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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Atp1a1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atp1a1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0043531ADP bindingAtp1a1IDARatPMID:12730684|RGD:1579857
Molecular FunctionGO:0030506ankyrin bindingAtp1a1IPIUniProtKB:P16157RatPMID:8159688|RGD:8554406
Molecular FunctionGO:0005524ATP bindingAtp1a1IDARatPMID:12730684|RGD:1579857
Molecular FunctionGO:0005524ATP bindingAtp1a1IDARatPMID:18075585|RGD:10047180
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityATP1A1IDAHumanPMID:10636900
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityATP1A1IGIUniProtKB:P05027HumanPMID:18052210
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityATP1A1IDAHumanPMID:19542013
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityAtp1a1IDAMousePMID:23229519
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityAtp1a1IMPMousePMID:10360172
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityAtp1a1IMPMousePMID:15485817
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityAtp1a1IDARatPMID:12531906|RGD:629542
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityAtp1a1IDARatPMID:16624992|RGD:2302992
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityAtp1a1IDARatPMID:16893515|RGD:1581763
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityAtp1a1IDARatPMID:17939993|RGD:8554378
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityAtp1a1IDARatPMID:18075585|RGD:10047180
Molecular FunctionGO:0005391P-type sodium:potassium-exchanging transporter activityatp1a1a.1IMPZfishPMID:14602677
Molecular FunctionGO:0016791phosphatase activityAtp1a1IMPMGI:MGI:2451290MousePMID:10360172
Molecular FunctionGO:0043548phosphatidylinositol 3-kinase bindingAtp1a1IPIRGD:3329RatPMID:17728397|RGD:4108501
Molecular FunctionGO:0030955potassium ion bindingAtp1a1IDARatPMID:16269407|RGD:1579784
Molecular FunctionGO:0030955potassium ion bindingAtp1a1IDARatPMID:18075585|RGD:10047180
Molecular FunctionGO:0005515protein bindingATP1A1IPIUniProtKB:P14415HumanPMID:11027149
Molecular FunctionGO:0005515protein bindingATP1A1IPIUniProtKB:P06239HumanPMID:15671290
Molecular FunctionGO:0005515protein bindingATP1A1IPIUniProtKB:P13693HumanPMID:16730713
Molecular FunctionGO:0005515protein bindingATP1A1IPIUniProtKB:Q969F2HumanPMID:18504258
Molecular FunctionGO:0005515protein bindingATP1A1IPIUniProtKB:P13693HumanPMID:21278788
Molecular FunctionGO:0005515protein bindingATP1A1IPIUniProtKB:Q2M3R5HumanPMID:22084111
Molecular FunctionGO:0005515protein bindingATP1A1IPIUniProtKB:P05026HumanPMID:25012180
Molecular FunctionGO:0005515protein bindingATP1A1IPIUniProtKB:P05026HumanPMID:30021884
Molecular FunctionGO:0005515protein bindingAtp1a1IPIUniProtKB:Q8C8R3MouseMGI:MGI:3610760|PMID:16292983
Molecular FunctionGO:0005515protein bindingAtp1a1IPIUniProtKB:O35157|UniProtKB:P11881MouseMGI:MGI:3610760|PMID:16292983
Molecular FunctionGO:0005515protein bindingAtp1a1IPIPR:P70414MousePMID:15485817
Molecular FunctionGO:0005515protein bindingAtp1a1IPIRGD:620830RatPMID:12093728|RGD:631775
Molecular FunctionGO:0005515protein bindingAtp1a1IPIRGD:619788RatPMID:16025302|RGD:10043786
Molecular FunctionGO:0005515protein bindingAtp1a1IPIRGD:2173RatPMID:16373350|RGD:1598988
Molecular FunctionGO:0019904protein domain specific bindingAtp1a1IPIRGD:737495RatPMID:16269407|RGD:1579784
Molecular FunctionGO:0046982protein heterodimerization activityAtp1a1IPIUniProtKB:P07340RatPMID:28787093|RGD:14995309
Molecular FunctionGO:0046982protein heterodimerization activityAtp1a1IPIUniProtKB:P13638RatPMID:28787093|RGD:14995309
Molecular FunctionGO:0019901protein kinase bindingAtp1a1IPIUniProtKB:Q9R1U5RatPMID:17939993|RGD:8554378
Molecular FunctionGO:0051087protein-folding chaperone bindingATP1A1IPIUniProtKB:P05026HumanPMID:10636900
Molecular FunctionGO:0051087protein-folding chaperone bindingATP1A1IPIUniProtKB:P14415HumanPMID:10636900
Molecular FunctionGO:0051087protein-folding chaperone bindingATP1A1IPIUniProtKB:P54709HumanPMID:10636900
Molecular FunctionGO:0051087protein-folding chaperone bindingAtp1a1IDARatPMID:18768923|RGD:8553946
Molecular FunctionGO:0031402sodium ion bindingAtp1a1IDARatPMID:16269407|RGD:1579784
Molecular FunctionGO:0031402sodium ion bindingAtp1a1IMPRatPMID:18075585|RGD:10047180
Molecular FunctionGO:1990239steroid hormone bindingATP1A1IDAHumanPMID:14742675
Cellular ComponentGO:0016324apical plasma membraneATP1A1IDAHumanPMID:11193188
Cellular ComponentGO:0016324apical plasma membraneAtp1a1IDAMousePMID:21705333
Cellular ComponentGO:0016323basolateral plasma membraneAtp1a1IDAMousePMID:22333836
Cellular ComponentGO:0016323basolateral plasma membraneAtp1a1IDAMousePMID:8144700
Cellular ComponentGO:0016323basolateral plasma membraneAtp1a1IMPRatPMID:16914892|RGD:42721996
Cellular ComponentGO:0005901caveolaAtp1a1IDARatPMID:16624992|RGD:2302992
Cellular ComponentGO:0005783endoplasmic reticulumAtp1a1IDARatPMID:18768923|RGD:8553946
Cellular ComponentGO:0005768endosomeAtp1a1IDARatPMID:16893515|RGD:1581763
Cellular ComponentGO:0070062extracellular exosomeATP1A1HDAHumanPMID:12519789
Cellular ComponentGO:0070062extracellular exosomeATP1A1HDAHumanPMID:19199708
Cellular ComponentGO:0070062extracellular exosomeATP1A1HDAHumanPMID:20458337
Cellular ComponentGO:1903561extracellular vesicleATP1A1HDAHumanPMID:24769233
Cellular ComponentGO:0005794Golgi apparatusAtp1a1IDARatPMID:18768923|RGD:8553946
Cellular ComponentGO:0014704intercalated discAtp1a1IDARatPMID:17442282|RGD:6903343
Cellular ComponentGO:0016328lateral plasma membraneATP1A1IDAHumanPMID:11193188
Cellular ComponentGO:0016020membraneAtp1a1IDAMousePMID:15755730
Cellular ComponentGO:0016020membraneAtp1a1IDARatPMID:16893515|RGD:1581763
Cellular ComponentGO:0016020membraneAtp1a1IDARatPMID:28787093|RGD:14995309
Cellular ComponentGO:0045121membrane raftAtp1a1IDARatPMID:18178552|RGD:6903211
Cellular ComponentGO:0043209myelin sheathAtp1a1HDAMouseMGI:MGI:3834050|PMID:17634366
Cellular ComponentGO:0031090organelle membraneATP1A1IGIUniProtKB:P05026HumanPMID:19751721
Cellular ComponentGO:0005886plasma membraneATP1A1HDAHumanPMID:16791210
Cellular ComponentGO:0005886plasma membraneATP1A1IDAHumanPMID:18522992
Cellular ComponentGO:0005886plasma membraneATP1A1IGIUniProtKB:P05026HumanPMID:19751721
Cellular ComponentGO:0005886plasma membraneATP1A1IDAHumanPMID:7711835
Cellular ComponentGO:0005886plasma membraneAtp1a1IDAMousePMID:10837135
Cellular ComponentGO:0005886plasma membraneAtp1a1IDAMousePMID:10468580
Cellular ComponentGO:0005886plasma membraneAtp1a1IDARatPMID:18768923|RGD:8553946
Cellular ComponentGO:0014069postsynaptic densityAtp1a1IDAMousePMID:17114649
Cellular ComponentGO:0032991protein-containing complexATP1A1IDAHumanPMID:22797923
Cellular ComponentGO:0042383sarcolemmaAtp1a1IDAMouseMGI:MGI:3610760|PMID:16292983
Cellular ComponentGO:0042383sarcolemmaAtp1a1IDAMousePMID:15485817
Cellular ComponentGO:0042383sarcolemmaAtp1a1IDARatPMID:17442282|RGD:6903343
Cellular ComponentGO:0005890sodium:potassium-exchanging ATPase complexATP1A1IDAHumanPMID:10636900
Cellular ComponentGO:0005890sodium:potassium-exchanging ATPase complexATP1A1IGIUniProtKB:P05027HumanPMID:18052210
Cellular ComponentGO:0005890sodium:potassium-exchanging ATPase complexATP1A1IDAHumanPMID:19542013
Cellular ComponentGO:0005890sodium:potassium-exchanging ATPase complexAtp1a1IDARatPMID:12093728|RGD:631775
Cellular ComponentGO:0005890sodium:potassium-exchanging ATPase complexAtp1a1IDARatPMID:16624992|RGD:2302992
Cellular ComponentGO:0005890sodium:potassium-exchanging ATPase complexAtp1a1IDARatPMID:16893515|RGD:1581763
Cellular ComponentGO:0005890sodium:potassium-exchanging ATPase complexAtp1a1IDARatPMID:28787093|RGD:14995309
Cellular ComponentGO:0036126sperm flagellumATP1A1IDAHumanPMID:16861705
Cellular ComponentGO:0030315T-tubuleATP1A1IGIUniProtKB:P05026HumanPMID:19751721
Cellular ComponentGO:0030315T-tubuleAtp1a1IDAMouseMGI:MGI:3610760|PMID:16292983
Cellular ComponentGO:0030315T-tubuleAtp1a1IDARatPMID:17442282|RGD:6903343
Biological ProcessGO:0007420brain developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-453ZfishPMID:9007241
Biological ProcessGO:0007420brain developmentatp1a1a.1IMPZFIN:ZDB-GENO-031230-1ZfishPMID:14602677
Biological ProcessGO:0007420brain developmentatp1a1a.1IMPZFIN:ZDB-GENO-050707-1ZfishPMID:15788456
Biological ProcessGO:0048854brain morphogenesisatp1a1a.1IMPZFIN:ZDB-GENO-980202-1563ZfishPMID:9007241
Biological ProcessGO:0048854brain morphogenesisatp1a1a.1IMPZFIN:ZDB-GENO-980202-1560ZfishPMID:9007241
Biological ProcessGO:0048854brain morphogenesisatp1a1a.1IMPZFIN:ZDB-GENO-980202-1554ZfishPMID:9007241
Biological ProcessGO:0048854brain morphogenesisatp1a1a.1IMPZFIN:ZDB-GENO-980202-1561ZfishPMID:9007241
Biological ProcessGO:0048854brain morphogenesisatp1a1a.1IMPZFIN:ZDB-GENO-980202-1562ZfishPMID:9007241
Biological ProcessGO:0048854brain morphogenesisatp1a1a.1IMPZFIN:ZDB-GENO-120302-4ZfishPMID:9007241
Biological ProcessGO:0048854brain morphogenesisatp1a1a.1IMPZFIN:ZDB-GENO-980202-1559ZfishPMID:9007241
Biological ProcessGO:0048854brain morphogenesisatp1a1a.1IMPZFIN:ZDB-GENO-980202-310ZfishPMID:9007241
Biological ProcessGO:0035051cardiocyte differentiationatp1a1a.1IMPZFIN:ZDB-GENO-031230-1ZfishPMID:14602677
Biological ProcessGO:0035051cardiocyte differentiationatp1a1a.1IMPZFIN:ZDB-GENO-041105-1ZfishPMID:15297381
Biological ProcessGO:0060974cell migration involved in heart formationatp1a1a.1IMPZFIN:ZDB-GENO-121029-1ZfishPMID:22182522
Biological ProcessGO:0071260cellular response to mechanical stimulusAtp1a1IDARatPMID:17458903|RGD:6903221
Biological ProcessGO:0071383cellular response to steroid hormone stimulusATP1A1IDAHumanPMID:11546672
Biological ProcessGO:0007368determination of left/right symmetryatp1a1a.1IMPZfishPMID:16628609
Biological ProcessGO:0007368determination of left/right symmetryatp1a1a.1IMPZFIN:ZDB-GENO-060308-1ZfishPMID:16628609
Biological ProcessGO:0010172embryonic body morphogenesisatp1a1a.1IMPZFIN:ZDB-GENO-031230-1ZfishPMID:14602677
Biological ProcessGO:0035050embryonic heart tube developmentatp1a1a.1IMPZFIN:ZDB-GENO-031230-1ZfishPMID:14602677
Biological ProcessGO:0035050embryonic heart tube developmentatp1a1a.1IMPZFIN:ZDB-MRPHLNO-060215-1ZfishPMID:22182522
Biological ProcessGO:0035050embryonic heart tube developmentatp1a1a.1IMPZFIN:ZDB-GENO-031230-1ZfishPMID:17227894
Biological ProcessGO:0035050embryonic heart tube developmentatp1a1a.1IMPZFIN:ZDB-MRPHLNO-060215-3ZfishPMID:22182522
Biological ProcessGO:0003143embryonic heart tube morphogenesisatp1a1a.1IMPZFIN:ZDB-GENO-121029-1ZfishPMID:22182522
Biological ProcessGO:0010248establishment or maintenance of transmembrane electrochemical gradientAtp1a1IMPMouseMGI:MGI:1337471|PMID:10360172
Biological ProcessGO:0030198extracellular matrix organizationatp1a1a.1IMPZFIN:ZDB-GENO-100525-1ZfishPMID:22182522
Biological ProcessGO:0030198extracellular matrix organizationatp1a1a.1IMPZFIN:ZDB-GENO-110118-8ZfishPMID:22182522
Biological ProcessGO:0060047heart contractionAtp1a1IMPMGI:MGI:2451290MousePMID:10360172
Biological ProcessGO:0007507heart developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1562ZfishPMID:9007241
Biological ProcessGO:0007507heart developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1554ZfishPMID:9007241
Biological ProcessGO:0007507heart developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1560ZfishPMID:9007241
Biological ProcessGO:0007507heart developmentatp1a1a.1IMPZFIN:ZDB-GENO-120302-4ZfishPMID:9007241
Biological ProcessGO:0007507heart developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1561ZfishPMID:9007241
Biological ProcessGO:0007507heart developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-453ZfishPMID:9007241
Biological ProcessGO:0007507heart developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1559ZfishPMID:9007241
Biological ProcessGO:0007507heart developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-310ZfishPMID:9007241
Biological ProcessGO:0007507heart developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1563ZfishPMID:9007241
Biological ProcessGO:0030007intracellular potassium ion homeostasisATP1A1IDAHumanPMID:10636900
Biological ProcessGO:0030007intracellular potassium ion homeostasisATP1A1IDAHumanPMID:19542013
Biological ProcessGO:0006883intracellular sodium ion homeostasisATP1A1IDAHumanPMID:10636900
Biological ProcessGO:0006883intracellular sodium ion homeostasisATP1A1IDAHumanPMID:19542013
Biological ProcessGO:0060081membrane hyperpolarizationAtp1a1IMPRatPMID:17001300|RGD:6903222
Biological ProcessGO:0086009membrane repolarizationATP1A1IDAHumanPMID:19542013
Biological ProcessGO:0030917midbrain-hindbrain boundary developmentatp1a1a.1IMPZFIN:ZDB-MRPHLNO-060215-3ZfishPMID:16566913
Biological ProcessGO:0031947negative regulation of glucocorticoid biosynthetic processAtp1a1IMPMGI:MGI:2451290MousePMID:17234593
Biological ProcessGO:0045822negative regulation of heart contractionAtp1a1IMPMGI:MGI:3527337MousePMID:15485817
Biological ProcessGO:0071599otic vesicle developmentatp1a1a.1IMPZfishPMID:9007247
Biological ProcessGO:0030916otic vesicle formationatp1a1a.1IMPZFIN:ZDB-MRPHLNO-060215-3ZfishPMID:16566913
Biological ProcessGO:0048840otolith developmentatp1a1a.1IMPZFIN:ZDB-MRPHLNO-060215-3ZfishPMID:16566913
Biological ProcessGO:0048840otolith developmentatp1a1a.1IMPZFIN:ZDB-MRPHLNO-060622-1ZfishPMID:16566913
Biological ProcessGO:0048840otolith developmentatp1a1a.1IGIZFIN:ZDB-MRPHLNO-060215-3,ZFIN:ZDB-MRPHLNO-060626-8ZfishPMID:16566913
Biological ProcessGO:0045823positive regulation of heart contractionAtp1a1IMPMGI:MGI:2451290MousePMID:10360172
Biological ProcessGO:0045989positive regulation of striated muscle contractionAtp1a1IMPMGI:MGI:2451290MousePMID:11507009
Biological ProcessGO:1990573potassium ion import across plasma membraneATP1A1IDAHumanPMID:10636900
Biological ProcessGO:1990573potassium ion import across plasma membraneATP1A1IDAHumanPMID:19542013
Biological ProcessGO:1990573potassium ion import across plasma membraneAtp1a1IDARatPMID:12531906|RGD:629542
Biological ProcessGO:1990573potassium ion import across plasma membraneAtp1a1IDARatPMID:18075585|RGD:10047180
Biological ProcessGO:0071805potassium ion transmembrane transportAtp1a1IMPMouseMGI:MGI:1337471|PMID:10360172
Biological ProcessGO:0006813potassium ion transportAtp1a1IDARatPMID:12093728|RGD:631775
Biological ProcessGO:0006813potassium ion transportAtp1a1IDARatPMID:16624992|RGD:2302992
Biological ProcessGO:0008217regulation of blood pressureAtp1a1IGIMGI:MGI:97742MousePMID:16243970
Biological ProcessGO:0086004regulation of cardiac muscle cell contractionAtp1a1IMPRatPMID:15629895|RGD:6903236
Biological ProcessGO:0008016regulation of heart contractionatp1a1a.1IMPZFIN:ZDB-GENO-070808-34ZfishPMID:9007249
Biological ProcessGO:0002027regulation of heart rateatp1a1a.1IMPZFIN:ZDB-GENO-070808-34ZfishPMID:29750993
Biological ProcessGO:0002028regulation of sodium ion transportAtp1a1IDARatPMID:17939993|RGD:8554378
Biological ProcessGO:0002026regulation of the force of heart contractionAtp1a1IMPMGI:MGI:2451290MousePMID:10360172
Biological ProcessGO:0002026regulation of the force of heart contractionAtp1a1IMPMGI:MGI:3527337MousePMID:15485817
Biological ProcessGO:1903416response to glycosideATP1A1IDAHumanPMID:11546672
Biological ProcessGO:0009410response to xenobiotic stimulusAtp1a1IMPMGI:MGI:2451290MousePMID:17234593
Biological ProcessGO:0048752semicircular canal morphogenesisatp1a1a.2IMPZFIN:ZDB-MRPHLNO-060622-3ZfishPMID:16566913
Biological ProcessGO:0048752semicircular canal morphogenesisatp1a1a.2IMPZFIN:ZDB-MRPHLNO-060622-2ZfishPMID:16566913
Biological ProcessGO:0036376sodium ion export across plasma membraneATP1A1IDAHumanPMID:10636900
Biological ProcessGO:0036376sodium ion export across plasma membraneATP1A1IDAHumanPMID:19542013
Biological ProcessGO:0036376sodium ion export across plasma membraneAtp1a1IDARatPMID:18075585|RGD:10047180
Biological ProcessGO:0035725sodium ion transmembrane transportAtp1a1IMPMouseMGI:MGI:1337471|PMID:10360172
Biological ProcessGO:0006814sodium ion transportAtp1a1IDARatPMID:12093728|RGD:631775
Biological ProcessGO:0006814sodium ion transportAtp1a1IDARatPMID:12531906|RGD:629542
Biological ProcessGO:0006814sodium ion transportAtp1a1IDARatPMID:16624992|RGD:2302992
Biological ProcessGO:0055085transmembrane transportAtp1a1IDARatPMID:18075585|RGD:10047180
Biological ProcessGO:0021591ventricular system developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1559ZfishPMID:9007241
Biological ProcessGO:0021591ventricular system developmentatp1a1a.1IMPZFIN:ZDB-GENO-120302-4ZfishPMID:9007241
Biological ProcessGO:0021591ventricular system developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1563ZfishPMID:9007241
Biological ProcessGO:0021591ventricular system developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1560ZfishPMID:9007241
Biological ProcessGO:0021591ventricular system developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-310ZfishPMID:9007238
Biological ProcessGO:0021591ventricular system developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1562ZfishPMID:9007241
Biological ProcessGO:0021591ventricular system developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-453ZfishPMID:9007241
Biological ProcessGO:0021591ventricular system developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1561ZfishPMID:9007241
Biological ProcessGO:0021591ventricular system developmentatp1a1a.1IMPZFIN:ZDB-GENO-980202-1554ZfishPMID:9007241

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory