Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BAG6
  • Mouse genes Bag6
  • Rat genes Bag6
  • Zfish genes bag6,bag6l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bag6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030544	Hsp70 protein binding	Bag6	IPI	UniProtKB:P17156	Mouse	MGI:MGI:3808636|PMID:18678708
Molecular Function	GO:0051787	misfolded protein binding	BAG6	IDA		Human	PMID:21636303
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	Bag6	IDA		Mouse	MGI:MGI:4887294|PMID:20713601
Molecular Function	GO:0070628	proteasome binding	Bag6	IDA		Mouse	MGI:MGI:4887294|PMID:20713601
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:O43765	Human	PMID:14667819
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q9BV68	Human	PMID:14667819
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:P02879	Human	PMID:14960581
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q53G59	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q09472	Human	PMID:17403783
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q8NI51	Human	PMID:18765639
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:O14931	Human	PMID:18852879
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q7Z434	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q19QW2	Human	PMID:22046132
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:O14931	Human	PMID:22807449
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q9UKV5	Human	PMID:23246001
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:O43765	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q12800	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q12805	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q53G59	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q8IZU0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q9BV68	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:P11441	Human	PMID:25535373
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q7L5D6	Human	PMID:25535373
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:P11441	Human	PMID:25713138
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q9BV68	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q8WV99	Human	PMID:26876100
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q9NRR5	Human	PMID:27113755
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:P52292|UniProtKB:Q7L5D6	Human	PMID:29042515
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:O43765	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q12805	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	BAG6	IPI	UniProtKB:Q9BV68	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Bag6	IPI	UniProtKB:Q9Z0X1	Mouse	MGI:MGI:3774040|PMID:18056262
Molecular Function	GO:0005515	protein binding	Bag6	IPI	UniProtKB:O35305|UniProtKB:P11798-2	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Bag6	IPI	PR:Q8K459	Mouse	PMID:21460186
Molecular Function	GO:0005515	protein binding	Bag6	IPI	UniProtKB:Q5PPK9	Rat	PMID:27191843|RGD:11344934
Molecular Function	GO:0043022	ribosome binding	BAG6	IDA		Human	PMID:20676083
Molecular Function	GO:0005102	signaling receptor binding	BAG6	IPI	UniProtKB:O14931	Human	PMID:18852879
Molecular Function	GO:0031625	ubiquitin protein ligase binding	BAG6	IPI	UniProtKB:Q86TM6	Human	PMID:21636303
Molecular Function	GO:0031625	ubiquitin protein ligase binding	BAG6	IPI	UniProtKB:Q9UKV5	Human	PMID:21636303
Molecular Function	GO:0031625	ubiquitin protein ligase binding	BAG6	IPI	UniProtKB:Q9BV68	Human	PMID:24981174
Molecular Function	GO:1990381	ubiquitin-specific protease binding	BAG6	IPI	UniProtKB:Q92995	Human	PMID:24424410
Cellular Component	GO:0071818	BAT3 complex	BAG6	IPI		Human	PMID:25535373
Cellular Component	GO:0071818	BAT3 complex	BAG6	IDA		Human	PMID:20676083
Cellular Component	GO:0071818	BAT3 complex	BAG6	IDA		Human	PMID:21636303
Cellular Component	GO:0071818	BAT3 complex	BAG6	IDA		Human	PMID:25535373
Cellular Component	GO:0005737	cytoplasm	BAG6	IDA		Human	PMID:21636303
Cellular Component	GO:0005737	cytoplasm	Bag6	IDA		Rat	PMID:10390159|RGD:70664
Cellular Component	GO:0005829	cytosol	BAG6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	BAG6	IDA		Human	PMID:17403783
Cellular Component	GO:0005829	cytosol	BAG6	IDA		Human	PMID:20676083
Cellular Component	GO:0005829	cytosol	BAG6	IDA		Human	PMID:23246001
Cellular Component	GO:0005829	cytosol	BAG6	IDA		Human	PMID:29042515
Cellular Component	GO:0005829	cytosol	Bag6	IDA		Mouse	MGI:MGI:3774040|PMID:18056262
Cellular Component	GO:0070062	extracellular exosome	BAG6	IDA		Human	PMID:18852879
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	BAG6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	BAG6	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	BAG6	IDA		Human	PMID:23246001
Cellular Component	GO:0005654	nucleoplasm	BAG6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	BAG6	IDA		Human	PMID:14960581
Cellular Component	GO:0005634	nucleus	BAG6	IDA		Human	PMID:17403783
Cellular Component	GO:0005634	nucleus	BAG6	IDA		Human	PMID:21636303
Cellular Component	GO:0005634	nucleus	BAG6	IDA		Human	PMID:29042515
Cellular Component	GO:0005634	nucleus	Bag6	IDA		Mouse	PMID:21460186
Biological Process	GO:0006915	apoptotic process	BAG6	IDA		Human	PMID:14960581
Biological Process	GO:0007420	brain development	Bag6	IMP		Mouse	MGI:MGI:3703386|PMID:16287848
Biological Process	GO:0061857	endoplasmic reticulum stress-induced pre-emptive quality control	BAG6	IMP		Human	PMID:26565908
Biological Process	GO:0071712	ER-associated misfolded protein catabolic process	BAG6	IDA		Human	PMID:23129660
Biological Process	GO:0071712	ER-associated misfolded protein catabolic process	BAG6	IDA		Human	PMID:24981174
Biological Process	GO:0002429	immune response-activating cell surface receptor signaling pathway	BAG6	IDA		Human	PMID:18852879
Biological Process	GO:0018393	internal peptidyl-lysine acetylation	BAG6	IDA		Human	PMID:17403783
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	BAG6	IMP		Human	PMID:17403783
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Bag6	IMP		Mouse	MGI:MGI:3774040|PMID:18056262
Biological Process	GO:0001822	kidney development	Bag6	IMP		Mouse	MGI:MGI:3703386|PMID:16287848
Biological Process	GO:0030324	lung development	Bag6	IMP		Mouse	MGI:MGI:3703386|PMID:16287848
Biological Process	GO:1904378	maintenance of unfolded protein involved in ERAD pathway	BAG6	IMP		Human	PMID:21636303
Biological Process	GO:0030101	natural killer cell activation	BAG6	IDA		Human	PMID:18852879
Biological Process	GO:0043066	negative regulation of apoptotic process	Bag6	IGI	MGI:MGI:1916557	Mouse	PMID:21460186
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Bag6	IMP		Mouse	MGI:MGI:3808636|PMID:18678708
Biological Process	GO:0045861	negative regulation of proteolysis	Bag6	IMP		Mouse	MGI:MGI:3774040|PMID:18056262
Biological Process	GO:1904294	positive regulation of ERAD pathway	BAG6	IMP		Human	PMID:24424410
Biological Process	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	BAG6	IDA		Human	PMID:25535373
Biological Process	GO:0010498	proteasomal protein catabolic process	BAG6	IMP		Human	PMID:26565908
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Bag6	IMP		Mouse	MGI:MGI:5780912|PMID:26692333
Biological Process	GO:0050821	protein stabilization	Bag6	IMP		Mouse	MGI:MGI:3808636|PMID:18678708
Biological Process	GO:0050821	protein stabilization	Bag6	IMP		Mouse	MGI:MGI:3774040|PMID:18056262
Biological Process	GO:0042981	regulation of apoptotic process	Bag6	IMP		Mouse	MGI:MGI:3703386|PMID:16287848
Biological Process	GO:0042127	regulation of cell population proliferation	Bag6	IEP		Rat	PMID:10390159|RGD:70664
Biological Process	GO:0045995	regulation of embryonic development	Bag6	IMP		Mouse	MGI:MGI:3703386|PMID:16287848
Biological Process	GO:0031647	regulation of protein stability	BAG6	IDA		Human	PMID:21636303
Biological Process	GO:0007283	spermatogenesis	Bag6	IMP		Mouse	MGI:MGI:3808636|PMID:18678708
Biological Process	GO:0007130	synaptonemal complex assembly	Bag6	IMP		Mouse	MGI:MGI:3808636|PMID:18678708
Biological Process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	BAG6	IDA		Human	PMID:20676083
Biological Process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	BAG6	IDA		Human	PMID:25535373
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	BAG6	IDA		Human	PMID:23129660
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	BAG6	IDA		Human	PMID:24981174
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	BAG6	IMP		Human	PMID:26565908
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	BAG6	IDA		Human	PMID:20676083
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Bag6	IMP		Mouse	MGI:MGI:4887294|PMID:20713601

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern