Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Atp2b4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ATP2B4
- Mouse genes Atp2b4
- Rat genes Atp2b4
- Zfish genes atp2b4
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atp2b4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015085	calcium ion transmembrane transporter activity	ATP2B4	IDA		Human	PMID:23549614
Molecular Function	GO:0005516	calmodulin binding	ATP2B4	IDA		Human	PMID:8530416
Molecular Function	GO:0050998	nitric-oxide synthase binding	ATP2B4	IPI	UniProtKB:P29476	Human	PMID:11591728
Molecular Function	GO:0050998	nitric-oxide synthase binding	ATP2B4	IPI	UniProtKB:P29476	Human	PMID:23549614
Molecular Function	GO:0036487	nitric-oxide synthase inhibitor activity	ATP2B4	IDA		Human	PMID:11591728
Molecular Function	GO:0036487	nitric-oxide synthase inhibitor activity	ATP2B4	IDA		Human	PMID:17242280
Molecular Function	GO:0005388	P-type calcium transporter activity	ATP2B4	IMP		Human	PMID:8530416
Molecular Function	GO:0005388	P-type calcium transporter activity	Atp2b4	IDA		Rat	PMID:11779484\|RGD:628395
Molecular Function	GO:0030165	PDZ domain binding	Atp2b4	IPI	RGD:628725	Rat	PMID:16554037\|RGD:1581788
Molecular Function	GO:0005515	protein binding	ATP2B4	IPI	UniProtKB:Q9Z0J4	Human	PMID:17242280
Molecular Function	GO:0005515	protein binding	ATP2B4	IPI	UniProtKB:P01258	Human	PMID:17689535
Molecular Function	GO:0005515	protein binding	ATP2B4	IPI	UniProtKB:Q2M3R5	Human	PMID:22084111
Molecular Function	GO:0005515	protein binding	ATP2B4	IPI	UniProtKB:Q5VYX0	Human	PMID:25906147
Molecular Function	GO:0005515	protein binding	Atp2b4	IPI	UniProtKB:P97300	Mouse	MGI:MGI:6114568\|PMID:28827723
Molecular Function	GO:0019901	protein kinase binding	Atp2b4	IPI	RGD:62004	Rat	PMID:12511555\|RGD:728219
Molecular Function	GO:0030346	protein phosphatase 2B binding	ATP2B4	IPI	UniProtKB:Q08209	Human	PMID:15955804
Molecular Function	GO:0030346	protein phosphatase 2B binding	ATP2B4	IDA		Human	PMID:19287093
Molecular Function	GO:0030346	protein phosphatase 2B binding	ATP2B4	IMP		Human	PMID:25147342
Molecular Function	GO:0097110	scaffold protein binding	Atp2b4	IPI	UniProtKB:Q13424	Mouse	MGI:MGI:5499724\|PMID:18591664
Molecular Function	GO:0017080	sodium channel regulator activity	Atp2b4	IMP		Mouse	MGI:MGI:5499724\|PMID:18591664
Cellular Component	GO:0016323	basolateral plasma membrane	Atp2b4	IDA		Rat	PMID:18057950\|RGD:6906890
Cellular Component	GO:0098978	glutamatergic synapse	Atp2b4	EXP		Rat	PMID:23622064\|RGD:13702180
Cellular Component	GO:0098978	glutamatergic synapse	Atp2b4	IDA		Rat	PMID:23622064\|RGD:13702180
Cellular Component	GO:0016020	membrane	ATP2B4	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	ATP2B4	IDA		Human	PMID:23549614
Cellular Component	GO:0016020	membrane	ATP2B4	IDA		Human	PMID:25147342
Cellular Component	GO:0016020	membrane	ATP2B4	IDA		Human	PMID:8530416
Cellular Component	GO:0045121	membrane raft	ATP2B4	IDA		Human	PMID:23549614
Cellular Component	GO:0043005	neuron projection	Atp2b4	IDA		Rat	PMID:16200642\|RGD:6906893
Cellular Component	GO:0005886	plasma membrane	ATP2B4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048787	presynaptic active zone membrane	Atp2b4	EXP		Rat	PMID:23622064\|RGD:13702180
Cellular Component	GO:0048787	presynaptic active zone membrane	Atp2b4	IDA		Rat	PMID:23622064\|RGD:13702180
Cellular Component	GO:0032991	protein-containing complex	Atp2b4	IDA		Mouse	MGI:MGI:5499724\|PMID:18591664
Cellular Component	GO:0042383	sarcolemma	Atp2b4	IDA		Mouse	MGI:MGI:3848765\|PMID:19287093
Cellular Component	GO:0036126	sperm flagellum	Atp2b4	IDA		Mouse	MGI:MGI:3709130\|PMID:15078889
Cellular Component	GO:0097228	sperm principal piece	Atp2b4	IDA		Rat	PMID:18057950\|RGD:6906890
Cellular Component	GO:0030315	T-tubule	ATP2B4	IDA		Human	PMID:19287093
Cellular Component	GO:0030315	T-tubule	Atp2b4	IDA		Mouse	MGI:MGI:3848765\|PMID:19287093
Cellular Component	GO:0030018	Z disc	ATP2B4	IDA		Human	PMID:19287093
Biological Process	GO:1901660	calcium ion export	ATP2B4	IDA		Human	PMID:25798335
Biological Process	GO:1901660	calcium ion export	Atp2b4	IMP		Rat	PMID:9227424\|RGD:2317732
Biological Process	GO:0070588	calcium ion transmembrane transport	ATP2B4	IMP		Human	PMID:8530416
Biological Process	GO:0070588	calcium ion transmembrane transport	Atp2b4	IMP		Rat	PMID:21325503\|RGD:6904221
Biological Process	GO:0006816	calcium ion transport	Atp2b4	IDA		Rat	PMID:11779484\|RGD:628395
Biological Process	GO:1905145	cellular response to acetylcholine	Atp2b4	IMP		Mouse	MGI:MGI:3703409\|PMID:16956963
Biological Process	GO:0071872	cellular response to epinephrine stimulus	ATP2B4	IDA		Human	PMID:19278978
Biological Process	GO:0030317	flagellated sperm motility	Atp2b4	IMP		Mouse	MGI:MGI:3709130\|PMID:15078889
Biological Process	GO:0021766	hippocampus development	Atp2b4	IEP		Rat	PMID:16200642\|RGD:6906893
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ATP2B4	IDA		Human	PMID:19278978
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ATP2B4	IDA		Human	PMID:25798335
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Atp2b4	IMP		Mouse	MGI:MGI:3709130\|PMID:15078889
Biological Process	GO:0140199	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	ATP2B4	IDA		Human	PMID:17242280
Biological Process	GO:0016525	negative regulation of angiogenesis	ATP2B4	IDA		Human	PMID:25147342
Biological Process	GO:0016525	negative regulation of angiogenesis	Atp2b4	IMP		Mouse	MGI:MGI:6368228\|PMID:25147342
Biological Process	GO:1900082	negative regulation of arginine catabolic process	ATP2B4	IDA		Human	PMID:19278978
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ATP2B4	IDA		Human	PMID:25147342
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	Atp2b4	IMP		Mouse	MGI:MGI:6368228\|PMID:25147342
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	ATP2B4	IMP		Human	PMID:15955804
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	ATP2B4	IDA		Human	PMID:19287093
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	ATP2B4	IDA		Human	PMID:25147342
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	Atp2b4	IMP		Mouse	MGI:MGI:6368228\|PMID:25147342
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	Atp2b4	IMP		Rat	PMID:19287093\|RGD:10047333
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	ATP2B4	IMP		Human	PMID:19287093
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	Atp2b4	IMP		Mouse	MGI:MGI:3848765\|PMID:19287093
Biological Process	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	ATP2B4	IDA		Human	PMID:25147342
Biological Process	GO:1903249	negative regulation of citrulline biosynthetic process	ATP2B4	IDA		Human	PMID:19278978
Biological Process	GO:0010629	negative regulation of gene expression	ATP2B4	IDA		Human	PMID:25147342
Biological Process	GO:0010629	negative regulation of gene expression	Atp2b4	IMP		Mouse	MGI:MGI:6368228\|PMID:25147342
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ATP2B4	IDA		Human	PMID:11591728
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ATP2B4	IDA		Human	PMID:19278978
Biological Process	GO:0010751	negative regulation of nitric oxide mediated signal transduction	ATP2B4	IDA		Human	PMID:19278978
Biological Process	GO:0051001	negative regulation of nitric-oxide synthase activity	ATP2B4	IDA		Human	PMID:11591728
Biological Process	GO:0051001	negative regulation of nitric-oxide synthase activity	ATP2B4	IDA		Human	PMID:17242280
Biological Process	GO:0051001	negative regulation of nitric-oxide synthase activity	ATP2B4	IDA		Human	PMID:19278978
Biological Process	GO:0051001	negative regulation of nitric-oxide synthase activity	ATP2B4	IDA		Human	PMID:19287093
Biological Process	GO:0098736	negative regulation of the force of heart contraction	ATP2B4	IDA		Human	PMID:17242280
Biological Process	GO:0003407	neural retina development	Atp2b4	IEP		Rat	PMID:16079002\|RGD:2317729
Biological Process	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	ATP2B4	IDA		Human	PMID:19278978
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ATP2B4	IDA		Human	PMID:19278978
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ATP2B4	IDA		Human	PMID:15955804
Biological Process	GO:1902806	regulation of cell cycle G1/S phase transition	ATP2B4	IMP		Human	PMID:24448801
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ATP2B4	IMP		Human	PMID:19287093
Biological Process	GO:0051599	response to hydrostatic pressure	ATP2B4	IMP		Human	PMID:19287093
Biological Process	GO:0007283	spermatogenesis	Atp2b4	IEP		Rat	PMID:18057950\|RGD:6906890
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	Atp2b4	IMP		Mouse	MGI:MGI:3703409\|PMID:16956963

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.