Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Asah2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ASAH2,ASAH2B
- Mouse genes Asah2
- Rat genes Asah2
- Zfish genes asah2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Asah2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	ASAH2	IDA		Human	PMID:26190575
Molecular Function	GO:0071633	dihydroceramidase activity	Asah2	IDA		Rat	PMID:11328816\|RGD:68675
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH2	IMP		Human	PMID:10781606
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH2	IMP		Human	PMID:11278489
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH2	IMP		Human	PMID:15946935
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH2	IDA		Human	PMID:16229686
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH2	IDA		Human	PMID:17475390
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH2	IDA		Human	PMID:26190575
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ASAH2	IDA		Human	PMID:30154232
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Asah2	IDA		Mouse	MGI:MGI:6275120\|PMID:10652340
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Asah2	IMP		Mouse	MGI:MGI:6274955\|PMID:21613224
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Asah2	IDA		Mouse	PMID:10753931
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Asah2	IDA		Rat	PMID:10488143\|RGD:13838800
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Asah2	IDA		Rat	PMID:11278489\|RGD:13838803
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Asah2	IDA		Rat	PMID:11328816\|RGD:68675
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Asah2	IDA		Rat	PMID:15123644\|RGD:13838793
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	Asah2	IDA		Rat	PMID:15217782\|RGD:13838794
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	asah2	IDA		Zfish	PMID:15271994
Molecular Function	GO:0070774	phytoceramidase activity	Asah2	IDA		Rat	PMID:11328816\|RGD:68675
Molecular Function	GO:0005515	protein binding	Asah2	IPI	UniProtKB:P49817	Mouse	MGI:MGI:6275114\|PMID:12921776
Molecular Function	GO:0008270	zinc ion binding	ASAH2	IDA		Human	PMID:26190575
Cellular Component	GO:0016324	apical plasma membrane	asah2	IDA		Zfish	PMID:15271994
Cellular Component	GO:0005901	caveola	Asah2	IDA		Mouse	MGI:MGI:6275114\|PMID:12921776
Cellular Component	GO:0005789	endoplasmic reticulum membrane	asah2	IDA		Zfish	PMID:15271994
Cellular Component	GO:0070062	extracellular exosome	ASAH2	IDA		Human	PMID:24798654
Cellular Component	GO:0005615	extracellular space	Asah2	IDA		Mouse	MGI:MGI:3608219\|PMID:16126722
Cellular Component	GO:0005615	extracellular space	Asah2	IDA		Rat	PMID:12499379\|RGD:13838791
Cellular Component	GO:0005615	extracellular space	Asah2	IDA		Rat	PMID:15123644\|RGD:13838793
Cellular Component	GO:0005794	Golgi apparatus	ASAH2	IDA		Human	PMID:30154232
Cellular Component	GO:0000139	Golgi membrane	asah2	IDA		Zfish	PMID:15271994
Cellular Component	GO:0016020	membrane	Asah2	IDA		Mouse	PMID:10753931
Cellular Component	GO:0045121	membrane raft	Asah2	IDA		Rat	PMID:11328816\|RGD:68675
Cellular Component	GO:0005739	mitochondrion	ASAH2	IDA		Human	PMID:10781606
Cellular Component	GO:0005739	mitochondrion	Asah2	IDA		Mouse	MGI:MGI:6274955\|PMID:21613224
Cellular Component	GO:0005739	mitochondrion	Asah2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Asah2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Asah2	IDA		Rat	PMID:21613224\|RGD:13838796
Cellular Component	GO:0005886	plasma membrane	ASAH2	IDA		Human	PMID:30154232
Cellular Component	GO:0005886	plasma membrane	Asah2	IDA		Mouse	MGI:MGI:3608219\|PMID:16126722
Cellular Component	GO:0005886	plasma membrane	Asah2	IDA		Mouse	MGI:MGI:6275114\|PMID:12921776
Cellular Component	GO:0005886	plasma membrane	Asah2	IDA		Rat	PMID:11328816\|RGD:68675
Cellular Component	GO:0005886	plasma membrane	Asah2	IDA		Rat	PMID:12499379\|RGD:13838791
Cellular Component	GO:0005886	plasma membrane	Asah2	IDA		Rat	PMID:15123644\|RGD:13838793
Cellular Component	GO:0005886	plasma membrane	asah2	IDA		Zfish	PMID:15271994
Biological Process	GO:0071345	cellular response to cytokine stimulus	ASAH2	IDA		Human	PMID:24798654
Biological Process	GO:0046513	ceramide biosynthetic process	ASAH2	IMP		Human	PMID:11278489
Biological Process	GO:0046513	ceramide biosynthetic process	ASAH2	IDA		Human	PMID:17475390
Biological Process	GO:0046513	ceramide biosynthetic process	Asah2	IMP		Mouse	MGI:MGI:6274955\|PMID:21613224
Biological Process	GO:0046513	ceramide biosynthetic process	Asah2	IDA		Rat	PMID:11278489\|RGD:13838803
Biological Process	GO:0046513	ceramide biosynthetic process	Asah2	IDA		Rat	PMID:15123644\|RGD:13838793
Biological Process	GO:0046514	ceramide catabolic process	ASAH2	IMP		Human	PMID:10781606
Biological Process	GO:0046514	ceramide catabolic process	ASAH2	IMP		Human	PMID:15946935
Biological Process	GO:0046514	ceramide catabolic process	ASAH2	IDA		Human	PMID:16229686
Biological Process	GO:0046514	ceramide catabolic process	ASAH2	IDA		Human	PMID:17475390
Biological Process	GO:0046514	ceramide catabolic process	ASAH2	IMP		Human	PMID:19345744
Biological Process	GO:0046514	ceramide catabolic process	ASAH2	IMP		Human	PMID:30154232
Biological Process	GO:0046514	ceramide catabolic process	Asah2	IMP		Mouse	MGI:MGI:3640407\|PMID:16380386
Biological Process	GO:0046514	ceramide catabolic process	Asah2	IDA		Mouse	MGI:MGI:6275120\|PMID:10652340
Biological Process	GO:0046514	ceramide catabolic process	Asah2	IMP		Mouse	MGI:MGI:3608219\|PMID:16126722
Biological Process	GO:0046514	ceramide catabolic process	Asah2	IDA		Rat	PMID:10488143\|RGD:13838800
Biological Process	GO:0046514	ceramide catabolic process	Asah2	IDA		Rat	PMID:15123644\|RGD:13838793
Biological Process	GO:0046514	ceramide catabolic process	Asah2	IDA		Rat	PMID:15217782\|RGD:13838794
Biological Process	GO:0006672	ceramide metabolic process	ASAH2	IDA		Human	PMID:26190575
Biological Process	GO:0006672	ceramide metabolic process	asah2	IDA		Zfish	PMID:15271994
Biological Process	GO:0044241	lipid digestion	Asah2	IMP		Mouse	MGI:MGI:3640407\|PMID:16380386
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	ASAH2	IMP		Human	PMID:15946935
Biological Process	GO:0007346	regulation of mitotic cell cycle	ASAH2	IMP		Human	PMID:19345744
Biological Process	GO:0010033	response to organic substance	Asah2	IDA		Rat	PMID:16942762\|RGD:1599260
Biological Process	GO:0046512	sphingosine biosynthetic process	ASAH2	IMP		Human	PMID:30154232
Biological Process	GO:0046512	sphingosine biosynthetic process	Asah2	IMP		Mouse	MGI:MGI:3640407\|PMID:16380386
Biological Process	GO:0046512	sphingosine biosynthetic process	Asah2	IMP		Mouse	MGI:MGI:3608219\|PMID:16126722
Biological Process	GO:0046512	sphingosine biosynthetic process	Asah2	IDA		Mouse	MGI:MGI:6275120\|PMID:10652340
Biological Process	GO:0046512	sphingosine biosynthetic process	Asah2	IDA		Rat	PMID:10488143\|RGD:13838800
Biological Process	GO:0046512	sphingosine biosynthetic process	Asah2	IDA		Rat	PMID:15123644\|RGD:13838793
Biological Process	GO:0046512	sphingosine biosynthetic process	Asah2	IDA		Rat	PMID:15217782\|RGD:13838794
Biological Process	GO:0006670	sphingosine metabolic process	ASAH2	IMP		Human	PMID:10781606
Biological Process	GO:0006670	sphingosine metabolic process	ASAH2	IMP		Human	PMID:15946935
Biological Process	GO:0006670	sphingosine metabolic process	ASAH2	IDA		Human	PMID:16229686
Biological Process	GO:0006670	sphingosine metabolic process	ASAH2	IDA		Human	PMID:17475390
Biological Process	GO:0006670	sphingosine metabolic process	ASAH2	IDA		Human	PMID:26190575

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.