Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BCL6
  • Mouse genes Bcl6
  • Rat genes Bcl6
  • Zfish genes bcl6aa,bcl6ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bcl6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	BCL6	IDA		Human	PMID:12097386
Molecular Function	GO:0003682	chromatin binding	Bcl6	IDA		Mouse	PMID:15240705
Molecular Function	GO:0003682	chromatin binding	Bcl6	IDA		Mouse	PMID:12817026
Molecular Function	GO:0031490	chromatin DNA binding	Bcl6	IDA		Mouse	PMID:17125145
Molecular Function	GO:0003700	DNA-binding transcription factor activity	BCL6	IMP		Human	PMID:15577913
Molecular Function	GO:0140297	DNA-binding transcription factor binding	BCL6	IPI	UniProtKB:Q9H165-1	Human	PMID:16704730
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	BCL6	IDA		Human	PMID:16704730
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Bcl6	IDA		Mouse	MGI:MGI:2182510|PMID:12097386
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Bcl6	IDA		Mouse	PMID:23209284
Molecular Function	GO:0042802	identical protein binding	BCL6	IPI	UniProtKB:P41182	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	BCL6	IPI	UniProtKB:P41182	Human	PMID:32296183
Molecular Function	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	Bcl6	IDA		Mouse	PMID:24863065
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9UKV0	Human	PMID:12590135
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:P56524	Human	PMID:16147992
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q96RU7	Human	PMID:16147992
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9UKV0	Human	PMID:16147992
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9ULU4	Human	PMID:16147992
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:P42229	Human	PMID:16819511
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:P45481	Human	PMID:21390126
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q86XK2	Human	PMID:22113614
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:A8KA13	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:O15156	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:P0CW20	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q08117	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q13077	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q8IUQ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9BVG8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9H2G9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9NTM9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q08379	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q13077	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:B2RV13	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:O43257	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:P0CW20	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:P28070	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q08379	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q12888	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q52LG2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q53G59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q6P656	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q8IUB9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q8N865	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q8N9V6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q8NCR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q8NI37	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q8WVV4-1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q8WW24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q96B67	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q96LM5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q96RU7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q99471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9BRX9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9BS75	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9BYU1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9NZN8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9Y6H3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BCL6	IPI	UniProtKB:Q9H2G9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Bcl6	IPI	UniProtKB:Q9JKD8	Mouse	MGI:MGI:5428372|PMID:22406686
Molecular Function	GO:0005515	protein binding	Bcl6	IPI	UniProtKB:Q7TPD1	Mouse	MGI:MGI:5619452|PMID:22113614
Molecular Function	GO:0005515	protein binding	Bcl6	IPI	UniProtKB:Q8CGN4	Mouse	MGI:MGI:5615321|PMID:25490446
Molecular Function	GO:0005515	protein binding	Bcl6	IPI	PR:Q64364	Mouse	PMID:15567177
Molecular Function	GO:0005515	protein binding	Bcl6	IPI	PR:Q9JLV5	Mouse	PMID:24863065
Molecular Function	GO:0005515	protein binding	Bcl6	IPI	PR:O88282	Mouse	PMID:9632807
Molecular Function	GO:0005515	protein binding	Bcl6	IPI	PR:P23611	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Bcl6	IPI	PR:Q923E4	Mouse	PMID:23160044
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Bcl6	IDA		Mouse	PMID:10490661
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Bcl6	IDA		Mouse	PMID:15611242
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Bcl6	IDA		Mouse	PMID:9110977
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Bcl6	IDA		Mouse	MGI:MGI:2182510|PMID:12097386
Molecular Function	GO:0043565	sequence-specific DNA binding	BCL6	IDA		Human	PMID:15577913
Molecular Function	GO:0043565	sequence-specific DNA binding	Bcl6	IDA		Mouse	PMID:15659391
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	BCL6	IDA		Human	PMID:28473536
Molecular Function	GO:0001222	transcription corepressor binding	BCL6	IPI	UniProtKB:Q6W2J9	Human	PMID:10898795
Cellular Component	GO:0005794	Golgi apparatus	BCL6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	BCL6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	BCL6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	BCL6	IDA		Human	PMID:10898795
Cellular Component	GO:0005634	nucleus	BCL6	IDA		Human	PMID:11929873
Cellular Component	GO:0005634	nucleus	BCL6	IDA		Human	PMID:7795255
Cellular Component	GO:0005634	nucleus	Bcl6	IDA		Mouse	PMID:9632807
Cellular Component	GO:0005634	nucleus	Bcl6	IDA		Mouse	PMID:24863065
Cellular Component	GO:0042382	paraspeckles	BCL6	IDA		Human	PMID:16704730
Cellular Component	GO:0005657	replication fork	BCL6	IDA		Human	PMID:10490843
Biological Process	GO:0030036	actin cytoskeleton organization	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:15860730
Biological Process	GO:0030183	B cell differentiation	Bcl6	IGI	MGI:MGI:88337	Mouse	PMID:14647274
Biological Process	GO:0042100	B cell proliferation	Bcl6	IMP	MGI:MGI:2158437	Mouse	PMID:9171827
Biological Process	GO:0000902	cell morphogenesis	Bcl6	IGI	MGI:MGI:1096342	Mouse	PMID:15860730
Biological Process	GO:0000902	cell morphogenesis	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:15860730
Biological Process	GO:0048870	cell motility	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:15860730
Biological Process	GO:0008283	cell population proliferation	Bcl6	IMP	MGI:MGI:2158439	Mouse	PMID:15507530
Biological Process	GO:0007160	cell-matrix adhesion	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:15860730
Biological Process	GO:0006974	DNA damage response	BCL6	IDA		Human	PMID:15577913
Biological Process	GO:0048821	erythrocyte development	Bcl6	IMP	MGI:MGI:2158436	Mouse	PMID:15661395
Biological Process	GO:0002467	germinal center formation	Bcl6	IMP	MGI:MGI:2158436	Mouse	PMID:12354385
Biological Process	GO:0002467	germinal center formation	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:9171827
Biological Process	GO:0002467	germinal center formation	Bcl6	IMP	MGI:MGI:2158436	Mouse	PMID:9236196
Biological Process	GO:0002467	germinal center formation	Bcl6	IMP	MGI:MGI:2158439	Mouse	PMID:9110977
Biological Process	GO:0031507	heterochromatin formation	Bcl6	IGI	MGI:MGI:2135607	Mouse	PMID:23160044
Biological Process	GO:0048289	isotype switching to IgE isotypes	Bcl6	IGI	MGI:MGI:103034	Mouse	PMID:10490661
Biological Process	GO:0048289	isotype switching to IgE isotypes	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:10490661
Biological Process	GO:0070661	leukocyte proliferation	Bcl6	IMP	MGI:MGI:2158439	Mouse	PMID:15507530
Biological Process	GO:0070661	leukocyte proliferation	Bcl6	IMP		Mouse	PMID:15611242
Biological Process	GO:0032762	mast cell cytokine production	Bcl6	IMP	MGI:MGI:2158436	Mouse	PMID:15950739
Biological Process	GO:0043066	negative regulation of apoptotic process	Bcl6	IMP	MGI:MGI:2158436	Mouse	PMID:11092811
Biological Process	GO:0043066	negative regulation of apoptotic process	Bcl6	IDA		Mouse	PMID:9927203
Biological Process	GO:0030308	negative regulation of cell growth	BCL6	IDA		Human	PMID:10490843
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:15860730
Biological Process	GO:2000773	negative regulation of cellular senescence	Bcl6	IMP	MGI:MGI:2158436	Mouse	PMID:23209284
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	BCL6	IMP		Human	PMID:15577913
Biological Process	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	bcl6aa	IMP	ZFIN:ZDB-MRPHLNO-130911-7	Zfish	PMID:23669349
Biological Process	GO:0048294	negative regulation of isotype switching to IgE isotypes	Bcl6	IGI	MGI:MGI:103034	Mouse	PMID:10490661
Biological Process	GO:0048294	negative regulation of isotype switching to IgE isotypes	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:10490661
Biological Process	GO:0070664	negative regulation of leukocyte proliferation	Bcl6	IMP	MGI:MGI:2158439	Mouse	PMID:15507530
Biological Process	GO:0070664	negative regulation of leukocyte proliferation	Bcl6	IMP		Mouse	PMID:15611242
Biological Process	GO:0032764	negative regulation of mast cell cytokine production	Bcl6	IMP	MGI:MGI:2158436	Mouse	PMID:15950739
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Bcl6	IGI	MGI:MGI:97363	Mouse	PMID:23160044
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Bcl6	IGI	MGI:MGI:1890504	Mouse	PMID:23160044
Biological Process	GO:1900099	negative regulation of plasma cell differentiation	Bcl6	IMP	MGI:MGI:2158439	Mouse	PMID:15240705
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:15860730
Biological Process	GO:0045629	negative regulation of T-helper 2 cell differentiation	Bcl6	IGI	MGI:MGI:96559	Mouse	PMID:12594267
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	BCL6	IDA		Human	PMID:11929873
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	BCL6	IDA		Human	PMID:15577913
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	BCL6	IDA		Human	PMID:16704730
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IDA		Mouse	PMID:12817026
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IDA		Mouse	PMID:17125145
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IGI	MGI:MGI:103034	Mouse	PMID:9110977
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IDA		Mouse	PMID:10490661
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IDA		Mouse	PMID:15659391
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IDA		Mouse	PMID:23160044
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IDA		Mouse	PMID:12097386
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IDA		Mouse	PMID:15507530
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IMP		Mouse	PMID:15611242
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IDA		Mouse	PMID:15240705
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IGI	MGI:MGI:96556	Mouse	PMID:9110977
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bcl6	IDA		Mouse	PMID:9632807
Biological Process	GO:0002829	negative regulation of type 2 immune response	Bcl6	IGI	MGI:MGI:103034	Mouse	PMID:10438949
Biological Process	GO:0002317	plasma cell differentiation	Bcl6	IMP	MGI:MGI:2158439	Mouse	PMID:15240705
Biological Process	GO:0043065	positive regulation of apoptotic process	BCL6	IDA		Human	PMID:10490843
Biological Process	GO:0030890	positive regulation of B cell proliferation	Bcl6	IMP	MGI:MGI:2158437	Mouse	PMID:9171827
Biological Process	GO:0045666	positive regulation of neuron differentiation	Bcl6	IDA		Mouse	PMID:23160044
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	BCL6	IMP		Human	PMID:20935202
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	BCL6	IMP		Human	PMID:22387553
Biological Process	GO:0008104	protein localization	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:15860730
Biological Process	GO:0021859	pyramidal neuron differentiation	Bcl6	IDA		Mouse	PMID:23160044
Biological Process	GO:0043087	regulation of GTPase activity	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:15860730
Biological Process	GO:0050727	regulation of inflammatory response	Bcl6	IMP	MGI:MGI:2158439	Mouse	PMID:9110977
Biological Process	GO:0043380	regulation of memory T cell differentiation	Bcl6	IMP	MGI:MGI:2158436	Mouse	PMID:15240675
Biological Process	GO:0042129	regulation of T cell proliferation	Bcl6	IMP	MGI:MGI:2158436	Mouse	PMID:15240675
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Bcl6	IGI	MGI:MGI:1347360	Mouse	PMID:24863065
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	bcl6aa	IMP	ZFIN:ZDB-MRPHLNO-130911-7	Zfish	PMID:23669349
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	bcl6aa	IGI	ZFIN:ZDB-GENE-020419-32,ZFIN:ZDB-MRPHLNO-130911-7	Zfish	PMID:23669349
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	bcl6aa	IGI	ZFIN:ZDB-MRPHLNO-130911-7,ZFIN:ZDB-MRPHLNO-130911-9	Zfish	PMID:23669349
Biological Process	GO:0007266	Rho protein signal transduction	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:15860730
Biological Process	GO:0007266	Rho protein signal transduction	Bcl6	IGI	MGI:MGI:1096342	Mouse	PMID:15860730
Biological Process	GO:0007283	spermatogenesis	Bcl6	IMP	MGI:MGI:2158436	Mouse	PMID:11092811
Biological Process	GO:0045064	T-helper 2 cell differentiation	Bcl6	IGI	MGI:MGI:96559	Mouse	PMID:12594267
Biological Process	GO:0006366	transcription by RNA polymerase II	Bcl6	IDA		Mouse	PMID:23160044
Biological Process	GO:0042092	type 2 immune response	Bcl6	IMP	MGI:MGI:2158438	Mouse	PMID:9171827

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern