Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATIC
  • Mouse genes Atic
  • Rat genes Atic
  • Zfish genes atic
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atic

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	ATIC	HDA		Human	PMID:25468996
Molecular Function	GO:0003937	IMP cyclohydrolase activity	ATIC	IDA		Human	PMID:26588576
Molecular Function	GO:0003937	IMP cyclohydrolase activity	Atic	IMP		Mouse	PMID:6480832
Molecular Function	GO:0003937	IMP cyclohydrolase activity	Atic	IDA		Rat	PMID:9332377|RGD:70804
Molecular Function	GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	Atic	IMP		Mouse	PMID:26144885
Molecular Function	GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	Atic	IDA		Rat	PMID:9332377|RGD:70804
Molecular Function	GO:0005515	protein binding	Atic	IPI	UniProtKB:P15127:PRO_0000016698	Rat	PMID:25687571|RGD:10047347
Molecular Function	GO:0042803	protein homodimerization activity	ATIC	IPI	UniProtKB:P31939	Human	PMID:14756553
Molecular Function	GO:0042803	protein homodimerization activity	ATIC	IPI	UniProtKB:P31939	Human	PMID:14966129
Cellular Component	GO:0005829	cytosol	ATIC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	ATIC	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ATIC	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ATIC	HDA		Human	PMID:23533145
Cellular Component	GO:0016020	membrane	ATIC	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	Atic	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005886	plasma membrane	ATIC	IDA		Human	GO_REF:0000052
Biological Process	GO:0044208	'de novo' AMP biosynthetic process	ATIC	IDA		Human	PMID:26588576
Biological Process	GO:0044208	'de novo' AMP biosynthetic process	Atic	IMP		Mouse	PMID:26144885
Biological Process	GO:0006189	'de novo' IMP biosynthetic process	ATIC	IDA		Human	PMID:26588576
Biological Process	GO:0006189	'de novo' IMP biosynthetic process	Atic	IMP		Mouse	PMID:26144885
Biological Process	GO:0006189	'de novo' IMP biosynthetic process	Atic	IDA		Rat	PMID:9332377|RGD:70804
Biological Process	GO:0097294	'de novo' XMP biosynthetic process	ATIC	IDA		Human	PMID:26588576
Biological Process	GO:0097294	'de novo' XMP biosynthetic process	Atic	IMP		Mouse	PMID:26144885
Biological Process	GO:0031100	animal organ regeneration	Atic	IEP		Rat	PMID:9332377|RGD:70804
Biological Process	GO:0003360	brainstem development	Atic	IEP		Rat	PMID:7057182|RGD:2301991
Biological Process	GO:0098761	cellular response to interleukin-7	Atic	IDA		Mouse	PMID:29581031
Biological Process	GO:0021549	cerebellum development	Atic	IEP		Rat	PMID:7057182|RGD:2301991
Biological Process	GO:0021987	cerebral cortex development	Atic	IEP		Rat	PMID:7057182|RGD:2301991
Biological Process	GO:0046452	dihydrofolate metabolic process	Atic	IDA		Rat	PMID:8948466|RGD:5144056
Biological Process	GO:0006177	GMP biosynthetic process	ATIC	IDA		Human	PMID:26588576
Biological Process	GO:0006177	GMP biosynthetic process	Atic	IMP		Mouse	PMID:26144885
Biological Process	GO:0009116	nucleoside metabolic process	Atic	IDA		Rat	PMID:7370986|RGD:5144068
Biological Process	GO:0010035	response to inorganic substance	Atic	IEP		Rat	PMID:4078017|RGD:2301990
Biological Process	GO:0009259	ribonucleotide metabolic process	Atic	IDA		Rat	PMID:4078017|RGD:2301990
Biological Process	GO:0046654	tetrahydrofolate biosynthetic process	Atic	IDA		Rat	PMID:7057182|RGD:2301991

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern