Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BHLHE41
  • Mouse genes Bhlhe41
  • Rat genes Bhlhe41
  • Zfish genes bhlhe41
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bhlhe41

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	BHLHE41	IPI	UniProtKB:O14503	Human	PMID:15193144
Molecular Function	GO:0043425	bHLH transcription factor binding	Bhlhe41	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:2388855|PMID:12397359
Molecular Function	GO:0043425	bHLH transcription factor binding	Bhlhe41	IDA		Mouse	MGI:MGI:5297791|PMID:12657651
Molecular Function	GO:0043425	bHLH transcription factor binding	Bhlhe41	IPI	UniProtKB:Q99PV5	Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Bhlhe41	IDA		Mouse	MGI:MGI:2388855|PMID:12397359
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Bhlhe41	IDA		Mouse	MGI:MGI:5297789|PMID:15147242
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	BHLHE41	IDA		Human	PMID:19786558
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Bhlhe41	IDA		Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Bhlhe41	IDA		Mouse	MGI:MGI:5574300|PMID:19786558
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Bhlhe41	IDA		Mouse	MGI:MGI:2388855|PMID:12397359
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Bhlhe41	IDA		Mouse	MGI:MGI:5297789|PMID:15147242
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Bhlhe41	IDA		Mouse	MGI:MGI:5297791|PMID:12657651
Molecular Function	GO:0070888	E-box binding	BHLHE41	IDA		Human	PMID:14672706
Molecular Function	GO:0070888	E-box binding	BHLHE41	IDA		Human	PMID:15193144
Molecular Function	GO:0070888	E-box binding	Bhlhe41	IDA		Mouse	MGI:MGI:5297791|PMID:12657651
Molecular Function	GO:0070888	E-box binding	Bhlhe41	IDA		Mouse	MGI:MGI:5297789|PMID:15147242
Molecular Function	GO:0070888	E-box binding	Bhlhe41	IDA		Mouse	MGI:MGI:2388855|PMID:12397359
Molecular Function	GO:0070888	E-box binding	Bhlhe41	IDA		Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:0042826	histone deacetylase binding	Bhlhe41	IDA		Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:0043426	MRF binding	Bhlhe41	IDA		Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:0043426	MRF binding	Bhlhe41	IDA		Mouse	MGI:MGI:5297791|PMID:12657651
Molecular Function	GO:0005515	protein binding	BHLHE41	IPI	UniProtKB:P19793	Human	PMID:19786558
Molecular Function	GO:0005515	protein binding	BHLHE41	IPI	UniProtKB:Q16665	Human	PMID:22801492
Molecular Function	GO:0005515	protein binding	Bhlhe41	IPI	UniProtKB:Q3TQ03	Mouse	MGI:MGI:5568140|PMID:24736997
Molecular Function	GO:0005515	protein binding	Bhlhe41	IPI	UniProtKB:P25789|UniProtKB:Q16665	Mouse	MGI:MGI:5914565|PMID:22801492
Molecular Function	GO:0005515	protein binding	Bhlhe41	IPI	UniProtKB:P28033	Mouse	MGI:MGI:5508587|PMID:19029947
Molecular Function	GO:0005515	protein binding	Bhlhe41	IPI	UniProtKB:P22361	Mouse	MGI:MGI:6282985|PMID:30555544
Molecular Function	GO:0005515	protein binding	Bhlhe41	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:2388855|PMID:12397359
Molecular Function	GO:0005515	protein binding	Bhlhe41	IPI	PR:P10085	Mouse	PMID:17487425
Molecular Function	GO:0046982	protein heterodimerization activity	BHLHE41	IPI	UniProtKB:O14503	Human	PMID:15193144
Molecular Function	GO:0046982	protein heterodimerization activity	Bhlhe41	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:2388855|PMID:12397359
Molecular Function	GO:0046982	protein heterodimerization activity	Bhlhe41	IPI	UniProtKB:O14503	Mouse	MGI:MGI:5306311|PMID:15560782
Molecular Function	GO:0042803	protein homodimerization activity	Bhlhe41	IPI	UniProtKB:Q99PV5	Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Bhlhe41	IDA		Mouse	MGI:MGI:5297791|PMID:12657651
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Bhlhe41	IDA		Mouse	MGI:MGI:5297789|PMID:15147242
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Bhlhe41	IDA		Mouse	MGI:MGI:5306297|PMID:17487425
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Bhlhe41	IPI	UniProtKB:O89090	Mouse	MGI:MGI:5297791|PMID:12657651
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	BHLHE41	IDA		Human	PMID:28473536
Biological Process	GO:0032922	circadian regulation of gene expression	Bhlhe41	IMP		Mouse	MGI:MGI:3798698|PMID:18411297
Biological Process	GO:0007623	circadian rhythm	Bhlhe41	IEP		Mouse	MGI:MGI:5574300|PMID:19786558
Biological Process	GO:0007623	circadian rhythm	Bhlhe41	IEP		Rat	PMID:12397359|RGD:625726
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Bhlhe41	IDA		Mouse	MGI:MGI:5568140|PMID:24736997
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Bhlhe41	IDA		Mouse	MGI:MGI:2388855|PMID:12397359
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	bhlhe41	IDA		Zfish	PMID:17097613
Biological Process	GO:0010832	negative regulation of myotube differentiation	Bhlhe41	IDA		Mouse	MGI:MGI:5297791|PMID:12657651
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	Bhlhe41	IDA		Mouse	MGI:MGI:5297791|PMID:12657651
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	BHLHE41	IDA		Human	PMID:14672706
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	BHLHE41	IDA		Human	PMID:15193144
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bhlhe41	IDA		Mouse	MGI:MGI:2388855|PMID:12397359
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	Bhlhe41	IEP		Rat	PMID:9532582|RGD:68312
Biological Process	GO:0009409	response to cold	bhlhe41	IDA		Zfish	PMID:27846817
Biological Process	GO:0030431	sleep	bhlhe41	IMP	ZFIN:ZDB-MRPHLNO-170615-1	Zfish	PMID:28223099

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern