Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AXIN2
  • Mouse genes Axin2
  • Rat genes Axin2
  • Zfish genes axin2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Axin2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	Axin2	IDA		Rat	PMID:9566905|RGD:68736
Molecular Function	GO:0019899	enzyme binding	AXIN2	IPI	UniProtKB:O95271	Human	PMID:19759537
Molecular Function	GO:0019899	enzyme binding	AXIN2	IPI	UniProtKB:Q9H2K2	Human	PMID:19759537
Molecular Function	GO:0019899	enzyme binding	AXIN2	IPI	UniProtKB:Q70CQ2	Human	PMID:21383061
Molecular Function	GO:0019899	enzyme binding	AXIN2	IPI	UniProtKB:O95271	Human	PMID:21478859
Molecular Function	GO:0019899	enzyme binding	AXIN2	IPI	UniProtKB:Q9H2K2	Human	PMID:21478859
Molecular Function	GO:0070411	I-SMAD binding	Axin2	IPI	PR:O35253	Mouse	PMID:16601693
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:P62714	Human	PMID:10698523
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:P53350	Human	PMID:16815967
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:P35222	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:P35222	Human	PMID:22056988
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q8N944	Human	PMID:24251807
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q15583	Human	PMID:25873176
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:A2BDD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:O75558	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:O75638-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:O95985	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:P09067	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:P40222	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:P49721	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:P60014	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q13895	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q14241	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q15172	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q15560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q15973	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q2NKX9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q2TBE0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q3B820	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q5T619	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q8N3L3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q8N8B7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q8NEF3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q8TAU3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q96EZ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q96SQ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q99728	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q9BVG8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q9BWG6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q9BXS5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q9BYQ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q9BYR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q9BZW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q9UKJ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q9Y297	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AXIN2	IPI	UniProtKB:Q9Y6W3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Axin2	IPI	UniProtKB:Q12834	Mouse	MGI:MGI:5508712|PMID:22322943
Molecular Function	GO:0005515	protein binding	Axin2	IPI	UniProtKB:Q8N944	Mouse	MGI:MGI:5544119|PMID:24251807
Molecular Function	GO:0005515	protein binding	Axin2	IPI	UniProtKB:Q9BV73	Mouse	MGI:MGI:4835108|PMID:20300119
Molecular Function	GO:0005515	protein binding	Axin2	IPI	UniProtKB:Q15583	Mouse	MGI:MGI:5634198|PMID:25873176
Molecular Function	GO:0005515	protein binding	Axin2	IPI	PR:Q61315	Mouse	PMID:9554852
Molecular Function	GO:0005515	protein binding	Axin2	IPI	PR:Q9WV60	Mouse	PMID:9554852
Molecular Function	GO:0005515	protein binding	Axin2	IPI	PR:Q02248	Mouse	PMID:9554852
Molecular Function	GO:0005515	protein binding	axin2	IPI	UniProtKB:E9QDC5	Zfish	PMID:30467143|ZFIN:ZDB-PUB-181127-52
Molecular Function	GO:0019901	protein kinase binding	Axin2	IPI	RGD:70982	Rat	PMID:9566905|RGD:68736
Molecular Function	GO:0031625	ubiquitin protein ligase binding	AXIN2	IPI	UniProtKB:Q9NTX7	Human	PMID:21478859
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Axin2	IPI	PR:Q99ML9	Mouse	PMID:16601693
Cellular Component	GO:0005813	centrosome	AXIN2	IDA		Human	PMID:20300119
Cellular Component	GO:0005813	centrosome	Axin2	IDA		Mouse	MGI:MGI:4835108|PMID:20300119
Cellular Component	GO:0005737	cytoplasm	AXIN2	IDA		Human	PMID:21383061
Cellular Component	GO:0005737	cytoplasm	Axin2	IDA		Rat	PMID:22152883|RGD:151356751
Cellular Component	GO:0005634	nucleus	AXIN2	IDA		Human	PMID:12072559
Cellular Component	GO:0005634	nucleus	AXIN2	IDA		Human	PMID:21383061
Cellular Component	GO:0005634	nucleus	Axin2	IDA		Mouse	PMID:21991325
Cellular Component	GO:0005634	nucleus	Axin2	IDA		Rat	PMID:22152883|RGD:151356751
Cellular Component	GO:0032991	protein-containing complex	Axin2	IDA		Rat	PMID:9566905|RGD:68736
Biological Process	GO:0003180	aortic valve morphogenesis	Axin2	IMP		Mouse	MGI:MGI:6108194|PMID:28069701
Biological Process	GO:0030282	bone mineralization	Axin2	IMP	MGI:MGI:3579503	Mouse	PMID:19623616
Biological Process	GO:0008219	cell death	Axin2	IDA		Rat	PMID:15572025|RGD:1599426
Biological Process	GO:0008283	cell population proliferation	Axin2	IMP	MGI:MGI:3579503	Mouse	PMID:15790973
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Axin2	IEP		Rat	PMID:23996200|RGD:151356748
Biological Process	GO:0071407	cellular response to organic cyclic compound	Axin2	IEP		Rat	PMID:19464575|RGD:4107035
Biological Process	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	Axin2	IMP	MGI:MGI:3579503	Mouse	PMID:19623616
Biological Process	GO:0009950	dorsal/ventral axis specification	axin2	IGI	ZFIN:ZDB-GENE-000403-2,ZFIN:ZDB-GENO-181017-1	Zfish	PMID:25335865
Biological Process	GO:0009953	dorsal/ventral pattern formation	axin2	IDA		Zfish	PMID:10704853
Biological Process	GO:0007507	heart development	axin2	IMP	ZFIN:ZDB-MRPHLNO-190924-1	Zfish	PMID:30760879
Biological Process	GO:0001957	intramembranous ossification	Axin2	IMP	MGI:MGI:3579503	Mouse	PMID:15790973
Biological Process	GO:0043570	maintenance of DNA repeat elements	AXIN2	IMP		Human	PMID:18755497
Biological Process	GO:0003183	mitral valve morphogenesis	Axin2	IMP		Mouse	MGI:MGI:6108194|PMID:28069701
Biological Process	GO:0048255	mRNA stabilization	AXIN2	IMP		Human	PMID:17072303
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	AXIN2	IMP		Human	PMID:11017067
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	AXIN2	IDA		Human	PMID:11940574
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	AXIN2	IMP		Human	PMID:16247484
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Axin2	IMP		Mouse	MGI:MGI:6108194|PMID:28069701
Biological Process	GO:0008285	negative regulation of cell population proliferation	AXIN2	IMP		Human	PMID:16247484
Biological Process	GO:0008285	negative regulation of cell population proliferation	Axin2	IDA		Rat	PMID:15572025|RGD:1599426
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Axin2	IMP	MGI:MGI:3579503	Mouse	PMID:15790973
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	Axin2	IMP	MGI:MGI:3579503	Mouse	PMID:15790973
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	Axin2	IDA		Rat	PMID:9566905|RGD:68736
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	axin2	IDA		Zfish	PMID:30467143|ZFIN:ZDB-PUB-181127-52
Biological Process	GO:0042476	odontogenesis	AXIN2	IMP		Human	PMID:15042511
Biological Process	GO:0042476	odontogenesis	AXIN2	IMP		Human	PMID:16432638
Biological Process	GO:0001649	osteoblast differentiation	Axin2	IMP	MGI:MGI:3579503	Mouse	PMID:15790973
Biological Process	GO:0033687	osteoblast proliferation	Axin2	IMP	MGI:MGI:3579503	Mouse	PMID:15790973
Biological Process	GO:0010942	positive regulation of cell death	AXIN2	IMP		Human	PMID:16247484
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	AXIN2	IMP		Human	PMID:17072303
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Axin2	IMP		Rat	PMID:23996200|RGD:151356748
Biological Process	GO:0045860	positive regulation of protein kinase activity	Axin2	IDA		Rat	PMID:9566905|RGD:68736
Biological Process	GO:0001934	positive regulation of protein phosphorylation	AXIN2	IMP		Human	PMID:20300119
Biological Process	GO:0008104	protein localization	AXIN2	IDA		Human	PMID:17072303
Biological Process	GO:0070602	regulation of centromeric sister chromatid cohesion	AXIN2	IMP		Human	PMID:20300119
Biological Process	GO:0070602	regulation of centromeric sister chromatid cohesion	Axin2	IMP		Mouse	MGI:MGI:4835108|PMID:20300119
Biological Process	GO:0061181	regulation of chondrocyte development	Axin2	IMP	MGI:MGI:3579503	Mouse	PMID:19623616
Biological Process	GO:1903053	regulation of extracellular matrix organization	Axin2	IMP		Mouse	MGI:MGI:6108194|PMID:28069701
Biological Process	GO:0032423	regulation of mismatch repair	AXIN2	IMP		Human	PMID:11017067
Biological Process	GO:0030111	regulation of Wnt signaling pathway	Axin2	IDA		Mouse	PMID:9554852
Biological Process	GO:0048545	response to steroid hormone	Axin2	IEP		Rat	PMID:22152883|RGD:151356751
Biological Process	GO:0003139	secondary heart field specification	Axin2	IGI	MGI:MGI:96522	Mouse	PMID:22711842
Biological Process	GO:0001756	somitogenesis	Axin2	IDA		Mouse	PMID:12636920
Biological Process	GO:0072089	stem cell proliferation	Axin2	IMP	MGI:MGI:3579503	Mouse	PMID:20569694

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern