Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATP6V1A
  • Mouse genes Atp6v1a
  • Rat genes Atp6v1a
  • Zfish genes atp6v1aa,atp6v1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atp6v1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ATP6V1A	IPI	UniProtKB:O76024	Human	PMID:23035048
Molecular Function	GO:0005515	protein binding	ATP6V1A	IPI	UniProtKB:P0DOF2	Human	PMID:33208464
Molecular Function	GO:0005515	protein binding	Atp6v1a	IPI	UniProtKB:Q5ZWW6	Rat	PMID:32165585|RGD:39458019
Molecular Function	GO:0015078	proton transmembrane transporter activity	atp6v1aa	IMP	ZFIN:ZDB-MRPHLNO-070627-1	Zfish	PMID:17272665
Molecular Function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	Atp6v1a	IMP		Mouse	MGI:MGI:6695676|PMID:23863464
Cellular Component	GO:0016324	apical plasma membrane	Atp6v1a	IDA		Mouse	MGI:MGI:4943380|PMID:18667600
Cellular Component	GO:1904949	ATPase complex	Atp6v1a	IDA		Mouse	PMID:28793259
Cellular Component	GO:0005737	cytoplasm	Atp6v1a	IDA		Mouse	MGI:MGI:6695676|PMID:23863464
Cellular Component	GO:0005829	cytosol	ATP6V1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Atp6v1a	IDA		Mouse	MGI:MGI:3850618|PMID:16177003
Cellular Component	GO:0070062	extracellular exosome	ATP6V1A	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ATP6V1A	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	ATP6V1A	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ATP6V1A	HDA		Human	PMID:23533145
Cellular Component	GO:0098850	extrinsic component of synaptic vesicle membrane	Atp6v1a	EXP		Rat	PMID:32165585|RGD:39458019
Cellular Component	GO:0098850	extrinsic component of synaptic vesicle membrane	Atp6v1a	IDA		Rat	PMID:32165585|RGD:39458019
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ATP6V1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005765	lysosomal membrane	ATP6V1A	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	ATP6V1A	IDA		Human	PMID:33065002
Cellular Component	GO:0005902	microvillus	Atp6v1a	IDA		Mouse	MGI:MGI:4943380|PMID:18667600
Cellular Component	GO:0005739	mitochondrion	Atp6v1a	HDA		Mouse	PMID:14651853
Cellular Component	GO:0043209	myelin sheath	Atp6v1a	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005654	nucleoplasm	ATP6V1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Atp6v1a	IDA		Mouse	MGI:MGI:3850618|PMID:16177003
Cellular Component	GO:0033176	proton-transporting V-type ATPase complex	Atp6v1a	IDA		Mouse	PMID:12527205
Cellular Component	GO:0033180	proton-transporting V-type ATPase, V1 domain	Atp6v1a	IDA		Mouse	PMID:28793259
Cellular Component	GO:0030141	secretory granule	ATP6V1A	IDA		Human	PMID:23035048
Cellular Component	GO:1902495	transmembrane transporter complex	Atp6v1a	IDA		Mouse	PMID:12527205
Cellular Component	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain	ATP6V1A	IDA		Human	PMID:33065002
Biological Process	GO:0045176	apical protein localization	atp6v1aa	IMP	ZFIN:ZDB-GENO-210929-4	Zfish	PMID:32328632
Biological Process	GO:0036295	cellular response to increased oxygen levels	ATP6V1A	IMP		Human	PMID:28296633
Biological Process	GO:0006874	intracellular calcium ion homeostasis	atp6v1aa	IMP	ZFIN:ZDB-MRPHLNO-070627-1	Zfish	PMID:17272665
Biological Process	GO:0006879	intracellular iron ion homeostasis	ATP6V1A	IMP		Human	PMID:28296633
Biological Process	GO:0006883	intracellular sodium ion homeostasis	atp6v1aa	IMP	ZFIN:ZDB-MRPHLNO-070627-1	Zfish	PMID:17272665
Biological Process	GO:1902600	proton transmembrane transport	atp6v1aa	IMP	ZFIN:ZDB-MRPHLNO-070627-1	Zfish	PMID:17272665|ZFIN:ZDB-PUB-070212-26
Biological Process	GO:1902600	proton transmembrane transport	atp6v1aa	IMP	ZFIN:ZDB-MRPHLNO-070627-1	Zfish	PMID:17272665
Biological Process	GO:0097401	synaptic vesicle lumen acidification	Atp6v1a	IDA		Mouse	PMID:28793259
Biological Process	GO:0097401	synaptic vesicle lumen acidification	Atp6v1a	EXP		Mouse	PMID:28793259
Biological Process	GO:0097401	synaptic vesicle lumen acidification	Atp6v1a	IMP		Mouse	PMID:28793259

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern