1581347
Molecular FunctionGO:0043422protein kinase B bindingArrb2IPIUniProtKB:P31750MouseMGI:MGI:3690676|PMID:16051150
Molecular FunctionGO:0044877protein-containing complex bindingArrb2IDARatPMID:15498833|RGD:5509962
Molecular FunctionGO:0005102signaling receptor bindingARRB2IPIUniProtKB:P43626HumanPMID:18604210
Molecular FunctionGO:0005102signaling receptor bindingARRB2IPIUniProtKB:P43628HumanPMID:18604210
Molecular FunctionGO:0005102signaling receptor bindingARRB2IPIUniProtKB:Q99706HumanPMID:18604210
Molecular FunctionGO:0031702type 1 angiotensin receptor bindingArrb2IPIRGD:2070RatPMID:19522833|RGD:5509965
Molecular FunctionGO:0031826type 2A serotonin receptor bindingArrb2IPIRGD:734107RatPMID:19919577|RGD:5509930
Molecular FunctionGO:0031625ubiquitin protein ligase bindingARRB2IPIUniProtKB:Q00987HumanPMID:15878855
Cellular ComponentGO:0016323basolateral plasma membraneArrb2IDARatPMID:16899567|RGD:4140424
Cellular ComponentGO:0005737cytoplasmARRB2IDAHumanPMID:12958365
Cellular ComponentGO:0005737cytoplasmARRB2IDAHumanPMID:15611106
Cellular ComponentGO:0005737cytoplasmARRB2IDAHumanPMID:16325578
Cellular ComponentGO:0005737cytoplasmARRB2IDAHumanPMID:16820410
Cellular ComponentGO:0005737cytoplasmARRB2IDAHumanPMID:23341447
Cellular ComponentGO:0005737cytoplasmArrb2IDARatPMID:14757828|RGD:15023477
Cellular ComponentGO:0005737cytoplasmArrb2IDARatPMID:16899567|RGD:4140424
Cellular ComponentGO:0031410cytoplasmic vesicleARRB2IDAHumanPMID:12958365
Cellular ComponentGO:0031410cytoplasmic vesicleARRB2IDAHumanPMID:15611106
Cellular ComponentGO:0005829cytosolARRB2IDAHumanGO_REF:0000052
Cellular ComponentGO:0043197dendritic spineArrb2IDARatPMID:1517224|RGD:631708
Cellular ComponentGO:0030139endocytic vesicleARRB2IDAHumanPMID:23341447
Cellular ComponentGO:0005768endosomeArrb2IDARatPMID:14757828|RGD:15023477
Cellular ComponentGO:0005768endosomeArrb2IDARatPMID:25016018|RGD:13506837
Cellular ComponentGO:0098978glutamatergic synapseArrb2IDAMousePMID:27886171
Cellular ComponentGO:0098978glutamatergic synapseArrb2IMPMousePMID:27886171
Cellular ComponentGO:0005622intracellular anatomical structureArrb2IDAMousePMID:11171997
Cellular ComponentGO:0005654nucleoplasmARRB2IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusARRB2IDAHumanPMID:16820410
Cellular ComponentGO:0005886plasma membraneARRB2IDAHumanGO_REF:0000052
Cellular ComponentGO:0005886plasma membraneARRB2IDAHumanPMID:18604210
Cellular ComponentGO:0014069postsynaptic densityArrb2IDARatPMID:1517224|RGD:631708
Cellular ComponentGO:0045211postsynaptic membraneArrb2IDARatPMID:1517224|RGD:631708
Cellular ComponentGO:0045211postsynaptic membraneArrb2IDARatPMID:157224|RGD:631704
Biological ProcessGO:0007628adult walking behaviorArrb2IMPMouseMGI:MGI:3690676|PMID:16051150
Biological ProcessGO:0007420brain developmentArrb2IEPRatPMID:11823056|RGD:5509889
Biological ProcessGO:0060326cell chemotaxisARRB2IMPHumanPMID:15635042
Biological ProcessGO:0002032desensitization of G protein-coupled receptor signaling pathway by arrestinARRB2IMPHumanPMID:12582207
Biological ProcessGO:0002032desensitization of G protein-coupled receptor signaling pathway by arrestinArrb2IMPRatPMID:20705669|RGD:5509896
Biological ProcessGO:0050965detection of temperature stimulus involved in sensory perception of painArrb2IMPRatPMID:21926413|RGD:5509871
Biological ProcessGO:0006897endocytosisArrb2IDARatPMID:12600992|RGD:1304363
Biological ProcessGO:0042699follicle-stimulating hormone signaling pathwayArrb2IDARatPMID:16899567|RGD:4140424
Biological ProcessGO:0002031G protein-coupled receptor internalizationARRB2IDAHumanPMID:10644702
Biological ProcessGO:0002031G protein-coupled receptor internalizationARRB2IMPHumanPMID:12582207
Biological ProcessGO:0007186G protein-coupled receptor signaling pathwayArrb2IDARatPMID:157224|RGD:631704
Biological ProcessGO:0050804modulation of chemical synaptic transmissionArrb2IMPMousePMID:27886171
Biological ProcessGO:0050804modulation of chemical synaptic transmissionArrb2IDAMousePMID:27886171
Biological ProcessGO:0007517muscle organ developmentarrb2bIMPZfishPMID:15618520
Biological ProcessGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processArrb2IMPRatPMID:19171933|RGD:5510006
Biological ProcessGO:0034260negative regulation of GTPase activityArrb2IDARatPMID:1517224|RGD:631708
Biological ProcessGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signalingARRB2IDAHumanPMID:26839314
Biological ProcessGO:0032691negative regulation of interleukin-1 beta productionArrb2IMPMouseMGI:MGI:3662828|PMID:16378096
Biological ProcessGO:0032695negative regulation of interleukin-12 productionArrb2IMPMouseMGI:MGI:3662828|PMID:16378096
Biological ProcessGO:0032715negative regulation of interleukin-6 productionArrb2IMPMouseMGI:MGI:3662828|PMID:16378096
Biological ProcessGO:0045953negative regulation of natural killer cell mediated cytotoxicityARRB2IMPHumanPMID:18604210
Biological ProcessGO:0043524negative regulation of neuron apoptotic processArrb2IMPRatPMID:26621121|RGD:11537517
Biological ProcessGO:0032088negative regulation of NF-kappaB transcription factor activityARRB2IDAHumanPMID:15125834
Biological ProcessGO:0032088negative regulation of NF-kappaB transcription factor activityARRB2IDAHumanPMID:16378096
Biological ProcessGO:0001933negative regulation of protein phosphorylationArrb2IMPMouseMGI:MGI:5784966|PMID:24974728
Biological ProcessGO:0031397negative regulation of protein ubiquitinationARRB2IDAHumanPMID:16378096
Biological ProcessGO:0031397negative regulation of protein ubiquitinationArrb2IMPRatPMID:20650893|RGD:5509917
Biological ProcessGO:0090201negative regulation of release of cytochrome c from mitochondriaArrb2IMPRatPMID:19171933|RGD:5510006
Biological ProcessGO:0034392negative regulation of smooth muscle cell apoptotic processArrb2IMPRatPMID:19171933|RGD:5510006
Biological ProcessGO:0034122negative regulation of toll-like receptor signaling pathwayArrb2IMPMouseMGI:MGI:3662828|PMID:16378096
Biological ProcessGO:0032720negative regulation of tumor necrosis factor productionArrb2IMPMouseMGI:MGI:3662828|PMID:16378096
Biological ProcessGO:0051928positive regulation of calcium ion transportArrb2IMPRatPMID:21078978|RGD:5509892
Biological ProcessGO:2000727positive regulation of cardiac muscle cell differentiationArrb2IDAMouseMGI:MGI:5784966|PMID:24974728
Biological ProcessGO:0032967positive regulation of collagen biosynthetic processArrb2IMPRatPMID:28274926|RGD:13506828
Biological ProcessGO:2000573positive regulation of DNA biosynthetic processArrb2IMPRatPMID:19254952|RGD:5509898
Biological ProcessGO:1904037positive regulation of epithelial cell apoptotic processArrb2IMPRatPMID:24719556|RGD:13506899
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeARRB2IDAHumanPMID:10644702
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeARRB2IMPHumanPMID:12582207
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeArrb2IMPRatPMID:19171933|RGD:5510006
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeArrb2IMPRatPMID:19254952|RGD:5509898
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeArrb2IMPRatPMID:28274926|RGD:13506828
Biological ProcessGO:0010628positive regulation of gene expressionArrb2IDAMouseMGI:MGI:5784966|PMID:24974728
Biological ProcessGO:0033138positive regulation of peptidyl-serine phosphorylationArrb2IMPRatPMID:19171933|RGD:5510006
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationArrb2IMPRatPMID:19254952|RGD:5509898
Biological ProcessGO:0051897positive regulation of protein kinase B signalingArrb2IMPMouseMGI:MGI:3690676|PMID:16051150
Biological ProcessGO:0051897positive regulation of protein kinase B signalingArrb2IMPRatPMID:19171933|RGD:5510006
Biological ProcessGO:0001934positive regulation of protein phosphorylationArrb2IMPMouseMGI:MGI:5784966|PMID:24974728
Biological ProcessGO:0001934positive regulation of protein phosphorylationArrb2IMPRatPMID:19254952|RGD:5509898
Biological ProcessGO:0002092positive regulation of receptor internalizationARRB2IMPHumanPMID:22457824
Biological ProcessGO:0002092positive regulation of receptor internalizationArrb2IMPRatPMID:16120787|RGD:5510008
Biological ProcessGO:0032226positive regulation of synaptic transmission, dopaminergicArrb2IMPMouseMGI:MGI:3690676|PMID:16051150
Biological ProcessGO:0098926postsynaptic signal transductionArrb2IMPMousePMID:27886171
Biological ProcessGO:0098926postsynaptic signal transductionArrb2IDAMousePMID:27886171
Biological ProcessGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic processARRB2IMPHumanPMID:15878855
Biological ProcessGO:0016567protein ubiquitinationARRB2IMPHumanPMID:15878855
Biological ProcessGO:0031623receptor internalizationARRB2IDAHumanPMID:12958365
Biological ProcessGO:1900136regulation of chemokine activityarrb2aIGIZFIN:ZDB-MRPHLNO-120821-1,ZFIN:ZDB-MRPHLNO-120821-3,ZFIN:ZDB-MRPHLNO-121119-1ZfishPMID:22791893
Biological ProcessGO:1900136regulation of chemokine activityarrb2bIGIZFIN:ZDB-MRPHLNO-120821-1,ZFIN:ZDB-MRPHLNO-120821-3,ZFIN:ZDB-MRPHLNO-121119-1ZfishPMID:22791893
Biological ProcessGO:0008277regulation of G protein-coupled receptor signaling pathwayArrb2IMPMGI:MGI:2157960MousePMID:10617462
Biological ProcessGO:0008277regulation of G protein-coupled receptor signaling pathwayArrb2IMPMGI:MGI:2157960MousePMID:11130073
Biological ProcessGO:0008277regulation of G protein-coupled receptor signaling pathwayArrb2IMPMGI:MGI:2157960MousePMID:11171997
Biological ProcessGO:0008277regulation of G protein-coupled receptor signaling pathwayArrb2IDARatPMID:1517224|RGD:631708
Biological ProcessGO:0001932regulation of protein phosphorylationArrb2IGIMGI:MGI:2159617MousePMID:15218143
Biological ProcessGO:0001932regulation of protein phosphorylationArrb2IDAMousePMID:15218143
Biological ProcessGO:0001919regulation of receptor recyclingarrb2aIGIZFIN:ZDB-MRPHLNO-120821-1,ZFIN:ZDB-MRPHLNO-120821-3,ZFIN:ZDB-MRPHLNO-121119-1ZfishPMID:22791893
Biological ProcessGO:0001919regulation of receptor recyclingarrb2bIGIZFIN:ZDB-MRPHLNO-120821-1,ZFIN:ZDB-MRPHLNO-120821-3,ZFIN:ZDB-MRPHLNO-121119-1ZfishPMID:22791893
Biological ProcessGO:0008589regulation of smoothened signaling pathwayarrb2bIMPZFIN:ZDB-MRPHLNO-050124-2ZfishPMID:15618520
Biological ProcessGO:0006366transcription by RNA polymerase IIARRB2IDAHumanPMID:16820410
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayARRB2IDAHumanPMID:12958365

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory