Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATG7
  • Mouse genes Atg7
  • Rat genes Atg7
  • Zfish genes atg7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atg7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019778	Atg12 activating enzyme activity	Atg7	IMP		Mouse	MGI:MGI:4835103|PMID:20723759
Molecular Function	GO:0019778	Atg12 activating enzyme activity	Atg7	IDA		Mouse	PMID:11890701
Molecular Function	GO:0019779	Atg8 activating enzyme activity	Atg7	IDA		Mouse	PMID:11890701
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:O94817	Human	PMID:11096062
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:O95166	Human	PMID:11096062
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:P60520	Human	PMID:11096062
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:Q9H492	Human	PMID:11096062
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:Q9NT62	Human	PMID:11825910
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:O95166	Human	PMID:16303767
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:P60520	Human	PMID:16303767
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:Q9GZQ8	Human	PMID:16303767
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:Q9GZQ8	Human	PMID:18083104
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:Q96EB6	Human	PMID:18296641
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:P29692	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:Q12778	Human	PMID:20543840
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:O95166	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:P60520	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:Q9GZQ8	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:Q9H0R8	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	ATG7	IPI	UniProtKB:P14316	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	Atg7	IPI	PR:Q8R1P4	Mouse	PMID:12482611
Molecular Function	GO:0005515	protein binding	Atg7	IPI	PR:Q9CQY1	Mouse	PMID:12482611
Molecular Function	GO:0005515	protein binding	Atg7	IPI	PR:Q9DCD6	Mouse	PMID:11890701
Molecular Function	GO:0005515	protein binding	Atg7	IPI	PR:Q9CQY1	Mouse	PMID:11890701
Molecular Function	GO:0005515	protein binding	Atg7	IPI	PR:O70435	Mouse	PMID:11890701
Molecular Function	GO:0005515	protein binding	Atg7	IPI	PR:Q9CQV6	Mouse	PMID:11890701
Molecular Function	GO:0042803	protein homodimerization activity	ATG7	IDA		Human	PMID:11096062
Cellular Component	GO:0030424	axon	Atg7	IDA		Rat	PMID:25040536|RGD:11553820
Cellular Component	GO:0005930	axoneme	Atg7	IDA		Mouse	MGI:MGI:5527012|PMID:24089209
Cellular Component	GO:0005737	cytoplasm	ATG7	IDA		Human	PMID:20543840
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Atg7	IDA		Mouse	PMID:14627652
Biological Process	GO:0007628	adult walking behavior	Atg7	IMP	MGI:MGI:2386545,MGI:MGI:3587769	Mouse	PMID:16625205
Biological Process	GO:0007568	aging	Atg7	IEP		Rat	PMID:19341788|RGD:11557992
Biological Process	GO:0006915	apoptotic process	Atg7	IMP		Mouse	PMID:17450150
Biological Process	GO:0006915	apoptotic process	Atg7	IMP	MGI:MGI:2386545,MGI:MGI:3587769	Mouse	PMID:16625205
Biological Process	GO:0000045	autophagosome assembly	Atg7	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Biological Process	GO:0000045	autophagosome assembly	Atg7	IMP		Mouse	PMID:23704209
Biological Process	GO:0000045	autophagosome assembly	atg7	IMP	ZFIN:ZDB-MRPHLNO-151021-3	Zfish	PMID:24441423
Biological Process	GO:0006914	autophagy	ATG7	IMP		Human	PMID:25327288
Biological Process	GO:0006914	autophagy	ATG7	IMP		Human	PMID:20543840
Biological Process	GO:0006914	autophagy	ATG7	IMP		Human	PMID:24681637
Biological Process	GO:0006914	autophagy	ATG7	IGI	UniProtKB:Q9H1Y0	Human	PMID:28389568
Biological Process	GO:0006914	autophagy	Atg7	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Biological Process	GO:0006914	autophagy	Atg7	IMP		Mouse	MGI:MGI:6208175|PMID:29937374
Biological Process	GO:0006914	autophagy	Atg7	IMP		Mouse	PMID:17450150
Biological Process	GO:0006914	autophagy	Atg7	IMP	MGI:MGI:3587771	Mouse	PMID:16885219
Biological Process	GO:0006914	autophagy	Atg7	IMP	MGI:MGI:2137515,MGI:MGI:3587769	Mouse	PMID:17726112
Biological Process	GO:0006914	autophagy	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:20577052
Biological Process	GO:0006914	autophagy	Atg7	IMP	MGI:MGI:2176052,MGI:MGI:3587769	Mouse	PMID:15866887
Biological Process	GO:0006914	autophagy	Atg7	IMP	MGI:MGI:2176073,MGI:MGI:3587769	Mouse	PMID:15866887
Biological Process	GO:0006914	autophagy	atg7	IMP	ZFIN:ZDB-MRPHLNO-151021-3	Zfish	PMID:24441423
Biological Process	GO:0000422	autophagy of mitochondrion	ATG7	IGI	UniProtKB:Q9BXM7	Human	PMID:19279012
Biological Process	GO:0000422	autophagy of mitochondrion	Atg7	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Biological Process	GO:0000422	autophagy of mitochondrion	Atg7	IMP		Mouse	PMID:23981124
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	Atg7	IMP		Mouse	PMID:17450150
Biological Process	GO:0055013	cardiac muscle cell development	Atg7	IMP		Mouse	PMID:17450150
Biological Process	GO:0071455	cellular response to hyperoxia	ATG7	IDA		Human	PMID:20543840
Biological Process	GO:0071315	cellular response to morphine	Atg7	IEP		Rat	PMID:23800874|RGD:11557986
Biological Process	GO:0034614	cellular response to reactive oxygen species	Atg7	IMP		Mouse	PMID:23981124
Biological Process	GO:1903936	cellular response to sodium arsenite	Atg7	IMP		Rat	PMID:25639566|RGD:11553824
Biological Process	GO:0009267	cellular response to starvation	ATG7	IDA		Human	PMID:20543840
Biological Process	GO:0009267	cellular response to starvation	Atg7	IMP		Mouse	PMID:22496425
Biological Process	GO:0021955	central nervous system neuron axonogenesis	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:20577052
Biological Process	GO:0021680	cerebellar Purkinje cell layer development	Atg7	IMP	MGI:MGI:2386545,MGI:MGI:3587769	Mouse	PMID:16625205
Biological Process	GO:0021680	cerebellar Purkinje cell layer development	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:20577052
Biological Process	GO:0021987	cerebral cortex development	Atg7	IMP	MGI:MGI:2386545,MGI:MGI:3587769	Mouse	PMID:16625205
Biological Process	GO:0061684	chaperone-mediated autophagy	Atg7	IMP		Rat	PMID:23434281|RGD:12793031
Biological Process	GO:0006325	chromatin organization	Atg7	IMP		Mouse	PMID:23863932
Biological Process	GO:0051607	defense response to virus	ATG7	IMP		Human	PMID:23290079
Biological Process	GO:0051649	establishment of localization in cell	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:24185898
Biological Process	GO:0007507	heart development	atg7	IMP	ZFIN:ZDB-MRPHLNO-151021-3	Zfish	PMID:24441423
Biological Process	GO:0007507	heart development	atg7	IMP	ZFIN:ZDB-MRPHLNO-151021-6	Zfish	PMID:24441423
Biological Process	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:24105478
Biological Process	GO:0080144	intracellular amino acid homeostasis	Atg7	IMP	MGI:MGI:2176052,MGI:MGI:3587769	Mouse	PMID:15866887
Biological Process	GO:0090156	intracellular sphingolipid homeostasis	Atg7	IMP	MGI:MGI:2176073,MGI:MGI:3587769	Mouse	PMID:25332431
Biological Process	GO:0001889	liver development	Atg7	IMP	MGI:MGI:2176073,MGI:MGI:3587769	Mouse	PMID:15866887
Biological Process	GO:0016236	macroautophagy	ATG7	IMP		Human	PMID:22354037
Biological Process	GO:0016236	macroautophagy	Atg7	IMP		Mouse	PMID:22496425
Biological Process	GO:0016236	macroautophagy	Atg7	IMP	MGI:MGI:1934631,MGI:MGI:3587769	Mouse	PMID:24035364
Biological Process	GO:0016236	macroautophagy	Atg7	IMP		Mouse	PMID:23704209
Biological Process	GO:0061024	membrane organization	Atg7	IMP	MGI:MGI:2137515,MGI:MGI:3587769	Mouse	PMID:17726112
Biological Process	GO:0007005	mitochondrion organization	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:21402742
Biological Process	GO:0000423	mitophagy	atg7	IMP	ZFIN:ZDB-MRPHLNO-160823-2	Zfish	PMID:26929344
Biological Process	GO:0070254	mucus secretion	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:24185898
Biological Process	GO:0043066	negative regulation of apoptotic process	Atg7	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Biological Process	GO:0043066	negative regulation of apoptotic process	Atg7	IMP	MGI:MGI:2386545,MGI:MGI:3587769	Mouse	PMID:16625205
Biological Process	GO:0043066	negative regulation of apoptotic process	Atg7	IMP		Rat	PMID:25241190|RGD:11552607
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Atg7	IMP		Mouse	PMID:17450150
Biological Process	GO:0060548	negative regulation of cell death	Atg7	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Biological Process	GO:0090298	negative regulation of mitochondrial DNA replication	Atg7	IMP		Rat	PMID:23800874|RGD:11557986
Biological Process	GO:0050765	negative regulation of phagocytosis	Atg7	IMP	MGI:MGI:1934631,MGI:MGI:3587769	Mouse	PMID:24035364
Biological Process	GO:0090155	negative regulation of sphingolipid biosynthetic process	Atg7	IMP	MGI:MGI:2176073,MGI:MGI:3587769	Mouse	PMID:25332431
Biological Process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:24105478
Biological Process	GO:0039689	negative stranded viral RNA replication	Atg7	IMP		Mouse	PMID:24550300
Biological Process	GO:0050877	nervous system process	Atg7	IMP	MGI:MGI:2386545,MGI:MGI:3587769	Mouse	PMID:16625205
Biological Process	GO:0031175	neuron projection development	Atg7	IMP	MGI:MGI:2137515,MGI:MGI:3587769	Mouse	PMID:17726112
Biological Process	GO:0006996	organelle organization	Atg7	IMP	MGI:MGI:2176073,MGI:MGI:3587769	Mouse	PMID:15866887
Biological Process	GO:0043065	positive regulation of apoptotic process	ATG7	IMP		Human	PMID:20543840
Biological Process	GO:0010508	positive regulation of autophagy	Atg7	IDA		Rat	PMID:24674959|RGD:11553823
Biological Process	GO:0010508	positive regulation of autophagy	Atg7	IMP		Rat	PMID:25639566|RGD:11553824
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:24105478
Biological Process	GO:0070257	positive regulation of mucus secretion	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:24185898
Biological Process	GO:0043068	positive regulation of programmed cell death	Atg7	IMP		Rat	PMID:25639566|RGD:11553824
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Atg7	IMP	MGI:MGI:2446434,MGI:MGI:3587769,MGI:MGI:3691571	Mouse	PMID:23152632
Biological Process	GO:0045732	positive regulation of protein catabolic process	ATG7	IMP		Human	PMID:20543840
Biological Process	GO:0031401	positive regulation of protein modification process	ATG7	IDA		Human	PMID:12890687
Biological Process	GO:0031401	positive regulation of protein modification process	Atg7	IDA		Mouse	PMID:12482611
Biological Process	GO:0009791	post-embryonic development	Atg7	IMP	MGI:MGI:2386545,MGI:MGI:3587769	Mouse	PMID:16625205
Biological Process	GO:0009791	post-embryonic development	Atg7	IMP	MGI:MGI:2176052,MGI:MGI:3587769	Mouse	PMID:15866887
Biological Process	GO:0030163	protein catabolic process	Atg7	IMP	MGI:MGI:2176073,MGI:MGI:3587769	Mouse	PMID:15866887
Biological Process	GO:0006497	protein lipidation	ATG7	IDA		Human	PMID:12890687
Biological Process	GO:0032446	protein modification by small protein conjugation	Atg7	IMP	MGI:MGI:2176052,MGI:MGI:3587769	Mouse	PMID:15866887
Biological Process	GO:0021860	pyramidal neuron development	Atg7	IMP	MGI:MGI:2386545,MGI:MGI:3587769	Mouse	PMID:16625205
Biological Process	GO:0060284	regulation of cell development	Atg7	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Biological Process	GO:0042752	regulation of circadian rhythm	Atg7	IMP		Mouse	MGI:MGI:6208175|PMID:29937374
Biological Process	GO:1903706	regulation of hemopoiesis	Atg7	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Biological Process	GO:1901214	regulation of neuron death	Atg7	IMP		Rat	PMID:23800795|RGD:11557991
Biological Process	GO:0031396	regulation of protein ubiquitination	Atg7	IMP	MGI:MGI:2386545,MGI:MGI:3587769	Mouse	PMID:16625205
Biological Process	GO:1902617	response to fluoride	Atg7	IEP		Rat	PMID:24296261|RGD:11553819
Biological Process	GO:0009749	response to glucose	Atg7	IEP		Rat	PMID:21384092|RGD:11557989
Biological Process	GO:0031667	response to nutrient levels	Atg7	IEP		Rat	PMID:17665967|RGD:1643198
Biological Process	GO:0042594	response to starvation	Atg7	IMP	MGI:MGI:2176073,MGI:MGI:3587769	Mouse	PMID:15866887
Biological Process	GO:0042594	response to starvation	Atg7	IMP	MGI:MGI:2176052,MGI:MGI:3587769	Mouse	PMID:15866887
Biological Process	GO:0030148	sphingolipid biosynthetic process	Atg7	IMP	MGI:MGI:2176073,MGI:MGI:3587769	Mouse	PMID:25332431
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	Atg7	IMP	MGI:MGI:3587769	Mouse	PMID:24105478

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern