Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATG12
  • Mouse genes Atg12
  • Rat genes Atg12
  • Zfish genes atg12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atg12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:O95352	Human	PMID:11096062
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q9H1Y0	Human	PMID:11096062
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q9NT62	Human	PMID:11825910
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q9NT62	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q9NT62	Human	PMID:23202584
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:O43186	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q9H1Y0	Human	PMID:26812546
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q14140	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q9BTL4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q9NT62	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q9UHV2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG12	IPI	UniProtKB:Q9H1Y0	Human	PMID:9852036
Molecular Function	GO:0005515	protein binding	Atg12	IPI	UniProtKB:Q9CPX6|UniProtKB:Q9WU78-1	Mouse	MGI:MGI:5914142|PMID:25686249
Molecular Function	GO:0005515	protein binding	Atg12	IPI	UniProtKB:Q99J83	Mouse	MGI:MGI:2137756|PMID:11266458
Molecular Function	GO:0005515	protein binding	Atg12	IPI	UniProtKB:Q99J83	Mouse	MGI:MGI:2661260|PMID:12665549
Molecular Function	GO:0005515	protein binding	Atg12	IPI	UniProtKB:Q99J83|UniProtKB:Q9CPX6	Mouse	MGI:MGI:4835103|PMID:20723759
Molecular Function	GO:0005515	protein binding	Atg12	IPI	PR:Q9D906	Mouse	PMID:12482611
Molecular Function	GO:0005515	protein binding	Atg12	IPI	PR:Q9D906	Mouse	PMID:11890701
Molecular Function	GO:0005515	protein binding	Atg12	IPI	PR:Q8R1P4	Mouse	PMID:12482611
Molecular Function	GO:0005515	protein binding	Atg12	IPI	RGD:1359580	Rat	PMID:18059433|RGD:2301217
Cellular Component	GO:0034274	Atg12-Atg5-Atg16 complex	ATG12	IPI		Human	PMID:23202584
Cellular Component	GO:0034274	Atg12-Atg5-Atg16 complex	Atg12	IDA		Mouse	MGI:MGI:2661260|PMID:12665549
Cellular Component	GO:0005776	autophagosome	ATG12	IDA		Human	PMID:24954904
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ATG12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Atg12	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Cellular Component	GO:0016020	membrane	Atg12	IDA		Rat	PMID:18059433|RGD:2301217
Cellular Component	GO:0005654	nucleoplasm	ATG12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0034045	phagophore assembly site membrane	Atg12	IDA		Mouse	MGI:MGI:2661260|PMID:12665549
Cellular Component	GO:0034045	phagophore assembly site membrane	Atg12	IDA		Mouse	MGI:MGI:2137756|PMID:11266458
Cellular Component	GO:0032991	protein-containing complex	Atg12	IDA		Rat	PMID:18059433|RGD:2301217
Cellular Component	GO:1990234	transferase complex	Atg12	IDA		Mouse	MGI:MGI:4835103|PMID:20723759
Biological Process	GO:0000045	autophagosome assembly	Atg12	IMP		Mouse	MGI:MGI:2137756|PMID:11266458
Biological Process	GO:0006914	autophagy	Atg12	IMP		Rat	PMID:18059433|RGD:2301217
Biological Process	GO:0016236	macroautophagy	ATG12	IMP		Human	PMID:25484072
Biological Process	GO:0016236	macroautophagy	Atg12	IMP		Mouse	MGI:MGI:2137756|PMID:11266458
Biological Process	GO:0050687	negative regulation of defense response to virus	ATG12	IDA		Human	PMID:19666601
Biological Process	GO:0050687	negative regulation of defense response to virus	Atg12	IDA		Mouse	MGI:MGI:3722754|PMID:17709747
Biological Process	GO:0045824	negative regulation of innate immune response	Atg12	IDA		Mouse	MGI:MGI:3722754|PMID:17709747
Biological Process	GO:0032480	negative regulation of type I interferon production	Atg12	IDA		Mouse	MGI:MGI:3722754|PMID:17709747
Biological Process	GO:1904973	positive regulation of viral translation	ATG12	IDA		Human	PMID:19666601
Biological Process	GO:0006497	protein lipidation	ATG12	IDA		Human	PMID:23202584
Biological Process	GO:1901096	regulation of autophagosome maturation	ATG12	IMP		Human	PMID:22342342

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern