Comparative GO Graph (mouse, human)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ASCL3
  • Mouse genes Ascl3
  • Rat genes
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ascl3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Ascl3	IDA		Mouse	PMID:11784080
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Ascl3	IDA		Mouse	MGI:MGI:2156263|PMID:11784080
Molecular Function	GO:0005515	protein binding	ASCL3	IPI	UniProtKB:A5D8V6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ASCL3	IPI	UniProtKB:P15884-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ASCL3	IPI	UniProtKB:P15923-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ASCL3	IPI	UniProtKB:P41134	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ASCL3	IPI	UniProtKB:Q99081-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ASCL3	IPI	UniProtKB:Q9Y5R4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Ascl3	IPI	PR:P15806	Mouse	PMID:11784080
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Ascl3	IDA		Mouse	MGI:MGI:2156263|PMID:11784080
Cellular Component	GO:0005634	nucleus	Ascl3	IDA		Mouse	PMID:11784080
Cellular Component	GO:0005667	transcription regulator complex	Ascl3	IPI	PR:P15806	Mouse	PMID:11784080
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ascl3	IDA		Mouse	MGI:MGI:2156263|PMID:11784080
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Ascl3	IDA		Mouse	PMID:11784080

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern