Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Bin1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes BIN1
- Mouse genes Bin1
- Rat genes Bin1
- Zfish genes bin1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bin1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	BIN1	IDA		Human	PMID:26506308
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	BIN1	IMP		Human	PMID:27179792
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	Bin1	IMP		Mouse	MGI:MGI:5811968\|PMID:27179792
Molecular Function	GO:0051020	GTPase binding	Bin1	IPI	RGD:71096	Rat	PMID:9348539\|RGD:631926
Molecular Function	GO:0042802	identical protein binding	BIN1	IPI	UniProtKB:O00499	Human	PMID:23917616
Molecular Function	GO:0042802	identical protein binding	BIN1	IPI	UniProtKB:O00499	Human	PMID:31413325
Molecular Function	GO:0002020	protease binding	BIN1	IPI	UniProtKB:P56817	Human	PMID:27179792
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:Q9UBW5	Human	PMID:10903846
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:12604805
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:O95219	Human	PMID:12668730
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:P09467	Human	PMID:16275660
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:Q13426	Human	PMID:16275660
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:Q9Y2H0	Human	PMID:16275660
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:16530520
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:Q9WMX2:PRO_0000037551	Human	PMID:16530520
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:P50570	Human	PMID:17676042
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:Q8NFH8	Human	PMID:18647389
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:Q9WMX2:PRO_0000037551	Human	PMID:18985028
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:P30622	Human	PMID:19004523
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:Q13496	Human	PMID:23917616
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:Q9WMX2:PRO_0000037551	Human	PMID:24169621
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:P30622	Human	PMID:26506308
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:Q8WXH0	Human	PMID:26506308
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:O95219	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	BIN1	IPI	UniProtKB:Q8TB24	Human	PMID:32552912
Molecular Function	GO:0005515	protein binding	Bin1	IPI	UniProtKB:Q9Z2C5	Mouse	MGI:MGI:5528957\|PMID:23917616
Molecular Function	GO:0005515	protein binding	Bin1	IPI	UniProtKB:P10637	Mouse	MGI:MGI:5516177\|PMID:23399914
Molecular Function	GO:0005515	protein binding	Bin1	IPI	UniProtKB:P01106	Mouse	PMID:8782822
Molecular Function	GO:0005515	protein binding	Bin1	IPI	UniProtKB:Q9CR95	Rat	PMID:17762867\|RGD:8554310
Molecular Function	GO:0005515	protein binding	Bin1	IPI	UniProtKB:Q9CR95	Rat	PMID:24130457\|RGD:13432276
Molecular Function	GO:0005515	protein binding	Bin1	IPI	UniProtKB:O08838	Rat	PMID:9348539\|RGD:631926
Molecular Function	GO:0005515	protein binding	Bin1	IPI	UniProtKB:P21575	Rat	PMID:9348539\|RGD:631926
Molecular Function	GO:0044877	protein-containing complex binding	Bin1	IPI	RGD:620274	Rat	PMID:9348539\|RGD:631926
Molecular Function	GO:0044877	protein-containing complex binding	Bin1	IPI	RGD:620274\|RGD:71096	Rat	PMID:9348539\|RGD:631926
Molecular Function	GO:0051087	protein-folding chaperone binding	BIN1	IPI	UniProtKB:P10909	Human	PMID:25051234
Molecular Function	GO:0070063	RNA polymerase binding	BIN1	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:16530520
Molecular Function	GO:0070063	RNA polymerase binding	BIN1	IPI	UniProtKB:Q9WMX2:PRO_0000037551	Human	PMID:16530520
Molecular Function	GO:0048156	tau protein binding	BIN1	IPI	UniProtKB:P10636	Human	PMID:23399914
Molecular Function	GO:0048156	tau protein binding	BIN1	IPI	UniProtKB:P10636	Human	PMID:25051234
Molecular Function	GO:0048156	tau protein binding	Bin1	IPI	UniProtKB:P10637	Mouse	MGI:MGI:5516177\|PMID:23399914
Cellular Component	GO:0030424	axon	BIN1	IDA		Human	PMID:23399914
Cellular Component	GO:0030424	axon	Bin1	IDA		Mouse	MGI:MGI:6478068\|PMID:32552912
Cellular Component	GO:0043194	axon initial segment	Bin1	IDA		Rat	PMID:9182667\|RGD:8553847
Cellular Component	GO:0043679	axon terminus	Bin1	IDA		Rat	PMID:9348539\|RGD:631926
Cellular Component	GO:0044300	cerebellar mossy fiber	Bin1	IDA		Rat	PMID:9348539\|RGD:631926
Cellular Component	GO:0005737	cytoplasm	BIN1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	BIN1	IDA		Human	PMID:25051234
Cellular Component	GO:0005856	cytoskeleton	BIN1	IDA		Human	PMID:25051234
Cellular Component	GO:0005829	cytosol	BIN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Bin1	IDA		Mouse	MGI:MGI:6478068\|PMID:32552912
Cellular Component	GO:0098850	extrinsic component of synaptic vesicle membrane	Bin1	IDA		Rat	PMID:9348539\|RGD:631926
Cellular Component	GO:0098978	glutamatergic synapse	Bin1	IDA		Mouse	PMID:11879655
Cellular Component	GO:0098978	glutamatergic synapse	Bin1	IMP		Mouse	PMID:11879655
Cellular Component	GO:0098978	glutamatergic synapse	Bin1	IDA		Rat	PMID:9348539\|RGD:631926
Cellular Component	GO:0031674	I band	Bin1	IDA		Rat	PMID:9182667\|RGD:8553847
Cellular Component	GO:0060987	lipid tube	BIN1	IMP		Human	PMID:19004523
Cellular Component	GO:0016020	membrane	BIN1	IDA		Human	PMID:16530520
Cellular Component	GO:0016020	membrane	BIN1	IDA		Human	PMID:25051234
Cellular Component	GO:0033268	node of Ranvier	Bin1	IDA		Rat	PMID:9182667\|RGD:8553847
Cellular Component	GO:0005635	nuclear envelope	Bin1	IDA		Mouse	MGI:MGI:5770026\|PMID:26506308
Cellular Component	GO:0005634	nucleus	BIN1	IDA		Human	PMID:25051234
Cellular Component	GO:0005634	nucleus	BIN1	IDA		Human	PMID:8782822
Cellular Component	GO:0005634	nucleus	Bin1	IDA		Mouse	PMID:8782822
Cellular Component	GO:0090571	RNA polymerase II transcription repressor complex	BIN1	IPI		Human	PMID:15992821
Cellular Component	GO:0045202	synapse	Bin1	IDA		Mouse	PMID:24534009
Cellular Component	GO:0045202	synapse	Bin1	EXP		Mouse	PMID:24534009
Cellular Component	GO:0008021	synaptic vesicle	Bin1	IDA		Rat	PMID:9348539\|RGD:631926
Cellular Component	GO:0030315	T-tubule	Bin1	IDA		Mouse	MGI:MGI:5583915\|PMID:24836577
Cellular Component	GO:0030315	T-tubule	Bin1	IDA		Rat	PMID:9182667\|RGD:8553847
Cellular Component	GO:0043196	varicosity	Bin1	IDA		Rat	PMID:9348539\|RGD:631926
Cellular Component	GO:0031982	vesicle	Bin1	IDA		Mouse	MGI:MGI:6478068\|PMID:32552912
Cellular Component	GO:0030018	Z disc	Bin1	IDA		Rat	PMID:9182667\|RGD:8553847
Biological Process	GO:0060048	cardiac muscle contraction	bin1b	IMP	ZFIN:ZDB-MRPHLNO-120925-2	Zfish	PMID:22138472
Biological Process	GO:0008333	endosome to lysosome transport	BIN1	IMP		Human	PMID:27179792
Biological Process	GO:0060988	lipid tube assembly	BIN1	IMP		Human	PMID:19004523
Biological Process	GO:0042692	muscle cell differentiation	Bin1	IMP		Mouse	PMID:10036185
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	BIN1	IMP		Human	PMID:27179792
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	Bin1	IMP		Mouse	MGI:MGI:5811968\|PMID:27179792
Biological Process	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	BIN1	IMP		Human	PMID:27179792
Biological Process	GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	Bin1	IMP		Mouse	MGI:MGI:5811968\|PMID:27179792
Biological Process	GO:1904878	negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	Bin1	IMP		Mouse	MGI:MGI:5583915\|PMID:24836577
Biological Process	GO:1901380	negative regulation of potassium ion transmembrane transport	Bin1	IMP		Mouse	MGI:MGI:5583915\|PMID:24836577
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	BIN1	IDA		Human	PMID:10412034
Biological Process	GO:1903946	negative regulation of ventricular cardiac muscle cell action potential	Bin1	IMP		Mouse	MGI:MGI:5583915\|PMID:24836577
Biological Process	GO:0051647	nucleus localization	Bin1	IMP		Mouse	MGI:MGI:5770026\|PMID:26506308
Biological Process	GO:0006997	nucleus organization	BIN1	IMP		Human	PMID:26506308
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Bin1	IDA		Mouse	MGI:MGI:5583915\|PMID:24836577
Biological Process	GO:0043065	positive regulation of apoptotic process	BIN1	IMP		Human	PMID:10412034
Biological Process	GO:0043065	positive regulation of apoptotic process	BIN1	IDA		Human	PMID:16530520
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	BIN1	IMP		Human	PMID:10412034
Biological Process	GO:0045807	positive regulation of endocytosis	Bin1	IMP		Rat	PMID:9348539\|RGD:631926
Biological Process	GO:0043547	positive regulation of GTPase activity	Bin1	IDA		Rat	PMID:9348539\|RGD:631926
Biological Process	GO:0010564	regulation of cell cycle process	BIN1	IDA		Human	PMID:8782822
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	Bin1	IMP		Mouse	MGI:MGI:5583915\|PMID:24836577
Biological Process	GO:0045664	regulation of neuron differentiation	BIN1	IMP		Human	PMID:10412034
Biological Process	GO:0048488	synaptic vesicle endocytosis	Bin1	IMP		Mouse	PMID:11879655
Biological Process	GO:0048488	synaptic vesicle endocytosis	Bin1	IDA		Mouse	PMID:11879655
Biological Process	GO:0048488	synaptic vesicle endocytosis	Bin1	IDA		Rat	PMID:9348539\|RGD:631926
Biological Process	GO:0048488	synaptic vesicle endocytosis	Bin1	IMP		Rat	PMID:9348539\|RGD:631926
Biological Process	GO:0033292	T-tubule organization	BIN1	IDA		Human	PMID:24755653
Biological Process	GO:0033292	T-tubule organization	Bin1	IMP		Mouse	MGI:MGI:5583915\|PMID:24836577

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.