Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Atg5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ATG5
- Mouse genes Atg5
- Rat genes Atg5
- Zfish genes atg5
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atg5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:O94817	Human	PMID:11096062
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:O95786-1	Human	PMID:17709747
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q7Z434-1	Human	PMID:17709747
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q8IZQ1	Human	PMID:20417604
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:O95166	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q676U5	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q7Z6L1	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q8WUD4	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q9GZQ8	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q7Z6L1	Human	PMID:21575909
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q7Z6L1	Human	PMID:22342342
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q676U5	Human	PMID:23202584
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q8C0J2-3	Human	PMID:23262492
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q8TDY2	Human	PMID:23262492
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q676U5	Human	PMID:23392225
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q8TDY2	Human	PMID:23392225
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:O94817	Human	PMID:26812546
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q8WW24	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:A5LHX3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q0VD86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q14145	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q4V328	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q7Z6L1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q86T90	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q8IXW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q8TD31-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q8WUD4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q8WW24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q96ED9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q9H0Y0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q9Y6D9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:Q9Y6H3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:P09936	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATG5	IPI	UniProtKB:O94817	Human	PMID:9852036
Molecular Function	GO:0005515	protein binding	Atg5	IPI	UniProtKB:Q8C0J2	Mouse	MGI:MGI:2661260\|PMID:12665549
Molecular Function	GO:0005515	protein binding	Atg5	IPI	UniProtKB:Q6KAU8	Mouse	MGI:MGI:6436405\|PMID:22082872
Molecular Function	GO:0005515	protein binding	Atg5	IPI	UniProtKB:Q9CQY1	Mouse	MGI:MGI:2137756\|PMID:11266458
Molecular Function	GO:0005515	protein binding	Atg5	IPI	UniProtKB:Q9CQY1	Mouse	MGI:MGI:2661260\|PMID:12665549
Molecular Function	GO:0005515	protein binding	Atg5	IPI	UniProtKB:Q9CQY1	Mouse	MGI:MGI:4835103\|PMID:20723759
Molecular Function	GO:0005515	protein binding	Atg5	IPI	PR:Q8R1P4	Mouse	PMID:12482611
Molecular Function	GO:0005515	protein binding	Atg5	IPI	RGD:1306306	Rat	PMID:18059433\|RGD:2301217
Cellular Component	GO:0034274	Atg12-Atg5-Atg16 complex	ATG5	IPI		Human	PMID:23202584
Cellular Component	GO:0034274	Atg12-Atg5-Atg16 complex	Atg5	IDA		Mouse	MGI:MGI:2661260\|PMID:12665549
Cellular Component	GO:0005776	autophagosome	ATG5	IDA		Human	PMID:15292400
Cellular Component	GO:0005776	autophagosome	Atg5	IDA		Mouse	PMID:11266458
Cellular Component	GO:0030424	axon	Atg5	IDA		Rat	PMID:25040536\|RGD:11553820
Cellular Component	GO:0005930	axoneme	Atg5	IDA		Mouse	MGI:MGI:5527012\|PMID:24089209
Cellular Component	GO:0005737	cytoplasm	Atg5	IDA		Mouse	PMID:11266458
Cellular Component	GO:0016020	membrane	ATG5	IDA		Human	PMID:23093945
Cellular Component	GO:0044233	mitochondria-associated endoplasmic reticulum membrane	Atg5	IDA		Mouse	PMID:23455425
Cellular Component	GO:0034045	phagophore assembly site membrane	Atg5	IDA		Mouse	MGI:MGI:2137756\|PMID:11266458
Cellular Component	GO:0034045	phagophore assembly site membrane	Atg5	IDA		Mouse	MGI:MGI:2661260\|PMID:12665549
Cellular Component	GO:0034045	phagophore assembly site membrane	Atg5	IDA		Mouse	PMID:23455425
Cellular Component	GO:0032991	protein-containing complex	Atg5	IDA		Rat	PMID:18059433\|RGD:2301217
Cellular Component	GO:1990234	transferase complex	Atg5	IDA		Mouse	MGI:MGI:4835103\|PMID:20723759
Biological Process	GO:0035973	aggrephagy	ATG5	IMP		Human	PMID:22982048
Biological Process	GO:0035973	aggrephagy	Atg5	IMP		Mouse	MGI:MGI:5751672\|PMID:22982048
Biological Process	GO:0019883	antigen processing and presentation of endogenous antigen	Atg5	IGI	MGI:MGI:1338803	Mouse	PMID:23382543
Biological Process	GO:0019883	antigen processing and presentation of endogenous antigen	Atg5	IMP	MGI:MGI:3612279	Mouse	PMID:23382543
Biological Process	GO:0006915	apoptotic process	Atg5	IMP	MGI:MGI:3050453,MGI:MGI:3663625	Mouse	PMID:17450150
Biological Process	GO:0000045	autophagosome assembly	Atg5	IMP		Mouse	MGI:MGI:2137756\|PMID:11266458
Biological Process	GO:0000045	autophagosome assembly	Atg5	IMP		Mouse	PMID:23704209
Biological Process	GO:0000045	autophagosome assembly	Atg5	IMP		Rat	PMID:16420522\|RGD:1643189
Biological Process	GO:0000045	autophagosome assembly	atg5	IMP	ZFIN:ZDB-MRPHLNO-151021-1	Zfish	PMID:24441423
Biological Process	GO:0006914	autophagy	ATG5	IMP		Human	PMID:26812546
Biological Process	GO:0006914	autophagy	ATG5	IGI	UniProtKB:O95352	Human	PMID:28389568
Biological Process	GO:0006914	autophagy	Atg5	IMP		Mouse	MGI:MGI:2137756\|PMID:11266458
Biological Process	GO:0006914	autophagy	Atg5	IMP		Mouse	MGI:MGI:5509101\|PMID:23878245
Biological Process	GO:0006914	autophagy	Atg5	IMP		Rat	PMID:18059433\|RGD:2301217
Biological Process	GO:0006914	autophagy	atg5	IMP	ZFIN:ZDB-MRPHLNO-121010-2	Zfish	PMID:27467399
Biological Process	GO:0006914	autophagy	atg5	IMP	ZFIN:ZDB-MRPHLNO-121010-2	Zfish	PMID:28779098
Biological Process	GO:0006914	autophagy	atg5	IMP	ZFIN:ZDB-MRPHLNO-151021-1	Zfish	PMID:24441423
Biological Process	GO:0000422	autophagy of mitochondrion	Atg5	IMP		Mouse	MGI:MGI:3796473\|PMID:18281291
Biological Process	GO:0001974	blood vessel remodeling	Atg5	IMP	MGI:MGI:3050453,MGI:MGI:3663625	Mouse	PMID:17450150
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	Atg5	IMP	MGI:MGI:3050453,MGI:MGI:3663625	Mouse	PMID:17450150
Biological Process	GO:0071500	cellular response to nitrosative stress	Atg5	IMP		Mouse	MGI:MGI:5509101\|PMID:23878245
Biological Process	GO:0009267	cellular response to starvation	Atg5	IMP		Mouse	PMID:22496425
Biological Process	GO:0061684	chaperone-mediated autophagy	Atg5	IMP		Rat	PMID:23434281\|RGD:12793031
Biological Process	GO:0006325	chromatin organization	Atg5	IMP		Mouse	PMID:23863932
Biological Process	GO:0051649	establishment of localization in cell	Atg5	IMP	MGI:MGI:3663625	Mouse	PMID:24185898
Biological Process	GO:0060047	heart contraction	Atg5	IMP	MGI:MGI:3050453,MGI:MGI:3663625	Mouse	PMID:17450150
Biological Process	GO:0007507	heart development	atg5	IMP	ZFIN:ZDB-MRPHLNO-151021-4	Zfish	PMID:24441423
Biological Process	GO:0007507	heart development	atg5	IMP	ZFIN:ZDB-MRPHLNO-151021-1	Zfish	PMID:24441423
Biological Process	GO:0016236	macroautophagy	ATG5	IMP		Human	PMID:25484072
Biological Process	GO:0016236	macroautophagy	Atg5	IMP		Mouse	MGI:MGI:2137756\|PMID:11266458
Biological Process	GO:0016236	macroautophagy	Atg5	IMP		Mouse	PMID:22496425
Biological Process	GO:0016236	macroautophagy	Atg5	IMP	MGI:MGI:3612279	Mouse	PMID:20453062
Biological Process	GO:0016236	macroautophagy	Atg5	IMP		Mouse	PMID:24035364
Biological Process	GO:0016236	macroautophagy	Atg5	IMP		Mouse	PMID:23704209
Biological Process	GO:0070254	mucus secretion	Atg5	IMP	MGI:MGI:3663625	Mouse	PMID:24185898
Biological Process	GO:0043066	negative regulation of apoptotic process	Atg5	IMP		Mouse	MGI:MGI:3796473\|PMID:18281291
Biological Process	GO:0043066	negative regulation of apoptotic process	Atg5	IMP		Rat	PMID:20075199\|RGD:11561916
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Atg5	IMP	MGI:MGI:3050453,MGI:MGI:3663625	Mouse	PMID:17450150
Biological Process	GO:0060548	negative regulation of cell death	ATG5	IMP		Human	PMID:19273585
Biological Process	GO:0050687	negative regulation of defense response to virus	ATG5	IDA		Human	PMID:19666601
Biological Process	GO:0050687	negative regulation of defense response to virus	Atg5	IDA		Mouse	MGI:MGI:3722754\|PMID:17709747
Biological Process	GO:0045824	negative regulation of innate immune response	Atg5	IDA		Mouse	MGI:MGI:3722754\|PMID:17709747
Biological Process	GO:0050765	negative regulation of phagocytosis	Atg5	IMP		Mouse	PMID:24035364
Biological Process	GO:0031397	negative regulation of protein ubiquitination	Atg5	IMP	MGI:MGI:3050453,MGI:MGI:3663625	Mouse	PMID:17450150
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	Atg5	IMP	UniProtKB:Q61221	Mouse	MGI:MGI:3796473\|PMID:18281291
Biological Process	GO:0032480	negative regulation of type I interferon production	Atg5	IDA		Mouse	MGI:MGI:3722754\|PMID:17709747
Biological Process	GO:0039689	negative stranded viral RNA replication	Atg5	IMP		Mouse	PMID:24550300
Biological Process	GO:0045060	negative thymic T cell selection	Atg5	IGI	MGI:MGI:1338803	Mouse	PMID:23382543
Biological Process	GO:0045060	negative thymic T cell selection	Atg5	IMP	MGI:MGI:3612279	Mouse	PMID:23382543
Biological Process	GO:0007399	nervous system development	atg5	IMP	ZFIN:ZDB-MRPHLNO-121017-4	Zfish	PMID:22082871
Biological Process	GO:0007399	nervous system development	atg5	IMP	ZFIN:ZDB-MRPHLNO-121010-2	Zfish	PMID:22082871
Biological Process	GO:0048840	otolith development	Atg5	IMP	MGI:MGI:3612279	Mouse	PMID:20577052
Biological Process	GO:0070257	positive regulation of mucus secretion	Atg5	IMP	MGI:MGI:3663625	Mouse	PMID:24185898
Biological Process	GO:1904973	positive regulation of viral translation	ATG5	IDA		Human	PMID:19666601
Biological Process	GO:0043687	post-translational protein modification	Atg5	IDA		Mouse	MGI:MGI:2137756\|PMID:11266458
Biological Process	GO:0006497	protein lipidation	ATG5	IDA		Human	PMID:23202584
Biological Process	GO:0061739	protein lipidation involved in autophagosome assembly	Atg5	IMP		Mouse	PMID:23918802
Biological Process	GO:0016567	protein ubiquitination	Atg5	IMP	MGI:MGI:3050453,MGI:MGI:3663625	Mouse	PMID:17450150
Biological Process	GO:1901096	regulation of autophagosome maturation	ATG5	IMP		Human	PMID:22342342
Biological Process	GO:1902017	regulation of cilium assembly	Atg5	IMP		Mouse	MGI:MGI:5527013\|PMID:24089205
Biological Process	GO:1902017	regulation of cilium assembly	Atg5	IMP		Mouse	MGI:MGI:5527012\|PMID:24089209
Biological Process	GO:0002718	regulation of cytokine production involved in immune response	Atg5	IMP		Mouse	PMID:22710871
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	Atg5	IMP	MGI:MGI:3663625	Mouse	PMID:24185898
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	Atg5	IMP	MGI:MGI:3663625	Mouse	PMID:24185898
Biological Process	GO:0043416	regulation of skeletal muscle tissue regeneration	atg5	IMP	ZFIN:ZDB-MRPHLNO-121010-2	Zfish	PMID:27467399
Biological Process	GO:1902617	response to fluoride	Atg5	IEP		Rat	PMID:24296261\|RGD:11553819
Biological Process	GO:0009620	response to fungus	Atg5	IMP		Mouse	PMID:22710871
Biological Process	GO:0010040	response to iron(II) ion	Atg5	IEP		Rat	PMID:23187302\|RGD:11561914
Biological Process	GO:0009410	response to xenobiotic stimulus	Atg5	IMP	MGI:MGI:3050453,MGI:MGI:3663625	Mouse	PMID:17450150
Biological Process	GO:0042311	vasodilation	Atg5	IMP	MGI:MGI:3050453,MGI:MGI:3663625	Mouse	PMID:17450150
Biological Process	GO:0055015	ventricular cardiac muscle cell development	Atg5	IMP	MGI:MGI:3050453,MGI:MGI:3663625	Mouse	PMID:17450150

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.