Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATXN3
  • Mouse genes Atxn3
  • Rat genes Atxn3
  • Zfish genes atxn3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atxn3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051117	ATPase binding	ATXN3	IPI	UniProtKB:Q01853	Human	PMID:17000876
Molecular Function	GO:0051117	ATPase binding	ATXN3	IPI	UniProtKB:P55072	Human	PMID:22970133
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	Atxn3	IDA		Mouse	MGI:MGI:5318000|PMID:21855799
Molecular Function	GO:0004407	histone deacetylase activity	Atxn3	IDA		Rat	PMID:17079677|RGD:5688291
Molecular Function	GO:0042826	histone deacetylase binding	Atxn3	IPI	RGD:619977	Rat	PMID:17079677|RGD:5688291
Molecular Function	GO:1990380	K48-linked deubiquitinase activity	ATXN3	IDA		Human	PMID:22970133
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	ATXN3	IDA		Human	PMID:22970133
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P55072	Human	PMID:16525503
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P54725	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q01844	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q14CB8	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9BSU1	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9BQE4	Human	PMID:17000876
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9BUN8	Human	PMID:17000876
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P25686-2	Human	PMID:21625540
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P54725	Human	PMID:22970133
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:O60260	Human	PMID:30455355
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P54725	Human	PMID:30455355
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P54727	Human	PMID:30455355
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P55072	Human	PMID:30455355
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8IWV8	Human	PMID:30455355
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q16891	Human	PMID:31379806
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:A4FUJ8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:O15287	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:O15530-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:O43488	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:O75330-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:O75409	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:O75925	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:O94851	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:O95416	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:O95551	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P06241-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P06276	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P13051-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P16581	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P17612	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P22692	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P23142-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P29466-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P37173	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P40227	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P42336	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P42574	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P50454	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P51665	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P54725	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P55072	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:P68431	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q01844	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q01844-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q01844-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q02930-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q03405-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q13064	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q14CB8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q15007-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q15466	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q15554-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q16740	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q3B7T1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q3SYB3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q5VV42	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q66K80	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q6PCB6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q6UWD8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q6UY14-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q6ZNA4-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8IUI8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8IUW3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8IVP1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8IYF3-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8N3R9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8N5Z7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8N865	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8N895	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8NA77	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8NBT0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8NEZ2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8NFH3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8TB36	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8TBK5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8TDW5-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q8WY64	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q92995	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q93062-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q969S8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q96DC9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q96DC9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q96EP0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q96FT7-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q96G97-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q96LX7-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q96NC0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q99932-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9BSU1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9BWI9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9BXR5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9BYZ2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9H0M0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9H4I2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9H7C9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9H816	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9H8H3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9H8Y8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9HBE1-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9NP61	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9NQ40	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9NRP7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9NS23-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9NVD7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9P1A6-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9UDY8-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9UHY8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9UMX0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9UPM6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9Y2M5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9Y458	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9Y483-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9Y4R8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATXN3	IPI	UniProtKB:Q9Y575-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Atxn3	IPI	PR:Q01853	Mouse	PMID:16525503
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Atxn3	IDA		Rat	PMID:17079677|RGD:5688291
Molecular Function	GO:0001222	transcription corepressor binding	Atxn3	IPI	RGD:3612	Rat	PMID:17079677|RGD:5688291
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ATXN3	IPI	UniProtKB:O60260	Human	PMID:24063750
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ATXN3	IPI	UniProtKB:Q86TM6	Human	PMID:24068323
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Atxn3	IPI	UniProtKB:Q9WUD1	Mouse	MGI:MGI:5318000|PMID:21855799
Cellular Component	GO:0005737	cytoplasm	Atxn3	IDA		Mouse	PMID:18353661
Cellular Component	GO:0005737	cytoplasm	Atxn3	IDA		Mouse	PMID:19843543
Cellular Component	GO:0005737	cytoplasm	Atxn3	IDA		Mouse	PMID:17626202
Cellular Component	GO:0005737	cytoplasm	Atxn3	IDA		Mouse	PMID:20347968
Cellular Component	GO:0005829	cytosol	ATXN3	IDA		Human	PMID:24548080
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ATXN3	IDA		Human	PMID:17000876
Cellular Component	GO:0005759	mitochondrial matrix	Atxn3	IDA		Mouse	PMID:18353661
Cellular Component	GO:0031966	mitochondrial membrane	Atxn3	IDA		Mouse	PMID:18353661
Cellular Component	GO:0042405	nuclear inclusion body	Atxn3	IDA		Mouse	PMID:17626202
Cellular Component	GO:0005730	nucleolus	ATXN3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ATXN3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ATXN3	IDA		Human	PMID:24548080
Cellular Component	GO:0005634	nucleus	Atxn3	IDA		Mouse	PMID:18353661
Cellular Component	GO:0005634	nucleus	Atxn3	IDA		Mouse	PMID:20347968
Cellular Component	GO:0005634	nucleus	Atxn3	IDA		Mouse	PMID:19843543
Cellular Component	GO:0005634	nucleus	Atxn3	IDA		Rat	PMID:17079677|RGD:5688291
Cellular Component	GO:0005886	plasma membrane	ATXN3	IDA		Human	GO_REF:0000052
Biological Process	GO:0030036	actin cytoskeleton organization	ATXN3	IMP		Human	PMID:20637808
Biological Process	GO:0034605	cellular response to heat	Atxn3	IMP		Mouse	PMID:19843543
Biological Process	GO:0071218	cellular response to misfolded protein	Atxn3	IMP		Mouse	MGI:MGI:5318000|PMID:21855799
Biological Process	GO:0035640	exploration behavior	Atxn3	IMP	MGI:MGI:3833681	Mouse	PMID:17764659
Biological Process	GO:0016570	histone modification	Atxn3	IDA		Rat	PMID:17079677|RGD:5688291
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	ATXN3	IMP		Human	PMID:20637808
Biological Process	GO:0000226	microtubule cytoskeleton organization	ATXN3	IMP		Human	PMID:20637808
Biological Process	GO:0035520	monoubiquitinated protein deubiquitination	Atxn3	IDA		Mouse	MGI:MGI:5318000|PMID:21855799
Biological Process	GO:0042461	photoreceptor cell development	atxn3	IMP	ZFIN:ZDB-MRPHLNO-210708-1	Zfish	PMID:33176149
Biological Process	GO:1904294	positive regulation of ERAD pathway	ATXN3	IMP		Human	PMID:17000876
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Atxn3	IMP		Mouse	MGI:MGI:5318000|PMID:21855799
Biological Process	GO:0016579	protein deubiquitination	ATXN3	IMP		Human	PMID:17000876
Biological Process	GO:0071108	protein K48-linked deubiquitination	ATXN3	IDA		Human	PMID:22970133
Biological Process	GO:0070536	protein K63-linked deubiquitination	ATXN3	IDA		Human	PMID:22970133
Biological Process	GO:1904379	protein localization to cytosolic proteasome complex involved in ERAD pathway	ATXN3	IMP		Human	PMID:17000876
Biological Process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	Atxn3	IMP		Mouse	MGI:MGI:5318000|PMID:21855799
Biological Process	GO:0010810	regulation of cell-substrate adhesion	ATXN3	IMP		Human	PMID:20637808
Biological Process	GO:0010810	regulation of cell-substrate adhesion	Atxn3	IMP		Mouse	PMID:20637808
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Atxn3	IMP	MGI:MGI:3833681	Mouse	PMID:17764659

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern