Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BHLHE40
  • Mouse genes Bhlhe40
  • Rat genes Bhlhe40
  • Zfish genes bhlhe40
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bhlhe40

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	BHLHE40	IPI	UniProtKB:Q9WTL8	Human	PMID:12397359
Molecular Function	GO:0043425	bHLH transcription factor binding	BHLHE40	IPI	UniProtKB:Q9C0J9	Human	PMID:15193144
Molecular Function	GO:0043425	bHLH transcription factor binding	BHLHE40	IPI	UniProtKB:Q9WTL8	Human	PMID:15193144
Molecular Function	GO:0003677	DNA binding	Bhlhe40	IDA		Mouse	PMID:12297495
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	BHLHE40	IDA		Human	PMID:12397359
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Bhlhe40	IDA		Mouse	MGI:MGI:5297789|PMID:15147242
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	BHLHE40	IDA		Human	PMID:12397359
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	BHLHE40	IDA		Human	PMID:12624110
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	BHLHE40	IDA		Human	PMID:15193144
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	BHLHE40	IDA		Human	PMID:18411297
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	BHLHE40	IDA		Human	PMID:19786558
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Bhlhe40	IDA		Mouse	MGI:MGI:5297789|PMID:15147242
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Bhlhe40	IDA		Mouse	MGI:MGI:5574300|PMID:19786558
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Bhlhe40	IDA		Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:0070888	E-box binding	BHLHE40	IDA		Human	PMID:12397359
Molecular Function	GO:0070888	E-box binding	BHLHE40	IDA		Human	PMID:12624110
Molecular Function	GO:0070888	E-box binding	BHLHE40	IDA		Human	PMID:14672706
Molecular Function	GO:0070888	E-box binding	BHLHE40	IDA		Human	PMID:15193144
Molecular Function	GO:0070888	E-box binding	BHLHE40	IDA		Human	PMID:15560782
Molecular Function	GO:0070888	E-box binding	BHLHE40	IDA		Human	PMID:18411297
Molecular Function	GO:0070888	E-box binding	BHLHE40	IDA		Human	PMID:28797635
Molecular Function	GO:0070888	E-box binding	Bhlhe40	IDA		Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:0070888	E-box binding	Bhlhe40	IDA		Mouse	MGI:MGI:2388855|PMID:12397359
Molecular Function	GO:0070888	E-box binding	Bhlhe40	IDA		Mouse	MGI:MGI:6282958|PMID:30012868
Molecular Function	GO:0070888	E-box binding	Bhlhe40	IDA		Mouse	MGI:MGI:5297789|PMID:15147242
Molecular Function	GO:0043426	MRF binding	Bhlhe40	IDA		Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P63279	Human	PMID:11278694
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9WTL8	Human	PMID:12397359
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P04637	Human	PMID:17347673
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P19793	Human	PMID:19786558
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P0C206	Human	PMID:22458338
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P04637	Human	PMID:22723347
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:A1A580	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:B7ZLI8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:C9JG97	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:O60248	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:O75553	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:O75909	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:O94955	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P10606	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P18545	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q08117	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q08426	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q08AM6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q13131	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q14106	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q16613	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q5W5X9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q6NVV7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q71RC2-6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q86U06	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q86U06-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q8NB12	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q8NEA9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q96CS7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9BVI4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9GZZ1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9H4E5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9NX01	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9Y5V3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q16613	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P19793	Human	PMID:29234281
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q8NB12	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:O94955	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P10606	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q8NB12	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:B7ZLI8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:O43189	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:O94955	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:O94964-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:O95231	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P19544-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P54253	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:P86480	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q01974	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q03060-25	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q08AM6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q13895	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q14847-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q15038	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q15911-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q3LI64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q3LI72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q3SYF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q6ZRY4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q70EL1-9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q86UY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q86YR5-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q8IUB9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q8IUC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q8NB12	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q8TAP4-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q8WU79	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q92997	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q96A09	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q96EZ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q96G42	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q99471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9GZZ1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9HC98-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9NWB1-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9Y4B4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BHLHE40	IPI	UniProtKB:Q9Y5V3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Bhlhe40	IPI	PR:P10085	Mouse	PMID:17487425
Molecular Function	GO:0005515	protein binding	Bhlhe40	IPI	PR:O35185	Mouse	PMID:12297495
Molecular Function	GO:0019904	protein domain specific binding	BHLHE40	IPI	UniProtKB:Q9WTL8	Human	PMID:15560782
Molecular Function	GO:0046982	protein heterodimerization activity	BHLHE40	IPI	UniProtKB:Q9WTL8	Human	PMID:12397359
Molecular Function	GO:0046982	protein heterodimerization activity	BHLHE40	IPI	UniProtKB:Q9C0J9	Human	PMID:15193144
Molecular Function	GO:0046982	protein heterodimerization activity	BHLHE40	IPI	UniProtKB:Q9WTL8	Human	PMID:15193144
Molecular Function	GO:0046982	protein heterodimerization activity	BHLHE40	IPI	UniProtKB:Q99PV5	Human	PMID:15560782
Molecular Function	GO:0042803	protein homodimerization activity	BHLHE40	IDA		Human	PMID:15560782
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Bhlhe40	IDA		Mouse	MGI:MGI:5297789|PMID:15147242
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Bhlhe40	IDA		Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	BHLHE40	IDA		Human	PMID:28473536
Cellular Component	GO:0016604	nuclear body	BHLHE40	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	BHLHE40	IDA		Human	PMID:12624110
Cellular Component	GO:0005634	nucleus	BHLHE40	IDA		Human	PMID:28797635
Cellular Component	GO:0005634	nucleus	Bhlhe40	IDA		Mouse	PMID:12297495
Cellular Component	GO:0005634	nucleus	Bhlhe40	IDA		Rat	PMID:12954728|RGD:1358397
Biological Process	GO:0032922	circadian regulation of gene expression	BHLHE40	IDA		Human	PMID:18411297
Biological Process	GO:0032922	circadian regulation of gene expression	Bhlhe40	IMP		Mouse	MGI:MGI:3798698|PMID:18411297
Biological Process	GO:0032922	circadian regulation of gene expression	Bhlhe40	IMP		Mouse	MGI:MGI:6282958|PMID:30012868
Biological Process	GO:0032922	circadian regulation of gene expression	bhlhe40	IDA		Zfish	PMID:24423866
Biological Process	GO:0007623	circadian rhythm	BHLHE40	IDA		Human	PMID:28797635
Biological Process	GO:0007623	circadian rhythm	Bhlhe40	IEP		Mouse	MGI:MGI:5574300|PMID:19786558
Biological Process	GO:0007623	circadian rhythm	Bhlhe40	IEP		Rat	PMID:12397359|RGD:625726
Biological Process	GO:0043153	entrainment of circadian clock by photoperiod	Bhlhe40	IMP		Mouse	MGI:MGI:3798698|PMID:18411297
Biological Process	GO:0045475	locomotor rhythm	bhlhe40	IMP	ZFIN:ZDB-MRPHLNO-140605-1	Zfish	PMID:24423866
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	BHLHE40	IDA		Human	PMID:18411297
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	BHLHE40	IDA		Human	PMID:12397359
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	BHLHE40	IMP		Human	PMID:28797635
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	BHLHE40	IDA		Human	PMID:30012868
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Bhlhe40	IMP		Mouse	MGI:MGI:6282958|PMID:30012868
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Bhlhe40	IDA		Mouse	PMID:12297495
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	bhlhe40	IDA		Zfish	PMID:17097613
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	BHLHE40	IDA		Human	PMID:12397359
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	BHLHE40	IDA		Human	PMID:12624110
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	BHLHE40	IDA		Human	PMID:14672706
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	BHLHE40	IDA		Human	PMID:15193144
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bhlhe40	IMP		Rat	PMID:12954728|RGD:1358397
Biological Process	GO:0042752	regulation of circadian rhythm	Bhlhe40	IMP		Mouse	MGI:MGI:6282958|PMID:30012868
Biological Process	GO:0006355	regulation of DNA-templated transcription	bhlhe40	IDA		Zfish	PMID:24423866
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	Bhlhe40	IEP		Rat	PMID:9532582|RGD:68312
Biological Process	GO:0009416	response to light stimulus	Bhlhe40	IDA		Rat	PMID:12397359|RGD:625726
Biological Process	GO:0009416	response to light stimulus	Bhlhe40	IEP		Rat	PMID:12397359|RGD:625726

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern