Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATF4
  • Mouse genes Atf4
  • Rat genes Atf4
  • Zfish genes atf4a,atf4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008140	cAMP response element binding protein binding	Atf4	IDA		Mouse	MGI:MGI:5496937|PMID:23624402
Molecular Function	GO:0003677	DNA binding	ATF4	IDA		Human	PMID:15788408
Molecular Function	GO:0003677	DNA binding	ATF4	IDA		Human	PMID:15911876
Molecular Function	GO:0003677	DNA binding	ATF4	IDA		Human	PMID:18940792
Molecular Function	GO:0003677	DNA binding	Atf4	IGI	MGI:MGI:2679336	Mouse	PMID:16751105
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Atf4	IMP		Mouse	MGI:MGI:5572880|PMID:15788408
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ATF4	IDA		Human	PMID:11960987
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ATF4	IDA		Human	PMID:15109498
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ATF4	IDA		Human	PMID:23123191
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ATF4	IDA		Human	PMID:32132707
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Atf4	IDA		Mouse	MGI:MGI:5496937|PMID:23624402
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Atf4	IDA		Mouse	MGI:MGI:5499916|PMID:23663782
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Atf4	IDA		Mouse	MGI:MGI:3040115|PMID:15109498
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Atf4	IMP		Mouse	MGI:MGI:3798818|PMID:12667446
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ATF4	IDA		Human	PMID:11478948
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ATF4	IDA		Human	PMID:12871976
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Atf4	IDA		Mouse	PMID:27812542
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Atf4	IPI	RGD:2282	Rat	PMID:18171674|RGD:9590341
Molecular Function	GO:0140296	general transcription initiation factor binding	Atf4	IPI	RGD:620720	Rat	PMID:18171674|RGD:9590341
Molecular Function	GO:0042802	identical protein binding	ATF4	IPI	UniProtKB:P18848	Human	PMID:16343488
Molecular Function	GO:0042802	identical protein binding	ATF4	IPI	UniProtKB:P18848	Human	PMID:23661758
Molecular Function	GO:0043522	leucine zipper domain binding	ATF4	IDA		Human	PMID:11478948
Molecular Function	GO:1990841	promoter-specific chromatin binding	ATF4	IDA		Human	PMID:17267404
Molecular Function	GO:1990841	promoter-specific chromatin binding	Atf4	IDA		Mouse	PMID:17267404
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9Y297	Human	PMID:11238952
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9Y297-2	Human	PMID:11238952
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q96RU7	Human	PMID:12743605
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9NRI5	Human	PMID:12812986
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P19387	Human	PMID:12860379
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P49454	Human	PMID:15677469
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9BWC9	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O95751	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P02766	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q13227	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q99871	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9NS37	Human	PMID:16343488
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O15078	Human	PMID:16682973
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P35638	Human	PMID:18330356
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P35638	Human	PMID:18940792
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P18847	Human	PMID:19164757
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q99871	Human	PMID:19447967
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O75444	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P01100	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P17676	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P18847	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P35638	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P49715	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P49716	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P53567	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q16520	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9NS37	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P53567	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q96RU7	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P05412	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9UIK4-2	Human	PMID:21408167
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P17275	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9Y297	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P68400	Human	PMID:23123191
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O75444	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P01100	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P05412	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P15336	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P15407	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P17275	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P18847	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P35638	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P49715	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P53567	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q15744	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q16236	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q16520	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9NR55	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9NS37	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P01100	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P05412	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O14777	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O95751	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P53567	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q08AF8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q0D2H9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q13227	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q13515	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q92805	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q96CN9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q96RU7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9BWC9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9Y297	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q13515	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q96RU7	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q16236	Human	PMID:26700459
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:A0A0S2Z507	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:B7Z3H4	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9Y297	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O14777	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O95751	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P02766	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q08AF8	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q13227	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q13515	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9BWC9	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9Y297	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9NRI5	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O14777	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O95751	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P02766	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q13515	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9BWC9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9Y297	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:A2RTX5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O14777	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P53567	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q13227	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q13515	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q86UD0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q8WYK2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q92805	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q96CN9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q96NT1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q96RU7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9BWC9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9BXS5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9NV70	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9Y297	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9Y592-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:Q16236	Human	PMID:32911434
Molecular Function	GO:0005515	protein binding	ATF4	IPI	UniProtKB:O54784	Human	PMID:9488481
Molecular Function	GO:0005515	protein binding	Atf4	IPI	UniProtKB:O54784	Mouse	MGI:MGI:3687891|PMID:12917339
Molecular Function	GO:0005515	protein binding	Atf4	IPI	UniProtKB:O54784	Mouse	MGI:MGI:1196722|PMID:9488481
Molecular Function	GO:0005515	protein binding	Atf4	IPI	UniProtKB:P35639	Mouse	MGI:MGI:5496937|PMID:23624402
Molecular Function	GO:0005515	protein binding	Atf4	IPI	UniProtKB:P53568	Mouse	MGI:MGI:51489|PMID:1371974
Molecular Function	GO:0005515	protein binding	Atf4	IPI	UniProtKB:Q8BHN1	Mouse	MGI:MGI:3587454|PMID:15911876
Molecular Function	GO:0005515	protein binding	Atf4	IPI	UniProtKB:P18654	Mouse	MGI:MGI:3040115|PMID:15109498
Molecular Function	GO:0005515	protein binding	Atf4	IPI	PR:Q9WV18	Mouse	PMID:15013631
Molecular Function	GO:0005515	protein binding	Atf4	IPI	MGI:MGI:99557	Mouse	PMID:18983980
Molecular Function	GO:0005515	protein binding	Atf4	IPI	PR:Q8K4K2	Mouse	PMID:12749859
Molecular Function	GO:0005515	protein binding	Atf4	IPI	PR:Q8VI24	Mouse	PMID:16751105
Molecular Function	GO:0005515	protein binding	Atf4	IPI	PR:Q3TCJ1	Mouse	PMID:22974638
Molecular Function	GO:0005515	protein binding	Atf4	IPI	PR:Q9CZA6	Mouse	PMID:18983980
Molecular Function	GO:0005515	protein binding	Atf4	IPI	PR:Q80T41	Mouse	PMID:15013631
Molecular Function	GO:0005515	protein binding	Atf4	IPI	PR:P28033	Mouse	PMID:27812542
Molecular Function	GO:0005515	protein binding	Atf4	IPI	RGD:621537	Rat	PMID:10924501|RGD:631878
Molecular Function	GO:0046982	protein heterodimerization activity	Atf4	IDA		Mouse	MGI:MGI:5496937|PMID:23624402
Molecular Function	GO:0019901	protein kinase binding	ATF4	IPI	UniProtKB:Q9HC98	Human	PMID:20873783
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Atf4	IDA		Mouse	MGI:MGI:5292598|PMID:21768648
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Atf4	IMP		Mouse	MGI:MGI:5572880|PMID:15788408
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Atf4	IDA		Mouse	PMID:27812542
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Atf4	IDA		Mouse	PMID:12749859
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Atf4	IDA		Mouse	PMID:15724149
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ATF4	IPI	UniProtKB:P35638	Human	PMID:11478948
Molecular Function	GO:0043565	sequence-specific DNA binding	ATF4	IDA		Human	PMID:22915762
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ATF4	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ATF4	IDA		Human	PMID:12871976
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ATF4	IDA		Human	PMID:21113145
Cellular Component	GO:1990590	ATF1-ATF4 transcription factor complex	ATF4	IDA		Human	PMID:12871976
Cellular Component	GO:1990590	ATF1-ATF4 transcription factor complex	Atf4	IDA		Mouse	MGI:MGI:5613480|PMID:12871976
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	ATF4	IDA		Human	PMID:12871976
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	Atf4	IDA		Mouse	MGI:MGI:5613480|PMID:12871976
Cellular Component	GO:0005813	centrosome	ATF4	IDA		Human	PMID:20873783
Cellular Component	GO:1990617	CHOP-ATF4 complex	ATF4	IDA		Human	PMID:11478948
Cellular Component	GO:1990617	CHOP-ATF4 complex	ATF4	IPI	UniProtKB:P35638	Human	PMID:18940792
Cellular Component	GO:0005737	cytoplasm	ATF4	IDA		Human	PMID:23392669
Cellular Component	GO:0005737	cytoplasm	Atf4	IDA		Mouse	MGI:MGI:3846505|PMID:19232401
Cellular Component	GO:0005737	cytoplasm	Atf4	IDA		Mouse	PMID:15013631
Cellular Component	GO:0005737	cytoplasm	Atf4	IDA		Mouse	PMID:22974638
Cellular Component	GO:0005737	cytoplasm	Atf4	IDA		Rat	PMID:10924501|RGD:631878
Cellular Component	GO:0032590	dendrite membrane	Atf4	IDA		Rat	PMID:10924501|RGD:631878
Cellular Component	GO:1990037	Lewy body core	ATF4	IDA		Human	PMID:23392669
Cellular Component	GO:0043005	neuron projection	ATF4	IDA		Human	PMID:23392669
Cellular Component	GO:0034399	nuclear periphery	ATF4	IDA		Human	PMID:23392669
Cellular Component	GO:0005654	nucleoplasm	ATF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ATF4	IDA		Human	PMID:11478948
Cellular Component	GO:0005634	nucleus	ATF4	IDA		Human	PMID:16682973
Cellular Component	GO:0005634	nucleus	ATF4	IDA		Human	PMID:23123191
Cellular Component	GO:0005634	nucleus	ATF4	IDA		Human	PMID:23392669
Cellular Component	GO:0005634	nucleus	Atf4	IDA		Mouse	MGI:MGI:3722921|PMID:14729979
Cellular Component	GO:0005634	nucleus	Atf4	IDA		Mouse	MGI:MGI:3846505|PMID:19232401
Cellular Component	GO:0005634	nucleus	Atf4	IDA		Mouse	MGI:MGI:3040115|PMID:15109498
Cellular Component	GO:0005634	nucleus	Atf4	IDA		Mouse	PMID:22974638
Cellular Component	GO:0005634	nucleus	Atf4	IDA		Mouse	PMID:15013631
Cellular Component	GO:0005634	nucleus	Atf4	IDA		Rat	PMID:10924501|RGD:631878
Cellular Component	GO:0005634	nucleus	Atf4	IDA		Rat	PMID:16912310|RGD:32733622
Cellular Component	GO:0032991	protein-containing complex	ATF4	IDA		Human	PMID:20873783
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ATF4	IPI		Human	PMID:20102225
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ATF4	IPI		Human	PMID:23661758
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Atf4	IPI		Mouse	MGI:MGI:5613480|PMID:12871976
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Atf4	IDA		Mouse	PMID:27812542
Cellular Component	GO:0005667	transcription regulator complex	Atf4	IDA		Mouse	PMID:16751105
Biological Process	GO:0030282	bone mineralization	Atf4	IMP		Mouse	MGI:MGI:3040115|PMID:15109498
Biological Process	GO:0034198	cellular response to amino acid starvation	Atf4	IDA		Mouse	MGI:MGI:3582244|PMID:11106749
Biological Process	GO:0034198	cellular response to amino acid starvation	Atf4	IMP		Mouse	MGI:MGI:3798818|PMID:12667446
Biological Process	GO:0034198	cellular response to amino acid starvation	Atf4	IMP		Mouse	MGI:MGI:3722921|PMID:14729979
Biological Process	GO:1903351	cellular response to dopamine	ATF4	IMP		Human	PMID:24136195
Biological Process	GO:0042149	cellular response to glucose starvation	ATF4	IMP		Human	PMID:22915762
Biological Process	GO:1990253	cellular response to leucine starvation	ATF4	IDA		Human	PMID:17267404
Biological Process	GO:1990253	cellular response to leucine starvation	Atf4	IDA		Mouse	PMID:17267404
Biological Process	GO:0034599	cellular response to oxidative stress	Atf4	IMP		Mouse	MGI:MGI:3798818|PMID:12667446
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Atf4	IEP		Rat	PMID:20444431|RGD:13464322
Biological Process	GO:0032922	circadian regulation of gene expression	Atf4	IMP		Mouse	MGI:MGI:5292598|PMID:21768648
Biological Process	GO:0007623	circadian rhythm	Atf4	IEP		Mouse	MGI:MGI:5292598|PMID:21768648
Biological Process	GO:0035162	embryonic hemopoiesis	Atf4	IMP		Mouse	MGI:MGI:2158533|PMID:11806972
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Atf4	IDA		Mouse	MGI:MGI:5496937|PMID:23624402
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	Atf4	IDA		Rat	PMID:10924501|RGD:631878
Biological Process	GO:0006094	gluconeogenesis	Atf4	IDA		Mouse	PMID:11916968
Biological Process	GO:0140468	HRI-mediated signaling	ATF4	IDA		Human	PMID:32132707
Biological Process	GO:0140467	integrated stress response signaling	ATF4	IDA		Human	PMID:32132707
Biological Process	GO:0140467	integrated stress response signaling	Atf4	IMP		Mouse	MGI:MGI:3798818|PMID:12667446
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Atf4	IMP	MGI:MGI:3819270,MGI:MGI:5812282	Mouse	PMID:27812542
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Atf4	IMP	MGI:MGI:2180373	Mouse	PMID:27812542
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Atf4	IMP	MGI:MGI:3819270,MGI:MGI:5550363	Mouse	PMID:27812542
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Atf4	IMP		Mouse	MGI:MGI:4879048|PMID:21159964
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Atf4	IDA		Mouse	MGI:MGI:5496937|PMID:23624402
Biological Process	GO:0070982	L-asparagine metabolic process	ATF4	IDA		Human	PMID:11960987
Biological Process	GO:0070309	lens fiber cell morphogenesis	Atf4	IMP		Mouse	MGI:MGI:2158533|PMID:11806972
Biological Process	GO:0070309	lens fiber cell morphogenesis	Atf4	IMP		Mouse	MGI:MGI:1339872|PMID:10096021
Biological Process	GO:0070309	lens fiber cell morphogenesis	Atf4	IMP		Mouse	MGI:MGI:1859108|PMID:10885750
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	Atf4	IDA		Mouse	MGI:MGI:3582244|PMID:11106749
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Atf4	IMP		Mouse	MGI:MGI:6101068|PMID:22980225
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	ATF4	IGI	UniProtKB:Q9ES19	Human	PMID:23392669
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	Atf4	IMP		Rat	PMID:23392669|RGD:10047168
Biological Process	GO:0043267	negative regulation of potassium ion transport	Atf4	IMP		Rat	PMID:10924501|RGD:631878
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Atf4	IMP		Mouse	MGI:MGI:2671714|PMID:12925279
Biological Process	GO:0030182	neuron differentiation	Atf4	IEP		Rat	PMID:19322020|RGD:11354958
Biological Process	GO:0036499	PERK-mediated unfolded protein response	Atf4	IMP		Mouse	MGI:MGI:3722921|PMID:14729979
Biological Process	GO:0036499	PERK-mediated unfolded protein response	Atf4	IDA		Mouse	MGI:MGI:3798818|PMID:12667446
Biological Process	GO:0070169	positive regulation of biomineral tissue development	Atf4	IMP	MGI:MGI:3819270,MGI:MGI:5550363	Mouse	PMID:27812542
Biological Process	GO:0070169	positive regulation of biomineral tissue development	Atf4	IMP	MGI:MGI:2180373	Mouse	PMID:27812542
Biological Process	GO:0070169	positive regulation of biomineral tissue development	Atf4	IMP	MGI:MGI:3819270,MGI:MGI:5812282	Mouse	PMID:27812542
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ATF4	IMP		Human	PMID:11960987
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ATF4	IDA		Human	PMID:15775988
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ATF4	IDA		Human	PMID:18940792
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Atf4	IDA		Mouse	MGI:MGI:5292598|PMID:21768648
Biological Process	GO:0010628	positive regulation of gene expression	ATF4	IMP	UniProtKB:Q96QD8	Human	PMID:16445384
Biological Process	GO:0010628	positive regulation of gene expression	ATF4	IMP		Human	PMID:24136195
Biological Process	GO:0010628	positive regulation of gene expression	ATF4	IMP		Human	PMID:24939851
Biological Process	GO:0010628	positive regulation of gene expression	Atf4	IMP		Mouse	MGI:MGI:3722921|PMID:14729979
Biological Process	GO:0010628	positive regulation of gene expression	Atf4	IMP	MGI:MGI:3819270,MGI:MGI:5812282	Mouse	PMID:27812542
Biological Process	GO:0010628	positive regulation of gene expression	Atf4	IMP	MGI:MGI:3819270,MGI:MGI:5550363	Mouse	PMID:27812542
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Atf4	IMP		Mouse	MGI:MGI:4879048|PMID:21159964
Biological Process	GO:2000120	positive regulation of sodium-dependent phosphate transport	Atf4	IMP	MGI:MGI:3819270,MGI:MGI:5812282	Mouse	PMID:27812542
Biological Process	GO:2000120	positive regulation of sodium-dependent phosphate transport	Atf4	IMP	MGI:MGI:3819270,MGI:MGI:5550363	Mouse	PMID:27812542
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	ATF4	IMP		Human	PMID:22915762
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATF4	IDA		Human	PMID:11478948
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATF4	IDA		Human	PMID:11960987
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATF4	IDA		Human	PMID:15109498
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATF4	IDA		Human	PMID:15775988
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATF4	IMP		Human	PMID:15788408
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATF4	IDA		Human	PMID:16343488
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATF4	IDA		Human	PMID:18940792
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATF4	IDA		Human	PMID:23123191
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IDA		Mouse	MGI:MGI:5613480|PMID:12871976
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IMP		Mouse	MGI:MGI:1859108|PMID:10885750
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IDA		Mouse	MGI:MGI:5499916|PMID:23663782
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IMP		Mouse	MGI:MGI:3040115|PMID:15109498
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IMP		Mouse	MGI:MGI:3798818|PMID:12667446
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IMP		Mouse	MGI:MGI:5572880|PMID:15788408
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IMP	MGI:MGI:2180371	Mouse	PMID:17267404
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IGI	MGI:MGI:87938	Mouse	PMID:15724149
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IDA		Mouse	PMID:27812542
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IDA		Mouse	PMID:12749859
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IGI	MGI:MGI:2679336	Mouse	PMID:16751105
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf4	IGI	MGI:MGI:88373	Mouse	PMID:27812542
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ATF4	IDA		Human	PMID:12871976
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ATF4	IMP		Human	PMID:21113145
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	Atf4	IMP		Mouse	MGI:MGI:5613480|PMID:12871976
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	Atf4	IMP		Mouse	MGI:MGI:5433837|PMID:21113145
Biological Process	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ATF4	IMP		Human	PMID:21113145
Biological Process	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	Atf4	IMP		Rat	PMID:23392669|RGD:10047168
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	Atf4	IMP	MGI:MGI:2180373	Mouse	PMID:27812542
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	Atf4	IMP	MGI:MGI:3819270,MGI:MGI:5550363	Mouse	PMID:27812542
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	Atf4	IMP	MGI:MGI:3819270,MGI:MGI:5812282	Mouse	PMID:27812542
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ATF4	IMP		Human	PMID:22915762
Biological Process	GO:0006355	regulation of DNA-templated transcription	Atf4	IMP		Mouse	MGI:MGI:4879048|PMID:21159964
Biological Process	GO:0006355	regulation of DNA-templated transcription	Atf4	IMP		Mouse	MGI:MGI:5447621|PMID:15775988
Biological Process	GO:0006355	regulation of DNA-templated transcription	Atf4	IDA		Mouse	PMID:11916968
Biological Process	GO:0045667	regulation of osteoblast differentiation	ATF4	IDA		Human	PMID:15109498
Biological Process	GO:0045667	regulation of osteoblast differentiation	Atf4	IMP		Mouse	MGI:MGI:3040115|PMID:15109498
Biological Process	GO:0048167	regulation of synaptic plasticity	Atf4	IMP		Mouse	MGI:MGI:2671714|PMID:12925279
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Atf4	IDA		Mouse	MGI:MGI:5613480|PMID:12871976
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Atf4	IDA		Mouse	PMID:12749859
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ATF4	IDA		Human	PMID:19061639
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ATF4	IMP		Human	PMID:24939851
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ATF4	IDA		Human	PMID:33384352
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Atf4	IDA		Mouse	MGI:MGI:4879048|PMID:21159964
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Atf4	IDA		Mouse	MGI:MGI:3582244|PMID:11106749
Biological Process	GO:1990737	response to manganese-induced endoplasmic reticulum stress	Atf4	IEP		Rat	PMID:23934647|RGD:10047151
Biological Process	GO:0031667	response to nutrient levels	ATF4	IDA		Human	PMID:11960987
Biological Process	GO:0009636	response to toxic substance	Atf4	IEP		Rat	PMID:20026213|RGD:13464338
Biological Process	GO:0006366	transcription by RNA polymerase II	Atf4	IGI	MGI:MGI:87938	Mouse	PMID:15724149

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern