Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BCKDHA
  • Mouse genes Bckdha
  • Rat genes Bckdha
  • Zfish genes bckdha
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bckdha

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	BCKDHA	IDA		Human	PMID:7883996
Molecular Function	GO:0005515	protein binding	BCKDHA	IPI	UniProtKB:P21953	Human	PMID:12902323
Molecular Function	GO:0005515	protein binding	BCKDHA	IPI	UniProtKB:P21953	Human	PMID:15166214
Molecular Function	GO:0005515	protein binding	BCKDHA	IPI	UniProtKB:P21953	Human	PMID:15576032
Molecular Function	GO:0005515	protein binding	BCKDHA	IPI	UniProtKB:P21953	Human	PMID:28514442
Molecular Function	GO:0044877	protein-containing complex binding	Bckdha	IPI	UniProtKB:P35738	Rat	PMID:3619032|RGD:1599470
Cellular Component	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex	BCKDHA	IPI		Human	PMID:3593587
Cellular Component	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex	BCKDHA	IDA		Human	PMID:7883996
Cellular Component	GO:0005739	mitochondrion	BCKDHA	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Bckdha	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Bckdha	HDA		Mouse	PMID:18614015
Biological Process	GO:0009083	branched-chain amino acid catabolic process	BCKDHA	IDA		Human	PMID:3593587
Biological Process	GO:0009083	branched-chain amino acid catabolic process	BCKDHA	IDA		Human	PMID:7883996
Biological Process	GO:0051591	response to cAMP	Bckdha	IEP		Rat	PMID:8034710|RGD:1599468
Biological Process	GO:0051384	response to glucocorticoid	Bckdha	IEP		Rat	PMID:8034710|RGD:1599468
Biological Process	GO:0007584	response to nutrient	Bckdha	IEP		Rat	PMID:8109974|RGD:1599469

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern