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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Bin1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bin1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0051015actin filament bindingBIN1IDAHumanPMID:26506308
Molecular FunctionGO:0019828aspartic-type endopeptidase inhibitor activityBIN1IMPHumanPMID:27179792
Molecular FunctionGO:0019828aspartic-type endopeptidase inhibitor activityBin1IMPMouseMGI:MGI:5811968|PMID:27179792
Molecular FunctionGO:0051020GTPase bindingBin1IPIRGD:71096RatPMID:9348539|RGD:631926
Molecular FunctionGO:0042802identical protein bindingBIN1IPIUniProtKB:O00499HumanPMID:23917616
Molecular FunctionGO:0042802identical protein bindingBIN1IPIUniProtKB:O00499HumanPMID:31413325
Molecular FunctionGO:0002020protease bindingBIN1IPIUniProtKB:P56817HumanPMID:27179792
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:Q9UBW5HumanPMID:10903846
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:P27958:PRO_0000037576HumanPMID:12604805
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:O95219HumanPMID:12668730
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:P09467HumanPMID:16275660
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:Q13426HumanPMID:16275660
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:Q9Y2H0HumanPMID:16275660
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:P27958:PRO_0000037576HumanPMID:16530520
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:Q9WMX2:PRO_0000037551HumanPMID:16530520
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:P50570HumanPMID:17676042
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:Q8NFH8HumanPMID:18647389
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:Q9WMX2:PRO_0000037551HumanPMID:18985028
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:P30622HumanPMID:19004523
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:Q13496HumanPMID:23917616
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:Q9WMX2:PRO_0000037551HumanPMID:24169621
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:P30622HumanPMID:26506308
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:Q8WXH0HumanPMID:26506308
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:O95219HumanPMID:31413325
Molecular FunctionGO:0005515protein bindingBIN1IPIUniProtKB:Q8TB24HumanPMID:32552912
Molecular FunctionGO:0005515protein bindingBin1IPIUniProtKB:Q9Z2C5MouseMGI:MGI:5528957|PMID:23917616
Molecular FunctionGO:0005515protein bindingBin1IPIUniProtKB:P10637MouseMGI:MGI:5516177|PMID:23399914
Molecular FunctionGO:0005515protein bindingBin1IPIUniProtKB:P01106MousePMID:8782822
Molecular FunctionGO:0005515protein bindingBin1IPIUniProtKB:Q9CR95RatPMID:17762867|RGD:8554310
Molecular FunctionGO:0005515protein bindingBin1IPIUniProtKB:Q9CR95RatPMID:24130457|RGD:13432276
Molecular FunctionGO:0005515protein bindingBin1IPIUniProtKB:O08838RatPMID:9348539|RGD:631926
Molecular FunctionGO:0005515protein bindingBin1IPIUniProtKB:P21575RatPMID:9348539|RGD:631926
Molecular FunctionGO:0044877protein-containing complex bindingBin1IPIRGD:620274RatPMID:9348539|RGD:631926
Molecular FunctionGO:0044877protein-containing complex bindingBin1IPIRGD:620274|RGD:71096RatPMID:9348539|RGD:631926
Molecular FunctionGO:0051087protein-folding chaperone bindingBIN1IPIUniProtKB:P10909HumanPMID:25051234
Molecular FunctionGO:0070063RNA polymerase bindingBIN1IPIUniProtKB:P27958:PRO_0000037576HumanPMID:16530520
Molecular FunctionGO:0070063RNA polymerase bindingBIN1IPIUniProtKB:Q9WMX2:PRO_0000037551HumanPMID:16530520
Molecular FunctionGO:0048156tau protein bindingBIN1IPIUniProtKB:P10636HumanPMID:23399914
Molecular FunctionGO:0048156tau protein bindingBIN1IPIUniProtKB:P10636HumanPMID:25051234
Molecular FunctionGO:0048156tau protein bindingBin1IPIUniProtKB:P10637MouseMGI:MGI:5516177|PMID:23399914
Cellular ComponentGO:0030424axonBIN1IDAHumanPMID:23399914
Cellular ComponentGO:0030424axonBin1IDAMouseMGI:MGI:6478068|PMID:32552912
Cellular ComponentGO:0043194axon initial segmentBin1IDARatPMID:9182667|RGD:8553847
Cellular ComponentGO:0043679axon terminusBin1IDARatPMID:9348539|RGD:631926
Cellular ComponentGO:0044300cerebellar mossy fiberBin1IDARatPMID:9348539|RGD:631926
Cellular ComponentGO:0005737cytoplasmBIN1IDAHumanGO_REF:0000054
Cellular ComponentGO:0005737cytoplasmBIN1IDAHumanPMID:25051234
Cellular ComponentGO:0005856cytoskeletonBIN1IDAHumanPMID:25051234
Cellular ComponentGO:0005829cytosolBIN1IDAHumanGO_REF:0000052
Cellular ComponentGO:0030425dendriteBin1IDAMouseMGI:MGI:6478068|PMID:32552912
Cellular ComponentGO:0098850extrinsic component of synaptic vesicle membraneBin1IDARatPMID:9348539|RGD:631926
Cellular ComponentGO:0098978glutamatergic synapseBin1IDAMousePMID:11879655
Cellular ComponentGO:0098978glutamatergic synapseBin1IMPMousePMID:11879655
Cellular ComponentGO:0098978glutamatergic synapseBin1IDARatPMID:9348539|RGD:631926
Cellular ComponentGO:0031674I bandBin1IDARatPMID:9182667|RGD:8553847
Cellular ComponentGO:0060987lipid tubeBIN1IMPHumanPMID:19004523
Cellular ComponentGO:0016020membraneBIN1IDAHumanPMID:16530520
Cellular ComponentGO:0016020membraneBIN1IDAHumanPMID:25051234
Cellular ComponentGO:0033268node of RanvierBin1IDARatPMID:9182667|RGD:8553847
Cellular ComponentGO:0005635nuclear envelopeBin1IDAMouseMGI:MGI:5770026|PMID:26506308
Cellular ComponentGO:0005634nucleusBIN1IDAHumanPMID:25051234
Cellular ComponentGO:0005634nucleusBIN1IDAHumanPMID:8782822
Cellular ComponentGO:0005634nucleusBin1IDAMousePMID:8782822
Cellular ComponentGO:0090571RNA polymerase II transcription repressor complexBIN1IPIHumanPMID:15992821
Cellular ComponentGO:0045202synapseBin1IDAMousePMID:24534009
Cellular ComponentGO:0045202synapseBin1EXPMousePMID:24534009
Cellular ComponentGO:0008021synaptic vesicleBin1IDARatPMID:9348539|RGD:631926
Cellular ComponentGO:0030315T-tubuleBin1IDAMouseMGI:MGI:5583915|PMID:24836577
Cellular ComponentGO:0030315T-tubuleBin1IDARatPMID:9182667|RGD:8553847
Cellular ComponentGO:0043196varicosityBin1IDARatPMID:9348539|RGD:631926
Cellular ComponentGO:0031982vesicleBin1IDAMouseMGI:MGI:6478068|PMID:32552912
Cellular ComponentGO:0030018Z discBin1IDARatPMID:9182667|RGD:8553847
Biological ProcessGO:0060048cardiac muscle contractionbin1bIMPZFIN:ZDB-MRPHLNO-120925-2ZfishPMID:22138472
Biological ProcessGO:0008333endosome to lysosome transportBIN1IMPHumanPMID:27179792
Biological ProcessGO:0060988lipid tube assemblyBIN1IMPHumanPMID:19004523
Biological ProcessGO:0042692muscle cell differentiationBin1IMPMousePMID:10036185
Biological ProcessGO:1902430negative regulation of amyloid-beta formationBIN1IMPHumanPMID:27179792
Biological ProcessGO:1902430negative regulation of amyloid-beta formationBin1IMPMouseMGI:MGI:5811968|PMID:27179792
Biological ProcessGO:1902960negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic processBIN1IMPHumanPMID:27179792
Biological ProcessGO:1902960negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic processBin1IMPMouseMGI:MGI:5811968|PMID:27179792
Biological ProcessGO:1904878negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channelBin1IMPMouseMGI:MGI:5583915|PMID:24836577
Biological ProcessGO:1901380negative regulation of potassium ion transmembrane transportBin1IMPMouseMGI:MGI:5583915|PMID:24836577
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIBIN1IDAHumanPMID:10412034
Biological ProcessGO:1903946negative regulation of ventricular cardiac muscle cell action potentialBin1IMPMouseMGI:MGI:5583915|PMID:24836577
Biological ProcessGO:0051647nucleus localizationBin1IMPMouseMGI:MGI:5770026|PMID:26506308
Biological ProcessGO:0006997nucleus organizationBIN1IMPHumanPMID:26506308
Biological ProcessGO:0030838positive regulation of actin filament polymerizationBin1IDAMouseMGI:MGI:5583915|PMID:24836577
Biological ProcessGO:0043065positive regulation of apoptotic processBIN1IMPHumanPMID:10412034
Biological ProcessGO:0043065positive regulation of apoptotic processBIN1IDAHumanPMID:16530520
Biological ProcessGO:0048711positive regulation of astrocyte differentiationBIN1IMPHumanPMID:10412034
Biological ProcessGO:0045807positive regulation of endocytosisBin1IMPRatPMID:9348539|RGD:631926
Biological ProcessGO:0043547positive regulation of GTPase activityBin1IDARatPMID:9348539|RGD:631926
Biological ProcessGO:0010564regulation of cell cycle processBIN1IDAHumanPMID:8782822
Biological ProcessGO:0086091regulation of heart rate by cardiac conductionBin1IMPMouseMGI:MGI:5583915|PMID:24836577
Biological ProcessGO:0045664regulation of neuron differentiationBIN1IMPHumanPMID:10412034
Biological ProcessGO:0048488synaptic vesicle endocytosisBin1IMPMousePMID:11879655
Biological ProcessGO:0048488synaptic vesicle endocytosisBin1IDAMousePMID:11879655
Biological ProcessGO:0048488synaptic vesicle endocytosisBin1IDARatPMID:9348539|RGD:631926
Biological ProcessGO:0048488synaptic vesicle endocytosisBin1IMPRatPMID:9348539|RGD:631926
Biological ProcessGO:0033292T-tubule organizationBIN1IDAHumanPMID:24755653
Biological ProcessGO:0033292T-tubule organizationBin1IMPMouseMGI:MGI:5583915|PMID:24836577

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory