Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BMP6
  • Mouse genes Bmp6
  • Rat genes Bmp6
  • Zfish genes bmp6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bmp6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070700	BMP receptor binding	BMP6	IDA		Human	PMID:7811286
Molecular Function	GO:0008083	growth factor activity	Bmp6	IDA		Rat	PMID:9168801|RGD:631742
Molecular Function	GO:0005515	protein binding	Bmp6	IPI	PR:Q8CJ69	Mouse	PMID:12897139
Molecular Function	GO:0005515	protein binding	Bmp6	IPI	UniProtKB:Q8CF09	Mouse	PMID:14623234
Molecular Function	GO:0005515	protein binding	Bmp6	IPI	PR:Q8VEA6	Mouse	PMID:14660436
Molecular Function	GO:0046982	protein heterodimerization activity	BMP6	IDA		Human	PMID:7811286
Cellular Component	GO:0005737	cytoplasm	Bmp6	IDA		Rat	PMID:15589212|RGD:2289014
Cellular Component	GO:0005615	extracellular space	Bmp6	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Bmp6	IDA		Rat	PMID:11245809|RGD:2289024
Cellular Component	GO:0005615	extracellular space	Bmp6	IDA		Rat	PMID:18758911|RGD:2301841
Cellular Component	GO:0031982	vesicle	Bmp6	IDA		Rat	PMID:18758911|RGD:2301841
Biological Process	GO:0030509	BMP signaling pathway	BMP6	IMP		Human	PMID:18326817
Biological Process	GO:0030509	BMP signaling pathway	BMP6	IDA		Human	PMID:18436533
Biological Process	GO:0030509	BMP signaling pathway	Bmp6	IMP		Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0030509	BMP signaling pathway	Bmp6	IDA		Mouse	PMID:19852960
Biological Process	GO:0030509	BMP signaling pathway	Bmp6	IDA		Mouse	PMID:14623234
Biological Process	GO:0060348	bone development	BMP6	IDA		Human	PMID:16798745
Biological Process	GO:0071773	cellular response to BMP stimulus	BMP6	IMP		Human	PMID:18326817
Biological Process	GO:0071281	cellular response to iron ion	Bmp6	IMP		Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0071260	cellular response to mechanical stimulus	Bmp6	IEP		Rat	PMID:23198877|RGD:7242187
Biological Process	GO:0001958	endochondral ossification	Bmp6	IMP	MGI:MGI:2136985	Mouse	PMID:9664685
Biological Process	GO:0001654	eye development	Bmp6	IGI	UniProtKB:P23359	Mouse	MGI:MGI:3610441|PMID:16154126
Biological Process	GO:0006955	immune response	BMP6	IMP		Human	PMID:16886151
Biological Process	GO:0006954	inflammatory response	Bmp6	IEP		Mouse	MGI:MGI:3693397|PMID:12151307
Biological Process	GO:0006879	intracellular iron ion homeostasis	Bmp6	IMP		Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0006879	intracellular iron ion homeostasis	Bmp6	IMP	MGI:MGI:2136985	Mouse	PMID:21703414
Biological Process	GO:0001822	kidney development	Bmp6	IGI	UniProtKB:P23359	Mouse	MGI:MGI:3610441|PMID:16154126
Biological Process	GO:0030539	male genitalia development	Bmp6	IGI	MGI:MGI:88181	Mouse	PMID:9664685
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	BMP6	IMP		Human	PMID:26582087
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	BMP6	IMP		Human	PMID:28335084
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	BMP6	IMP		Human	PMID:32464486
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Bmp6	IMP		Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:1903392	negative regulation of adherens junction organization	BMP6	IDA		Human	PMID:26598555
Biological Process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	BMP6	IDA		Human	PMID:26598555
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Bmp6	IMP		Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0030182	neuron differentiation	Bmp6	IMP	MGI:MGI:2159013	Mouse	PMID:14623245
Biological Process	GO:0001503	ossification	Bmp6	IDA		Rat	PMID:16761078|RGD:7242406
Biological Process	GO:0001649	osteoblast differentiation	Bmp6	IGI	MGI:MGI:88177	Mouse	PMID:16109715
Biological Process	GO:0001649	osteoblast differentiation	Bmp6	IEP		Rat	PMID:11995934|RGD:2289023
Biological Process	GO:0032349	positive regulation of aldosterone biosynthetic process	BMP6	IDA		Human	PMID:16527843
Biological Process	GO:2000860	positive regulation of aldosterone secretion	Bmp6	IDA		Rat	PMID:22538126|RGD:7242193
Biological Process	GO:0030501	positive regulation of bone mineralization	BMP6	IDA		Human	PMID:18436533
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	Bmp6	IDA		Rat	PMID:23077084|RGD:7242190
Biological Process	GO:0045603	positive regulation of endothelial cell differentiation	Bmp6	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Bmp6	IDA		Mouse	MGI:MGI:4830635|PMID:20406889
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	BMP6	IDA		Human	PMID:11865031
Biological Process	GO:0010628	positive regulation of gene expression	BMP6	IMP		Human	PMID:26598555
Biological Process	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	Bmp6	IMP		Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0045666	positive regulation of neuron differentiation	Bmp6	IDA		Mouse	PMID:9786991
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	BMP6	IDA		Human	PMID:18436533
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Bmp6	IMP		Rat	PMID:9202223|RGD:2289027
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	BMP6	IDA		Human	PMID:17244894
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	BMP6	IDA		Human	PMID:19366699
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	Bmp6	IMP		Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	BMP6	IDA		Human	PMID:26598555
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	Bmp6	IMP		Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	BMP6	IDA		Human	PMID:16527843
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	BMP6	IGI	UniProtKB:Q6ZVN8	Human	PMID:18326817
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Bmp6	IMP		Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0043117	positive regulation of vascular permeability	BMP6	IDA		Human	PMID:26598555
Biological Process	GO:0014823	response to activity	Bmp6	IEP		Rat	PMID:23198877|RGD:7242187
Biological Process	GO:0051384	response to glucocorticoid	Bmp6	IEP		Rat	PMID:9202223|RGD:2289027
Biological Process	GO:0010039	response to iron ion	Bmp6	IEP		Rat	PMID:21859731|RGD:7242407
Biological Process	GO:0032026	response to magnesium ion	Bmp6	IEP		Rat	PMID:21736832|RGD:7242408
Biological Process	GO:0032526	response to retinoic acid	Bmp6	IEP		Rat	PMID:8385738|RGD:2289028
Biological Process	GO:0060395	SMAD protein signal transduction	BMP6	IDA		Human	PMID:17244894
Biological Process	GO:0060395	SMAD protein signal transduction	Bmp6	IMP		Mouse	MGI:MGI:4352622|PMID:19252488
Biological Process	GO:0003323	type B pancreatic cell development	BMP6	IDA		Human	PMID:11865031

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern