Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BLM
  • Mouse genes Blm
  • Rat genes Blm
  • Zfish genes blm
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Blm

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043138	3'-5' DNA helicase activity	Blm	IDA		Mouse	PMID:9840919
Molecular Function	GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	BLM	IDA		Human	PMID:19734539
Molecular Function	GO:0005524	ATP binding	BLM	IDA		Human	PMID:24816114
Molecular Function	GO:0005524	ATP binding	BLM	IDA		Human	PMID:25901030
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	BLM	IDA		Human	PMID:10359700
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	BLM	IDA		Human	PMID:24816114
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	BLM	IDA		Human	PMID:25901030
Molecular Function	GO:0000405	bubble DNA binding	BLM	IDA		Human	PMID:11433031
Molecular Function	GO:0000405	bubble DNA binding	BLM	IDA		Human	PMID:11735402
Molecular Function	GO:0003677	DNA binding	BLM	IDA		Human	PMID:24257077
Molecular Function	GO:0003677	DNA binding	BLM	IDA		Human	PMID:24816114
Molecular Function	GO:0003678	DNA helicase activity	BLM	IDA		Human	PMID:12181313
Molecular Function	GO:0003678	DNA helicase activity	BLM	IDA		Human	PMID:12818200
Molecular Function	GO:0003678	DNA helicase activity	BLM	IDA		Human	PMID:17878217
Molecular Function	GO:0003678	DNA helicase activity	BLM	IDA		Human	PMID:19734539
Molecular Function	GO:0003678	DNA helicase activity	BLM	IMP		Human	PMID:21325134
Molecular Function	GO:0003678	DNA helicase activity	BLM	IDA		Human	PMID:24816114
Molecular Function	GO:0003678	DNA helicase activity	BLM	IDA		Human	PMID:25901030
Molecular Function	GO:0003678	DNA helicase activity	BLM	IDA		Human	PMID:9388193
Molecular Function	GO:1990814	DNA/DNA annealing activity	BLM	IDA		Human	PMID:17878217
Molecular Function	GO:0061749	forked DNA-dependent helicase activity	BLM	IDA		Human	PMID:11735402
Molecular Function	GO:0061749	forked DNA-dependent helicase activity	BLM	IDA		Human	PMID:25901030
Molecular Function	GO:0000400	four-way junction DNA binding	BLM	IDA		Human	PMID:11735402
Molecular Function	GO:0000400	four-way junction DNA binding	BLM	IDA		Human	PMID:20639533
Molecular Function	GO:0000400	four-way junction DNA binding	BLM	IDA		Human	PMID:25901030
Molecular Function	GO:0009378	four-way junction helicase activity	BLM	IDA		Human	PMID:11433031
Molecular Function	GO:0009378	four-way junction helicase activity	BLM	IDA		Human	PMID:11735402
Molecular Function	GO:0009378	four-way junction helicase activity	BLM	IDA		Human	PMID:12818200
Molecular Function	GO:0009378	four-way junction helicase activity	BLM	IDA		Human	PMID:25901030
Molecular Function	GO:0051880	G-quadruplex DNA binding	BLM	IDA		Human	PMID:11433031
Molecular Function	GO:0051880	G-quadruplex DNA binding	BLM	IDA		Human	PMID:11735402
Molecular Function	GO:0004386	helicase activity	BLM	IDA		Human	PMID:10871376
Molecular Function	GO:0042802	identical protein binding	BLM	IDA		Human	PMID:10359700
Molecular Function	GO:0140677	molecular function activator activity	BLM	IDA		Human	PMID:24257077
Molecular Function	GO:0002039	p53 binding	BLM	IPI	UniProtKB:P04637	Human	PMID:11781842
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q13472	Human	PMID:10728666
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:P27694	Human	PMID:10825162
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q06609	Human	PMID:11309417
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q14191	Human	PMID:11919194
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q15554	Human	PMID:12181313
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:O75771	Human	PMID:12975363
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:P39748	Human	PMID:14688284
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:P54274	Human	PMID:15229185
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q15554	Human	PMID:15229185
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:P27694	Human	PMID:15775963
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q13472	Human	PMID:15775963
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q9H9A7	Human	PMID:15775963
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:P27694	Human	PMID:15965237
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q9NUX5	Human	PMID:16030011
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:P42677	Human	PMID:16864798
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:P53350	Human	PMID:16864798
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q8IYB8	Human	PMID:17961633
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q13472	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q9H9A7	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q13472	Human	PMID:20711169
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q9H9A7	Human	PMID:20711169
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q9H9A7	Human	PMID:20826342
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q9BX63	Human	PMID:21240188
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:P51530	Human	PMID:21325134
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q13472	Human	PMID:23509288
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q14159	Human	PMID:23509288
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q9H9A7	Human	PMID:23509288
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q96RL1	Human	PMID:23708797
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:P27694	Human	PMID:24126761
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q13472	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q9H9A7	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	BLM	IPI	UniProtKB:Q9BQ15	Human	PMID:28506294
Molecular Function	GO:0005515	protein binding	Blm	IPI	UniProtKB:Q61510|UniProtKB:Q9CWE6|UniProtKB:Q9CWU5	Mouse	MGI:MGI:6467697|PMID:29125140
Molecular Function	GO:0005515	protein binding	Blm	IPI	PR:P70399	Mouse	PMID:15364958
Molecular Function	GO:0005515	protein binding	Blm	IPI	PR:O35280	Mouse	PMID:15364958
Molecular Function	GO:0042803	protein homodimerization activity	BLM	IDA		Human	PMID:28228481
Molecular Function	GO:0003697	single-stranded DNA binding	BLM	IDA		Human	PMID:12818200
Molecular Function	GO:0003697	single-stranded DNA binding	BLM	IDA		Human	PMID:20639533
Molecular Function	GO:0061821	telomeric D-loop binding	BLM	IDA		Human	PMID:19734539
Molecular Function	GO:0061849	telomeric G-quadruplex DNA binding	BLM	IDA		Human	PMID:19734539
Molecular Function	GO:0000403	Y-form DNA binding	BLM	IDA		Human	PMID:11735402
Molecular Function	GO:0008270	zinc ion binding	BLM	IDA		Human	PMID:24816114
Molecular Function	GO:0008270	zinc ion binding	BLM	IDA		Human	PMID:25901030
Cellular Component	GO:0000781	chromosome, telomeric region	BLM	IDA		Human	PMID:10779560
Cellular Component	GO:0000781	chromosome, telomeric region	Blm	IMP		Mouse	MGI:MGI:5700122|PMID:26195664
Cellular Component	GO:0005737	cytoplasm	Blm	IDA		Mouse	PMID:17982445
Cellular Component	GO:0005829	cytosol	BLM	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000800	lateral element	BLM	IDA		Human	PMID:10728666
Cellular Component	GO:0001673	male germ cell nucleus	Blm	IDA		Mouse	PMID:17696610
Cellular Component	GO:0000228	nuclear chromosome	BLM	IDA		Human	PMID:23509288
Cellular Component	GO:0016363	nuclear matrix	BLM	IDA		Human	PMID:11309417
Cellular Component	GO:0005730	nucleolus	BLM	IDA		Human	PMID:10779560
Cellular Component	GO:0005654	nucleoplasm	BLM	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	BLM	IDA		Human	PMID:11500040
Cellular Component	GO:0005634	nucleus	BLM	IDA		Human	PMID:9388480
Cellular Component	GO:0005634	nucleus	Blm	IDA		Mouse	MGI:MGI:6467697|PMID:29125140
Cellular Component	GO:0016605	PML body	BLM	IDA		Human	PMID:10779560
Cellular Component	GO:0016605	PML body	BLM	IDA		Human	PMID:10728666
Cellular Component	GO:0045120	pronucleus	Blm	IDA		Mouse	PMID:17982445
Cellular Component	GO:0032991	protein-containing complex	BLM	IDA		Human	PMID:10359700
Cellular Component	GO:0031422	RecQ family helicase-topoisomerase III complex	BLM	IPI		Human	PMID:24984776
Cellular Component	GO:0005657	replication fork	Blm	IMP		Mouse	MGI:MGI:5700122|PMID:26195664
Cellular Component	GO:0005657	replication fork	Blm	IDA		Mouse	PMID:15364958
Biological Process	GO:0046632	alpha-beta T cell differentiation	Blm	IMP	MGI:MGI:3663359	Mouse	PMID:17210642
Biological Process	GO:0046632	alpha-beta T cell differentiation	Blm	IMP	MGI:MGI:3053044	Mouse	PMID:17210642
Biological Process	GO:0046633	alpha-beta T cell proliferation	Blm	IMP	MGI:MGI:3053044	Mouse	PMID:17210642
Biological Process	GO:0046633	alpha-beta T cell proliferation	Blm	IMP	MGI:MGI:3663359	Mouse	PMID:17210642
Biological Process	GO:0072757	cellular response to camptothecin	BLM	IDA		Human	PMID:23509288
Biological Process	GO:0072711	cellular response to hydroxyurea	BLM	IDA		Human	PMID:23509288
Biological Process	GO:0071479	cellular response to ionizing radiation	BLM	IDA		Human	PMID:23509288
Biological Process	GO:1901655	cellular response to ketone	Blm	IGI	MGI:MGI:2448558	Mouse	PMID:25520194
Biological Process	GO:0071407	cellular response to organic cyclic compound	Blm	IGI	MGI:MGI:2448558	Mouse	PMID:25520194
Biological Process	GO:0071417	cellular response to organonitrogen compound	Blm	IGI	MGI:MGI:2448558	Mouse	PMID:25520194
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Blm	IGI	MGI:MGI:2448558	Mouse	PMID:25520194
Biological Process	GO:0051276	chromosome organization	Blm	IMP	MGI:MGI:1857708	Mouse	PMID:9808625
Biological Process	GO:0051276	chromosome organization	Blm	IMP	MGI:MGI:2158670	Mouse	PMID:15450411
Biological Process	GO:1904157	DN4 thymocyte differentiation	Blm	IMP	MGI:MGI:3663359	Mouse	PMID:17210642
Biological Process	GO:1904157	DN4 thymocyte differentiation	Blm	IMP	MGI:MGI:3053044	Mouse	PMID:17210642
Biological Process	GO:0006974	DNA damage response	BLM	IMP		Human	PMID:12818200
Biological Process	GO:0006974	DNA damage response	BLM	IDA		Human	PMID:23509288
Biological Process	GO:0000729	DNA double-strand break processing	BLM	IDA		Human	PMID:21325134
Biological Process	GO:0032508	DNA duplex unwinding	BLM	IDA		Human	PMID:11735402
Biological Process	GO:0032508	DNA duplex unwinding	BLM	IDA		Human	PMID:24816114
Biological Process	GO:0032508	DNA duplex unwinding	BLM	IDA		Human	PMID:25901030
Biological Process	GO:0006281	DNA repair	Blm	IDA		Mouse	PMID:15364958
Biological Process	GO:0006260	DNA replication	Blm	IMP		Mouse	MGI:MGI:5700122|PMID:26195664
Biological Process	GO:0006260	DNA replication	Blm	IGI	UniProtKB:O09053	Mouse	MGI:MGI:5700122|PMID:26195664
Biological Process	GO:0000724	double-strand break repair via homologous recombination	BLM	IDA		Human	PMID:23543748
Biological Process	GO:0044806	G-quadruplex DNA unwinding	BLM	IDA		Human	PMID:11735402
Biological Process	GO:0044806	G-quadruplex DNA unwinding	Blm	IGI	UniProtKB:O09053	Mouse	MGI:MGI:5700122|PMID:26195664
Biological Process	GO:0044806	G-quadruplex DNA unwinding	Blm	IMP		Mouse	MGI:MGI:5700122|PMID:26195664
Biological Process	GO:0007281	germ cell development	blm	IMP	ZFIN:ZDB-GENO-221206-7	Zfish	PMID:35436990
Biological Process	GO:0007281	germ cell development	blm	IMP	ZFIN:ZDB-GENO-221205-2	Zfish	PMID:35436990
Biological Process	GO:0007281	germ cell development	blm	IMP	ZFIN:ZDB-GENO-221206-4	Zfish	PMID:35436990
Biological Process	GO:0007281	germ cell development	blm	IMP	ZFIN:ZDB-GENO-221206-2	Zfish	PMID:35436990
Biological Process	GO:0033080	immature T cell proliferation in thymus	Blm	IMP	MGI:MGI:3663359	Mouse	PMID:17210642
Biological Process	GO:0033080	immature T cell proliferation in thymus	Blm	IMP	MGI:MGI:3053044	Mouse	PMID:17210642
Biological Process	GO:0051321	meiotic cell cycle	blm	IMP	ZFIN:ZDB-GENO-221205-2	Zfish	PMID:35436990
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	BLM	IDA		Human	PMID:11309417
Biological Process	GO:0006312	mitotic recombination	Blm	IMP	MGI:MGI:2158669	Mouse	PMID:11101838
Biological Process	GO:0006312	mitotic recombination	Blm	IMP	MGI:MGI:2158670	Mouse	PMID:11101838
Biological Process	GO:0006312	mitotic recombination	Blm	IMP	MGI:MGI:3663359	Mouse	PMID:17210642
Biological Process	GO:0006312	mitotic recombination	Blm	IMP	MGI:MGI:3053044	Mouse	PMID:17210642
Biological Process	GO:0006312	mitotic recombination	Blm	IMP	MGI:MGI:1857708	Mouse	PMID:9808625
Biological Process	GO:0051782	negative regulation of cell division	BLM	IMP		Human	PMID:11781842
Biological Process	GO:0045910	negative regulation of DNA recombination	BLM	IMP		Human	PMID:9671747
Biological Process	GO:0045950	negative regulation of mitotic recombination	Blm	IMP		Mouse	MGI:MGI:5800654|PMID:27010503
Biological Process	GO:0045950	negative regulation of mitotic recombination	Blm	IGI	UniProtKB:A8VU90	Mouse	MGI:MGI:5800654|PMID:27010503
Biological Process	GO:0045950	negative regulation of mitotic recombination	Blm	IMP	MGI:MGI:1857708	Mouse	PMID:9808625
Biological Process	GO:0045950	negative regulation of mitotic recombination	Blm	IMP	MGI:MGI:2158670	Mouse	PMID:11101838
Biological Process	GO:0045950	negative regulation of mitotic recombination	Blm	IMP	MGI:MGI:1857708	Mouse	PMID:16914751
Biological Process	GO:0045950	negative regulation of mitotic recombination	Blm	IMP	MGI:MGI:3053044	Mouse	PMID:17210642
Biological Process	GO:0045950	negative regulation of mitotic recombination	Blm	IMP	MGI:MGI:2158669	Mouse	PMID:11101838
Biological Process	GO:0045950	negative regulation of mitotic recombination	Blm	IMP	MGI:MGI:3663359	Mouse	PMID:17210642
Biological Process	GO:0045950	negative regulation of mitotic recombination	blm	IMP		Zfish	PMID:17483412
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	Blm	IGI	MGI:MGI:98834	Mouse	PMID:11046052
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	Blm	IMP	MGI:MGI:2386448,MGI:MGI:3663359	Mouse	PMID:11046052
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	Blm	IMP	MGI:MGI:3663359	Mouse	PMID:17210642
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	Blm	IMP	MGI:MGI:3053044	Mouse	PMID:17210642
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	BLM	IDA		Human	PMID:11781842
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	Blm	IGI	MGI:MGI:2448558	Mouse	PMID:25520194
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	Blm	IMP	MGI:MGI:3053044	Mouse	PMID:17210642
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	Blm	IMP	MGI:MGI:3663359	Mouse	PMID:17210642
Biological Process	GO:0051259	protein complex oligomerization	BLM	IDA		Human	PMID:28228481
Biological Process	GO:0051260	protein homooligomerization	BLM	IDA		Human	PMID:28228481
Biological Process	GO:0051098	regulation of binding	Blm	IDA		Mouse	PMID:15364958
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	BLM	IMP		Human	PMID:15604258
Biological Process	GO:0090329	regulation of DNA-templated DNA replication	BLM	IMP		Human	PMID:25901030
Biological Process	GO:0031297	replication fork processing	BLM	IDA		Human	PMID:17115688
Biological Process	GO:0031297	replication fork processing	Blm	IMP		Mouse	MGI:MGI:6467697|PMID:29125140
Biological Process	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	Blm	IMP		Mouse	PMID:25597246
Biological Process	GO:0071139	resolution of recombination intermediates	BLM	IDA		Human	PMID:23543748
Biological Process	GO:0010165	response to X-ray	BLM	IDA		Human	PMID:11309417
Biological Process	GO:0000723	telomere maintenance	Blm	IGI	MGI:MGI:109635	Mouse	PMID:15367665
Biological Process	GO:0000723	telomere maintenance	Blm	IGI	MGI:MGI:109558	Mouse	PMID:15367665
Biological Process	GO:0061820	telomeric D-loop disassembly	BLM	IDA		Human	PMID:19734539

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern