Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATRX
  • Mouse genes Atrx
  • Rat genes Atrx
  • Zfish genes atrx
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atrx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	ATRX	IDA		Human	PMID:27029610
Molecular Function	GO:0003682	chromatin binding	Atrx	IDA		Mouse	PMID:15522233
Molecular Function	GO:0070087	chromo shadow domain binding	ATRX	IPI	UniProtKB:P45973	Human	PMID:15882967
Molecular Function	GO:0015616	DNA translocase activity	ATRX	IDA		Human	PMID:12953102
Molecular Function	GO:0042393	histone binding	ATRX	IDA		Human	PMID:20211137
Molecular Function	GO:0042393	histone binding	ATRX	IDA		Human	PMID:22391447
Molecular Function	GO:0042393	histone binding	Atrx	IPI	UniProtKB:P84243	Mouse	MGI:MGI:4454526|PMID:20110566
Molecular Function	GO:0042393	histone binding	Atrx	IDA		Mouse	MGI:MGI:4881400|PMID:20211137
Molecular Function	GO:0035064	methylated histone binding	ATRX	IDA		Human	PMID:21421568
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:P45973	Human	PMID:10699177
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q9UER7	Human	PMID:12953102
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q00566	Human	PMID:17296936
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q9UER7	Human	PMID:22102817
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:O75367	Human	PMID:22391447
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q92878	Human	PMID:24651726
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q9UER7	Human	PMID:24651726
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q9UER7	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q15910	Human	PMID:25417162
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:O75367-2	Human	PMID:26373281
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q9UER7	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q13263	Human	PMID:27029610
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q15047	Human	PMID:27029610
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q96GC6	Human	PMID:27029610
Molecular Function	GO:0005515	protein binding	ATRX	IPI	UniProtKB:Q9UER7	Human	PMID:27029610
Molecular Function	GO:0005515	protein binding	Atrx	IPI	UniProtKB:Q9CU62	Mouse	MGI:MGI:4439201|PMID:20159591
Molecular Function	GO:0005515	protein binding	Atrx	IPI	UniProtKB:Q9Z2D6	Mouse	MGI:MGI:4439201|PMID:20159591
Molecular Function	GO:0005515	protein binding	Atrx	IPI	UniProtKB:Q9Z2D6	Mouse	MGI:MGI:6695677|PMID:24270455
Molecular Function	GO:0005515	protein binding	Atrx	IPI	UniProtKB:O60934|UniProtKB:P49959|UniProtKB:Q92878	Mouse	MGI:MGI:5568153|PMID:24651726
Molecular Function	GO:0005515	protein binding	Atrx	IPI	PR:Q61686	Mouse	PMID:8978696
Molecular Function	GO:0005515	protein binding	Atrx	IPI	PR:O35613	Mouse	PMID:15252119
Molecular Function	GO:0005515	protein binding	Atrx	IPI	PR:Q9Z2D6	Mouse	PMID:17296936
Molecular Function	GO:0005515	protein binding	Atrx	IPI	PR:P19091	Mouse	PMID:21427128
Molecular Function	GO:0005515	protein binding	Atrx	IPI	PR:P83917	Mouse	PMID:8978696
Molecular Function	GO:0005515	protein binding	Atrx	IPI	RGD:1605736	Rat	PMID:8667030|RGD:631943
Cellular Component	GO:0099115	chromosome, subtelomeric region	ATRX	IDA		Human	PMID:26055325
Cellular Component	GO:0000781	chromosome, telomeric region	Atrx	IDA		Mouse	MGI:MGI:5705215|PMID:23444137
Cellular Component	GO:0000781	chromosome, telomeric region	Atrx	IDA		Mouse	MGI:MGI:4454526|PMID:20110566
Cellular Component	GO:0000781	chromosome, telomeric region	Atrx	IDA		Mouse	PMID:26159997
Cellular Component	GO:0000779	condensed chromosome, centromeric region	Atrx	IDA		Mouse	PMID:15242786
Cellular Component	GO:0005737	cytoplasm	Atrx	IDA		Rat	PMID:19444003|RGD:9586025
Cellular Component	GO:0000792	heterochromatin	Atrx	IDA		Mouse	PMID:15252119
Cellular Component	GO:0000792	heterochromatin	Atrx	IDA		Mouse	PMID:14519686
Cellular Component	GO:0000792	heterochromatin	Atrx	IDA		Mouse	PMID:17296936
Cellular Component	GO:0016604	nuclear body	ATRX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000228	nuclear chromosome	Atrx	IDA		Mouse	PMID:11555636
Cellular Component	GO:0005654	nucleoplasm	ATRX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Atrx	IDA		Mouse	PMID:17296936
Cellular Component	GO:0005634	nucleus	Atrx	IDA		Rat	PMID:19444003|RGD:9586025
Cellular Component	GO:0005721	pericentric heterochromatin	Atrx	IDA		Mouse	MGI:MGI:4454526|PMID:20110566
Cellular Component	GO:0005721	pericentric heterochromatin	Atrx	IDA		Mouse	PMID:15242786
Cellular Component	GO:0005721	pericentric heterochromatin	Atrx	IDA		Mouse	PMID:26159997
Cellular Component	GO:0016605	PML body	Atrx	IDA		Mouse	MGI:MGI:5705215|PMID:23444137
Biological Process	GO:0072711	cellular response to hydroxyurea	Atrx	IMP		Mouse	MGI:MGI:5568153|PMID:24651726
Biological Process	GO:0006325	chromatin organization	ATRX	IMP		Human	PMID:22391447
Biological Process	GO:0006338	chromatin remodeling	ATRX	IDA		Human	PMID:20651253
Biological Process	GO:0006338	chromatin remodeling	ATRX	IMP		Human	PMID:27029610
Biological Process	GO:0070192	chromosome organization involved in meiotic cell cycle	Atrx	IMP		Mouse	PMID:15242786
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	Atrx	IMP		Mouse	MGI:MGI:5568153|PMID:24651726
Biological Process	GO:0030900	forebrain development	Atrx	IMP	MGI:MGI:3528480	Mouse	PMID:15668733
Biological Process	GO:0000212	meiotic spindle organization	Atrx	IMP		Mouse	PMID:15242786
Biological Process	GO:0035264	multicellular organism growth	Atrx	IMP		Mouse	PMID:24386478
Biological Process	GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	ATRX	IMP		Human	PMID:26373281
Biological Process	GO:0006334	nucleosome assembly	ATRX	IDA		Human	PMID:20651253
Biological Process	GO:0010571	positive regulation of nuclear cell cycle DNA replication	Atrx	IMP		Mouse	MGI:MGI:5568153|PMID:24651726
Biological Process	GO:0032206	positive regulation of telomere maintenance	Atrx	IMP		Mouse	MGI:MGI:4454526|PMID:20110566
Biological Process	GO:1901582	positive regulation of telomeric RNA transcription from RNA pol II promoter	ATRX	IMP		Human	PMID:26055325
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATRX	IMP		Human	PMID:22391447
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATRX	IMP		Human	PMID:26055325
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atrx	IGI	MGI:MGI:88064	Mouse	PMID:21427128
Biological Process	GO:0035128	post-embryonic forelimb morphogenesis	Atrx	IMP		Mouse	PMID:24386478
Biological Process	GO:0070198	protein localization to chromosome, telomeric region	Atrx	IMP		Mouse	MGI:MGI:4454526|PMID:20110566
Biological Process	GO:0031297	replication fork processing	Atrx	IMP		Mouse	MGI:MGI:5568153|PMID:24651726
Biological Process	GO:0072520	seminiferous tubule development	Atrx	IMP	MGI:MGI:3528480	Mouse	PMID:21427128
Biological Process	GO:0060009	Sertoli cell development	Atrx	IMP	MGI:MGI:3528480	Mouse	PMID:21427128
Biological Process	GO:0007283	spermatogenesis	Atrx	IMP	MGI:MGI:3528480	Mouse	PMID:21427128
Biological Process	GO:0031509	subtelomeric heterochromatin formation	Atrx	IMP		Mouse	MGI:MGI:4881400|PMID:20211137
Biological Process	GO:0006366	transcription by RNA polymerase II	Atrx	IGI	MGI:MGI:88064	Mouse	PMID:21427128

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern