Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ASAH1
  • Mouse genes Asah1
  • Rat genes Asah1
  • Zfish genes asah1a,asah1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Asah1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0102121	ceramidase activity	asah1b	IDA		Zfish	PMID:30399382
Molecular Function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	ASAH1	IDA		Human	PMID:15655246
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH1	IMP		Human	PMID:10610716
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH1	IDA		Human	PMID:11451951
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH1	IDA		Human	PMID:12764132
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH1	IDA		Human	PMID:12815059
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH1	IDA		Human	PMID:7744740
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Asah1	IDA		Mouse	PMID:9653654
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	asah1b	IMP	ZFIN:ZDB-MRPHLNO-120724-2	Zfish	PMID:22703880
Molecular Function	GO:0005515	protein binding	ASAH1	IPI	UniProtKB:Q13285	Human	PMID:22927646
Molecular Function	GO:0005515	protein binding	asah1b	IPI	ZFIN:ZDB-GENE-040426-1512	Zfish	PMID:30399382
Cellular Component	GO:0070062	extracellular exosome	ASAH1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ASAH1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ASAH1	IDA		Human	PMID:11451951
Cellular Component	GO:0005615	extracellular space	ASAH1	IDA		Human	PMID:25645918
Cellular Component	GO:0005615	extracellular space	ASAH1	IDA		Human	PMID:7744740
Cellular Component	GO:0005764	lysosome	ASAH1	IDA		Human	PMID:12764132
Cellular Component	GO:0005634	nucleus	Asah1	IDA		Mouse	MGI:MGI:5444795|PMID:22927646
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Asah1	IDA		Mouse	MGI:MGI:6275115|PMID:10974027
Biological Process	GO:0046513	ceramide biosynthetic process	ASAH1	IDA		Human	PMID:12764132
Biological Process	GO:0046513	ceramide biosynthetic process	ASAH1	IDA		Human	PMID:12815059
Biological Process	GO:0046514	ceramide catabolic process	ASAH1	IMP		Human	PMID:10610716
Biological Process	GO:0046514	ceramide catabolic process	ASAH1	IDA		Human	PMID:12815059
Biological Process	GO:0046514	ceramide catabolic process	Asah1	IDA		Mouse	MGI:MGI:1267186|PMID:9653654
Biological Process	GO:0046514	ceramide catabolic process	Asah1	IMP		Mouse	MGI:MGI:5505361|PMID:23770692
Biological Process	GO:0048668	collateral sprouting	asah1b	IMP	ZFIN:ZDB-MRPHLNO-120724-2	Zfish	PMID:22703880
Biological Process	GO:0030216	keratinocyte differentiation	ASAH1	IMP		Human	PMID:17713573
Biological Process	GO:0030324	lung development	Asah1	IDA		Rat	PMID:9160843|RGD:1599262
Biological Process	GO:0062098	regulation of programmed necrotic cell death	Asah1	IMP		Mouse	MGI:MGI:6275115|PMID:10974027
Biological Process	GO:0050810	regulation of steroid biosynthetic process	ASAH1	IMP		Human	PMID:22261821
Biological Process	GO:0010033	response to organic substance	Asah1	IDA		Rat	PMID:16942762|RGD:1599260
Biological Process	GO:0097264	self proteolysis	asah1b	IDA		Zfish	PMID:30399382
Biological Process	GO:0046512	sphingosine biosynthetic process	ASAH1	IMP		Human	PMID:10610716
Biological Process	GO:0046512	sphingosine biosynthetic process	ASAH1	IDA		Human	PMID:12815059
Biological Process	GO:0046512	sphingosine biosynthetic process	Asah1	IDA		Mouse	MGI:MGI:1267186|PMID:9653654

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern