Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AXL
  • Mouse genes Axl
  • Rat genes Axl
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Axl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032036	myosin heavy chain binding	Axl	IPI	RGD:71000	Rat	PMID:20479336|RGD:2325835
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Axl	IPI	RGD:3329	Rat	PMID:18292389|RGD:4108493
Molecular Function	GO:0001786	phosphatidylserine binding	AXL	IDA		Human	PMID:21501828
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:Q14393-1	Human	PMID:16362042
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:Q14393	Human	PMID:18760998
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:Q14393	Human	PMID:20088931
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:P00533	Human	PMID:25873175
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:P0DTC2	Human	PMID:33420426
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:P27986	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:P29317	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:P62993	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:Q14393	Human	PMID:7854420
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:P27986	Human	PMID:9178760
Molecular Function	GO:0005515	protein binding	AXL	IPI	UniProtKB:P62993	Human	PMID:9178760
Molecular Function	GO:0005515	protein binding	Axl	IPI	PR:P55144	Mouse	PMID:18787040
Molecular Function	GO:0004713	protein tyrosine kinase activity	AXL	EXP		Human	PMID:22327215
Molecular Function	GO:0001618	virus receptor activity	AXL	IDA		Human	PMID:22156524
Cellular Component	GO:0015629	actin cytoskeleton	AXL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009986	cell surface	AXL	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	AXL	IDA		Human	PMID:19657094
Cellular Component	GO:0009986	cell surface	AXL	IDA		Human	PMID:21529875
Cellular Component	GO:0070062	extracellular exosome	AXL	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	AXL	IDA		Human	PMID:20088931
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	AXL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	AXL	IDA		Human	GO_REF:0000052
Biological Process	GO:0031100	animal organ regeneration	Axl	IEP		Rat	PMID:16285961|RGD:1579881
Biological Process	GO:0043277	apoptotic cell clearance	Axl	IGI	MGI:MGI:96965	Mouse	PMID:23878224
Biological Process	GO:0043277	apoptotic cell clearance	Axl	IGI	MGI:MGI:104294	Mouse	PMID:18159085
Biological Process	GO:0043277	apoptotic cell clearance	Axl	IGI	MGI:MGI:96965	Mouse	PMID:18159085
Biological Process	GO:0043277	apoptotic cell clearance	Axl	IGI	MGI:MGI:104294	Mouse	PMID:17442946
Biological Process	GO:0043277	apoptotic cell clearance	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:18804096
Biological Process	GO:0006915	apoptotic process	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:16627783
Biological Process	GO:0001974	blood vessel remodeling	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:16627783
Biological Process	GO:0030154	cell differentiation	Axl	IMP		Rat	PMID:20479336|RGD:2325835
Biological Process	GO:0048469	cell maturation	AXL	IEP		Human	PMID:19657094
Biological Process	GO:0031668	cellular response to extracellular stimulus	Axl	IDA		Mouse	PMID:10322635
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Axl	IDA		Rat	PMID:20479336|RGD:2325835
Biological Process	GO:0035457	cellular response to interferon-alpha	AXL	IDA		Human	PMID:19657094
Biological Process	GO:0071222	cellular response to lipopolysaccharide	AXL	IDA		Human	PMID:19657094
Biological Process	GO:0097028	dendritic cell differentiation	AXL	IEP		Human	PMID:19657094
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	Axl	IGI	MGI:MGI:95660	Mouse	PMID:9395235
Biological Process	GO:0034101	erythrocyte homeostasis	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:18188450
Biological Process	GO:0034101	erythrocyte homeostasis	Axl	IGI	MGI:MGI:95660	Mouse	PMID:18188450
Biological Process	GO:0051649	establishment of localization in cell	Axl	IGI	MGI:MGI:96965	Mouse	PMID:19602523
Biological Process	GO:0051649	establishment of localization in cell	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:15650770
Biological Process	GO:0051649	establishment of localization in cell	Axl	IGI	MGI:MGI:104294	Mouse	PMID:19602523
Biological Process	GO:0021885	forebrain cell migration	Axl	IGI	MGI:MGI:104294	Mouse	PMID:18787040
Biological Process	GO:0006954	inflammatory response	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:16627783
Biological Process	GO:0046649	lymphocyte activation	Axl	IGI	MGI:MGI:104294	Mouse	PMID:11452127
Biological Process	GO:0046649	lymphocyte activation	Axl	IGI	MGI:MGI:96965	Mouse	PMID:11452127
Biological Process	GO:0010934	macrophage cytokine production	Axl	IGI	MGI:MGI:107670	Mouse	PMID:16831897
Biological Process	GO:0001779	natural killer cell differentiation	Axl	IGI	MGI:MGI:104294	Mouse	PMID:16751775
Biological Process	GO:0001779	natural killer cell differentiation	Axl	IGI	MGI:MGI:96965	Mouse	PMID:16751775
Biological Process	GO:0043066	negative regulation of apoptotic process	Axl	IMP		Mouse	MGI:MGI:5315346|PMID:16723520
Biological Process	GO:0043066	negative regulation of apoptotic process	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:16627783
Biological Process	GO:0043066	negative regulation of apoptotic process	Axl	IGI	MGI:MGI:95660	Mouse	PMID:9395235
Biological Process	GO:0043066	negative regulation of apoptotic process	Axl	IMP		Rat	PMID:15380678|RGD:2325841
Biological Process	GO:0001818	negative regulation of cytokine production	Axl	IGI	MGI:MGI:96965	Mouse	PMID:23878224
Biological Process	GO:2000669	negative regulation of dendritic cell apoptotic process	AXL	IDA		Human	PMID:19657094
Biological Process	GO:0051250	negative regulation of lymphocyte activation	Axl	IGI	MGI:MGI:96965	Mouse	PMID:11452127
Biological Process	GO:0051250	negative regulation of lymphocyte activation	Axl	IGI	MGI:MGI:104294	Mouse	PMID:11452127
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	Axl	IGI	MGI:MGI:107670	Mouse	PMID:16831897
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Axl	IMP		Mouse	PMID:18787040
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Axl	IGI	MGI:MGI:104294	Mouse	PMID:18787040
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Axl	IGI	MGI:MGI:107670	Mouse	PMID:16831897
Biological Process	GO:0032689	negative regulation of type II interferon production	AXL	IDA		Human	PMID:18840707
Biological Process	GO:0051402	neuron apoptotic process	Axl	IGI	MGI:MGI:104294	Mouse	PMID:18787040
Biological Process	GO:0001764	neuron migration	Axl	IMP		Mouse	PMID:19463168
Biological Process	GO:0001764	neuron migration	Axl	IGI	MGI:MGI:95660	Mouse	PMID:18787040
Biological Process	GO:0001764	neuron migration	Axl	IGI	MGI:MGI:104294	Mouse	PMID:18787040
Biological Process	GO:0097350	neutrophil clearance	Axl	IGI	MGI:MGI:96965	Mouse	PMID:23878224
Biological Process	GO:0042698	ovulation cycle	Axl	IGI	MGI:MGI:104294	Mouse	PMID:18787040
Biological Process	GO:0006909	phagocytosis	AXL	IDA		Human	PMID:21501828
Biological Process	GO:0006909	phagocytosis	Axl	IGI	MGI:MGI:104294	Mouse	PMID:19602523
Biological Process	GO:0006909	phagocytosis	Axl	IGI	MGI:MGI:96965	Mouse	PMID:19602523
Biological Process	GO:0030168	platelet activation	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:15650770
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	AXL	IDA		Human	PMID:18840707
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	AXL	IDA		Human	PMID:18840707
Biological Process	GO:0048549	positive regulation of pinocytosis	AXL	IMP		Human	PMID:21047970
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Axl	IMP		Mouse	MGI:MGI:5315346|PMID:16723520
Biological Process	GO:1903902	positive regulation of viral life cycle	AXL	IMP		Human	PMID:22673088
Biological Process	GO:0043491	protein kinase B signaling	Axl	IGI	MGI:MGI:95660	Mouse	PMID:15650770
Biological Process	GO:0043491	protein kinase B signaling	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:16627783
Biological Process	GO:0048678	response to axon injury	Axl	IEP		Rat	PMID:20187850|RGD:151665810
Biological Process	GO:0032940	secretion by cell	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:15650770
Biological Process	GO:0007283	spermatogenesis	Axl	IGI	MGI:MGI:96965	Mouse	PMID:19602523
Biological Process	GO:0007283	spermatogenesis	Axl	IGI	MGI:MGI:104294	Mouse	PMID:10227296
Biological Process	GO:0007283	spermatogenesis	Axl	IGI	MGI:MGI:104294	Mouse	PMID:19602523
Biological Process	GO:0007283	spermatogenesis	Axl	IGI	MGI:MGI:96965	Mouse	PMID:10227296
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	Axl	IMP	MGI:MGI:2387750	Mouse	PMID:15650770
Biological Process	GO:0032640	tumor necrosis factor production	Axl	IGI	MGI:MGI:107670	Mouse	PMID:16831897
Biological Process	GO:0060068	vagina development	Axl	IGI	MGI:MGI:104294	Mouse	PMID:18393392
Biological Process	GO:0060068	vagina development	Axl	IGI	MGI:MGI:96965	Mouse	PMID:18393392
Biological Process	GO:0046718	viral entry into host cell	AXL	IMP		Human	PMID:21047970

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern