Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATOH1
  • Mouse genes Atoh1
  • Rat genes Atoh1
  • Zfish genes atoh1a,atoh1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atoh1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	atoh1a	IDA		Zfish	PMID:25568117
Molecular Function	GO:0031490	chromatin DNA binding	Atoh1	IDA		Mouse	PMID:15788459
Molecular Function	GO:0003677	DNA binding	Atoh1	IDA		Mouse	PMID:14757642
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Atoh1	IDA		Mouse	MGI:MGI:5574303|PMID:17826772
Molecular Function	GO:0005515	protein binding	Atoh1	IPI	UniProtKB:Q91YV0	Mouse	MGI:MGI:3758155|PMID:17878293
Molecular Function	GO:0005515	protein binding	Atoh1	IPI	PR:P15806	Mouse	PMID:14757642
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Atoh1	IDA		Mouse	MGI:MGI:5574303|PMID:17826772
Molecular Function	GO:0043565	sequence-specific DNA binding	Atoh1	IDA		Mouse	PMID:16679559
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ATOH1	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Atoh1	IDA		Mouse	MGI:MGI:5009203|PMID:10648228
Biological Process	GO:0042668	auditory receptor cell fate determination	Atoh1	IDA		Mouse	PMID:16407553
Biological Process	GO:0042668	auditory receptor cell fate determination	atoh1b	IGI	ZFIN:ZDB-MRPHLNO-070507-1,ZFIN:ZDB-MRPHLNO-070507-4	Zfish	PMID:17166920
Biological Process	GO:0042668	auditory receptor cell fate determination	atoh1b	IMP	ZFIN:ZDB-MRPHLNO-070507-1	Zfish	PMID:17166920
Biological Process	GO:0042668	auditory receptor cell fate determination	atoh1a	IMP		Zfish	PMID:11287207
Biological Process	GO:0042667	auditory receptor cell fate specification	Atoh1	IMP	MGI:MGI:2155983	Mouse	PMID:10364557
Biological Process	GO:0007411	axon guidance	Atoh1	IMP	MGI:MGI:2155984	Mouse	PMID:16145671
Biological Process	GO:0007420	brain development	Atoh1	IMP	MGI:MGI:2155983	Mouse	PMID:12223565
Biological Process	GO:0030154	cell differentiation	Atoh1	IMP	MGI:MGI:2155983	Mouse	PMID:15543141
Biological Process	GO:0021987	cerebral cortex development	Atoh1	IMP	MGI:MGI:2155983	Mouse	PMID:16325379
Biological Process	GO:1904019	epithelial cell apoptotic process	Atoh1	IMP	MGI:MGI:2155984	Mouse	PMID:11973280
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Atoh1	IDA		Mouse	PMID:19154718
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Atoh1	IDA		Mouse	PMID:15543141
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Atoh1	IMP	MGI:MGI:2155983	Mouse	PMID:15543141
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Atoh1	IMP	MGI:MGI:2155984	Mouse	PMID:11973280
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	atoh1b	IGI	ZFIN:ZDB-GENO-980202-1107,ZFIN:ZDB-MRPHLNO-070507-1,ZFIN:ZDB-MRPHLNO-070507-4	Zfish	PMID:17166920
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	atoh1a	IGI	ZFIN:ZDB-MRPHLNO-070507-1,ZFIN:ZDB-MRPHLNO-070507-4	Zfish	PMID:17166920
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	atoh1a	IMP	ZFIN:ZDB-MRPHLNO-070507-4	Zfish	PMID:17166920
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	atoh1a	IGI	ZFIN:ZDB-GENO-980202-1107,ZFIN:ZDB-MRPHLNO-070507-1,ZFIN:ZDB-MRPHLNO-070507-4	Zfish	PMID:17166920
Biological Process	GO:0048839	inner ear development	Atoh1	IMP	MGI:MGI:3767172	Mouse	PMID:21146598
Biological Process	GO:0048839	inner ear development	atoh1a	IMP	ZFIN:ZDB-MRPHLNO-061106-8	Zfish	PMID:17035528
Biological Process	GO:0048839	inner ear development	atoh1a	IMP	ZFIN:ZDB-MRPHLNO-070507-4	Zfish	PMID:25568117
Biological Process	GO:0042472	inner ear morphogenesis	Atoh1	IMP	MGI:MGI:2155983	Mouse	PMID:15543141
Biological Process	GO:0042472	inner ear morphogenesis	Atoh1	IMP	MGI:MGI:2155984	Mouse	PMID:16145671
Biological Process	GO:0060119	inner ear receptor cell development	atoh1a	IMP	ZFIN:ZDB-GENO-140225-3	Zfish	PMID:20025865
Biological Process	GO:0060119	inner ear receptor cell development	atoh1a	IGI	ZFIN:ZDB-GENO-140225-3,ZFIN:ZDB-MRPHLNO-060922-4	Zfish	PMID:20025865
Biological Process	GO:0060119	inner ear receptor cell development	atoh1a	IGI	ZFIN:ZDB-GENO-140225-2	Zfish	PMID:20025865
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Atoh1	IMP	MGI:MGI:2155984	Mouse	PMID:11973280
Biological Process	GO:0014014	negative regulation of gliogenesis	Atoh1	IGI	UniProtKB:Q10574	Mouse	MGI:MGI:6796503|PMID:32665354
Biological Process	GO:0097402	neuroblast migration	Atoh1	IMP	MGI:MGI:2155983	Mouse	PMID:16202707
Biological Process	GO:0048884	neuromast development	atoh1a	IMP	ZFIN:ZDB-MRPHLNO-070507-4	Zfish	PMID:17166920
Biological Process	GO:0035675	neuromast hair cell development	atoh1a	IMP		Zfish	PMID:21084119
Biological Process	GO:0030182	neuron differentiation	Atoh1	IMP	MGI:MGI:2155983	Mouse	PMID:14999071
Biological Process	GO:0001764	neuron migration	Atoh1	IMP	MGI:MGI:2155983	Mouse	PMID:16202707
Biological Process	GO:0007219	Notch signaling pathway	Atoh1	IDA		Mouse	PMID:25535395
Biological Process	GO:0048840	otolith development	atoh1b	IMP	ZFIN:ZDB-MRPHLNO-070507-1	Zfish	PMID:17166920
Biological Process	GO:0045609	positive regulation of inner ear auditory receptor cell differentiation	Atoh1	IDA		Mouse	PMID:11023859
Biological Process	GO:0045609	positive regulation of inner ear auditory receptor cell differentiation	Atoh1	IDA		Mouse	PMID:19154718
Biological Process	GO:2000982	positive regulation of inner ear receptor cell differentiation	Atoh1	IMP		Mouse	MGI:MGI:3625195|PMID:12208538
Biological Process	GO:2000982	positive regulation of inner ear receptor cell differentiation	Atoh1	IMP	MGI:MGI:3767172	Mouse	PMID:21146598
Biological Process	GO:0045666	positive regulation of neuron differentiation	Atoh1	IDA		Mouse	MGI:MGI:5009203|PMID:10648228
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atoh1	IDA		Mouse	MGI:MGI:5574303|PMID:17826772
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atoh1	IMP		Mouse	PMID:15788459
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atoh1	IMP	MGI:MGI:2155983	Mouse	PMID:16325379
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atoh1	IDA		Mouse	PMID:16679559
Biological Process	GO:0048919	posterior lateral line neuromast development	atoh1a	IMP	ZFIN:ZDB-MRPHLNO-070507-4	Zfish	PMID:18599504
Biological Process	GO:0048923	posterior lateral line neuromast hair cell differentiation	atoh1a	IMP	ZFIN:ZDB-MRPHLNO-070507-2	Zfish	PMID:16678150
Biological Process	GO:0045664	regulation of neuron differentiation	Atoh1	IDA		Mouse	PMID:14757642
Biological Process	GO:0006366	transcription by RNA polymerase II	Atoh1	IMP		Mouse	PMID:15788459

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern