Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BDNF
  • Mouse genes Bdnf
  • Rat genes Bdnf
  • Zfish genes bdnf
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bdnf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005169	neurotrophin TRKB receptor binding	Bdnf	IDA		Rat	PMID:1889806|RGD:631710
Molecular Function	GO:0005515	protein binding	BDNF	IPI	UniProtKB:P34130	Human	PMID:10631974
Molecular Function	GO:0005515	protein binding	BDNF	IPI	UniProtKB:P34130	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	BDNF	IPI	UniProtKB:P34130	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	Bdnf	IPI	PR:Q5STE3	Mouse	PMID:24573299
Molecular Function	GO:0005515	protein binding	Bdnf	IPI	PR:Q9Z0W1	Mouse	PMID:11684666
Cellular Component	GO:0030424	axon	Bdnf	IDA		Mouse	MGI:MGI:4457852|PMID:19448629
Cellular Component	GO:0030424	axon	Bdnf	IDA		Rat	PMID:11050383|RGD:8655586
Cellular Component	GO:0005737	cytoplasm	Bdnf	IDA		Mouse	MGI:MGI:5487510|PMID:22209827
Cellular Component	GO:0031410	cytoplasmic vesicle	Bdnf	IDA		Mouse	PMID:15242649
Cellular Component	GO:0031410	cytoplasmic vesicle	Bdnf	IDA		Mouse	PMID:14715936
Cellular Component	GO:0030425	dendrite	Bdnf	IDA		Mouse	MGI:MGI:4457852|PMID:19448629
Cellular Component	GO:0030425	dendrite	Bdnf	IDA		Rat	PMID:8726105|RGD:8657068
Cellular Component	GO:0005615	extracellular space	Bdnf	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Bdnf	IDA		Rat	PMID:10779676|RGD:8657114
Cellular Component	GO:0098978	glutamatergic synapse	Bdnf	IDA		Mouse	PMID:19448629
Cellular Component	GO:0098978	glutamatergic synapse	Bdnf	EXP		Mouse	PMID:19448629
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Bdnf	IDA		Mouse	PMID:22412021
Cellular Component	GO:0030061	mitochondrial crista	Bdnf	IDA		Rat	PMID:16626872|RGD:8655644
Cellular Component	GO:0043025	neuronal cell body	Bdnf	IDA		Rat	PMID:8726105|RGD:8657068
Cellular Component	GO:0098992	neuronal dense core vesicle	Bdnf	IDA		Mouse	PMID:22412021
Cellular Component	GO:0043204	perikaryon	Bdnf	IDA		Rat	PMID:16626872|RGD:8655644
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Bdnf	IDA		Mouse	MGI:MGI:5487510|PMID:22209827
Cellular Component	GO:0030141	secretory granule	Bdnf	IDA		Mouse	PMID:24573299
Cellular Component	GO:0008021	synaptic vesicle	Bdnf	IDA		Rat	PMID:17192436|RGD:1600576
Cellular Component	GO:0043195	terminal bouton	Bdnf	IDA		Rat	PMID:16626872|RGD:8655644
Biological Process	GO:0007568	aging	Bdnf	IEP		Rat	PMID:28320273|RGD:13503327
Biological Process	GO:0048675	axon extension	Bdnf	IDA		Mouse	PMID:24035762
Biological Process	GO:0007411	axon guidance	Bdnf	IMP	MGI:MGI:1929986	Mouse	PMID:15014133
Biological Process	GO:0007412	axon target recognition	Bdnf	IMP	MGI:MGI:1930038	Mouse	PMID:15464571
Biological Process	GO:0001662	behavioral fear response	Bdnf	IMP	MGI:MGI:2176750	Mouse	PMID:15249684
Biological Process	GO:0048148	behavioral response to cocaine	Bdnf	IMP		Rat	PMID:23583595|RGD:38501054
Biological Process	GO:0007420	brain development	bdnf	IEP		Zfish	PMID:9641529
Biological Process	GO:0071229	cellular response to acid chemical	Bdnf	IDA		Mouse	PMID:25542970
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Bdnf	IEP		Rat	PMID:21958434|RGD:8657122
Biological Process	GO:0071874	cellular response to norepinephrine stimulus	Bdnf	IEP		Rat	PMID:16292510|RGD:8655645
Biological Process	GO:0035865	cellular response to potassium ion	Bdnf	IEP		Rat	PMID:25424568|RGD:11060597
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Bdnf	IEP		Rat	PMID:21958434|RGD:8657122
Biological Process	GO:0002544	chronic inflammatory response	Bdnf	IEP		Rat	PMID:20223282|RGD:4891140
Biological Process	GO:0048512	circadian behavior	bdnf	IMP	ZFIN:ZDB-GENO-221121-1	Zfish	PMID:35345456
Biological Process	GO:0007623	circadian rhythm	Bdnf	IEP		Mouse	MGI:MGI:5503234|PMID:23785138
Biological Process	GO:0007623	circadian rhythm	bdnf	IMP	ZFIN:ZDB-GENO-221121-1	Zfish	PMID:35345456
Biological Process	GO:0050890	cognition	Bdnf	IEP		Rat	PMID:20852970|RGD:4891128
Biological Process	GO:0048668	collateral sprouting	BDNF	IDA		Human	PMID:19036963
Biological Process	GO:1990708	conditioned place preference	Bdnf	IMP		Rat	PMID:23583595|RGD:38501054
Biological Process	GO:0016358	dendrite development	Bdnf	IMP		Mouse	PMID:12890780
Biological Process	GO:0097484	dendrite extension	Bdnf	IDA		Mouse	PMID:24035762
Biological Process	GO:0071542	dopaminergic neuron differentiation	bdnf	IMP	ZFIN:ZDB-GENO-041111-2	Zfish	PMID:24291744
Biological Process	GO:0060079	excitatory postsynaptic potential	Bdnf	IMP		Rat	PMID:17192436|RGD:1600576
Biological Process	GO:0042596	fear response	Bdnf	IMP	MGI:MGI:2176750	Mouse	PMID:15249684
Biological Process	GO:0007631	feeding behavior	Bdnf	IMP	MGI:MGI:2663046	Mouse	PMID:12796784
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	Bdnf	IDA		Mouse	PMID:16754670
Biological Process	GO:0014047	glutamate secretion	Bdnf	IPI	PR:P15209	Mouse	PMID:16819522
Biological Process	GO:0060080	inhibitory postsynaptic potential	Bdnf	IMP	MGI:MGI:2176750	Mouse	PMID:24201284
Biological Process	GO:0048839	inner ear development	Bdnf	IMP	MGI:MGI:1857136	Mouse	PMID:7605630
Biological Process	GO:0007612	learning	Bdnf	IMP		Rat	PMID:22056599|RGD:8657115
Biological Process	GO:0007611	learning or memory	Bdnf	IMP	MGI:MGI:2176750	Mouse	PMID:15249684
Biological Process	GO:0042490	mechanoreceptor differentiation	Bdnf	IGI	MGI:MGI:97380	Mouse	PMID:15376326
Biological Process	GO:0042490	mechanoreceptor differentiation	Bdnf	IGI	MGI:MGI:97381	Mouse	PMID:15376326
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	Bdnf	IMP		Rat	PMID:15341590|RGD:1358393
Biological Process	GO:0033555	multicellular organismal response to stress	bdnf	IEP		Zfish	PMID:25748166
Biological Process	GO:0043066	negative regulation of apoptotic process	Bdnf	IDA		Mouse	PMID:12904469
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Bdnf	IGI	RNAcentral:URS000055128B_10090	Mouse	MGI:MGI:6295053|PMID:26708520
Biological Process	GO:0010832	negative regulation of myotube differentiation	Bdnf	IMP		Rat	PMID:16723531|RGD:1580249
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	Bdnf	IDA		Mouse	PMID:12798291
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Bdnf	IMP		Mouse	PMID:8861722
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Bdnf	IMP	MGI:MGI:1930038	Mouse	PMID:15869495
Biological Process	GO:1901215	negative regulation of neuron death	Bdnf	IMP		Rat	PMID:11050383|RGD:8655586
Biological Process	GO:0043069	negative regulation of programmed cell death	Bdnf	IMP	MGI:MGI:1857136	Mouse	PMID:24378336
Biological Process	GO:0045843	negative regulation of striated muscle tissue development	Bdnf	IMP		Rat	PMID:16723531|RGD:1580249
Biological Process	GO:0032229	negative regulation of synaptic transmission, GABAergic	Bdnf	IDA		Mouse	PMID:16754670
Biological Process	GO:0021675	nerve development	Bdnf	IMP	MGI:MGI:1857136	Mouse	PMID:7605630
Biological Process	GO:0007399	nervous system development	Bdnf	IDA		Rat	PMID:12427830|RGD:628430
Biological Process	GO:0051402	neuron apoptotic process	Bdnf	IMP		Mouse	PMID:8861722
Biological Process	GO:0051402	neuron apoptotic process	Bdnf	IMP	MGI:MGI:1930038	Mouse	PMID:15869495
Biological Process	GO:1990138	neuron projection extension	Bdnf	IDA		Rat	PMID:8469387|RGD:8655659
Biological Process	GO:0008038	neuron recognition	Bdnf	IMP		Mouse	PMID:15844198
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Bdnf	IMP		Mouse	PMID:23878391
Biological Process	GO:0048672	positive regulation of collateral sprouting	BDNF	IDA		Human	PMID:19036963
Biological Process	GO:0048672	positive regulation of collateral sprouting	Bdnf	IMP		Mouse	PMID:24573299
Biological Process	GO:0048672	positive regulation of collateral sprouting	Bdnf	IDA		Mouse	PMID:24573299
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Bdnf	IDA		Rat	PMID:23878391|RGD:10047172
Biological Process	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway	Bdnf	IDA		Rat	PMID:23878391|RGD:10047172
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	Bdnf	IMP		Rat	PMID:14699417|RGD:4891114
Biological Process	GO:0045666	positive regulation of neuron differentiation	Bdnf	IDA		Mouse	PMID:12798291
Biological Process	GO:0010976	positive regulation of neuron projection development	Bdnf	IGI	RNAcentral:URS000055128B_10090	Mouse	MGI:MGI:6295053|PMID:26708520
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Bdnf	IMP		Mouse	PMID:23878391
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Bdnf	IGI	UniProtKB:Q63604	Rat	PMID:23878391|RGD:10047172
Biological Process	GO:1900122	positive regulation of receptor binding	BDNF	IDA		Human	PMID:12130635
Biological Process	GO:1900122	positive regulation of receptor binding	Bdnf	IDA		Rat	PMID:12130635|RGD:11558005
Biological Process	GO:0051965	positive regulation of synapse assembly	BDNF	IDA		Human	PMID:19036963
Biological Process	GO:0099054	presynapse assembly	bdnf	IGI	ZFIN:ZDB-MRPHLNO-100205-1,ZFIN:ZDB-MRPHLNO-171016-1	Zfish	PMID:28371371
Biological Process	GO:0031099	regeneration	Bdnf	IDA		Rat	PMID:24388817|RGD:10059363
Biological Process	GO:0030516	regulation of axon extension	Bdnf	IMP		Rat	PMID:14697662|RGD:8655852
Biological Process	GO:0048670	regulation of collateral sprouting	Bdnf	IGI	MGI:MGI:2443199	Mouse	PMID:24573299
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Bdnf	IDA		Rat	PMID:12201640|RGD:724690
Biological Process	GO:0043523	regulation of neuron apoptotic process	Bdnf	IDA		Mouse	PMID:16516892
Biological Process	GO:0046668	regulation of retinal cell programmed cell death	Bdnf	IDA		Mouse	PMID:11747369
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	Bdnf	IDA		Rat	PMID:12201640|RGD:724690
Biological Process	GO:0048167	regulation of synaptic plasticity	Bdnf	IDA		Mouse	PMID:16819522
Biological Process	GO:0048167	regulation of synaptic plasticity	Bdnf	IDA		Mouse	PMID:17442827
Biological Process	GO:0014823	response to activity	Bdnf	IEP		Rat	PMID:15199375|RGD:8655883
Biological Process	GO:0072347	response to anesthetic	Bdnf	IEP		Rat	PMID:16738805|RGD:4891109
Biological Process	GO:0010996	response to auditory stimulus	Bdnf	IEP		Rat	PMID:21034795|RGD:5684781
Biological Process	GO:0051602	response to electrical stimulus	Bdnf	IEP		Rat	PMID:11007900|RGD:8655537
Biological Process	GO:0032094	response to food	Bdnf	IEP		Rat	PMID:12770552|RGD:8655863
Biological Process	GO:0009725	response to hormone	Bdnf	IEP		Rat	PMID:20018181|RGD:2317764
Biological Process	GO:0055093	response to hyperoxia	Bdnf	IEP		Rat	PMID:15821016|RGD:4891113
Biological Process	GO:0001666	response to hypoxia	Bdnf	IEP		Rat	PMID:14699417|RGD:4891114
Biological Process	GO:1902065	response to L-glutamate	Bdnf	IEP		Rat	PMID:12654519|RGD:8655631
Biological Process	GO:0009642	response to light intensity	Bdnf	IEP		Rat	PMID:21076359|RGD:8655612
Biological Process	GO:0009416	response to light stimulus	Bdnf	IEP		Rat	PMID:17640634|RGD:8655603
Biological Process	GO:1990089	response to nerve growth factor	Bdnf	IEP		Rat	PMID:10366647|RGD:8657096
Biological Process	GO:0031667	response to nutrient levels	Bdnf	IEP		Rat	PMID:20655333|RGD:4891130
Biological Process	GO:0035864	response to potassium ion	Bdnf	IEP		Rat	PMID:11007900|RGD:8655537
Biological Process	GO:0034612	response to tumor necrosis factor	Bdnf	IEP		Rat	PMID:18830614|RGD:8655602
Biological Process	GO:0033189	response to vitamin A	Bdnf	IEP		Rat	PMID:21188516|RGD:4891124
Biological Process	GO:0009410	response to xenobiotic stimulus	Bdnf	IMP	MGI:MGI:2176750	Mouse	PMID:15249684
Biological Process	GO:0009410	response to xenobiotic stimulus	Bdnf	IEP		Rat	PMID:12049586|RGD:8655589
Biological Process	GO:0009410	response to xenobiotic stimulus	Bdnf	IEP		Rat	PMID:19211973|RGD:4891118
Biological Process	GO:0099083	retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission	Bdnf	IMP		Mouse	MGI:MGI:4457852|PMID:19448629
Biological Process	GO:0007416	synapse assembly	BDNF	IDA		Human	PMID:19036963
Biological Process	GO:0061193	taste bud development	Bdnf	IMP	MGI:MGI:1857136	Mouse	PMID:24378336
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	Bdnf	EXP		Mouse	PMID:19448629
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	Bdnf	IDA		Mouse	PMID:19448629
Biological Process	GO:0001657	ureteric bud development	Bdnf	IDA		Mouse	PMID:16018995

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern