Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BACE1
  • Mouse genes Bace1
  • Rat genes Bace1
  • Zfish genes bace1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bace1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	BACE1	IPI	UniProtKB:P05067	Human	PMID:16407538
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	BACE1	IDA		Human	PMID:10531052
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	Bace1	IMP		Mouse	MGI:MGI:6316502|PMID:29325091
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	Bace1	IDA		Mouse	PMID:25592972
Molecular Function	GO:0004175	endopeptidase activity	BACE1	IDA		Human	PMID:10677483
Molecular Function	GO:0004175	endopeptidase activity	Bace1	IMP	MGI:MGI:2389228	Mouse	PMID:17099708
Molecular Function	GO:0004175	endopeptidase activity	Bace1	IDA		Mouse	PMID:15123597
Molecular Function	GO:0019899	enzyme binding	BACE1	IPI	UniProtKB:O15162	Human	PMID:12586838
Molecular Function	GO:0008233	peptidase activity	BACE1	IDA		Human	PMID:8562317
Molecular Function	GO:0008233	peptidase activity	Bace1	IDA		Rat	PMID:10531052|RGD:69771
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:P05067	Human	PMID:10677483
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:P05067	Human	PMID:12901838
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:P49768	Human	PMID:12901838
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:O75298	Human	PMID:15286784
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:O95197	Human	PMID:15286784
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q16799	Human	PMID:15286784
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9NQC3	Human	PMID:15286784
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9UJY5	Human	PMID:15466887
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9UJY5	Human	PMID:15886016
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q92673	Human	PMID:16407538
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:P04925	Human	PMID:17573534
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9UHE5	Human	PMID:19011241
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9UHF3	Human	PMID:19011241
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9UNH7	Human	PMID:20354142
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9UMY4	Human	PMID:22709416
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:P05067	Human	PMID:22801501
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9Y287	Human	PMID:23701002
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:O75955	Human	PMID:24612608
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9Z1E1	Human	PMID:24612608
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9Z2S9	Human	PMID:24612608
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q8BNX1	Human	PMID:25957769
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9NZ52	Human	PMID:26053850
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9UJY4	Human	PMID:26053850
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q9UJY5	Human	PMID:26053850
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:P10997	Human	PMID:26840340
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:O00499	Human	PMID:27179792
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:Q03721	Human	PMID:29507146
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:O14672	Human	PMID:30538620
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:P05067	Human	PMID:30538620
Molecular Function	GO:0005515	protein binding	BACE1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Bace1	IPI	UniProtKB:Q6DR98,UniProtKB:Q8BHG1	Mouse	MGI:MGI:4414693|PMID:19935654
Molecular Function	GO:0005515	protein binding	Bace1	IPI	UniProtKB:O35598	Mouse	MGI:MGI:6316502|PMID:29325091
Molecular Function	GO:0005515	protein binding	Bace1	IPI	UniProtKB:O95415	Mouse	PMID:15606899
Cellular Component	GO:0030424	axon	Bace1	IDA		Mouse	PMID:11740561
Cellular Component	GO:0030424	axon	Bace1	IDA		Rat	PMID:26552445|RGD:11353216
Cellular Component	GO:0009986	cell surface	BACE1	IDA		Human	PMID:15886016
Cellular Component	GO:0009986	cell surface	BACE1	IDA		Human	PMID:23109336
Cellular Component	GO:0009986	cell surface	Bace1	IDA		Mouse	PMID:26467158
Cellular Component	GO:0031410	cytoplasmic vesicle	Bace1	IDA		Mouse	PMID:11740561
Cellular Component	GO:0030425	dendrite	Bace1	IDA		Rat	PMID:26552445|RGD:11353216
Cellular Component	GO:0005769	early endosome	BACE1	IDA		Human	PMID:15886016
Cellular Component	GO:0005769	early endosome	BACE1	IDA		Human	PMID:23109336
Cellular Component	GO:0005769	early endosome	BACE1	IDA		Human	PMID:24305806
Cellular Component	GO:0005769	early endosome	BACE1	IDA		Human	PMID:27084579
Cellular Component	GO:0005769	early endosome	BACE1	IDA		Human	PMID:27302062
Cellular Component	GO:0005769	early endosome	Bace1	IDA		Mouse	PMID:25592972
Cellular Component	GO:0005768	endosome	BACE1	IDA		Human	PMID:10531052
Cellular Component	GO:0005768	endosome	Bace1	IDA		Mouse	MGI:MGI:5780539|PMID:19074428
Cellular Component	GO:0005768	endosome	Bace1	IDA		Rat	PMID:10531052|RGD:69771
Cellular Component	GO:0005794	Golgi apparatus	BACE1	IDA		Human	PMID:10531052
Cellular Component	GO:0005794	Golgi apparatus	BACE1	IDA		Human	PMID:11466313
Cellular Component	GO:0005794	Golgi apparatus	BACE1	IDA		Human	PMID:12586838
Cellular Component	GO:0005794	Golgi apparatus	Bace1	IDA		Rat	PMID:10531052|RGD:69771
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Bace1	IDA		Mouse	PMID:18753368
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Bace1	IMP		Mouse	PMID:18753368
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Bace1	IDA		Mouse	PMID:23820808
Cellular Component	GO:0005770	late endosome	BACE1	IDA		Human	PMID:16033761
Cellular Component	GO:0005770	late endosome	BACE1	IDA		Human	PMID:23109336
Cellular Component	GO:0005770	late endosome	BACE1	IDA		Human	PMID:24612608
Cellular Component	GO:0005770	late endosome	BACE1	IDA		Human	PMID:27084579
Cellular Component	GO:0005770	late endosome	BACE1	IDA		Human	PMID:27302062
Cellular Component	GO:0005764	lysosome	BACE1	IDA		Human	PMID:16033761
Cellular Component	GO:0005764	lysosome	BACE1	IDA		Human	PMID:23109336
Cellular Component	GO:0005764	lysosome	BACE1	IDA		Human	PMID:27084579
Cellular Component	GO:0005764	lysosome	BACE1	IDA		Human	PMID:27302062
Cellular Component	GO:0016020	membrane	Bace1	IDA		Mouse	PMID:15886206
Cellular Component	GO:0005771	multivesicular body	BACE1	IDA		Human	PMID:24612608
Cellular Component	GO:0043025	neuronal cell body	Bace1	IDA		Rat	PMID:26552445|RGD:11353216
Cellular Component	GO:0005886	plasma membrane	BACE1	IDA		Human	PMID:12586838
Cellular Component	GO:0005886	plasma membrane	BACE1	IDA		Human	PMID:24612608
Cellular Component	GO:0005886	plasma membrane	Bace1	IDA		Mouse	MGI:MGI:6316502|PMID:29325091
Cellular Component	GO:0005886	plasma membrane	Bace1	IMP	MGI:MGI:2389228	Mouse	PMID:17099708
Cellular Component	GO:0098793	presynapse	Bace1	IDA		Mouse	PMID:23820808
Cellular Component	GO:0055037	recycling endosome	BACE1	IDA		Human	PMID:15886016
Cellular Component	GO:0055037	recycling endosome	BACE1	IDA		Human	PMID:27084579
Cellular Component	GO:0055037	recycling endosome	BACE1	IDA		Human	PMID:27302062
Cellular Component	GO:0055037	recycling endosome	Bace1	IDA		Mouse	MGI:MGI:6241579|PMID:23931995
Cellular Component	GO:0008021	synaptic vesicle	Bace1	IDA		Rat	PMID:26296617|RGD:13782154
Cellular Component	GO:0005802	trans-Golgi network	BACE1	IDA		Human	PMID:11466313
Cellular Component	GO:0005802	trans-Golgi network	BACE1	IDA		Human	PMID:15886016
Cellular Component	GO:0005802	trans-Golgi network	BACE1	IDA		Human	PMID:23109336
Cellular Component	GO:0005802	trans-Golgi network	Bace1	IDA		Mouse	MGI:MGI:5780539|PMID:19074428
Biological Process	GO:0042987	amyloid precursor protein catabolic process	Bace1	IGI	UniProtKB:Q9BZC7	Mouse	MGI:MGI:6356260|PMID:20704561
Biological Process	GO:0034205	amyloid-beta formation	BACE1	IDA		Human	PMID:24352696
Biological Process	GO:0050435	amyloid-beta metabolic process	BACE1	IDA		Human	PMID:10677483
Biological Process	GO:0050435	amyloid-beta metabolic process	BACE1	IDA		Human	PMID:15080893
Biological Process	GO:0050435	amyloid-beta metabolic process	Bace1	IDA		Mouse	PMID:25592972
Biological Process	GO:0050435	amyloid-beta metabolic process	Bace1	IMP		Rat	PMID:10531052|RGD:69771
Biological Process	GO:1904646	cellular response to amyloid-beta	Bace1	IEP		Rat	PMID:26984601|RGD:13782151
Biological Process	GO:0071280	cellular response to copper ion	Bace1	IEP		Rat	PMID:18583042|RGD:13782134
Biological Process	GO:0071287	cellular response to manganese ion	Bace1	IEP		Rat	PMID:18583042|RGD:13782134
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Bace1	IMP		Rat	PMID:28012171|RGD:13782150
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	BACE1	IDA		Human	PMID:18353773
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Bace1	IMP		Mouse	MGI:MGI:6316502|PMID:29325091
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Bace1	IGI	UniProtKB:P49582	Mouse	MGI:MGI:5819343|PMID:20943921
Biological Process	GO:0022011	myelination in peripheral nervous system	bace1	IMP	ZFIN:ZDB-GENO-130617-6	Zfish	PMID:23637177
Biological Process	GO:0031643	positive regulation of myelination	bace1	IMP		Zfish	PMID:23406323
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	BACE1	IGI	UniProtKB:P05067:PRO_0000000092	Human	PMID:29371969
Biological Process	GO:0060134	prepulse inhibition	Bace1	IMP		Rat	PMID:28281673|RGD:13782149
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Bace1	IMP		Mouse	PMID:18753368
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Bace1	IDA		Mouse	PMID:18753368
Biological Process	GO:0016485	protein processing	BACE1	IDA		Human	PMID:10531052
Biological Process	GO:0006508	proteolysis	BACE1	IDA		Human	PMID:10531052
Biological Process	GO:0006508	proteolysis	BACE1	IDA		Human	PMID:10677483
Biological Process	GO:0006508	proteolysis	Bace1	IDA		Mouse	PMID:15123597
Biological Process	GO:0010288	response to lead ion	Bace1	IEP		Rat	PMID:29908845|RGD:13782138
Biological Process	GO:0009314	response to radiation	Bace1	IEP		Rat	PMID:26972535|RGD:13782153
Biological Process	GO:0140448	signaling receptor ligand precursor processing	Bace1	IMP	MGI:MGI:2389228	Mouse	PMID:17099708

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern