Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AURKB
  • Mouse genes Aurkb
  • Rat genes Aurkb
  • Zfish genes aurkb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aurkb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0044022	histone H3S28 kinase activity	Aurkb	IDA		Mouse	MGI:MGI:5527017|PMID:24034696
Molecular Function	GO:0019900	kinase binding	AURKB	IPI	UniProtKB:P53350	Human	PMID:23036704
Molecular Function	GO:0140678	molecular function inhibitor activity	AURKB	IDA		Human	PMID:30409912
Molecular Function	GO:0140678	molecular function inhibitor activity	AURKB	IDA		Human	PMID:33542149
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9H0H5	Human	PMID:12689593
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O75410-6	Human	PMID:15064709
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q8WYJ6	Human	PMID:16179162
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7	Human	PMID:16239925
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O15392	Human	PMID:16291752
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O15392-1	Human	PMID:16291752
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O15392-2	Human	PMID:16291752
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O15392	Human	PMID:17099693
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O15392	Human	PMID:17681274
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q8IXJ6	Human	PMID:17726514
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q53HL2	Human	PMID:17956729
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7	Human	PMID:17956729
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q53HL2	Human	PMID:18243099
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q15691	Human	PMID:18477699
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O15392	Human	PMID:19357306
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7	Human	PMID:19357306
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7-1	Human	PMID:19357306
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7	Human	PMID:20562864
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q53HL2	Human	PMID:20739936
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7	Human	PMID:20739936
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:P04637	Human	PMID:20959462
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9Y3T9	Human	PMID:20959462
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O15392	Human	PMID:21051298
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q53HL2	Human	PMID:21051298
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7	Human	PMID:21051298
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7	Human	PMID:21346195
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q8WYJ6	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O43663	Human	PMID:23036704
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q96AY4	Human	PMID:23036704
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O15392	Human	PMID:24571573
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q86XJ1	Human	PMID:24571573
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:P06748	Human	PMID:24857377
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q16543	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:P30153	Human	PMID:26829474
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q92993	Human	PMID:26829474
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O15392	Human	PMID:27332895
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7	Human	PMID:27332895
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:P08238	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q16695	Human	PMID:29340707
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q99986	Human	PMID:29340707
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:O15392	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:P08238	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q16543	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q53HL2	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:P30153	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q16543	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	AURKB	IPI	UniProtKB:Q9NQS7	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Aurkb	IPI	UniProtKB:P61079|UniProtKB:Q99LG0	Mouse	MGI:MGI:5527017|PMID:24034696
Molecular Function	GO:0004672	protein kinase activity	Aurkb	IMP		Rat	PMID:9450992|RGD:730040
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AURKB	EXP		Human	PMID:21397845
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AURKB	IDA		Human	PMID:22724069
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AURKB	IDA		Human	PMID:28751710
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AURKB	IDA		Human	PMID:30409912
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AURKB	IDA		Human	PMID:33542149
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Aurkb	IDA		Mouse	MGI:MGI:6280798|PMID:29518391
Cellular Component	GO:0010369	chromocenter	Aurkb	IDA		Mouse	PMID:19283064
Cellular Component	GO:0005694	chromosome	Aurkb	IDA		Mouse	PMID:26919979
Cellular Component	GO:0032133	chromosome passenger complex	AURKB	IPI		Human	PMID:17956729
Cellular Component	GO:0032133	chromosome passenger complex	AURKB	IPI	UniProtKB:Q53HL2	Human	PMID:15260989
Cellular Component	GO:0032133	chromosome passenger complex	AURKB	IPI	UniProtKB:O15392	Human	PMID:18591255
Cellular Component	GO:0032133	chromosome passenger complex	Aurkb	IDA		Mouse	PMID:20562830
Cellular Component	GO:0000775	chromosome, centromeric region	Aurkb	IDA		Mouse	PMID:26919979
Cellular Component	GO:0000779	condensed chromosome, centromeric region	AURKB	IDA		Human	PMID:18195732
Cellular Component	GO:0000779	condensed chromosome, centromeric region	AURKB	IDA		Human	PMID:19465021
Cellular Component	GO:0000779	condensed chromosome, centromeric region	Aurkb	IDA		Mouse	PMID:14751927
Cellular Component	GO:0000776	kinetochore	AURKB	IDA		Human	PMID:26829474
Cellular Component	GO:0000776	kinetochore	AURKB	IDA		Human	PMID:22024163
Cellular Component	GO:0015630	microtubule cytoskeleton	AURKB	IDA		Human	PMID:9859993
Cellular Component	GO:0030496	midbody	AURKB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030496	midbody	AURKB	IDA		Human	PMID:17726514
Cellular Component	GO:0030496	midbody	Aurkb	IDA		Mouse	PMID:9514916
Cellular Component	GO:0030496	midbody	Aurkb	IDA		Rat	PMID:9450992|RGD:730040
Cellular Component	GO:1990023	mitotic spindle midzone	Aurkb	IDA		Mouse	PMID:14751927
Cellular Component	GO:0097431	mitotic spindle pole	Aurkb	IDA		Mouse	PMID:26919979
Cellular Component	GO:0005654	nucleoplasm	AURKB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	AURKB	IDA		Human	PMID:20959462
Cellular Component	GO:0005634	nucleus	Aurkb	IDA		Mouse	PMID:14751927
Cellular Component	GO:0005819	spindle	Aurkb	IDA		Rat	PMID:9450992|RGD:730040
Biological Process	GO:0007568	aging	Aurkb	IEP		Rat	PMID:19204916|RGD:2315123
Biological Process	GO:0044839	cell cycle G2/M phase transition	AURKB	IDA		Human	PMID:33542149
Biological Process	GO:0008283	cell population proliferation	Aurkb	IEP		Rat	PMID:17914147|RGD:2317922
Biological Process	GO:0034644	cellular response to UV	AURKB	IDA		Human	PMID:20959462
Biological Process	GO:0007059	chromosome segregation	aurkb	IMP	ZFIN:ZDB-GENO-090720-1	Zfish	PMID:19543364
Biological Process	GO:0036089	cleavage furrow formation	AURKB	IDA		Human	PMID:16103226
Biological Process	GO:0036089	cleavage furrow formation	Aurkb	IMP		Rat	PMID:9450992|RGD:730040
Biological Process	GO:0036089	cleavage furrow formation	aurkb	IMP	ZFIN:ZDB-GENO-090720-1	Zfish	PMID:19543364
Biological Process	GO:0000226	microtubule cytoskeleton organization	aurkb	IMP	ZFIN:ZDB-GENO-090720-1	Zfish	PMID:19543364
Biological Process	GO:0000281	mitotic cytokinesis	aurkb	IMP	ZFIN:ZDB-GENO-090720-1	Zfish	PMID:19543364
Biological Process	GO:0051256	mitotic spindle midzone assembly	AURKB	IMP		Human	PMID:16103226
Biological Process	GO:0002903	negative regulation of B cell apoptotic process	AURKB	IDA		Human	PMID:20959462
Biological Process	GO:0045824	negative regulation of innate immune response	AURKB	IDA		Human	PMID:33542149
Biological Process	GO:0032091	negative regulation of protein binding	AURKB	IDA		Human	PMID:21820309
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	AURKB	IDA		Human	PMID:20959462
Biological Process	GO:0032467	positive regulation of cytokinesis	AURKB	IMP		Human	PMID:16103226
Biological Process	GO:1905116	positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	AURKB	IDA		Human	PMID:28751710
Biological Process	GO:0062033	positive regulation of mitotic sister chromatid segregation	AURKB	IDA		Human	PMID:26829474
Biological Process	GO:0062033	positive regulation of mitotic sister chromatid segregation	AURKB	IDA		Human	PMID:30409912
Biological Process	GO:0051973	positive regulation of telomerase activity	AURKB	IMP		Human	PMID:21531765
Biological Process	GO:1904355	positive regulation of telomere capping	AURKB	IMP		Human	PMID:21531765
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	AURKB	IMP		Human	PMID:21531765
Biological Process	GO:0043687	post-translational protein modification	Aurkb	IDA		Mouse	MGI:MGI:5527017|PMID:24034696
Biological Process	GO:0034501	protein localization to kinetochore	AURKB	IMP		Human	PMID:19468067
Biological Process	GO:0006468	protein phosphorylation	AURKB	IDA		Human	PMID:21820309
Biological Process	GO:0006468	protein phosphorylation	AURKB	IDA		Human	PMID:22724069
Biological Process	GO:0007051	spindle organization	AURKB	IMP		Human	PMID:21820309

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern