Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ASIC1
  • Mouse genes Asic1
  • Rat genes Asic1
  • Zfish genes asic1a,asic1b,asic1c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Asic1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0044736	acid-sensing ion channel activity	ASIC1	IDA		Human	PMID:22760635
Molecular Function	GO:0044736	acid-sensing ion channel activity	Asic1	IDA		Mouse	PMID:24247984
Molecular Function	GO:0022890	inorganic cation transmembrane transporter activity	Asic1	IDA		Rat	PMID:11448963|RGD:70652
Molecular Function	GO:0015280	ligand-gated sodium channel activity	asic1b	IDA		Zfish	PMID:14970195
Molecular Function	GO:0015280	ligand-gated sodium channel activity	asic1a	IDA		Zfish	PMID:14970195
Molecular Function	GO:0015280	ligand-gated sodium channel activity	asic1c	IDA		Zfish	PMID:14970195
Molecular Function	GO:0005261	monoatomic cation channel activity	Asic1	IDA		Mouse	PMID:11854527
Molecular Function	GO:0005261	monoatomic cation channel activity	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:11854527
Molecular Function	GO:0005261	monoatomic cation channel activity	asic1a	IGI	ZFIN:ZDB-GENE-040513-3	Zfish	PMID:14970195
Molecular Function	GO:0005261	monoatomic cation channel activity	asic1c	IPI	ZFIN:ZDB-GENE-040513-6	Zfish	PMID:17686779
Molecular Function	GO:0005261	monoatomic cation channel activity	asic1c	IPI	ZFIN:ZDB-GENE-040513-5	Zfish	PMID:17686779
Molecular Function	GO:0005261	monoatomic cation channel activity	asic1c	IGI	ZFIN:ZDB-GENE-040513-2	Zfish	PMID:14970195
Molecular Function	GO:0005216	monoatomic ion channel activity	Asic1	IDA		Rat	PMID:9707631|RGD:70653
Molecular Function	GO:0022839	monoatomic ion gated channel activity	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:14960591
Molecular Function	GO:0022839	monoatomic ion gated channel activity	Asic1	IDA		Mouse	PMID:14960591
Molecular Function	GO:0005515	protein binding	ASIC1	IPI	UniProtKB:Q9NRD5	Human	PMID:11802773
Molecular Function	GO:0005515	protein binding	ASIC1	IPI	UniProtKB:Q8N743	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ASIC1	IPI	UniProtKB:Q99735	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Asic1	IPI	UniProtKB:Q12791	Mouse	MGI:MGI:6092628|PMID:18287010
Molecular Function	GO:0005515	protein binding	Asic1	IPI	PR:Q925H0	Mouse	PMID:19571134
Cellular Component	GO:0009986	cell surface	Asic1	IDA		Rat	PMID:19074149|RGD:7242197
Cellular Component	GO:0005794	Golgi apparatus	ASIC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Asic1	IDA		Rat	PMID:11448963|RGD:70652
Cellular Component	GO:0005886	plasma membrane	ASIC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ASIC1	IMP		Human	PMID:22760635
Cellular Component	GO:0005886	plasma membrane	Asic1	IDA		Mouse	PMID:11854527
Cellular Component	GO:0005886	plasma membrane	asic1b	IDA		Zfish	PMID:14970195
Cellular Component	GO:0005886	plasma membrane	asic1a	IDA		Zfish	PMID:14970195
Cellular Component	GO:0005886	plasma membrane	asic1c	IPI	ZFIN:ZDB-GENE-040513-6	Zfish	PMID:17686779
Cellular Component	GO:0005886	plasma membrane	asic1c	IDA		Zfish	PMID:14970195
Cellular Component	GO:0005886	plasma membrane	asic1c	IPI	ZFIN:ZDB-GENE-040513-5	Zfish	PMID:17686779
Cellular Component	GO:0045202	synapse	Asic1	IDA		Mouse	PMID:11988176
Biological Process	GO:0008306	associative learning	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:11988176
Biological Process	GO:0001662	behavioral fear response	Asic1	IMP		Mouse	PMID:25828470
Biological Process	GO:0070588	calcium ion transmembrane transport	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:19376200
Biological Process	GO:0071467	cellular response to pH	ASIC1	IDA		Human	PMID:22760635
Biological Process	GO:0051649	establishment of localization in cell	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:15470133
Biological Process	GO:0051649	establishment of localization in cell	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:14960591
Biological Process	GO:0098662	inorganic cation transmembrane transport	Asic1	IDA		Rat	PMID:11448963|RGD:70652
Biological Process	GO:0007613	memory	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:11988176
Biological Process	GO:0006812	monoatomic cation transport	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:11854527
Biological Process	GO:0006812	monoatomic cation transport	Asic1	IDA		Mouse	PMID:11854527
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:19376200
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:14960591
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Asic1	IDA		Mouse	PMID:14960591
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:15470133
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Asic1	IMP		Rat	PMID:19074149|RGD:7242197
Biological Process	GO:0046929	negative regulation of neurotransmitter secretion	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:18094106
Biological Process	GO:0007269	neurotransmitter secretion	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:18094106
Biological Process	GO:0042391	regulation of membrane potential	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:19376200
Biological Process	GO:0010447	response to acidic pH	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:11854527
Biological Process	GO:0010447	response to acidic pH	Asic1	IMP	MGI:MGI:2179834	Mouse	PMID:11988176
Biological Process	GO:0010447	response to acidic pH	Asic1	IDA		Mouse	PMID:11854527
Biological Process	GO:0001975	response to amphetamine	Asic1	IMP		Mouse	PMID:25828470
Biological Process	GO:0050915	sensory perception of sour taste	ASIC1	IMP		Human	PMID:19812697
Biological Process	GO:0035725	sodium ion transmembrane transport	ASIC1	IDA		Human	PMID:22760635
Biological Process	GO:0035725	sodium ion transmembrane transport	asic1c	IDA		Zfish	PMID:14970195|ZFIN:ZDB-PUB-040225-4

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern